Radical cascade reactions triggered by single electron transfer

Coupling Radical Homoallylic Expansions with C–C Fragmentations for the Synthesis of Heteroaromatics: Quinolines from Reactions of o-Alkenylarylisonitriles with Aryl, Alkyl, and Perfluoroalkyl Radicals

(2017) Christopher J. Evoniuk et al.   JOURNAL OF ORGANIC CHEMISTRY

Dearomatizing Radical Cyclizations and Cyclization Cascades Triggered by Electron-Transfer Reduction of Amide-Type Carbonyls

(2017) Huan-Ming Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Scalable, Electrochemical Oxidation of Unactivated C–H Bonds

(2017) Yu Kawamata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photoredox-Catalyzed Reductive Carbamoyl Radical Generation: A Redox-Neutral Intermolecular Addition–Cyclization Approach to Functionalized 3,4-Dihydroquinolin-2-ones

(2017) Wade F. Petersen et al.   ORGANIC LETTERS

Catalytic asymmetric radical aminoperfluoroalkylation and aminodifluoromethylation of alkenes to versatile enantioenriched-fluoroalkyl amines

(2017) Jin-Shun Lin et al.   Nature Communications

Expeditious diastereoselective synthesis of elaborated ketones via remote Csp3–H functionalization

(2017) Wei Shu et al.   Nature Communications

A Radical Cascade Enabling Collective Syntheses of Natural Products

(2017) Xiaobei Wang et al.   Chem

The merger of transition metal and photocatalysis

(2017) Jack Twilton et al.   Nature Reviews Chemistry

Photochemical Stereocontrol Using Tandem Photoredox–Chiral Lewis Acid Catalysis

(2016) Tehshik P. Yoon   ACCOUNTS OF CHEMICAL RESEARCH

Photoredox Catalysis for the Generation of Carbon Centered Radicals

(2016) Jean-Philippe Goddard et al.   ACCOUNTS OF CHEMICAL RESEARCH

Free Radical Chemistry Enabled by Visible Light-Induced Electron Transfer

(2016) Daryl Staveness et al.   ACCOUNTS OF CHEMICAL RESEARCH

Organic Photoredox Catalysis

(2016) Nathan A. Romero et al.   CHEMICAL REVIEWS

Dual Catalysis Strategies in Photochemical Synthesis

(2016) Kazimer L. Skubi et al.   CHEMICAL REVIEWS

Cascade polycyclizations in natural product synthesis

(2016) R. Ardkhean et al.   CHEMICAL SOCIETY REVIEWS

Copper Catalyzed Atom Transfer Radical Cyclization Reactions

(2016) Andrew J. Clark   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Silver-Catalyzed Cascade Radical Cyclization: A Direct Approach to 3,4-Disubstituted Dihydroquinolin-2(1H)-ones through Activation of the P–H Bond and Functionalization of the C(sp2)–H Bond

(2016) Honglin Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Photoredox Catalysis in Organic Chemistry

(2016) Megan H. Shaw et al.   JOURNAL OF ORGANIC CHEMISTRY

KOtBu: A Privileged Reagent for Electron Transfer Reactions?

(2016) Joshua P. Barham et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visible-Light-Mediated Synthesis of Amidyl Radicals: Transition-Metal-Free Hydroamination and N-Arylation Reactions

(2016) Jacob Davies et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Annulative Methods Enable a Total Synthesis of the Complex Meroterpene Berkeleyone A

(2016) Chi P. Ting et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radical–Radical Cyclization Cascades of Barbiturates Triggered by Electron-Transfer Reduction of Amide-Type Carbonyls

(2016) Huan-Ming Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Dual-Catalytic Strategy To Direct Asymmetric Radical Aminotrifluoromethylation of Alkenes

(2016) Jin-Shun Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Photocatalytic [3 + 2] Cycloadditions of Aryl Cyclopropyl Ketones

