Review
Pharmacology & Pharmacy
Chunkun Yang, Yanguang Mu, Shuanghong Li, Yang Zhang, Xiaoyuan Liu, Jun Li
Summary: Tanshinone IIA (Tan IIA), a fat-soluble compound extracted from Salvia miltiorrhiza, has a protective effect against atherosclerosis (AS). It improves AS through multiple pathways, including inhibiting oxidative stress and inflammatory damage, improving endothelial cell function, reducing vascular smooth muscle cell proliferation and migration, stabilizing fibrous cap of atherosclerotic plaque, and inhibiting inflammation and foam cell formation. However, there is a lack of high-quality evidence-based medical data on the efficacy of Tan IIA in AS treatment, and a randomized controlled clinical trial is recommended to evaluate its exact efficacy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Tingting Li, Si Gao, Wei Han, Zhenqiu Gao, Yundong Wei, Gang Wu, Wei Qiqiu, Li Chen, Yiping Feng, Shijiao Yue, Haixue Kuang, Xudong Jiang
Summary: Psoriasis is a chronic inflammatory dermatosis with increasing incidence. Chinese herbal medicine (CHM) has been considered as an alternative and efficient therapy for patients who are concerned about the side effects of synthetic drugs. CHM provides a diverse source for the development of anti-psoriatic drugs with fewer adverse reactions. This review comprehensively summarizes the existing therapeutic mechanisms of CHM in the treatment of psoriasis, including the suppression of oxidative stress, the inhibition of abnormal proliferation and differentiation, the inhibition of immune responses, and the suppression of angiogenesis. The positive reports about the treatment of psoriasis using CHM bring hope for its promising future in clinical therapy.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Lan Wang, Yan-Fang Xian, Zhen Hu, Steven King Fan Loo, Siu Po Ip, Wood Yee Chan, Zhi-Xiu Lin, Justin Che Yuen Wu
Summary: The study showed that Shi Zhen Formula alleviated DNCB-induced AD-like skin lesions in mice by regulating Th1/Th2 balance, improving epidermal barrier, and inhibiting skin inflammation. These findings provide scientific evidence for the use of this Chinese herbal formula in the treatment of AD.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Integrative & Complementary Medicine
Mu-Feng Xiang, Cheng-Tao Jin, Li-Hua Sun, Zhi-Hui Zhang, Jing-Jing Yao, Liu-Cheng Li
Summary: The ongoing COVID-19 pandemic has prompted the use of emerging Chinese herbal compounds in clinical practice, with some showing beneficial effects in improving symptoms and outcomes. These compounds primarily work by relieving clinical symptoms, inhibiting cytokine storm, and enhancing organ function. Further research, including randomized controlled trials and real-world studies, is needed to support their efficacy and safety in combating COVID-19.
Article
Pharmacology & Pharmacy
Zhenzhen Yan, Ling Zhong, Wandi Zhu, Sookja Kim Chung, Panpan Hou
Summary: Cardiovascular disease (CVD) is the leading cause of disability and death worldwide, and cardiac ion channels play a crucial role in the formation of cardiac action potentials and the control of heartbeats. Chinese herbal remedies have shown promise in regulating cardiac ion channels and alleviating arrhythmia and CVD. This review discusses the role of cardiac ion channels, the efficacy of Chinese herbal compounds, and the potential for developing new anti-CVD drugs based on Chinese herbal medicines.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Plant Sciences
Sijia Ma, Mingming Zhao, Meiying Chang, Xiujie Shi, Yue Shi, Yu Zhang
Summary: This review summarizes the clinical efficacy of Chinese herbal medicines (CHMs) and their active ingredients in the treatment and management of IgAN. The study found that CHMs have antioxidant, anti-inflammatory, anti-fibrosis, and autophagy-regulating effects, and can provide a multitarget treatment for IgAN. CHMs can be considered as a first-choice or alternative therapy for IgAN treatment.
