Article
Radiology, Nuclear Medicine & Medical Imaging
Yasunori Nagayama, Taihei Inoue, Seitaro Oda, Shota Tanoue, Takeshi Nakaura, Jun Morinaga, Osamu Ikeda, Toshinori Hirai
Summary: The study showed that unenhanced dual-layer spectral-detector CT can improve the characterization of adrenal lesions, particularly in distinguishing lipid-poor adrenal adenomas from nonadenomas, with higher sensitivity compared to conventional CT imaging methods.
Review
Biochemistry & Molecular Biology
Roxana-Elena Cirjaliu, Mariana Deacu, Ioana Gherghisan, Angela Stefania Marghescu, Manuela Enciu, Gabriela Izabela Baltatescu, Antonela Anca Nicolau, Doina-Ecaterina Tofolean, Oana Cristina Arghir, Ariadna-Petronela Fildan
Summary: This review provides a comprehensive analysis of the risk factors, clinical, radiologic, and histological features of both post-COVID-19 pulmonary fibrosis (PCPF) and idiopathic pulmonary fibrosis (IPF). It highlights the similarities and differences between these two diseases by gathering relevant articles published in English up until October 2022 using multiple databases. This review aims to assist clinicians, pathologists, and researchers in making accurate diagnoses and selecting patients for anti-fibrotic therapies and future therapeutic perspectives.
Article
Critical Care Medicine
Jonathan R. Weir-McCall, Elise Debruyn, Scott Harris, Nagmi R. Qureshi, Robert C. Rintoul, Fergus Gleeson, Fiona J. Gilbert
Summary: A lung cancer prediction convolutional neural network (LCP-CNN) demonstrates diagnostic performance comparable to PET with CT imaging in the diagnosis of solitary pulmonary nodules. The LCP-CNN outperforms dynamic contrast-enhanced (DCE) CT imaging in accuracy, while being equal to PET with CT imaging.
Article
Medicine, General & Internal
Moshe Rav Acha, Oholi Tovia-Brodie, Yoav Michowitz, Feras Bayya, Fauzi F. Shaheen, Shalom Abuhatzera, Aharon Medina, Michael Glikson, Arik Wolak
Summary: This study evaluated post-ablation pulmonary vein (PV) ostial gaps in patients with atrial fibrillation (AF) and found that cryoballoon ablation induced PV fibrosis, which correlated with AF recurrence. The study suggests that MRI has the ability to predict AF recurrence.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Khaoula Bouazizi, Mohamed Zarai, Florian Marquet, Judith Aron-Wisnewsky, Karine Clement, Alban Redheuil, Nadjia Kachenoura
Summary: This study utilized high-field ex vivo MRI to quantify fibrosis percentage in human subcutaneous adipose tissue samples, demonstrating excellent correlations and levels of agreement with histology results.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Multidisciplinary Sciences
Akinori Hata, Masahiro Yanagawa, Mitsuko Tsubamoto, Shuhei Doi, Yuriko Yoshida, Tomo Miyata, Noriko Kikuchi, Nobuo Kashiwagi, Noriyuki Tomiyama
Summary: The prevalence of nodular pulmonary ossifications (POs) is higher in patients with honeycombing, and they are more easily detected in images reconstructed with the ultra-high-resolution setting (UHR-setting) compared to the conventional setting (C-setting).
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Kyungsoo Bae, Kyung-Nyeo Jeon
Summary: Dual-energy CT shows added value in diagnosing pulmonary embolism, but the role of non-contrast-enhanced dual-energy CT in this area has not been reported.