(2016) Adrian G. Amador et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Redox-Active Esters in Fe-Catalyzed C–C Coupling

(2016) Fumihiko Toriyama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radicals: Reactive Intermediates with Translational Potential

(2016) Ming Yan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amide-directed photoredox-catalysed C–C bond formation at unactivated sp3 C–H bonds

(2016) John C. K. Chu et al.   NATURE

Scalable and sustainable electrochemical allylic C–H oxidation

(2016) Evan J. Horn et al.   NATURE

Catalytic alkylation of remote C–H bonds enabled by proton-coupled electron transfer

(2016) Gilbert J. Choi et al.   NATURE

Silver-promoted cinnamamidyl radical-mediated oxidative cascade cyclization: highly regioselective synthesis of phosphorylated azaspiro[4.5]decenones

(2016) Zhao-Zhao Zhou et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Stereoselective Radical Cyclization Cascades Triggered by Addition of Diverse Radicals to Alkynes To Construct 6(5)–6–5 Fused Rings

(2016) Lin Huang et al.   ORGANIC LETTERS

Gold-Catalyzed Photoredox C(sp2) Cyclization: Formal Synthesis of (±)-Triptolide

(2016) Alexandre Cannillo et al.   ORGANIC LETTERS

Catalytic Diverse Radical-Mediated 1,2-Cyanofunctionalization of Unactivated Alkenes via Synergistic Remote Cyano Migration and Protected Strategies

(2016) Na Wang et al.   ORGANIC LETTERS

Enantioselective synthesis of an ophiobolin sesterterpene via a programmed radical cascade

(2016) Z. G. Brill et al.   SCIENCE

A concise total synthesis of sespenine, a structurally unusual indole terpenoid from Streptomyces

(2016) Yu Sun et al.   Organic Chemistry Frontiers

Synthetic Organic Electrochemistry: An Enabling and Innately Sustainable Method

(2016) Evan J. Horn et al.   ACS Central Science

Sm(II)-Mediated Electron Transfer to Carboxylic Acid Derivatives: Development of Complexity-Generating Cascades

(2015) Xavier Just-Baringo et al.   ACCOUNTS OF CHEMICAL RESEARCH

Copper-Catalyzed Aerobic Oxidations of Organic Molecules: Pathways for Two-Electron Oxidation with a Four-Electron Oxidant and a One-Electron Redox-Active Catalyst

(2015) Scott D. McCann et al.   ACCOUNTS OF CHEMICAL RESEARCH

Electrolytic Macrocyclizations: Scalable Synthesis of a Diazonamide-Based Drug Development Candidate

(2015) Hui Ding et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of Limonin

(2015) Shuji Yamashita et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible-Light-Mediated Generation of Nitrogen-Centered Radicals: Metal-Free Hydroimination and Iminohydroxylation Cyclization Reactions

(2015) Jacob Davies et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalysis of Radical Reactions: A Radical Chemistry Perspective

(2015) Armido Studer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Visible-Light-Mediated Radical Smiles Rearrangement and its Application to the Synthesis of a Difluoro-Substituted Spirocyclic ORL-1 Antagonist

(2015) James J. Douglas et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Double Additions and Radical Cyclization Cascades in the Re-Engineering of the Antibacterial Pleuromutilin

(2015) Rebecca E. Ruscoe et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Dual 1,1-H-Abstraction/Insertion for Domino Spirocyclizations

(2015) Jiang-Kai Qiu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Alkene Carboaminations Enabled by Oxidative Proton-Coupled Electron Transfer

(2015) Gilbert J. Choi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Preparation of Antimalarial Endoperoxides by a Formal [2 + 2 + 2] Cycloaddition

(2015) Christophe Daeppen et al.   ORGANIC LETTERS

Anti-Diastereoselective Synthesis of CF3-Containing Spirooxazolines and Spirooxazines via Regiospecific Trifluoromethylative Spirocyclization by Photoredox Catalysis