Review
Pharmacology & Pharmacy
Mingming Zhao, Yi Yu, Rumeng Wang, Meiying Chang, Sijia Ma, Hua Qu, Yu Zhang
Summary: Through reviewing publications in peer-reviewed English-language journals, it is found that Chinese herbal medicines (CHMs) have anti-inflammatory, antioxidative, anti-apoptotic, autophagy-mediated, and antifibrotic effects in the treatment of chronic kidney disease (CKD). Some studies suggest that CHMs as an adjuvant therapy may benefit CKD patients. However, issues such as unknown active ingredients, low quality and small sample sizes in clinical trials limit the development and safety of CHMs. Further research and well-conducted randomized controlled trials (RCTs) are urgently needed to evaluate the efficacy and safety of CHMs in CKD treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Luxia Song, Jie Zhang, Runmin Lai, Qiuyi Li, Jianqing Ju, Hao Xu
Summary: Atherosclerosis is a complex chronic disease involving oxidative stress and dysfunction of the endothelium. Chinese herbal medicines and traditional Chinese medicine have shown potential in regulating oxidative stress and treating atherosclerosis-related diseases. Further research is needed to explore new drugs targeting diseases associated with oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Sijian Wang, Ruolan Yuan, Miao Liu, Yiwen Zhang, Bona Jia, Jingya Ruan, Jiayan Shen, Yi Zhang, Mengyang Liu, Tao Wang
Summary: Atherosclerosis, characterized by the formation of plaques in arterial walls, is a common cardiovascular disease. Natural compounds from herbs and natural products have been found to induce autophagy and inhibit the occurrence and development of atherosclerosis, offering potential therapeutic strategies.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Pharmacology & Pharmacy
Yun Zhang, Xing Wang, He Zhang, Hongmei Tang, Hang Hu, Songping Wang, Vincent Kam Wai Wong, Yuying Li, Jun Deng
Summary: Asthma is a global health issue affecting over 300 million people worldwide, and treatment options include using different agents targeting different pathways. Autophagy modulation may offer new therapeutic approaches for asthma.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Wei Jin, Juan Zhong, Yang Song, Ming-Fei Li, Shi-Yi Song, Chun-Run Li, Wei-Wei Hou, Qing-Jie Li
Summary: This study systematically evaluated the clinical evidence and potential mechanisms of Shen-ling-bai-zhu san (SLBZS) for the treatment of chronic gastritis (CG). Meta-analysis showed that SLBZS was more effective than conventional therapies for CG, but its safety remains unclear. Network pharmacology analysis suggested that SLBZS may treat CG by acting on related targets and pathways.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Plant Sciences
Siyuan Zhang, Hua Luo, Dechao Tan, Bo Peng, Zhangfeng Zhong, Yitao Wang
Summary: This review evaluates the potential of Chinese herbal medicine prescriptions (CHMPs) in managing Inflammatory Bowel Disease (IBD) from a holistic perspective, emphasizing the complexity and sophistication of CHMP treatments. By analyzing the clinical effectiveness and mechanisms of action of CHMPs, as well as exploring omics, gut microbiome, and network pharmacology, this review provides insights for further development and application of CHMPs in treating not only IBD but also other diseases.
Review
Plant Sciences
Siyuan Zhang, Hua Luo, Dechao Tan, Bo Peng, Zhangfeng Zhong, Yitao Wang
Summary: This review appraised the anti-IBD capacity of CHMPs through preclinical and clinical research, discussing their holistic characteristics for improved management of IBD. The review explored the complexity of IBD and the sophistication of CHMP treatments, highlighting the potential of omics, gut microbiome, and network pharmacology for understanding the dynamic bioactions of CHMPs.
Review
Multidisciplinary Sciences
Cuiping Liu, Wuxi Wang, Junling Gu
Summary: This review summarizes the relationship between ferroptosis and diabetes and diabetic complications, and discusses its molecular mechanisms. It also reviews the studies of herbal medicines or herbal natural compounds that improve diabetes or diabetic complications via the ferroptosis pathway.