Article
Respiratory System
Nicholas D. Weatherley, James A. Eaden, Paul J. C. Hughes, Matthew Austin, Laurie Smith, Jody Bray, Helen Marshall, Stephen Renshaw, Stephen M. Bianchi, Jim M. Wild
Summary: The study found correlations between DCE-MRI first pass perfusion and existing physiological gas exchange metrics in IPF patients, suggesting that capillary perfusion deficit may contribute to gas exchange limitation. The FWHMmean metric showed a significant increase over a 6-month period and may serve as a quantitative biomarker for pulmonary vascular disease progression in IPF.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yasunori Nagayama, Taihei Inoue, Yuki Kato, Shota Tanoue, Masafumi Kidoh, Seitaro Oda, Takeshi Nakaura, Toshinori Hirai
Summary: In this study, the combined assessment of unenhanced and portal venous phase CT images allowed for the accurate differentiation of lipid-poor adrenal adenomas from nonadenomas. The relative enhancement ratio was found to be more sensitive in distinguishing adenomas from nonadenomas, particularly for lesions with unenhanced attenuation of 10-30 HU.
Article
Biochemistry & Molecular Biology
Kun Qing, Talissa A. Altes, John P. Mugler III, Jaime F. Mata, Nicholas J. Tustison, Kai Ruppert, Juliana Bueno, Lucia Flors, Yun M. Shim, Li Zhao, Joanne Cassani, William G. Teague, John S. Kim, Zhixing Wang, Iulian C. Ruset, F. William Hersman, Borna Mehrad
Summary: The use of hyperpolarized xenon-129 gas as a contrast agent in lung MRI imaging is a promising technique for assessing lung function and detecting impaired lung physiology in UIP patients.
Article
Multidisciplinary Sciences
Ghassan Dandache, Umut Aksoy, Mehmet Birol Ozel, Kaan Orhan
Summary: The present study used micro-CT to measure and compare anatomic parameters in contralateral maxillary second molars. The results showed a high degree of symmetry in linear measurements and root canal anatomy configuration. A significant proportion of the roots had lateral canals, with the apical third being the most common location. This study provides valuable insight into the root canal anatomy of contralateral maxillary second molars.
Article
Radiology, Nuclear Medicine & Medical Imaging
Iulia Skoda, Markus Henningsson, Sofia Stenberg, Jonathan Sundin, Carl-Johan Carlhall
Summary: The study demonstrates that LA fibrosis and EAT can be assessed simultaneously using LGE-Dixon MRI, with high repeatability and agreement with reference methods, within a clinically feasible scan time.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Floris Heutink, Tim M. Klabbers, Wendy J. Huinck, Federica Lucev, Willem Jan van der Woude, Emmanuel A. M. Mylanus, Berit M. Verbist
Summary: This study used ultra-high-spatial-resolution CT to assess new bone formation after cochlear implantation and found that most recipients develop new bone formation, predominantly located at the base of the cochlea. New bone formation adversely affects long-term residual hearing preservation.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lara Marchetti, Luca Perrucci, Fabio Pellegrino, Luca Baroni, Annalisa Merlo, Massimo Tilli, Ilaria Rambaldi, Elisa Maietti, Aldo Carnevale, Mirco Bartolomei, Melchiore Giganti
Summary: The study aimed to evaluate the diagnostic value of contrast-enhanced CT (CECT) compared to unenhanced CT (UECT) in PET/CT staging and treatment response assessment of F-18-FDG-avid lymphomas. Results showed that CECT did not provide significant additional diagnostic value compared to UECT, suggesting that CECT examination may be unnecessary for these purposes.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Qing Fu, Qiguang Cheng, Xiangchuang Kong, Hui Ma, Ziqiao Lei
Summary: The study analyzed the diagnostic accuracy of different magnetic resonance sequences in detecting pulmonary embolisms and found that the VIBE sequence had the highest accuracy in revealing PE, particularly in segmental analysis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Editorial Material
Respiratory System
Brian Gaffney, Liam Chawke, Michaela Larkin, Gaith Qsous, David Healy, Michael P. Keane, Aurelie Fabre, David J. Murphy, Cormac McCarthy
Letter