(2015) Naoki Noto et al.   ORGANIC LETTERS

Practical olefin hydroamination with nitroarenes

(2015) J. Gui et al.   SCIENCE

Diastereoselective Synthesis of (±)-Ambrox by Titanium(III)-Catalyzed Radical Tandem Cyclization

(2015) Antonio Rosales et al.   SYNLETT

An approach for the synthesis of nakamuric acid

(2015) Xiaolei Wang et al.   TETRAHEDRON

Unified total synthesis of the natural products endiandric acid A, kingianic acid E, and kingianins A, D, and F

(2015) S. L. Drew et al.   Chemical Science

[2+2] Cycloaddition of 1,3-Dienes by Visible Light Photocatalysis

(2014) Anna E. Hurtley et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Evolution of neutral organic super-electron-donors and their applications

(2014) Eswararao Doni et al.   CHEMICAL COMMUNICATIONS

Cross-Coupling Reactions Using Samarium(II) Iodide

(2014) Michal Szostak et al.   CHEMICAL REVIEWS

Four-Step Synthesis of the Antimalarial Cardamom Peroxide via an Oxygen Stitching Strategy

(2014) Xirui Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total synthesis and biological studies of cryptocin and derivatives of equisetin and fusarisetin A

(2014) Lili Kong et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Butyrolactone Synthesis via Polar Radical Crossover Cycloaddition Reactions: Diastereoselective Syntheses of Methylenolactocin and Protolichesterinic Acid

(2014) Mary A. Zeller et al.   ORGANIC LETTERS

Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence

(2014) Z. Ma et al.   SCIENCE

A Dual-Catalysis Approach to Enantioselective [2 + 2] Photocycloadditions Using Visible Light

(2014) J. Du et al.   SCIENCE

Recent applications of Cp2TiCl in natural product synthesis

(2014) Sara P. Morcillo et al.   Organic Chemistry Frontiers

Tandem Cyclizations of 1,6-Enynes with Arylsulfonyl Chlorides by Using Visible-Light Photoredox Catalysis

(2013) Guo-Bo Deng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of (+)-Crotogoudin

(2013) Simon Breitler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organic Electron Donors as Powerful Single-Electron Reducing Agents in Organic Synthesis

(2013) Julie Broggi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Oxindoles by Iron-Catalyzed Oxidative 1,2-Alkylarylation of Activated Alkenes with an Aryl C(sp2)H Bond and a C(sp3)H Bond Adjacent to a Heteroatom

(2013) Wen-Ting Wei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Alkene Trifluoromethylation Coupled with CC Bond Formation: Construction of Trifluoromethylated Carbocycles and Heterocycles

(2013) Hiromichi Egami et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Annulations toward Phosphorylated Oxindoles: Silver-Catalyzed Carbon-Phosphorus Functionalization of Alkenes

(2013) Ya-Min Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in the chemoselective reduction of functional groups mediated by samarium(ii) iodide: a single electron transfer approach

(2013) Michal Szostak et al.   CHEMICAL SOCIETY REVIEWS

Total Synthesis of (+)-Pleuromutilin

(2013) Neal J. Fazakerley et al.   CHEMISTRY-A EUROPEAN JOURNAL

Efficient Copper-Catalyzed Direct Intramolecular Aminotrifluoromethylation of Unactivated Alkenes with Diverse Nitrogen-Based Nucleophiles

(2013) Jin-Shun Lin et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Lewis Acid Catalysis of Intramolecular Enone [2+2] Photocycloaddition Reactions

(2013) R. Brimioulle et al.   SCIENCE

Synthesis of cyclobutane lignans via an organic single electron oxidant–electron relay system

(2013) Michelle Riener et al.   Chemical Science

Catalytic Radical Domino Reactions in Organic Synthesis

(2013) Leanne J. Sebren et al.   ACS Catalysis

Pyrrole Aminoimidazole Alkaloid Metabiosynthesis with Marine Sponges Agelas conifera and Stylissa caribica

