Article
Pharmacology & Pharmacy
Ridhima Jasrotia, Daljeet Singh Dhanjal, Sonali Bhardwaj, Parvarish Sharma, Chirag Chopra, Reena Singh, Anupam Kumar, Anamika Mubayi, Deepak Kumar, Raj Kumar, Abhineet Goyal
Summary: Cervical cancer, caused by Human papillomavirus (HPV), is the most common gynecological malignancy globally and a major cause of cancer-related death in women. HPV vaccines are effective in preventing neoplastic disease and infection, but not in treating established infection. Therapeutic vaccines targeting early genes E6 and E7 have been developed, and nanotechnological approaches are being explored for targeted delivery of therapeutic agents. This review comprehends the current knowledge about cervical cancer and conventional approaches for its treatment, as well as recent developments in vaccine strategies and nanotechnological approaches for effective management and prevention.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Oncology
Biyuan Xing, Jianfeng Guo, Yuhan Sheng, Gang Wu, Yingchao Zhao
Summary: HPV-negative cervical cancers, predominantly adenocarcinomas, pose challenges in diagnosis and management due to unclear etiology and possible false negative results. It is important to pay greater attention to these cases as they are often diagnosed at advanced stages with poor prognoses.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Lauri E. Markowitz, John T. Schiller
Summary: HPV vaccines are highly effective in preventing HPV-attributable cancers and have been introduced into national immunization programs in over 100 countries. The success of these vaccines has sparked interest in ambitious disease reduction goals.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Virology
Alexandre Santos Matos, Maria da Conceicao Viana Invencao, Ingrid Andressa de Moura, Antonio Carlos de Freitas, Marcus Vinicius de Aragao Batista
Summary: The human papillomavirus (HPV) is the most prevalent sexually transmitted infectious agent worldwide, causing cervical cancer by penetrating the epithelium through microlesions and establishing an infectious focus. In silico prediction tools can be used to select vaccine candidate T cell epitopes, based on their conservation within a group of antigenic proteins, enabling comprehensive genotypic coverage with a small set of epitopes. Therefore, this paper reviews the general characteristics of HPV biology and the current knowledge on developing therapeutic peptide vaccines against HPV-related infections and cervical cancer.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Oncology
Linea Landgrebe Ring, Christian Munk, Michael Galanakis, Joseph E. Tota, Louise T. Thomsen, Susanne K. Kjaer
Summary: A study in Denmark found that the incidence of CIN3, AIS, and SCC decreased after the implementation of multi-cohort HPV vaccination.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Marlieke de Fouw, Yael Stroeken, Ben Niwagaba, Mwalimu Musheshe, John Tusiime, Isingoma F. Sadayo, Ria F. Reis, Alexander Arnold Willem F. Peters, Jogchum Jan F. Beltman
Summary: This qualitative study aimed to understand the perspectives of males on cervical cancer screening and HPV vaccination in Western-Uganda. The study found that there were misconceptions about the causes of cervical cancer and limited knowledge about the preventative aspect of screening and vaccination among men. However, after being informed about cervical cancer, men were willing to support prevention for their wives and daughters. Therefore, active involvement of men in creating awareness is crucial to increase uptake and acceptance of prevention services.
Article
Medicine, General & Internal
Erin Peacock, Leslie S. Craig, Michelle Wilson, Lakeisha Williams, Sara Al Dahir, Wan Tang, Alecia Cyprian, Markalain Dery, Darie Gilliam, Diem Nguyen, Kabrina Smith, Matthew Valliere, Shondra Williams, Gary Wiltz, Keith Winfrey, Terry Davis, Connie Arnold, Katherine Theall, Daniel Sarpong, Marie Krousel-Wood
Summary: This study found that trust in healthcare providers and government sources of COVID-19 information was associated with the likelihood of vaccination among FQHC patients during the initial rollout of COVID-19 vaccines.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Mervat M. Alsous, Ahlam Ali, Sayer Al-Azzam, Reema Karasneh, Haneen Amawi
Summary: Medical students in Jordan have a moderate level of knowledge about cervical cancer and HPV, with a majority supporting the introduction of HPV vaccination for school girls in Jordan. However, there is limited awareness about the availability of the HPV vaccine and its target population among the students.
