Article
Chemistry, Physical
Weixiao Zhou, Yinling Zhang, Si Meng, Chenyang Xing, Mingze Ma, Zhou Liu, Chengbin Yang, Tiantian Kong
Summary: The study demonstrates that the photothermal and anti-tumor effects of Mg@PLGA particulate carriers are determined by their magnesium content, regardless of their size and structural features.
Review
Engineering, Environmental
Shuaipeng Feng, Junya Lu, Kaili Wang, Donghua Di, Zhenning Shi, Qinfu Zhao, Siling Wang
Summary: Mesoporous carbon nanoparticles and their derivatives have been extensively studied in photothermal therapy for cancer treatment due to their unique structure and excellent photothermal conversion efficiency. The current research focuses on the application of these nanoparticles in multimodal therapies and the development of low-power efficient photothermal therapy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Yingjie Yu, Dongsheng Tang, Chaoyong Liu, Qi Zhang, Lin Tang, Yunfeng Lu, Haihua Xiao
Summary: Photothermal therapy shows great potential for cancer treatment due to its effective tumor ablation and minimal invasiveness. This study introduces a new class of biodegradable photothermal agents that effectively absorb near-infrared light for deep tumor therapy, demonstrating successful results in a deep-seated ovarian cancer model. This work paves the way for the design of more effective photothermal agents.
ADVANCED MATERIALS
(2022)
Article
Oncology
Yuhang Bao, Xiuxian Wu, Xinghua Jin, Akihiro Kanematsu, Michio Nojima, Yoshiyuki Kakehi, Shingo Yamamoto
Summary: Apigenin has inhibitory effects on renal cell carcinoma (RCC), suppressing cell growth and inducing cell cycle arrest. It shows potential as a novel therapeutic strategy for RCC treatment due to its anticancer activity and ability to modulate the cell cycle.
Article
Oncology
Jiuhong Zhao, Nan Gao, Jiaqi Xu, Xiaoguang Zhu, Guixia Ling, Peng Zhang
Summary: Melanoma, with its high morbidity and mortality, has gained significant attention in recent years. Conventional treatment methods still have limitations, leading to the continuous development of novel approaches. Silver nanoparticles (AgNPs) have shown great potential in cancer research, particularly in melanoma treatment, due to their diverse abilities including antioxidant, antiproliferative, anti-inflammatory, antibacterial, antifungal, and antitumor effects. This review mainly focuses on the applications of AgNPs in preventing, diagnosing, and treating cutaneous melanoma, discussing the strategies of photodynamic therapy (PDT), photothermal therapy (PTT), and chemotherapy. Overall, AgNPs play an increasingly crucial role in cutaneous melanoma treatment and hold promising prospects for future applications.
Article
Materials Science, Biomaterials
Qian Xie, Yang Liu, Ying Long, Zhou Wang, Sai Jiang, Rida Ahmed, Muhammad Daniyal, Bin Li, Bin Liu, Wei Wang
Summary: This study successfully developed nanocomplexes using a combination of plant compounds and a photosensitizer, incorporating them into liposomes to enhance therapeutic efficacy against breast cancer without causing side effects to normal tissues.
BIOMATERIALS SCIENCE
(2021)
Article
Oncology
Hanan R. H. Mohamed, Maria M. H. Ibrahim, Ayman Diab
Summary: The study found that CaTiO3-NPs induced cytotoxicity, genomic instability, and apoptosis in human MCF-7 cells. These effects were time- and concentration-dependent.