(2012) E. Paige Stout et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Synthesis and Biosynthetic Implications of (+)-Fusarisetin A

(2012) Jun Yin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A “Renaissance” in Radical Trifluoromethylation

(2012) Armido Studer   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Biomimetic Route for Construction of the [4+2] and [3+2] Core Skeletons of Dimeric Pyrrole–Imidazole Alkaloids and Asymmetric Synthesis of Ageliferins

(2012) Xiao Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lactone Radical Cyclizations and Cyclization Cascades Mediated by SmI2–H2O

(2012) Dixit Parmar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Catalyzed Oxytrifluoromethylation of Unactivated Alkenes

(2012) Rong Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fusarisetin A: scalable total synthesis and related studies

(2012) Jing Xu et al.   Chemical Science

Copper-Catalyzed Trifluoromethylation of Unactivated Olefins

(2011) Andrew T. Parsons et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aromatic Trifluoromethylation with Metal Complexes

(2011) Olesya A. Tomashenko et al.   CHEMICAL REVIEWS

Samarium diiodide induced ketyl-(het)arene cyclisations towards novel N-heterocycles

(2011) Christine Beemelmanns et al.   CHEMICAL SOCIETY REVIEWS

Enantioselective Intramolecular [2 + 2]-Photocycloaddition Reactions of 4-Substituted Quinolones Catalyzed by a Chiral Sensitizer with a Hydrogen-Bonding Motif

(2011) Christiane Müller et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reductive Cyclization Cascades of Lactones Using SmI2−H2O

(2011) Dixit Parmar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Catalyzed Trifluoromethylation of Terminal Alkenes through Allylic C–H Bond Activation

(2011) Jun Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Concise Total Synthesis of (−)-Maoecrystal Z

(2011) Jacob Y. Cha et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Catalyzed C(sp3)–C(sp3) Bond Formation Using a Hypervalent Iodine Reagent: An Efficient Allylic Trifluoromethylation

(2011) Xi Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

[3+2] Cycloadditions of Aryl Cyclopropyl Ketones by Visible Light Photocatalysis

(2011) Zhan Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalysis for fluorination and trifluoromethylation

(2011) Takeru Furuya et al.   NATURE

Radical Cyclization Cascades of Unsaturated Meldrum’s Acid Derivatives

(2011) Brice Sautier et al.   ORGANIC LETTERS

Tandem Visible Light-Mediated Radical Cyclization–Divinylcyclopropane Rearrangement to Tricyclic Pyrrolidinones

(2011) Joseph W. Tucker et al.   ORGANIC LETTERS

Minisci reactions: Versatile CH-functionalizations for medicinal chemists

(2011) Matthew A. J. Duncton   MedChemComm

A Short Formal Total Synthesis of Strychnine with a Samarium Diiodide Induced Cascade Reaction as the Key Step

(2010) Christine Beemelmanns et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Lewis Acid Catalysis in Intramolecular [2+2] Photocycloaddition Reactions of Coumarins

(2010) Hao Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Polyene Cyclization via Organo-SOMO Catalysis

(2010) Sebastian Rendler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total synthesis of diazonamide A

(2010) Robert R. Knowles et al.   Chemical Science

Light-Driven Enantioselective Organocatalysis

(2009) Christiane Müller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Dialdehyde Cyclization Cascade: An Approach to Pleuromutilin

(2009) Matthew D. Helm et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Samarium Diiodide Mediated Reactions in Total Synthesis

(2009) K. C. Nicolaou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Radical and Radical-Ionic Multicomponent Processes

(2009) Edouard Godineau et al.   CHEMISTRY-A EUROPEAN JOURNAL

Electron Transfer Photoredox Catalysis: Intramolecular Radical Addition to Indoles and Pyrroles

(2009) Joseph W. Tucker et al.   ORGANIC LETTERS