Article
Biochemistry & Molecular Biology
Jonghwan Jegal, No-June Park, Beom-Geun Jo, Tae-Young Kim, Sim-Kyu Bong, Sangho Choi, Jin-Hyub Paik, Jung-Won Kim, Su-Nam Kim, Min Hye Yang
Summary: The study demonstrated the potential of Wikstroemia ganpi in treating atopic dermatitis (AD) by alleviating symptoms, reducing infiltration of inflammatory cells, and lowering levels of key substances in the blood.
Article
Biochemistry & Molecular Biology
Tae-Young Kim, No-June Park, Beom-Geun Jo, Jin-Hyub Paik, Sangho Choi, Su-Nam Kim, Min Hye Yang
Summary: 7-O-methylluteolin (7-ML) has antioxidant and anti-atopic dermatitis (AD) activities. Results from cell and animal models showed that 7-ML inhibited the activation of Nrf2, upregulated antioxidant protein expression, and improved skin barrier functions.
Article
Biochemistry & Molecular Biology
Lian Yang, Qing Zhang, Yili Yang, Qun Wang
Summary: The study investigated the therapeutic effects of PYR-41 on atopic dermatitis. The results showed that PYR-41 can activate the NF-?B signaling pathway by reducing the ubiquitination levels of specific molecules and inhibiting the degradation of I?Ba. In addition, in a mouse model, PYR-41 treatment significantly improved symptoms and reduced the expression of inflammatory markers.
Article
Medicine, Research & Experimental
Jinjoo Kang, Soyoung Lee, Namkyung Kim, Hima Dhakal, Young-Ae Choi, Taeg Kyu Kwon, Dongwoo Khang, Sang-Hyun Kim
Summary: The study investigated the efficacy of Hispidulin on atopic dermatitis-like skin inflammation, suggesting that HPD could be a potential drug candidate for the treatment of AD.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Nutrition & Dietetics
Wei-jie Lv, Jie-yi Huang, Shu-peng Li, Xiao-pei Gong, Jing-bo Sun, Wei Mao, Shi-ning Guo
Summary: This study compared the therapeutic effects of Portulaca oleracea L. (PO) aqueous extract (POAE) and PO ultrasound-assisted ethanol extract (POEE) on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in mice. The results showed that both POAE and POEE alleviated clinical symptoms of AD and inhibited the expression of immune cells, inflammatory mediators, and cytokines associated with allergic responses.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Tae-Young Kim, Ye Jin Kim, Jonghwan Jegal, Beom-Geun Jo, Han-Seok Choi, Min Hye Yang
Summary: The study demonstrated that haplopine has anti-inflammatory, antioxidant, and anti-atopic dermatitis effects by inhibiting inflammatory cytokines, enhancing oxidative stress defense enzymes, and reducing AD symptoms. Therefore, haplopine may serve as a novel anti-atopic agent for treating AD.
Article
Biochemistry & Molecular Biology
Tae-Young Kim, No-June Park, Hyun Jegal, Jin-Hyub Paik, Sangho Choi, Su-Nam Kim, Min Hye Yang
Summary: Nymphoides peltata is used in traditional Chinese and Ayurvedic medicine for various purposes and has shown potential therapeutic use for the prevention and treatment of AD.
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Food Science & Technology
Xi Chen, Chunyan Yang, Jiaqi Zeng, Zhengyumeng Zhu, Liyun Zhang, Jonathan A. Lane, Xueling Wu, Daming Zuo
Summary: This study found that oral administration of 2'-FL and OPN significantly improved symptoms of atopic dermatitis in mice, reducing inflammatory cell numbers in skin tissues and inhibiting the differentiation of Th2 cells.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Pharmacology & Pharmacy
Fangli Peng, Junwei Zong, Tianqi Zhao, Peng Shi, Ming Lu, Xueling Qu, Xin Han, Lin Zhao, Zhuqiang Jia, Shouyu Wang
Summary: The polysaccharide extracted from the traditional Chinese medicine Wuguchong (PEW) has been found to have anti-inflammatory and immunomodulatory effects on atopic dermatitis (AD). It can inhibit Th1 and Th17 responses, downregulate the NF-κB and MAPK pathways, and potentially serve as a promising immune therapy for AD.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Ju-Hyun Lee, Dong-Soon Im
Summary: The study evaluated the therapeutic effects of honokiol on atopic dermatitis, and found that honokiol significantly suppressed symptoms of atopic dermatitis, indicating its potential as a therapeutic agent for the disease.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yeun Soo Jung, Jae Young Choi, Young-Sam Kwon, Gyu-Ryeul Park, VinayKumar Dachuri, Young Woo Kim, Sae-Kwang Ku, Chang-Hyun Song
Summary: Fermented red ginseng marc (fRGM) has anti-allergic effects and can alleviate skin lesions and reduce serum IgE levels in atopic dermatitis. It also has anti-inflammatory and antioxidant properties, and can suppress hypertrophic changes and inflammatory responses in the spleen and lymph nodes.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Jinjoo Kang, Soyoung Lee, Namkyung Kim, Hima Dhakal, Taeg-Kyu Kwon, Eun-Nam Kim, Gil-Saeng Jeong, Sang-Hyun Kim
Summary: GM2 has beneficial effects on AD-like skin lesions by reducing epidermal and dermal thickness and suppressing the expression of inflammatory mediators. It also inhibits the phosphorylation of STAT1 and NF-kappa B in AD-like lesions, as well as reduces levels of IgE and IgG2a in sera. Through these mechanisms, GM2 may serve as a remedy for inflammatory skin diseases, specifically atopic dermatitis.
Article
Chemistry, Multidisciplinary
Komal Saini, Nancy Modgill, Kamalinder K. Singh, Vandita Kakkar
Summary: This study investigated the therapeutic effectiveness of tetrahydrocurcumin solid lipid nanoparticle-based gels in the treatment of atopic dermatitis. The results showed that the gel had superior anti-inflammatory properties, enhanced skin hydration, and deeper skin penetration. In vivo experiments on AD mice demonstrated increased bioactivity, reduced inflammation levels, and complete healing.
Article
Biochemistry & Molecular Biology
Jin-Su Oh, Geum-Su Seong, Yong-Deok Kim, Se-Young Choung
Summary: The prevalence of atopic dermatitis (AD) is rapidly increasing worldwide. A study found that deacetylasperulosidic acid (DAA) has anti-atopic activity and can alleviate symptoms of AD by reducing pruritus, modulating immune imbalance, and restoring skin barrier function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)