Review
Integrative & Complementary Medicine
Ya-li Wang, Hui-xiang Zhang, Yan-qi Chen, Li-li Yang, Zheng-jun Li, Min Zhao, Wen-lin Li, Yao-yao Bian, Li Zeng
Summary: This review summarizes the role of traditional Chinese medicine (TCM) in the prevention and treatment of postoperative adhesion (PA), including its mechanisms, pharmacological effects, and advantages. The aim is to enhance the understanding of clinicians and researchers on TCM prevention of PA and promote the development and industrialization of related drugs.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Social Issues
Kelly Lynn Mulvey, Luke McGuire, Channing Mathews, Adam J. Hoffman, Fidelia Law, Angelina Joy, Adam Hartstone-Rose, Mark Winterbottom, Frances Balkwill, Grace Fields, Laurence Butler, Karen Burns, Marc Drews, Adam Rutland
Summary: This study aims to identify clusters of adolescents who vary in math and science motivation as well as interpersonal skills and explore the factors related to membership in a high motivation and skills cluster. The findings suggest that STEM program belonging and STEM identity are related to membership in the high motivation and skills cluster.
Article
Psychology, Developmental
Mengya Zhao, Channing J. Mathews, Kelly Lynn Mulvey, Adam Hartstone-Rose, Luke McGuire, Adam J. Hoffman, Mark Winterbottom, Angelina Joy, Fidelia Law, Frances Balkwill, Karen P. Burns, Laurence Butler, Marc Drews, Grace Fields, Hannah Smith, Adam Rutland
Summary: This study found that perceived inclusivity within informal science learning sites is related to youth program belonging and perceptions of program career preparation among adolescents participating in STEM youth programs.
JOURNAL OF YOUTH AND ADOLESCENCE
(2023)
Article
Psychology, Developmental
Angelina Joy, Channing J. Mathews, Mengya Zhao, Fidelia Law, Luke McGuire, Adam J. Hoffman, Frances Balkwill, Karen P. Burns, Laurence Butler, Marc Drews, Grace Fields, Hannah Smith, Emine Ozturk, Mark Winterbottom, Adam Rutland, Adam Hartstone-Rose, Kelly Lynn Mulvey
Summary: Little is known about the factors that influence engagement for adolescents participating in informal youth science programs. This study examined the reciprocal associations between adolescents' science engagement, interest, and growth mindset. The findings suggest that informal programs can encourage positive STEM trajectories by fostering engagement, growth mindset, and interest.
JOURNAL OF YOUTH AND ADOLESCENCE
(2023)
Editorial Material
Anatomy & Morphology
Adam Hartstone-Rose, Arin Berger, Mot Tuman, Anthony R. Fiorillo
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2023)
Article
Anatomy & Morphology
Edwin Dickinson, Adam Hartstone-Rose
Summary: This article summarizes the relationship between muscle structure and function, focusing on the intermediate level of muscle architecture. It highlights the role of The Anatomical Record in advancing our understanding of functional morphology within muscle and recognizes the contributions of Editor-in-Chief Kurt Albertine.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2023)
Article
Anatomy & Morphology
Edwin Dickinson, Emily Tomblin, Madison Rose, Zoe Tate, Mihika Gottimukkula, Michael C. Granatosky, Sharlene E. Santana, Adam Hartstone-Rose
Summary: Echolocation is the primary sense used by bats for navigation, but its influence on the morphology of the auditory apparatus is not well understood. This study used mu CT datasets to investigate the relationships between body size, habitat use, diet, and the morphology of the inner and middle ear in 27 bat species. The results showed that ossicle size scaled negatively with body mass, and cochlear spirality was associated with wing aspect ratio. Malleus and incus morphology varied with diet and call frequency, while stapes morphology was more closely tied to body size. Future research will explore these relationships in other bat lineages and compare echolocating and non-echolocating taxa.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Decai Zhu, Dawei Wang, Zhen Zhao, Qingqing Liu, Rongyuan Yang, Qing Liu
Summary: Meta-analysis showed that nanoliposome alprostadil could effectively reduce the occurrence of in-stent restenosis (ISR) after percutaneous coronary intervention (PCI) in patients with coronary atherosclerotic heart disease (CHD).
