Review
Neurosciences
Xiao Zhang, Mengyao Wan, Xiaoli Min, Guanglei Chu, Yumin Luo, Ziping Han, Wei Li, Ran Xu, Jichang Luo, Wenjing Li, Yutong Yang, Yan Ma, Liqun Jiao, Tao Wang
Summary: This study aims to identify circRNAs as potential biomarkers for acute ischemic stroke (AIS) by analyzing published literature. The researchers found that circRNAs have potential discriminative ability in the diagnosis of AIS and identified several circRNAs that may serve as biomarkers for AIS.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Clinical Neurology
Mariana Fidalgo, Joana Ricardo Pires, Ines Viseu, Pedro Magalhaes, Hugo Gregorio, Vera Afreixo, Tiago Gregorio
Summary: Edaravone treatment shows promising effects in improving functional outcomes and reducing mortality in ischemic stroke patients, especially in Asian populations, but more randomized studies in diverse populations are needed to confirm these findings.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Review
Immunology
Hui Xia, Ziyao Wang, Min Tian, Zunjing Liu, Zhenhua Zhou
Summary: This study evaluates the difference between low-molecular-weight heparin (LMWH) and aspirin in preventing early neurological deterioration (END) and recurrent ischemic stroke (RIS), as well as their impact on post-recovery independence and safety outcomes in acute ischemic stroke patients. The results show that LMWH treatment is more effective in reducing the incidence of END and RIS, and improving independence at 6 months compared to aspirin treatment, particularly in patients with large-artery stenosis. However, LMWH is associated with an increased likelihood of extracranial hemorrhage.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Thilan Tudor, Eleonora F. Spinazzi, Julia E. Alexander, Grace K. Mandigo, Sean D. Lavine, Jack Grinband, E. Sander Connolly Jr
Summary: This study conducted a systematic review, meta-analysis, and novel time course analysis to explore microvascular failure in acute ischemic stroke patients undergoing endovascular therapy and/or thrombolytic administration. The analysis revealed a 22% event rate of microvascular failure following successful recanalization, indicating progressive microvascular failure in stroke management.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Clinical Neurology
Xin Wu, Yi Ge, Shujun Chen, Zeya Yan, Zilan Wang, Wei Zhang, Zhouqing Chen, Tao Xue, Zhong Wang
Summary: The study found no significant differences in efficacy and safety between direct mechanical thrombectomy (d-MT) and intravenous thrombolysis before MT (IVT + MT) for acute ischemic stroke (AIS) patients. However, d-MT had a lower risk of any intracranial hemorrhage (ICH) compared to IVT + MT.
JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Ahmed Mohamed, Ashfaq Shuaib, Maher Saqqur, Nida Fatima
Summary: The study found that good collateral blood flow in acute stroke is associated with a higher likelihood of favorable clinical outcomes, successful recanalization, and lower risk of symptomatic intracranial hemorrhage and mortality.
NEUROLOGICAL SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Yang Wang, Feng Wan, Peiqun Hu, Benxiang He, Yushi Hu, Yunlu Liu
Summary: This study evaluated the efficacy and safety of anisodine hydrobromide (Ani) injection in the treatment of acute ischemic stroke (AIS). The meta-analysis showed that Ani injection significantly reduced stroke severity and relative time to peak, while significantly improving quality of life index, cerebral blood flow, and clinical efficacy. There was no significant difference in the rate of adverse events between the Ani injection group and the control group. However, more high-quality studies are still needed to verify the efficacy and safety of Ani injection in patients with AIS.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Plant Sciences
Xiu Zhou, Tianyu Shao, Xiuzhen Xie, Minrui Ding, Xumin Jiang, Pingping Su, Zhuqing Jin
Summary: The study evaluates Tongqiao Huoxue Decoction in treating acute ischemic stroke and finds positive effects in clinical outcomes, neurological deficits, daily activities, and hemorheology. Further research is needed on adverse events to confirm its safety and efficacy.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Clinical Neurology
Hassan Kobeissi, Sherief Ghozy, Bilal Turfe, Cem Bilgin, Ramanathan Kadirvel, David F. F. Kallmes, Waleed Brinjikji, Alejandro A. A. Rabinstein
Summary: Through a meta-analysis of randomized controlled trials (RCTs), we found that tenecteplase and alteplase have similar safety and efficacy for the treatment of acute ischemic stroke (AIS).