Review
Medicine, General & Internal
Paddy Ssentongo, Jennifer S. McCall-Hosenfeld, William A. Calo, Jennifer Moss, Eugene J. Lengerich, Vernon M. Chinchilli, Djibril M. Ba
Summary: This study found that HPV vaccination is associated with higher rates of cervical cancer screening, suggesting that vaccinated individuals are more likely to engage in preventive health behaviors.
Article
Public, Environmental & Occupational Health
Talitha L. Bruney, Xueting Zhang
Summary: This study retrospectively analyzed the cases of 1042 women receiving perinatal care and investigated the effectiveness of on-site management and barriers to care. The study found that the follow-up rate after a positive depression screen was 64%, and non-English language could be a barrier to accessing mental health care.
JOURNAL OF PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Ariel M. Domlyn, Carolyn Crowder, Howard Eisenson, Kathryn I. Pollak, James M. Davis, Patrick S. Calhoun, Sarah M. Wilson
Summary: This pilot study aimed to implement a computerized tobacco cessation strategy within a federally qualified health center using the Implementation Mapping (IM) method. Despite initial indicators of acceptability, the intervention was not adopted within the study timeframe, likely due to the impact of the COVID-19 pandemic. Lessons learned include the importance of reassessing barriers over time and allowing for a longer observation period for implementation outcomes.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Pediatrics
R. Christopher Sheldrick, Megan H. Bair-Merritt, Michelle P. Durham, Jessica Rosenberg, Mahader Tamene, Cathleen Bonacci, Genevieve Daftary, Michael H. Tang, Nandini Sengupta, Anita Morris, Emily Feinberg
Summary: The results of the study demonstrate that integrated behavioral health care can improve services for children of all ages in federally qualified health centers that predominantly serve marginalized populations. This study adds to the growing literature on the topic, but there are still some evidence gaps that need to be addressed.
Article
Multidisciplinary Sciences
Yvonne T. Nartey, Kwabena H. Amo-Antwi, Philip M. Hill, Edward Dassah, Richard O. Asmah, Kofi Nyarko, Ramatu Agambire, Thomas Konney, Joel Yarney, Nelson Damale, Brian Cox
Summary: This study aimed to compare the distribution of high-risk human papillomavirus (HR-HPV) genotypes in women with and without cervical cancer in order to develop a population-based prevention strategy for cervical cancer in Ghana. The results showed that the most common HR-HPV genotypes among women with cervical cancer were 16, 18, 45, 35, and 52, while 66, 52, 35, 43, and 31 were frequently detected in women without cancer. HPV DNA testing and multivalent vaccines targeting HPV 16, 18, 45, and 35 genotypes are crucial for cervical cancer control in Ghana.
Article
Health Policy & Services
Debra M. Vinci, Jessica Ryan, Maureen Howard, Dallas Snider, Brandy Strahan, Gregg Smith, Rebecca McClain
Summary: This study aimed to increase HPV vaccination rates in adolescents aged 11 to 16 through a systems-based intervention in nine pediatric clinics. The intervention, which included automated HPV prompts, postcard reminders, and provider assessments, resulted in improved vaccination rates, with 80.5% of patients receiving the first dose and 47% receiving the second dose. Logistic regression showed age was significantly associated with first dose completion, while males did not show a significant association compared to females. The overall counts of first and second HPV vaccination rates increased post-intervention.
