Article
Medicine, General & Internal
Kassoum Kayentao, Aissata Ongoiba, Anne C. Preston, Sara A. Healy, Safiatou Doumbo, Didier Doumtabe, Abdrahamane Traore, Hamadi Traore, Adama Djiguiba, Shanping Li, Mary E. Peterson, Shinyi Telscher, Azza H. Idris, Neville K. Kisalu, Kevin Carlton, Leonid Serebryannyy, Sandeep Narpala, Adrian B. McDermott, Martin Gaudinski, Siriman Traore, Hamidou Cisse, Mamadou Keita, Jeff Skinner, Zonghui Hu, Amatigue Zeguime, Adama Ouattara, M'Bouye Doucoure, Amagana Dolo, Abdoulaye Djimde, Boubacar Traore, Robert A. Seder, Peter D. Crompton
Summary: A phase 2 trial in Mali showed that CIS43LS was protective against P. falciparum infection over a 6-month malaria season, with 40 mg dosage showing 88.2% efficacy and 10 mg dosage showing 75.0% efficacy compared to placebo.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Kassoum Kayentao, Aissata Ongoiba, Anne C. Preston, Sara A. Healy, Safiatou Doumbo, Didier Doumtabe, Abdrahamane Traore, Hamadi Traore, Adama Ouattara, Shanping Li, Mary E. Peterson, Shinyi Telscher, Azza H. Idris, Neville K. Kisalu, Kevin Carlton, Leonid Serebryannyy, Sandeep Narpala, Adrian B. McDermott, Martin Gaudinski, Siriman Traore, Hamidou Cisse, Mamadou Keita, Jeff Skinner, Zonghui Hu, Amatigue Zeguime, Adama Ouattara, M'Bouye Doucoure, Amagana Dolo, Abdoulaye Djimde, Boubacar Traore, Robert A. Seder, Peter D. Crompton
Summary: A phase 2 trial conducted in Mali showed that a single intravenous infusion of CIS43LS was safe and effective in preventing Plasmodium falciparum infection over a 6-month malaria season.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Kassoum Kayentao, Aissata Ongoiba, Anne C. Preston, Sara A. Healy, Safiatou Doumbo, Didier Doumtabe, Abdrahamane Traore, Hamadi Traore, Adama Djiguiba, Shanping Li, Mary E. Peterson, Shinyi Telscher, Azza H. Idris, Neville K. Kisalu, Kevin Carlton, Leonid Serebryannyy, Sandeep Narpala, Adrian B. McDermott, Martin Gaudinski, Siriman Traore, Hamidou Cisse, Mamadou Keita, Jeff Skinner, Zonghui Hu, Amatigue Zeguime, Adama Ouattara, M'Bouye Doucoure, Amagana Dolo, Abdoulaye Djimde, Boubacar Traore, Robert A. Seder, Peter D. Crompton, Mali Malaria mAb Trial Team
Summary: CIS43LS, a monoclonal antibody, showed protective effects against Plasmodium falciparum infection during the malaria season in Mali without significant safety concerns.
Article
Immunology
Ankur Sharma, Bethany Jenkins, Adovi Akue, Lynn E. Lambert, Sachy Orr-Gonzalez, Marvin L. Thomas, Almahamoudou Mahamar, Bacary S. Diarra, Alassane Dicko, Michal Fried, Patrick E. Duffy
Summary: Infection of pregnant Aotus monkeys with P. falciparum parasites can replicate the key features of placental malaria in pregnant women, including parasitemia, placental sequestration, and antibody response to VAR2CSA.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biotechnology & Applied Microbiology
Geetanjali Pendyala, J. Mauricio Calvo-Calle, Alberto Moreno, Ravi S. Kane
Summary: A vaccine based on SpyCatcher-mi3 nanoparticles presenting a chimeric PfCSP antigen was designed to target the malaria parasite Plasmodium falciparum (Pf). This vaccine incorporates recently identified T1/junctional epitopes and reduces the number of (NANP)(n) repeats. Immunization with this vaccine in mice resulted in high and durable IgG antibody levels and a balanced antibody response against T1/junctional epitopes and (NANP)(n) repeats. Refocusing the immune response towards functionally relevant epitopes may lead to a more effective second generation PfCSP-based vaccine.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Wenn-Chyau Lee, Bruce Russell, Bernett Lee, Cindy S. Chu, Aung Pyae Phyo, Kanlaya Sriprawat, Yee-Ling Lau, Francois Nosten, Laurent Renia
Summary: Brief exposure to artesunate (AS) stimulates rosetting, with AS-resistant isolates forming more rosettes rapidly for protection. Deletions in genes associated with AS-mediated rosetting are significantly selected in the parasite population, along with the K13 mutations as a marker of ART resistance.