JOURNAL OF INTERVENTIONAL CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Adam J. Hoffman, Luke McGuire, Channing J. Mathews, Angelina Joy, Fidelia Law, Marc Drews, Adam Rutland, Adam Hartstone-Rose, Mark Winterbottom, Kelly Lynn Mulvey
Summary: During the COVID-19 pandemic, it is crucial to examine the effects of social media use on the mental health and well-being of young people, who have been exposed to unreliable information. This study found that exposure to COVID-19 information on social media had a null to positive relation with well-being, but when trust in the information was high, the relation became positive. For those with lower trust, the association between exposure to information on social media and well-being was null or negative. These findings emphasize the importance of trust in assessing the impact of COVID-19 information on well-being.
Article
Cell Biology
Rongyuan Yang, Dawei Wang, Yu Ding, Qing Liu
Summary: This study investigated the role of macrophage autophagy-related pyroptosis in atherosclerosis through various analyses using R software and datasets such as GEO and GSE. The findings revealed differentially expressed autophagy-related genes, enriched pathways, and immune cell distribution. Six hub genes were identified as regulators of macrophage-related autophagy, with high prediction value. Functional analysis and immune correlation indicated their involvement in macrophages and T cells. Venn plot and single-cell analysis provided further evidence, validated in human samples. The discovery of these hub genes and their significance in atherosclerosis highlights the importance of macrophage autophagy-mediated pyroptosis in the disease pathogenesis.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Anatomy & Morphology
Ashley. R. R. Deutsch, R. Brian Langerhans, Deanna Flores, Adam Hartstone-Rose
Summary: Animal vocalization is important in ecology and evolution. Hyoid elements play a role in vocalization in mammals but are rare in the fossil record. However, enough hyoids have been preserved in the La Brea tar pits in Los Angeles to allow for quantitative analyses.
JOURNAL OF MORPHOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Lara L. Martens, Sarah Jessica Piersanti, Arin Berger, Nicole A. Kida, Ashley R. Deutsch, Kathryn Bertok, Lauren Humphries, Angela Lassiter, Adam Hartstone-Rose
Summary: This study evaluates the forearms of declawed and non-declawed cats to investigate the effects of declawing on muscle architecture. The study found that the deep muscles that flex the digits, which are the muscles most directly affected by declawing, are significantly lighter (about 73%) and less powerful (46-66%) in declawed animals, while other muscles do not compensate for these reductions. Therefore, declawing has a substantial impact on the muscular capabilities of cats, especially larger cats.
Review
Multidisciplinary Sciences
Rongyuan Yang, Yingming Gu, Jinying Qin, Qingqing Liu, Qing Liu
Summary: This review explores the potential and advantages of nanoparticles loaded with Chinese medicine for the treatment of coronary artery disease (CAD). It concludes that nanoparticle-based drug delivery systems offer promising approaches for CAD treatment.
Article
Critical Care Medicine
Rongyuan Yang, Yong Duan, Dawei Wang, Qing Liu
Summary: This study investigated the predictive factors for prognosis in patients with pneumonia complicated with heart failure using next-generation sequencing (NGS) of metagenome. More microbial species were detected with NGS of metagenome. Enterococcus, Hb, and ProBNP were identified as potential predictive factors for the prognosis. A nomogram was constructed based on these factors and its performance was validated. The nomogram showed good predictive value for the prognosis of pneumonia complicated with heart failure.
CRITICAL CARE RESEARCH AND PRACTICE
(2023)
Meeting Abstract
Zoology
Chris Law, Emily Blackwell, Abigail Curtis, Edwin Dickinson, Adam Hartstone-Rose, Sharlene Santana
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2023)
Meeting Abstract
Zoology
Edwin Dickinson, Aleksandra Ratkiewicz, Michael Granatosky, Julia Molnar, Adam Hartstone-Rose
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2023)