FRONTIERS IN NEUROLOGY
(2023)
Review
Clinical Neurology
Qi Li, Mohamad Abdalkader, James E. Siegler, Shadi Yaghi, Amrou Sarraj, Bruce C. V. Campbell, Albert J. Yoo, Osama O. Zaidat, Johannes Kaesmacher, Deep Pujara, Raul G. Nogueira, Jeffrey L. Saver, Lei Li, Qin Han, Yi Dai, Hongfei Sang, Qingwu Yang, Thanh N. Nguyen, Zhongming Qiu
Summary: This study compared the efficacy and safety of endovascular thrombectomy (EVT) versus medical management (MM) in patients with large vessel occlusion (LVO) and found that EVT improved functional outcomes without increasing the risk of symptomatic intracranial hemorrhage.
Review
Pharmacology & Pharmacy
Huan Wang, Kaili Ye, Dan Li, Yuxin Liu, Deren Wang
Summary: This article confirms that NBP can help acute ischemic stroke patients regain the ability to perform activities of daily living, reduce their neurological deficit, and short-term death rates, based on an updated systematic review and meta-analysis. However, the available evidence on whether NBP reduces the risk of long-term death or dependence after ischemic stroke remains insufficient.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Catarina Garcia, Marcelo Silva, Mariana Araujo, Mariana Henriques, Marta Margarido, Patricia Vicente, Hipolito Nzwalo, Ana Macedo
Summary: Patients with pre-admission therapeutical VKA or DOAC for AF-AIS have a reduced severity of stroke upon admission compared to patients without any anticoagulation, with a greater protective effect seen with DOAC.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Clinical Neurology
Guoyi Tang, Zhixin Cao, Yuting Luo, Shaoqing Wu, Xunsha Sun
Summary: This meta-analysis explores the association between asymptomatic intracranial hemorrhage (aICH) and poor neurological outcomes after acute ischemic stroke. The findings suggest that patients with aICH during the acute stage of ischemic stroke have an increased risk of worse outcomes, especially in those receiving endovascular therapy.
JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Pengju Ma, Yi Zhang, Li Chang, Xiangsheng Li, Yuling Diao, Haigang Chang, Lei Hui
Summary: This systematic review and meta-analysis compared the efficacy and safety of tenecteplase with alteplase for the treatment of acute ischemic stroke (AIS) patients. The results showed no significant difference between the two drugs in terms of good outcome and excellent outcome at 90 days. However, patients receiving tenecteplase might have a higher incidence of early neurologic improvement compared to those receiving alteplase.
JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Deborah Rose, Annie Cavalier, Wayneho Kam, Sarah Cantrell, Jay Lusk, Matthew Schrag, Shadi Yaghi, Christoph Stretz, Adam de Havenon, Ian J. Saldanha, Teddy Y. Wu, Anna Ranta, P. Alan Barber, Elizabeth Marriott, Wayne Feng, Andrzej S. Kosinski, Daniel Laskowitz, Sven Poli, Brian Mac Grory
Summary: This study compared the risk of treatment complications between intravenous tenecteplase and alteplase in acute ischemic stroke. It found that the risks of complications were generally comparable between the two agents in medium- and low-dose tiers.
Article
Cell Biology
Shuang Chen, Yanyun Sun, Fei Li, Xinyu Zhang, Xiaoyan Hu, Xiaoyun Zhao, Yixuan Li, Hui Li, Jianliang Zhang, Wenlan Liu, Guo-qing Zheng, Xinchun Jin
Summary: Studies have suggested that melatonin can reduce ischemia/reperfusion-induced blood-brain barrier damage by modulating alpha 7nACh receptor. The experimental results showed that melatonin can inhibit the increase in BBB permeability, reduce microglia activation, decrease HMGB1 release, and protect neurons by modulating alpha 7nAChR.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Geochemistry & Geophysics
Hongyan Qi, Zhenlin Wang, Jianglong Yu, Peirong Yu, Guoqing Zheng
Summary: In this study, a fractal model for CO2 adsorption was developed and applied to analyze the measured isotherms on shale samples. Results showed that the fractal dimension from the new model agreed with fractal geometry, indicating its potential for characterizing micropore structures in shales.
