Hypoxic Stress Forces Adaptive and Maladaptive Placental Stress Responses in Early Pregnancy

Variable DAXX gene methylation is a common feature of placental trophoblast differentiation, preeclampsia, and response to hypoxia

(2017) Boris Novakovic et al.   FASEB JOURNAL

Using stem cell oxygen physiology to optimize blastocyst culture while minimizing hypoxic stress

(2017) Alan Bolnick et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Departure from optimal O2 level for mouse trophoblast stem cell proliferation and potency leads to most rapid AMPK activation

(2017) Yu YANG et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

AMPK Knockdown in Placental Labyrinthine Progenitor Cells Results in Restriction of Critical Energy Resources and Terminal Differentiation Failure

(2017) Christopher A. Waker et al.   STEM CELLS AND DEVELOPMENT

Down-regulation of PDK4 is Critical for the Switch of Carbohydrate Catabolism during Syncytialization of Human Placental Trophoblasts

(2017) Xiaohui Liu et al.   Scientific Reports

Hypoxic Stress Forces Irreversible Differentiation of a Majority of Mouse Trophoblast Stem Cells Despite FGF4

(2016) Y. Yang et al.   BIOLOGY OF REPRODUCTION

Primary Cilium-Autophagy-Nrf2 (PAN) Axis Activation Commits Human Embryonic Stem Cells to a Neuroectoderm Fate

(2016) Jiwon Jang et al.   CELL

Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos

(2016) Sophie Petropoulos et al.   CELL

Terminal differentiation induction as DNA damage response in hematopoietic stem cells by GADD45A

(2016) Susanne Wingert et al.   EXPERIMENTAL HEMATOLOGY

Correlation between aneuploidy, standard morphology evaluation and morphokinetic development in 1730 biopsied blastocysts: a consecutive case series study

(2016) Maria Giulia Minasi et al.   HUMAN REPRODUCTION

Commonly used fertility drugs, a diet supplement, and stress force AMPK-dependent block of stemness and development in cultured mammalian embryos

(2016) Alan Bolnick et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Comparison of 2, 5, and 20 % O2 on the development of post-thaw human embryos

(2016) Yu Yang et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia

(2016) Damayanti Chakraborty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development and Validation of a Rex1-RFP Potency Activity Reporter Assay That Quantifies Stress-Forced Potency Loss in Mouse Embryonic Stem Cells

(2016) Quanwen Li et al.   STEM CELLS AND DEVELOPMENT

Placenta: The Forgotten Organ

(2015) Emin Maltepe et al.   Annual Review of Cell and Developmental Biology

Lactate production by the mammalian blastocyst: Manipulating the microenvironment for uterine implantation and invasion?

(2015) David K. Gardner   BIOESSAYS

Dynamic single cell measurements of kinase activity by synthetic kinase activity relocation sensors

(2015) Eric Durandau et al.   BMC BIOLOGY

Stress lowers the threshold dose at which bisphenol A disrupts blastocyst implantation, in conjunction with decreased uterine closure and e-cadherin

(2015) Evan D. Borman et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Single-cell epigenomics: techniques and emerging applications

(2015) Omer Schwartzman et al.   NATURE REVIEWS GENETICS

Maternal–fetal conflict, genomic imprinting and mammalian vulnerabilities to cancer

(2015) David Haig   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Tracking nutrient transfer at the human maternofetal interface from 4 weeks to term

(2015) C.J.P. Jones et al.   PLACENTA

Loss of Endometrial Plasticity in Recurrent Pregnancy Loss

(2015) Emma S. Lucas et al.   STEM CELLS

The Human Endometrium as a Sensor of Embryo Quality1

(2014) Nick S. Macklon et al.   BIOLOGY OF REPRODUCTION

Signaling pathways in mouse and human trophoblast differentiation: a comparative review

(2014) Francesca Soncin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hypoxic stress induces, but cannot sustain trophoblast stem cell differentiation to labyrinthine placenta due to mitochondrial insufficiency

(2014) Yufen Xie et al.   Stem Cell Research

Stress-Induced Enzyme Activation Primes Murine Embryonic Stem Cells to Differentiate Toward the First Extraembryonic Lineage

(2014) Jill A. Slater et al.   STEM CELLS AND DEVELOPMENT

Uterine Selection of Human Embryos at Implantation

(2014) Jan J. Brosens et al.   Scientific Reports

The Cell-Cycle State of Stem Cells Determines Cell Fate Propensity

(2013) Siim Pauklin et al.   CELL

AICAR Sustains J1 Mouse Embryonic Stem Cell Self-Renewal and Pluripotency by Regulating Transcription Factor and Epigenetic Modulator Expression

(2013) Xiaoyan Shi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Hypoxia alters the epigenetic profile in cultured human placental trophoblasts

(2013) Ryan K.C. Yuen et al.   Epigenetics

Suppression of Mitochondrial Electron Transport Chain Function in the Hypoxic Human Placenta: A Role for miRNA-210 and Protein Synthesis Inhibition