JOURNAL OF COMMUNITY HEALTH
(2022)
Review
Public, Environmental & Occupational Health
Hyunjeong Shin, Songi Jeon, Inhae Cho, HyunJi Park
Summary: This review identified factors affecting HPV vaccine initiation in men, including sociodemographic factors, belief-related variables, family factors, community factors, variables related to needs, and environmental factors. Strategies targeting young males and their families, such as frequent visits to or contact with health care providers, should be implemented to increase HPV vaccination rates in men.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2022)
Article
Oncology
Stacey A. Fedewa, Alexander J. Preiss, Marcie Fisher-Borne, Ann Goding Sauer, Ahmedin Jemal, Debbie Saslow
Article
Public, Environmental & Occupational Health
Cam Escoffery, Kara Riehman, Lesley Watson, A. Sandy Priess, Marcie Fisher Borne, Sean Nathaniel Halpin, Carlie Rhiness, Emily Wiggins, Michelle C. Kegler
PREVENTING CHRONIC DISEASE
(2019)
Article
Biotechnology & Applied Microbiology
Natoshia Askelsono, Grace Ryan, Laura Seegmiller, Alexander Preiss, Sara Comstock
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2020)
Article
Public, Environmental & Occupational Health
Dalia Khoury, Alexander Preiss, Paul Geiger, Mohd Anwar, Kevin Paul Conway
Summary: This study examined changes in the occurrence of naloxone administrations and multiple naloxone administrations during EMS runs for opioid-related overdoses during the COVID-19 pandemic in Guilford County, North Carolina. The results showed that all outcomes increased during the COVID-19 period, with significant proportional increases.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2021)
Article
Substance Abuse
Jessica K. Pepper, Lauren Zitney, Alexander Preiss, Thomas Bukowski, Glen Szczypka, Annice E. Kim
Summary: This study analyzed Reddit conversations and found that discussions about vitamin E acetate (VEA) and counterfeit brand Dank Vapes emerged following the outbreak of e-cigarette, or vaping, product use-associated lung injury (EVALI) in 2019-2020. While Reddit conversations did not predict the outbreak, they can serve as early signals for public health monitoring and research on health concerns related to vaping and THC products.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Article
Multidisciplinary Sciences
Stacy Endres-Dighe, Kasey Jones, Emily Hadley, Alexander Preiss, Caroline Kery, Marie Stoner, Susan Eversole, Sarah Rhea
Summary: The first case of COVID-19 in North Carolina was detected on March 3, 2020, with confirmed cases soaring to over 10,000 by the end of April. Health systems faced intense strain, requiring forecasting techniques to provide reliable data to support decision-making.
Article
Biochemical Research Methods
Alexander M. Waldrop, John B. Cheadle, Kira Bradford, Alexander Preiss, Robert Chew, Jonathan R. Holt, Yaphet Kebede, Nathan Braswell, Matt Watson, Virginia Hench, Andrew Crerar, Chris M. Ball, Carl Schreep, P. J. Linebaugh, Hannah Hiles, Rebecca Boyles, Chris Bizon, Ashok Krishnamurthy, Steve Cox
Summary: Researchers can use Dug, a semantic search tool for biomedical datasets, to easily find relevant datasets and understand why those results are returned. In performance testing, Dug outperformed Elasticsearch in terms of recall rate, and when using synonyms or related concepts as search queries, Dug had a significantly higher recall rate without sacrificing the precision of its top results.
Article
Public, Environmental & Occupational Health
Kasey Jones, Emily Hadley, Sandy Preiss, Eric T. Lofgren, Donald P. Rice, Marie C. D. Stoner, Sarah Rhea, Joella W. Adams
Summary: This study found through simulation research that serial antigen testing in acute-care hospitals can detect over 85% of asymptomatic SARS-CoV-2 infections, with lower false positive rates and lower costs compared to combined antigen plus PCR testing.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Health Care Sciences & Services
Alexander Preiss, Peter Baumgartner, Mark J. Edlund, Georgiy Bobashev
Summary: This study validated a methodology for identifying substances used to treat symptoms of opioid withdrawal by analyzing data from the Reddit community. Through named entity recognition, 458 unique substances and 235 unique effects were extracted, with 130 potential remedies associated with withdrawal symptoms identified.
JMIR FORMATIVE RESEARCH
(2022)
Article
Mathematical & Computational Biology
Alexander Preiss, Emily Hadley, Kasey Jones, Marie C. D. Stoner, Caroline Kery, Peter Baumgartner, Georgiy Bobashev, Jessica Tenenbaum, Charles Carter, Kimberly Clement, Sarah Rhea
Summary: Public health decision makers rely on accurate and timely hospitalization forecasts for COVID-19 pandemic planning. This study rapidly adapted an agent-based model to provide weekly 30-day hospitalization forecasts for North Carolina, and found that integrating near-real-time hospital occupancy data into the model improves forecast accuracy.
INFECTIOUS DISEASE MODELLING
(2022)