CANCER CELL INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Huisi Zhao, Chuanqi Zhao, Zhengwei Liu, Jiadai Yi, Xuemeng Liu, Jinsong Ren, Xiaogang Qu
Summary: Due to their reversible multi-electron redox transformations, polyoxometalates (POMs) have been utilized to modulate the electronic environment of metal nanoparticles for catalysis. Additionally, POMs possess unique electronic structures and acid-responsive self-assembly ability. Leveraging these properties, we have developed copper-doped molybdenum-based POM nanoclusters (Cu-POM NCs) as a highly efficient bioorthogonal catalyst, demonstrating selective antibiofilm therapy responsive to pathologically acidic conditions and H2S.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Ana Katrina Mapanao, Melissa Santi, Valerio Voliani
Summary: This study presents a synergistic chemophotothermal treatment method using ultrasmall-in-nano gold architectures for head and neck squamous cell carcinomas, showing more pronounced antitumor action on HPV-positive HNSCCs. The findings suggest the potential clinical relevance of noble metal-based synergistic treatments for tumor management.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Review
Oncology
Kave Moloudi, Heidi Abrahamse, Blassan P. George
Summary: Cell cycle arrest (CCA) is considered a potential approach for cancer therapy. Photodynamic treatment (PDT) has been shown to have a biological effect on CCA in cancer cells, but the mechanism is not fully understood. In addition to conventional forms of cell death, various unconventional types of cell death have been reported after PDT. Factors such as oxygen, tumor microenvironment, light characteristics, and photosensitizers (PS) influence the effectiveness of PDT treatment. This review focuses on CCA induced by PDT using different PS agents and provides suggestions for standardizing and optimizing the PDT methodology.
FRONTIERS IN ONCOLOGY
(2023)
Review
Medicine, Research & Experimental
Xingyue Huang, Yang Lu, Mingxue Guo, Shouying Du, Ning Han
Summary: The review summarized cutting-edge strategies in combining nano-based photothermal therapy (PTT) with immunotherapy for cancer treatment, which includes four categories of combination strategies. Various photothermal agents and nanoplatforms characteristics, as well as the immunological mechanisms for the synergism, were introduced in detail. Existing challenges and future prospects in combined PTT and immunotherapy were also discussed.
Article
Biochemistry & Molecular Biology
Darja Koutova, Radim Havelek, Eva Peterova, Darina Muthna, Karel Kralovec, Katerina Breiterova, Lucie Cahlikova, Martina Rezacova
Summary: Pancracine, a potent compound among natural isoquinolines, exhibited strong antiproliferative activity on A549 cells and induced apoptotic cell death in MOLT-4 cells. The mechanistic understanding of pancracine activity in vitro revealed perturbation of the cell cycle and induction of apoptotic cell death as key mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zhenyao Yu, Yixue Hou, Wei Zhou, Zizhen Zhao, Zesheng Liu, Ailing Fu
Summary: Mitochondrial transplantation therapy has been actively researched as a treatment for mitochondria-associated diseases, including malignant melanoma. This study investigated the signal mechanism and gender differences in the anti-tumor activity of healthy mitochondria. The results showed that intact mitochondria significantly inhibited tumor cell proliferation and showed anti-tumor effects in melanoma-bearing mice, with female mitochondria demonstrating greater efficiency and a possible stronger mitochondria-nuclear communication than male mitochondria.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Angela-Patricia Hernandez, Paula Diez, Pablo A. Garcia, Martin Perez-Andres, Anzhela Veselinova, Pablo G. Jambrina, Arturo San Feliciano, David Diez, Manuel Fuentes, Ma Angeles Castro
Summary: New lignohydroquinone conjugates (L-HQs) were synthesized using the hybridization strategy and showed dual cytotoxic effect against colorectal cancer cells. These conjugates were obtained from natural product podophyllotoxin and semisynthetic terpenylnaphthohydroquinones. The results demonstrate the validity of the hybridization strategy and suggest further research on non-lactonic cyclolignans.
Article
Environmental Sciences
Ozgur Vatan
Summary: This study investigated the effects of Fe-Ni ANP exposure on human health at the cellular level. The results showed that Fe-Ni ANPs had cytotoxic and genotoxic potentials, and exerted their effects through apoptotic pathways and cell cycle arrest mechanisms. Additionally, the increased intracellular ROS was identified as the primary mechanism leading to cytotoxic, genotoxic, and apoptotic activity. These findings further demonstrated the potential risks of Fe-Ni ANPs to human health.