Dermatology
L. Roche, B. Moriarty, A. Fabre, J. Crowne, A. Lally
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Article
Immunology
Lydia Dyck, Hannah Prendeville, Mathilde Raverdeau, Mieszko M. Wilk, Roisin M. Loftus, Aaron Douglas, Janet McCormack, Bruce Moran, Michael Wilkinson, Evanna L. Mills, Michael Doughty, Aurelie Fabre, Helen Heneghan, Carel LeRoux, Andrew Hogan, Edward T. Chouchani, Donal O'Shea, Donal Brennan, Lydia Lynch
Summary: Obesity suppresses the activity of CD8 T cells in anti-tumor immunity, and this suppression can be partially reversed by weight loss and immunotherapy.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Biology
Christopher J. Brereton, Liudi Yao, Elizabeth R. Davies, Yilu Zhou, Milica Vukmirovic, Joseph A. Bell, Siyuan Wang, Robert A. Ridley, Lareb S. N. Dean, Orestis G. Andriotis, Franco Conforti, Lennart Brewitz, Soran Mohammed, Timothy Wallis, Ali Tavassoli, Rob M. Ewing, Aiman Alzetani, Benjamin G. Marshall, Sophie Fletcher, Philipp J. Thurner, Aurelie Fabre, Naftali Kaminski, Luca Richeldi, Atul Bhaskar, Christopher J. Schofield, Matthew Loxham, Donna E. Davies, Yihua Wang, Mark G. Jones
Summary: This study provides evidence that the activation of the hypoxia-inducible factor (HIF) pathway is a critical regulator of pathogenetic collagen structure-function in fibrosis. Oxidative stress can drive the activation of pseudohypoxic HIF pathway, which alters collagen nanostructure and increases tissue stiffness.
Article
Medical Laboratory Technology
Tony Loughman, Stephen Barron, Chan-Ju Angel Wang, Peter Dynoodt, Bozena Fender, Cesar Lopez-Ruiz, Sharon Stapleton, Aurelie Fabre, Cecily Quinn, Bjorn Nodin, Karin Jirstrom, Fatemeh Razmara, Anthony O'Grady, Anne-Marie Baird, Steven G. Gray, Ana Freixo, Cathy B. Moelans, Paul J. van Diest, Michael J. Duffy, Desmond O'Leary, John Crown, Adrian P. Bracken, William M. Gallagher
Summary: This study describes the analytical performance characteristics of the OncoMasTR multigene prognostic test for early-stage breast cancer. The test shows high precision, reproducibility, and suitability for decentralized use in molecular pathology laboratories.
CLINICAL CHEMISTRY
(2022)
Correction
Immunology
Lydia Dyck, Hannah Prendeville, Mathilde Raverdeau, Mieszko M. Wilk, Roisin M. Loftus, Aaron Douglas, Janet McCormack, Bruce Moran, Michael Wilkinson, Evanna L. Mills, Michael Doughty, Aurelie Fabre, Helen Heneghan, Carel LeRoux, Andrew Hogan, Edward T. Chouchani, Donal O'Shea, Donal Brennan, Lydia Lynch
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Respiratory System
Michelle Terwiel, Raphael Borie, Bruno Crestani, Liam Galvin, Francesco Bonella, Aurelie Fabre, Antoine Froidure, Matthias Griese, Jan C. Grutters, Kerri Johannson, Caroline Kannengiesser, Leticia Kawano-Dourado, Maria Molina-Molina, Antje Prasse, Elisabetta A. Renzoni, Jasper van Der Smagt, Venerino Poletti, Katerina Antoniou, Coline H. M. van Moorsel
Summary: This study surveyed the experiences and needs of patients, their relatives, and pulmonologists regarding genetic testing in ILD. The results showed that there is widespread support for the implementation of genetic testing in ILD, and there is a high demand for information, guidelines, and access to testing among all groups surveyed. However, a significant number of pulmonologists currently do not offer genetic testing due to limited access to tests.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jonathan D. Dodd, Roisin MacDermott
Article
Cell Biology
Michael Eyres, Joseph A. Bell, Elizabeth R. Davies, Aurelie Fabre, Aiman Alzetani, Sanjay Jogai, Ben G. Marshall, David A. Johnston, Zijian Xu, Sophie Fletcher, Yihua Wang, Gayle Marshall, Donna E. Davies, Emil Offer, Mark G. Jones
Summary: This study investigates spatial gene expression in human lung fibrosis using digital profiling technology and identifies distinct gene expression signatures in different regions. Through integration with single-cell data, the study maps the cellular composition and cellular cross-talk within the fibrotic niche. The findings reveal cell dysregulation and impaired response to environmental stress in fibrotic lung.
Article
Pathology
Diarmuid O'Connor, Aurelie Fabre, David Gibbons
Summary: This study aimed to analyze the effectiveness of our respiratory cytology coding system by calculating the estimated risk of malignancy (ROM) and rates of each diagnostic category. The results showed that our ROM rates were consistent with other international studies, and our rates of diagnostic accuracy were in line with international standards, providing valuable information for the development of the WHO-IARC IAC joint project.
Article
Dermatology
Aoife Granahan, Aurelie Fabre, Aisling Ryan, Aoife Lally
Summary: We present a clinicopathological case of a patient who experienced rapid growth of a nonpigmented nodule on the chest wall. There was no personal or family history of skin disease or cutaneous malignancy.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Respiratory System
Raphael Borie, Caroline Kannengiesser, Katerina Antoniou, Francesco Bonella, Bruno Crestani, Aurelie Fabre, Antoine Froidure, Liam Galvin, Matthias Griese, Jan C. Grutters, Maria Molina-Molina, Venerino Poletti, Antje Prasse, Elisabetta Renzoni, Jasper van der Smagt, Coline H. M. van Moorsel
Summary: The discovery of gene mutations that cause pulmonary fibrosis confirms the genetic predisposition to this condition. While genetic sequencing is already part of routine clinical practice for familial pulmonary fibrosis cases in some countries, it has not been widely incorporated into interstitial lung disease services and lacks international consensus.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Georgios Tzimas, David T. Ryan, David J. Murphy, Jonathon A. Leipsic, Jonathan D. Dodd
Summary: This review summarizes key publications in 2021 related to three key noninvasive cardiac imaging modalities: cardiac CT angiography (CTA), MRI, and PET/CT. The review focuses primarily on articles published in Radiology but also includes important studies from other major journals in the field of cardiovascular imaging. It highlights the value of cardiac CTA, the evolving role of artificial intelligence in cardiovascular disease, and the emphasis on nonischemic cardiomyopathies, valvular heart disease, and COVID-19 disease cardiac manifestations in cardiac MRI studies. The increasing role of cardiac PET/CT in the assessment of cardiac sarcoidosis and prosthetic valves is also discussed.
Article
Pathology
Daniel M. Di Capua, William Shanahan, Michele Bourke, Navneet Ramlaul, Josh Appel, Aoife Canney, Neil G. Docherty, Erinn McGrath, Eabha Ring, Fiona Jones, Marie Boyle, Janet McCormack, Tom Gallagher, Emir Hoti, Niamh Nolan, John D. Ryan, Diarmaid D. Houlihan, Aurelie Fabre
Summary: The study compares the clinical course, treatment outcomes, and tumor characteristics of patients with HFE-HCC and those without HFE-HCC. It finds that HFE-HCC patients have a more aggressive disease progression and tumors with increased expression of progenitor markers. The study suggests that transplant should be considered at an earlier stage for patients with HFE-HCC.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Medicine, General & Internal
Marissa O'Callaghan, Niamh Boyle, Aurelie Fabre, Michael P. Keane, Cormac McCarthy
Summary: This review article provides an overview of the background, popularity, and mechanism of lung injury caused by e-cigarette or vaping use.
MEDICINA-LITHUANIA
(2022)
