Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 10, Issue 26, Pages 21901-21908Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b06416
Keywords
iron oxide nanoparticles; superparamagnetic nanoparticles; polymeric analogue of DMSO; magnetic resonance imaging; MRI contrast agent; T-2-weighted contrast agent
Funding
- National Science Foundation [DMR-1501324]
- Richard King Mellon Foundation Presidential Fellowship
- [P30CA047904]
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Novel water-dispersible hybrid iron oxide nanoparticles grafted with a polymeric analogue of dimethyl sulfoxide (DMSO) were prepared. Superparamagnetic iron oxide nanoparticles with immobilized atom-transfer radical polymerization (ATRP) initiators were prepared via an in situ method using 12-(2-bromoisobutyramido)dodecanoic acid as a surface ligand/initiator. The initiator-functionalized particles were employed in a surface-initiated initiator for continuous activator regeneration ATRP to graft poly(2-(methylsulfinyl)ethyl acrylate) (a polyacrylate analogue of DMSO) from the surface. The resulting hybrid nanoparticles showed a high magnetic relaxivity ratio (r(2)/r(1)) of 600 at 7 T in fetal bovine serum, and a good biocompatibility up to 1000 mg L-1.
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