Article
Biotechnology & Applied Microbiology
Matthew B. Laurens
Summary: Malaria vaccines, including the RTS,S/AS01 vaccine, are showing moderate efficacy and new approaches are being developed for next-generation vaccines. Techniques such as RNA vaccine delivery and whole organism vaccination are being explored, with the goal of creating highly effective malaria vaccines that provide sustained protection.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Microbiology
Vladimir Vigdorovich, Hardik Patel, Alexander Watson, Andrew Raappana, Laura Reynolds, William Selman, Suzannah Beeman, Paul T. Edlefsen, Stefan H. I. Kappe, D. Noah Sather
Summary: The currently approved malaria vaccine only provides partial protection and targets a single parasite protein (CSP). This study tested multiple additional vaccine targets in combination with CSP and found that certain combinations enhanced protection against malaria infection in mice. This research suggests that a multiprotein immunization approach could lead to higher levels of protection.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Kesley A. O. Pontes, Leandro S. Silva, Edgleyson C. Santos, Alessandro S. Pinheiro, Douglas E. Teixeira, Diogo B. Peruchetti, Rodrigo P. Silva-Aguiar, Camila H. C. Wendt, Kildare R. Miranda, Andrelina N. Coelho-de-Souza, Jose Henrique Leal-Cardoso, Celso Caruso-Neves, Ana Acacia S. Pinheiro
Summary: The study demonstrated the potential anti-malarial effect of eugenol against Plasmodium sp., reducing parasitemia and cerebral edema. By affecting the development of the erythrocytic cycle and inducing morphological changes, eugenol showed promise as a therapeutic strategy for malaria treatment.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Immunology
Deanna J. Friedman-Klabanoff, Andrea A. Berry, Mark A. Travassos, Catherine Cox, Yingjun Zhou, Annie X. Mo, Effie Y. H. Nomicos, Gregory A. Deye, Marcela F. Pasetti, Matthew B. Laurens
Summary: The new full-length rCSP vaccine combined with the GLA-LSQ adjuvant showed a good safety and immunogenicity profile in clinical trials, confirming the immunostimulatory capacity of GLA-LSQ and supporting further steps in clinical product development.
Article
Cell Biology
Dennis O. Odera, James Tuju, Kennedy Mwai, Irene N. Nkumama, Kristin Fuerle, Timothy Chege, Rinter Kimathi, Stefan Diehl, Fauzia K. Musasia, Micha Rosenkranz, Patricia Njuguna, Mainga Hamaluba, Melissa C. Kapulu, Roland Frank, Faith H. A. Osier
Summary: NK cells can be activated through Fc receptor engagement by antibodies, leading to degranulation and IFN-gamma release upon stimulation with antibody-opsonized Plasmodium falciparum merozoites. Antibody-dependent NK activity plays a crucial role in controlling parasitemia after experimental malaria challenge in adults and reducing the risk of clinical episodes of malaria in children. Several vaccine candidates, including less characterized antigens such as P41, P113, MSP11, RHOPH3, and Pf_11363200, induce antibody-dependent NK response, suggesting their potential in evaluating malaria vaccines.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Immunology
Srinivasa Reddy Bonam, Laurent Renia, Ganesh Tadepalli, Jagadeesh Bayry, Halmuthur Mahabalarao Sampath Kumar
Summary: Malaria, particularly caused by Plasmodium falciparum, is a global health problem with deadly consequences for humans. While progress has been made in understanding the host response to the parasite, various aspects of its biology in its mammalian host remain unclear. Therefore, there is a need to develop new drugs and vaccines to address this issue.
Article
Biochemistry & Molecular Biology
Jessica Correa Bezerra Bellei, Nicolas Glanzmann, Barbara Albuquerque Carpinter, Daniela Chaves Renhe, Carolina Brandi Marques, Marina Rocha Azevedo, Livia Maria Barreto, Vinicius Novaes Rocha, Isabelle Karine da Costa Nunes, Henrique Marcelo Gualberto Pereira, Elaine Soares Coimbra, Eduardo Antonio Ferraz Coelho, Adilson David da Silva, Fernando de Pilla Varotti, Kezia Katiani Gorza Scopel
Summary: Chloroquine remains the most effective drug for malaria treatment, although resistance to it has emerged. This study focuses on the synthesis of quinoline derivatives to develop new antimalarials. Compound 3 showed promising activity against malaria, inhibiting parasite growth and protecting against severe malaria development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Immunology
Benoit Gamain, Arnaud Chene, Nicola K. Viebig, Nicaise Tuikue Ndam, Morten A. Nielsen
Summary: Adults in malaria endemic areas usually acquire clinical immunity against malaria, but pregnant women, especially during their first pregnancies, are susceptible to placental malaria. Placental malaria is characterized by the accumulation of P. falciparum-infected erythrocytes and monocytes in the placenta, leading to maternal anaemia, hypertension, and fetal growth retardation. However, the prevalence of placental malaria decreases significantly with successive pregnancies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Manon Alkema, X. Zen Yap, Gerdie M. de Jong, Isaie J. Reuling, Quirijn de Mast, Reinout van Crevel, Christian F. Ockenhouse, Katharine A. Collins, Teun Bousema, Matthew B. B. McCall, Robert W. Sauerwein
Summary: Malaria infection caused by Plasmodium falciparum through mosquito bites induces stronger inflammation response in healthy volunteers compared to intravenous administration of infected red blood cells.
Article
Environmental Sciences
Annika K. Gunderson, Rani E. Kumar, Cristina Recalde-Coronel, Luis E. Vasco, Andree Valle-Campos, Carlos F. Mena, Benjamin F. Zaitchik, Andres G. Lescano, William K. Pan, Mark M. Janko
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Nanoscience & Nanotechnology
Kalaimathi Murugesan, Padmapriya Srinivasan, Raghunandan Mahadeva, Chhitar M. Gupta, Wahajul Haq
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Biology
Marc A. Schureck, Joseph E. Darling, Alan Merk, Jinfeng Shao, Geervani Daggupati, Prakash Srinivasan, Paul Dominic B. Olinares, Michael P. Rout, Brian T. Chait, Kurt Wollenberg, Sriram Subramaniam, Sanjay A. Desai
Summary: Malaria parasites use the RhopH complex for erythrocyte invasion and nutrient uptake, with the complex integrating into the erythrocyte membrane through a PTEX translocon-dependent process after transferring to a new host cell. The complex is tightly assembled with extensive disulfide bonding and predicted transmembrane helices, poised for large-scale rearrangements for host membrane insertion.
Article
Pharmacology & Pharmacy
Jasmin Federizon, Conrard Giresse Tetsassi Feugmo, Wei-Chiao Huang, Xuedan He, Kazutoyo Miura, Aida Razi, Joaquin Ortega, Mikko Karttunen, Jonathan F. Lovell
Summary: CoPoP facilitates non-covalent surface-display of antigens on liposomes, enhancing vaccine efficacy. Compared to aquocobalamin or cobalt nitrilotriacetic acid (Co-NTA) liposomes, Pfs25 binds more strongly to CoPoP liposomes, enhancing antigen internalization by macrophages. Molecular dynamics simulations reveal that CoPoP-containing bilayers create nanodomains allowing for efficient stabilization of antigens.
Article
Immunology
Cosette G. Schneider, Justin A. Taylor, Michael Q. Sibilo, Kazutoyo Miura, Katherine L. Mallory, Christopher Mann, Christopher Karch, Zoltan Beck, Gary R. Matyas, Carole A. Long, Elke Bergmann-Leitner, Peter Burkhard, Evelina Angov
Summary: This study investigates the folding and immunogenicity of heterogeneous antigen display, demonstrating that antigen orientation and folding impact the elicited immune response. When appropriately designed, SAPN can serve as an adaptable platform for effective multi-antigen display.
Article
Biochemical Research Methods
Daming Zhu, Weili Dai, Prakash Srinivasan, Holly McClellan, Dennis Braden, Alec Allee-Munoz, Patricia A. Gonzales Hurtado, Louis H. Miller, Patrick E. Duffy
Summary: The AMA1-RON2L complex is a promising candidate for a malaria vaccine, but careful assessment is needed to determine its identity and stability. Using Tris-glycine gel separation, Western blotting with mass spectrometry, and cIEF techniques, the complex was successfully identified and confirmed, showing stability for up to 72 hours at 4 degrees C.
Retraction
Nanoscience & Nanotechnology
K. Murugesan, J. Koroth, Srinivasan Pp
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Multidisciplinary Sciences
Shiva Prakash Srinivasan, Chiranjeevi Arumugam, E. Rangeela, Vijaya Raghavan, Ramachandran Padmavati
Summary: This scoping review focused on bullying research in South Asian Association for Regional Cooperation (SAARC) nations, revealing significant variations in research quantity and fluctuation in bullying victimization and perpetration rates across these countries. Culturally relevant interventions for bullying in India and Pakistan have shown some efficacy, highlighting the need for more research in this area.
Article
Environmental Sciences
Alycia K. Silman, Raveena Chhabria, George W. Hafzalla, Leahanne Giffin, Kimberly Kucharski, Katherine Myers, Carlos Culquichicon, Stephanie Montero, Andres G. Lescano, Claudia M. Vega, Luis E. Fernandez, Miles R. Silman, Michael J. Kane, John W. Sanders
Summary: The Matsigenka people who live in remote areas of the Amazon are exposed to high levels of methylmercury, which may lead to a decrease in working memory. The study found a correlation between methylmercury levels and cognitive performance, particularly in tasks that require executive functions. These findings suggest that the Self-Ordered Pointing Task (SOPT) and the Corsi Block Task could be alternative measures to general intelligence tests when studying remote groups with extensive cultural differences.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Immunology
Kazutoyo Miura, Thao P. Pham, Shwu-Maan Lee, Jordan Plieskatt, Ababacar Diouf, Issaka Sagara, Camila H. Coelho, Patrick E. Duffy, Yimin Wu, Carole A. Long
Summary: Monitoring the integrity of recombinant proteins is critical during the development of subunit vaccines. This study developed a sandwich ELISA-based in vitro potency assay, called the Antigen Integrity Assay (AIA), to monitor the potency of Pfs230 protein. The AIA demonstrated excellent precision, sensitivity, and high throughput, making it a useful tool for future subunit vaccine development.
Article
Chemistry, Inorganic & Nuclear
Glen. G. G. Briand, Tanner George, Gregory. A. A. MacNeil, Jason. D. D. Masuda, Brian. J. J. MacLean, Michael W. R. Mosher, Gregory. M. M. Sandala, Padmapriya Srinivasan, Alexander. H. H. Stockli, Rachel. L. L. Vanderkloet, Charles. J. J. Walsby
Summary: Organoindium compounds with redox active 1,2-benzenedithiolate and 2-amidobenzenethiolate ligands were synthesized and tested for reactivity against mild oxidants. The reactivity of these compounds varied with different oxidants and exhibited structural differences.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Dermatology
Gopalsing R. R. Rajput, Jandhyala Sridhar, Manas Chatterjee, Padmapriya Srinivasan
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Health Care Sciences & Services
Stella M. Hartinger, Marisol Yglesias-Gonzalez, Luciana Blanco-Villafuerte, Yasna K. Palmeiro-Silva, Andres G. Lescano, Anna Stewart-Ibarra, David Rojas-Rueda, Oscar Melo, Bruno Takahashi, Daniel Buss, Max Callaghan, Francisco Chesini, Elaine C. Flores, Carolina Gil Posse, Nelson Gouveia, Slava Jankin, Zaray Miranda-Chacon, Nahid Mohajeri, Juliana Helo, Laura Ortiz, Chrissie Pantoja, Maria Fernanda Salas, Raquel Santiago, Milena Sergeeva, Tatiana Souza de Camargo, Armando Valdes-Velasquez, Maria Walawender, Marina Romanello
LANCET REGIONAL HEALTH-AMERICAS
(2023)
Article
Pediatrics
Ananya Anandan, Rangeela Elumalai, Shiva Prakash Srinivasan
Summary: The study aimed to test the psychometric properties of the Odia translated Child and Youth Resilience Measure (CYRM-R) scale. A total of 167 participants were recruited, and the English version of the CYRM-R scale was translated into Odia and back-translated into English. Exploratory factor analysis confirmed the factor structure, and good internal consistency was established for the scale. Results indicated good inter-item correlation and the removal of the contextual resilience scale due to low internal consistency. The final scale comprised two subscales: individual and relational resilience. Significant differences in resilience were found between genders and the CNCP & CCL population. The translated CYRM-R appears to be a reliable scale for measuring resilience among youth, but further cross-cultural studies are needed for generalization.
JOURNAL OF INDIAN ASSOCIATION FOR CHILD AND ADOLESCENT MENTAL HEALTH
(2022)
Article
Pathology
B. Archana, Bhawna Dev, Suresh Varadarajan, Leena Dennis Joseph, M. C. Sheela, V Pavithra, Sandhya Sundaram, Jai Prakash Srinivasan
Summary: Imaging-guided breast tissue biopsy is an acceptable alternative to open surgical biopsy for nonpalpable breast lesions. Discussing the discordance between imaging and pathological results can be challenging but helpful for further treatment decisions. The sensitivity of biopsies to detect malignancy is 85%, specificity is 96%, and the accuracy of biopsy in diagnosing cancer is 90%.
INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY
(2022)