Article
Energy & Fuels
Zhenlin Wang, Xuyang Guo, Guoqing Zheng, Peirong Yu, Wei Wang, Yan Jin, Gang Chen
Summary: This study investigates the poroelastic changes induced by parent well depletion in the infill zone using a coupled flow and geomechanics model. The results show that increasing parent well spacing helps to maintain the pore pressure in the infill zone, but slightly increases the difficulties of initiating hydraulic fracture networks.
ENERGY SCIENCE & ENGINEERING
(2022)
Article
Plant Sciences
Hecang Zang, Yanjing Wang, Linyuan Ru, Meng Zhou, Dandan Chen, Qing Zhao, Jie Zhang, Guoqiang Li, Guoqing Zheng
Summary: This study proposes an improved YOLOv5s method to accurately detect the number of small-scale wheat spikes and solve the problems of occlusion and cross-overlapping. The results show that the improved model achieved an accuracy of 71.61% in the task of wheat spike number and had higher counting accuracy.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Materials Science, Composites
Yunong Zhao, Xiaohui Guo, Weiqiang Hong, Tong Zhu, Tianxu Zhang, Zihao Yan, Kangli Zhu, Jingyi Wang, Guoqing Zheng, Shanan Mao, Kaikai Wang, Yuqing Wang, Chengchao Jin, Guopeng Tang, Shuang Shao, Yun Xia, Guoliang Xing, Qi Hong, Yaohua Xu, Jun Wu
Summary: This paper presents a flexible capacitive pressure sensor that utilizes a biomimetic frog-leg structure as the dielectric layer. A low-cost 3D printing technique is used to fabricate the dielectric layer with 3D features. The dimensional parameters of the dielectric layer structure are optimized through experimental studies, and the feasibility of using the bionic frog-leg structure is evaluated. The sensor exhibits improved sensing performance, rapid response and recovery, and reliable long-term stability.
COMPOSITES SCIENCE AND TECHNOLOGY
(2023)
Article
Physics, Multidisciplinary
Akihiko Sumiyama, Takumi Nagaeki, Akira Yamaguchi, Ke Jia, Jie Yang, Youguo Shi, Guo-qing Zheng
Summary: We measured the DC magnetic susceptibility of single crystals of the quasi-one-dimensional superconductor Cs2Cr3As3. Diamagnetism appears below 1.2 and 2 K for magnetic fields parallel and perpendicular to the c-axis, respectively, whereas the Meissner effect emerges at 1.2 K in both directions, suggesting that, between 1.2 and 2 K, superconductivity is filamentary along the c-axis.
JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN
(2023)
Article
Pharmacology & Pharmacy
Xiao-Jie Zhang, Yi-Jing Wang, Xiao Lu, Peng-Jie Ying, Shi-Yan Qian, Jie Liang, Guo-Qing Zheng
Summary: This study evaluates the reporting quality of randomized controlled trials (RCTs) on HuatuoZaizao pill (HZP) for stroke. The results show that the overall report quality of RCTs related to HZP is low, indicating a need for higher quality RCTs to prove its effectiveness and safety.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Decheng Xu, Bing Hu, Guoqing Zheng, Jingyi Wang, Cuicui Li, Yunong Zhao, Zihao Yan, Ziyang Jiao, Yongci Wu, Ming Wang, Huarui Li, Xiaohui Guo
Summary: A sandwich-like flexible tactile sensor with high sensitivity, wide detection range and rapid response time was developed for electronic skin applications. The sensor demonstrated excellent performance in detecting both normal and tangential forces, with low hysteresis. Simulation modeling confirmed the working principle and characteristics of the sensor. Its application in soft manipulator grasping and gamepad rotation highlighted its potential in robotic sensing. This research opens up possibilities for tactile/pressure perception strategies in various fields such as e-skin, soft robotics, dexterous manipulation, and intelligent prosthetics.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2023)
Article
Materials Science, Multidisciplinary
X. Y. Feng, Z. Zhao, J. Luo, J. Yang, A. F. Fang, H. T. Yang, H. J. Gao, R. Zhou, Guo-qing Zheng
Summary: Clarifying the interplay between charge-density waves (CDWs) and superconductivity is important in CsV3Sb5. Under hydrostatic pressures, CDW gradually changes from a commensurate to an incommensurate modulation. The appearance of short-range CDW order and the existence of a CDW quantum critical point (QCP) at a specific pressure suggest their role in determining the maximum superconducting temperature (Tc) in CsV3Sb5.