(2013) Francesca Colleoni et al.   PLoS One

Stress responses at the endometrial–placental interface regulate labyrinthine placental differentiation from trophoblast stem cells

(2013) D A Rappolee et al.   REPRODUCTION

Stress Induces AMPK-Dependent Loss of Potency Factors Id2 and Cdx2 in Early Embryos and Stem Cells

(2013) Yufen Xie et al.   STEM CELLS AND DEVELOPMENT

NK cells, hypoxia and trophoblast cell differentiation

(2012) Damayanti Chakraborty et al.   CELL CYCLE

Evidence of endoplasmic reticulum stress and protein synthesis inhibition in the placenta of non-native women at high altitude

(2012) Hong Wa Yung et al.   FASEB JOURNAL

Regulatory Pathways Controlling the Endovascular Invasive Trophoblast Cell Lineage

(2012) Michael J. SOARES et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Coordinated control of replication and transcription by a SAPK protects genomic integrity

(2012) Alba Duch et al.   NATURE

Metabolism of the preimplantation embryo: 40 years on

(2012) Henry J Leese   REPRODUCTION

Toxic stress prioritizes and imbalances stem cell differentiation: implications for new biomarkers andin vitrotoxicology tests

(2012) Daniel A. Rappolee et al.   Systems Biology in Reproductive Medicine

Eomesodermin, HAND1, and CSH1 proteins are induced by cellular stress in a stress-activated protein kinase-dependent manner

(2011) A.O. Awonuga et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Oxygen levels that optimize TSC culture are identified by maximizing growth rates and minimizing stress

(2011) S. Zhou et al.   PLACENTA

Natural killer cells direct hemochorial placentation by regulating hypoxia-inducible factor dependent trophoblast lineage decisions

(2011) D. Chakraborty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

5-Aminoimidazole-4-carboxyamide Ribonucleoside Induces G1/S Arrest and Nanog Downregulation via p53 and Enhances Erythroid Differentiation

(2011) Hee-Don Chae et al.   STEM CELLS

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

(2010) Ahmed Mohyeldin et al.   Cell Stem Cell

Initiation of trophectoderm lineage specification in mouse embryos is independent of Cdx2

(2010) G. Wu et al.   DEVELOPMENT

The placenta: transcriptional, epigenetic, and physiological integration during development

(2010) Emin Maltepe et al.   JOURNAL OF CLINICAL INVESTIGATION

Benzo(a)pyrene causes PRKAA1/2-dependent ID2 loss in trophoblast stem cells

(2010) Yufen Xie et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Natural Selection of Human Embryos: Impaired Decidualization of Endometrium Disables Embryo-Maternal Interactions and Causes Recurrent Pregnancy Loss

(2010) Madhuri Salker et al.   PLoS One

Natural Selection of Human Embryos: Decidualizing Endometrial Stromal Cells Serve as Sensors of Embryo Quality upon Implantation

(2010) Gijs Teklenburg et al.   PLoS One

Cellular stress causes reversible, PRKAA1/2-, and proteasome-dependent ID2 protein loss in trophoblast stem cells

(2010) W Zhong et al.   REPRODUCTION

Rapid and dynamic alterations of gene expression profiles of adult porcine bone marrow-derived stem cell in response to hypoxia

(2010) Suna Wang et al.   Stem Cell Research

Agitation can Induce Differentiation of Human Pluripotent Stem Cells in Microcarrier Cultures

(2010) Hau Wan Leung et al.   TISSUE ENGINEERING PART C-METHODS

Genotoxic Stress Abrogates Renewal of Melanocyte Stem Cells by Triggering Their Differentiation

(2009) Ken Inomata et al.   CELL

Hyperbaric Oxygen Inhibits Growth But Not Differentiation of Normal and Irradiated Osteoblasts

(2009) Alex K. Wong et al.   JOURNAL OF CRANIOFACIAL SURGERY

Comparative systems biology of human and mouse as a tool to guide the modeling of human placental pathology

(2009) Brian Cox et al.   Molecular Systems Biology

Intrauterine Fate of Invasive Trophoblast Cells☆

(2009) G.X. Rosario et al.   PLACENTA

Endometrium as an early sensor of in vitro embryo manipulation technologies

(2009) N. Mansouri-Attia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and characterization of subpopulations in undifferentiated ES cell culture

(2008) Y. Toyooka et al.   DEVELOPMENT

Maternal hypoxia activates endovascular trophoblast cell invasion

(2008) Gracy X. Rosario et al.   DEVELOPMENTAL BIOLOGY

Oxygen, the Janus gas; its effects on human placental development and function

(2008) Graham J. Burton   JOURNAL OF ANATOMY

The role of oxygen availability in embryonic development and stem cell function

(2008) M. Celeste Simon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hyperosmolar Stress Induces Global mRNA Responses in Placental Trophoblast Stem Cells that Emulate Early Post-implantation Differentiation

(2008) J. Liu et al.   PLACENTA

Stress granules: the Tao of RNA triage

(2008) Paul Anderson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Efficient propagation of single cells accutase-dissociated human embryonic stem cells

(2007) Ruchi Bajpai et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT