Article
Chemistry, Medicinal
Sarah Geahchan, Parnian Baharlouei, Azizur Rahman
Summary: Marine organisms contain bioactive substances like collagen that have various applications in pharmaceutical and cosmetic industries. Marine collagen, being water soluble, metabolically compatible, and easily accessible, can serve as a biomaterial. It has been found effective in healing skin injuries and combating the aging process. Marine collagen has also shown potential in preventing and treating osteoporosis and osteoarthritis by promoting bone density and cell growth.
Article
Biochemistry & Molecular Biology
Zheng Kou, Balun Li, Aili Aierken, Ning Tan, Chenchen Li, Miao Han, Yuanxiang Jing, Na Li, Shiqiang Zhang, Sha Peng, Xianjun Zhao, Jinlian Hua
Summary: The existing treatment modalities for skin injuries, such as dressings, negative-pressure wound treatment, autologous skin grafting, and high-pressure wound treatment, have limitations such as high time cost and inability to remove inactivated tissue in a timely manner. Mesenchymal stem cells (MSCs) have great potential in cell therapy and regenerative medicine due to their unique self-renewal ability and differentiation potential. The addition of collagen to cell cultures promotes cell proliferation and accelerates the healing of skin wounds in mice and canines by promoting epidermal layer repair, collagen deposition, hair follicle angiogenesis, and an inflammatory response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Ziying Zhu, Xiaona Zhang, Haojie Hao, Heran Xu, Jun Shu, Qian Hou, Min Wang
Summary: Exosomes derived from umbilical cord mesenchymal stem cells (UC-MSCs) play a key role in promoting wound repair and skin regeneration by recruiting and stimulating fibroblasts to secrete nerve growth factors (NGFs) for skin nerve repair.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Yuzhen Wang, Xingyu Yuan, Bin Yao, Shuoji Zhu, Ping Zhu, Sha Huang
Summary: This review discusses the potential and limitations of extrusion-based bioprinting (EBB) for skin regeneration, and introduces strategies for improving the physical properties of bioinks and reinforcing bioinks in EBB approaches. It highlights the applications and effects of current EBB-based bioinks on wound healing, wound scar formation, vascularization, and the regeneration of skin appendages, along with the challenges and future perspectives.
BIOACTIVE MATERIALS
(2022)
Article
Medicine, Research & Experimental
Parand Khadivar, Morteza Alipour
Summary: Profound wounds can result in infection or organ malfunction, and conventional therapies have drawbacks. Tissue engineering provides a potential alternative for wound regeneration. This study used a pre-synthesized nano scaffold and cell therapy to observe their synergistic effect on wound healing in rats. The results showed that the scaffold alone or combined with cell therapy can promote wound healing, with the combination of scaffold and differentiated cells being the most effective treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Biomedical
Jiang-Shan Gong, Guo-Qiang Zhu, Yu Zhang, Bei Chen, Yi-Wei Liu, Hong-Ming Li, Ze-Hui He, Jing-Tao Zou, Yu-Xuan Qian, Sheng Zhu, Xin-Yue Hu, Shan-Shan Rao, Jia Cao, Hui Xie, Zhen-Xing Wang, Wei Du
Summary: This study developed a novel BMSC-aptamer functionalized hydrogel and demonstrated its effectiveness in recruiting BMSCs and promoting bone regeneration.
MATERIALS TODAY BIO
(2023)
Article
Engineering, Biomedical
Zhengbo Wen, Yuxin Chen, Peilin Liao, Fengyu Wang, Weiping Zeng, Shoupei Liu, Haibing Wu, Ning Wang, Lorenzo Moroni, Minmin Zhang, Yuyou Duan, Honglin Chen
Summary: In this study, an in situ cell electrospinning system was developed as an attractive approach for stem cell delivery, which could promote cutaneous wound healing through direct deposition of bioactive fish gelatin fibers and MSCs onto wound sites, leading to a synergistic therapeutic effect.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Che-Chang Tu, Zhao-Cheng Zheng, Nai-Chen Cheng, Jiashing Yu, Wei-Chiu Tai, Yi-Xuan Pan, Po-Chun Chang
Summary: This study evaluated the potential of alveolar mucosal cell (AMC) spheroids for promoting extraction socket healing and calvarial osseous defect regeneration. The results showed that AMC spheroids can accelerate wound healing and bone tissue regeneration. The effects of socket healing and bone defect regeneration can be further enhanced by promoting osteogenesis of AMC.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Cell & Tissue Engineering
Yan Shi, Shang Wang, Weiwei Zhang, Yihan Zhu, Zhiqiang Fan, Yuesheng Huang, Furong Li, Ronghua Yang
Summary: This study reveals that hypoxic BMSCs can regulate the autophagy of epidermal cells through the HIF-1 alpha/TGF-beta 1/SMAD pathway, promoting the repair and healing of diabetic wounds.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell Biology
Xiao He, Dawei Wang, Yi Yi, Yufang Tan, Min Wu, Haiping Wang, Weijie Hu, Hongbo Chen, Qi Zhang, Yiping Wu
Summary: This study found that δ-tocotrienol (δ-TT) can enhance the wound healing ability of bone marrow-derived mesenchymal stem cells (BMSCs). Through in vitro and in vivo experiments, it was found that δ-TT-BMSCs can inhibit the progression of ferroptosis and promote wound healing. This study provides a new strategy for treating wounds.
CELL DEATH DISCOVERY
(2023)
Article
Chemistry, Multidisciplinary
M. Asadniaye Fardjahromi, H. Nazari, S. M. Ahmadi Tafti, A. Razmjou, S. Mukhopadhyay, M. E. Warkiani
Summary: The use of nano-metal organic framework (nanoMOF) scaffolds presents a promising opportunity to enhance the properties of bone and wound tissue engineering scaffolds due to their unique characteristics such as high internal surface areas, high porosity, good mechanical stability, biocompatibility, and tunability. Incorporating nano-MOFs into scaffolds has been shown to be favorable for regenerating imperfect tissues, offering advantages such as high antibacterial activity, high drug loading capacity, and controlled drug release. However, challenges and clinical barriers need to be addressed for the implementation of these nanomaterials in orthopedic and wound clinics.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Cell Biology
Di Li, Jin-wei Ren, Teng Xu, Lin Li, Peng Liu, Yong Li
Summary: The study showed that oral administration of bovine bone collagen oligopeptides (BCOP) significantly promoted wound healing in mice by increasing protein levels and tensile strength, reducing inflammatory markers, and enhancing the expression of vascular growth factors.
Review
Chemistry, Multidisciplinary
Yongping Liang, Jiahui He, Baolin Guo
Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.
Review
Biochemistry & Molecular Biology
Kotaro Tanaka, Ryohei Ogino, Sho Yamakawa, Shota Suda, Kenji Hayashida
Summary: Skin wounds usually heal on their own, but this is only true for healthy individuals. Mesenchymal stem cells (MSCs) have been found to play a significant role in wound healing and regeneration, with their ability to self-renew and differentiate, as well as their anti-inflammatory and immunomodulatory properties. This review aims to explain the functions and effects of MSCs in wound healing.
Article
Immunology
Rogerio Marchete, Sarah Oliveira, Leonardo Bagne, Jennyffer Ione de Souza Silva, Ana Paula Valverde, Andrea Aparecida de Aro, Mariana Moreira Figueira, Marcio Fronza, Thaina Mikaela Bressam, Vivian Fernandes Furletti de Goes, Fernanda Oliveira de Gaspari de Gaspi, Glaucia Maria Tech dos Santos, Thiago Antonio Moretti Andrade
Summary: The extract of Alternanthera brasiliana exhibits important anti-inflammatory and antioxidant activities, promoting angiogenesis and tissue formation, accelerating wound healing process.
INFLAMMOPHARMACOLOGY
(2021)
Article
Cell & Tissue Engineering
Jinghui Xu, Zhenxiao Ren, Tianzuo Niu, Siyuan Li
Summary: This study discovers that MSCs-EVs attenuate inflammation and oxidative stress in spinal cord injury (SCI) by delivering miR-26b-5p to target the KDM6A/NOX4 axis, facilitating recovery.
REGENERATIVE THERAPY
(2024)
Article
Cell & Tissue Engineering
Shant Nepal, Jinyan Si, Shohei Ishikawa, Masaki Nishikawa, Yasuyuki Sakai, Aya M. Akimoto, Hiroyuki Okada, Shinsuke Ohba, Ung-il Chung, Takamasa Sakai, Hironori Hojo
Summary: In this study, we evaluated the potential of oligo-tetra-PEG gel (Oligo gel) as a growth factor-releasing scaffold. Compared to tetra-PEG hydrogel (Tetra gel), Oligo gel underwent a higher degree of gel-gel phase separation, demonstrating better protein release and osteogenic potential, and achieving superior regeneration in a mouse calvarial defect model. Therefore, Oligo gel is considered a promising therapeutic biomaterial.
REGENERATIVE THERAPY
(2024)
Article
Cell & Tissue Engineering
Yasuhiro Homma, Sayuri Uchino, Masashi Nagao, Takanori Wakayama, Shin Fukusato, Tomonori Baba, Taiji Watari, Koju Hayashi, Yoshitomo Saita, Muneaki Ishijima
Summary: This study investigates the safety and feasibility of locoregional PRP injection for iliopsoas impingement after THA, and finds that it is both safe and feasible.
REGENERATIVE THERAPY
(2024)
Article
Cell & Tissue Engineering
Taichi Tenkumo, Benedikt Kruse, Kathrin Kostka, Viktoriya Sokolova, Toru Ogawa, Nobuhiro Yoda, Oleg Prymak, Osamu Suzuki, Keiichi Sasaki, Matthias Epple
Summary: This study evaluated the bone-healing effects of a triple-functionalized CaP paste in the rat femoral head. The results showed that the paste significantly accelerated bone healing after 21 days and increased the levels of bone formation-related markers at the protein and gene levels.
REGENERATIVE THERAPY
(2024)
