Article
Biochemistry & Molecular Biology
Wei-Lun Hung, Yi-Ting Hsiao, Yi-Shiou Chiou, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hsiung Pan
Summary: Piceatannol shows hepatoprotective effects by improving liver function, reducing collagen deposition, and inhibiting hepatic oxidative damage induced by CCl4 through regulating the TGF-beta/Smad signaling pathway and increasing glutathione and catalase activity.
Article
Plant Sciences
Xin-Hong Feng, Hai-Yan Xu, Jian-Ye Wang, Shen Duan, Ying-Chun Wang, Chao-Mei Ma
Summary: Chebulinic acid (CA), a major chemical constituent of Terminalia chebula fruit, has shown potent hepatoprotective effects in cell, zebrafish, and mouse models by regulating the MAPK/Nrf2 signaling pathway.
Article
Pharmacology & Pharmacy
Xichuan Wei, Chuanhong Luo, Yanan He, Haozhou Huang, Fei Ran, Wei Liao, Peng Tan, Sanhu Fan, Yuan Cheng, Dingkun Zhang, Junzhi Lin, Li Han
Summary: This study evaluated the hepatoprotective effects of Triphala extracts obtained by different methods in a mouse model of CCl4-induced liver injury. The findings indicate that ultrasonic extraction of Triphala was the most effective in preventing acute liver injury induced by CCl4.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Malak A. Jaber, Bayan Y. Ghanim, Mohammad Al-Natour, Duaa Abu Arqoub, Qasem Abdallah, Salah Abdelrazig, Jamal Alyousse Alkrad, Dong-Hyun Kim, Nidal A. Qinna
Summary: Alcohol consumption has significant toxic effects on population health worldwide, and the concurrent intake of Acetaminophen and alcohol is a concern in clinical settings. Understanding the molecular mechanisms behind this synergistic toxicity and acute effects can be improved through analyzing metabolomics changes. This study assessed the molecular toxic activities using metabolomics profiling to identify potential biomarkers and significant variables that could aid in managing drug-alcohol interactions.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Food Science & Technology
Fengguang Pan, Zhuanzhang Cai, Huifang Ge, Sitong Ma, Yiding Yu, Jingbo Liu, Ting Zhang
Summary: Soybean meal peptides (SPs) exhibited potent antioxidant capacity and showed hepatoprotective potential by increasing cell viability, reducing oxidative stress, and alleviating alcohol-induced liver injury without toxicity. Transcriptome analysis suggested that the hepatoprotective effects of SPs may be related to genes involved in inflammation, lipid metabolism, and oxidation.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Medicine, Research & Experimental
Vicenc Ruiz de Porras, Mariona Figols, Albert Font, Eva Pardina
Summary: Chemotherapy-induced hepatotoxicity is a significant concern in cancer treatment, but curcumin has emerged as a potential strategy to mitigate this adverse effect. By targeting specific molecular mechanisms, curcumin exhibits anti-inflammatory, antioxidant, antifibrotic, and hypolipidemic properties that can help prevent and reduce chemotherapy-induced liver injury. Further clinical investigation is needed to demonstrate the efficacy of bioavailable curcumin formulations as hepatoprotective agents in cancer patients.
Article
Virology
Xuemin Wei, Shuhan Li, Yan Lu, Ling Qiu, Nannan Xu, Xianhu Guo, Mengting Chen, Hao Liang, Dong Cheng, Li Zhao, Shubin Hao, Zengqiang Kou, Hongling Wen
Summary: This study aimed to verify if the SFTSV could be transmitted by aerosols. Firstly, the researchers demonstrated that the SFTSV can infect BEAS-2B cells and can be isolated from mild patient's sputum, laying the foundation for SFTSV aerosol transmission. Then, they evaluated the presence of antibodies and viral load in mice infected with SFTSV by aerosols, finding that the presence of antibodies is related to the dose of virus infection and SFTSV replicates preferentially in the lungs of mice following an aerosol exposure.
Article
Food Science & Technology
Yali Yu, Shiyao Guan, Mengmeng Feng, Lijun Wang, Feng Gao
Summary: Albumin peptide fractions from corn germ meal (APF4) have a hepatoprotective effect on acute alcoholic liver damage in mice. APF4 at a dose of 800 mg/kg/bw significantly enhanced alcohol metabolism, reduced liver enzyme levels, decreased blood alcohol concentration, and increased antioxidant activity. These findings suggest that APF4 protects against alcohol-induced liver damage.
Article
Immunology
Samia Salem Sokar, Mahmoud Abdelrahman Alkabbani, El-Sayed Akool, Sally El- Sayed Abu-Risha
Summary: The study demonstrated that carvedilol, crocin, and their combination have significant protective effects against leflunomide-induced liver injury. The combination treatment was found to be more effective than either drug alone.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Environmental Sciences
Mengyao Zhao, Linlin Deng, Xiaoxuan Lu, Liqiang Fan, Yang Zhu, Liming Zhao
Summary: This study investigates the molecular mechanisms underlying the neurotoxicity caused by acrylamide (ACR), including oxidative stress, neurotransmission impairment, and neuroinflammation-related signal cascade.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Kuan Lin, Mei Zhou, Changlong Leng, Xiaoqing Tao, Rong Zhou, Youwei Li, Binlian Sun, Xiji Shu, Wei Liu
Summary: The polyphenol extracts from Terminalia chebula showed strong antioxidant activity and protective effects against cerebral ischemia-reperfusion injury by stimulating the Nrf2 signaling pathway and inhibiting apoptosis.
Article
Plant Sciences
Longhe Zhao, Ziyun Duan, Yu Wang, Meizhu Wang, Yan Liu, Xin Wang, Hongyu Li
Summary: The study demonstrates that Terminalia chebula extract can protect C.elegans against A beta 1-42-induced toxicity, inhibit A beta 142 aggregation, and delay A beta-induced paralysis through the activation of the DAF-16/HSF-1/Hsp-16.2 pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Shuo-Lei Zheng, Yue-Zheng Wang, Yu-Qin Zhao, Wang-Yu Zhu, Chang-Feng Chi, Bin Wang
Summary: This study aimed to prepare high Fischer ratio oligopeptides from hard-shelled mussel (HFOPs-HM) and investigate their hepatoprotective effects against acetaminophen-induced liver injury in mice. HFOPs-HM significantly improved liver function, decreased liver enzyme activities, increased antioxidant levels, and reduced liver inflammation. This suggests that HFOPs-HM could be used as a functional dietary molecule for alleviating drug-induced liver injury.
Article
Biochemistry & Molecular Biology
Wenwen Mu, Qi Wang, Mingxia Jia, Sijia Dong, Sijie Li, Jie Yang, Guoyun Liu
Summary: This study prepared COP-22-loaded nanoparticles and demonstrated their significant hepatoprotective effects in the treatment of acute liver injury. These nanoparticles exert therapeutic effects through multiple pathways, such as inhibiting inflammation, oxidative stress, and apoptosis, and can passively accumulate in the liver through the retention effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Weiling Guo, Shumao Cui, Xin Tang, Qiuxiang Zhang, Jianxin Zhao, Bingyong Mao, Hao Zhang
Summary: This study suggests that Lactobacillus paracasei CCFM1222 supplementation may have beneficial effects in preventing acute liver injury (ALI). It can inhibit inflammatory responses, alter intestinal microbiota composition and metabolites to prevent the occurrence and development of ALI.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)