Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 10, Issue 26, Pages 21782-21787Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b02724
Keywords
delivery; microparticle; cardiac cell; biological function; bioelectronics
Funding
- Air Force Office of Sponsored Research [FA9550-15-1-0273]
- Office of Naval Research Young National Investigator Award
- National Institutes of Health [1R01EB021857-01A1]
- Presidential Early Career Award for Scientists and Engineers (PECASE)
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Biological systems exchange information often with chemical signals. Here, we demonstrate the chemical delivery of a fluorescent label using a bioelectronic trigger. Acid-sensitive microparticles release fluorescin diacetate upon low pH induced by a bioelectronic device. Cardiac fibroblast cells (CFs) uptake fluorescin diacetate, which transforms into fluorescein and emits a fluorescent signal. This proof-of-concept bioelectronic triggered delivery may be used in the future for real-time programming and control of cells and cell systems.
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