NPJ QUANTUM MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Yang Zheng, Cenglin Xu, Jinyi Sun, Wenjie Ming, Sijie Dai, Yuying Shao, Xiaoyun Qiu, Menghan Li, Chunhong Shen, Jinghong Xu, Fan Fei, Jiajia Fang, Xuhong Jiang, Guoqing Zheng, Weiwei Hu, Yi Wang, Shuang Wang, Meiping Ding, Zhong Chen
Summary: This study demonstrates the epileptogenic role of the hippocampus in patients with late-stage cortical dysplasia and identifies the involvement of somatostatin-positive interneurons in seizure generalization. This findings provide new insights into the cellular basis of cortical dysplasia-related seizures.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Materials Science, Multidisciplinary
M. Yokoyama, H. Nishigaki, S. Ogawa, S. Nita, H. Shiokawa, K. Matano, Guo-qing Zheng
Summary: Electronic nematicity is observed in various new materials as a result of rotational symmetry breaking. In this study, we successfully manipulate the nematic director, the d vector, in the spin-triplet superconducting state of CuxBi2Se3 by magnetic fields. The ac susceptibility related to the upper critical field exhibits a twofold symmetry at H = 0.5 T and a sixfold symmetry at H = 1.5 T, which is unprecedented in any superconductor. The d vector is initially locked in a certain direction but becomes unlocked by a threshold field, respecting the trigonal crystal symmetry.
Article
Chemistry, Applied
Hecang Zang, Yanjing Wang, Xiuzhong Yang, Jia He, Meng Zhou, Guoqing Zheng, Guoqiang Li
Summary: To quickly and accurately obtain density and height information of winter wheat varieties, the use of unmanned aerial vehicles (UAV) images and digital models can provide efficient and precise monitoring methods. The extracted coverage and estimation models based on the images and models showed good applicability in predicting the plant density and height of new wheat varieties.
JOURNAL OF BIOBASED MATERIALS AND BIOENERGY
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Guoqing Zheng, Giannis Karamanolakis, Kai Shu, Ahmed Hassan Awadallah
Summary: This paper introduces a benchmark called WALNUT for weak supervision in natural language understanding (NLU) to promote and facilitate further research. WALNUT consists of NLU tasks with weak labels generated by real-world weak sources and a small set of clean labels. Evaluations on WALNUT demonstrate the effectiveness of weak supervision for low-resource NLU tasks and reveal interesting patterns across tasks.
NAACL 2022: THE 2022 CONFERENCE OF THE NORTH AMERICAN CHAPTER OF THE ASSOCIATION FOR COMPUTATIONAL LINGUISTICS: HUMAN LANGUAGE TECHNOLOGIES
(2022)
Article
Remote Sensing
Yan Guo, Jia He, Jingyi Huang, Yuhang Jing, Shaobo Xu, Laigang Wang, Shimin Li, Guoqing Zheng
Summary: This study evaluated the predictability of models established using UAV multispectral images with different spatial resolutions for nitrogen content of winter wheat. The results showed that model performance increased with decreasing image spatial resolution. Additionally, the transferability of models differed when applied to images with coarser or finer resolutions.
Proceedings Paper
Business
Hanjie Chen, Guoqing Zheng, Ahmed Hassan Awadallah, Yangfeng Ji
Summary: This paper aims to explain the performance improvement of pre-trained language models in few-shot fine-tuning by interpreting the model predictions. The study reveals that pre-trained models exhibit prediction bias and that the performance gain is achieved by capturing non-task-related features or shallow data patterns.
PROCEEDINGS OF THE THIRD WORKSHOP ON INSIGHTS FROM NEGATIVE RESULTS IN NLP (INSIGHTS 2022)
(2022)
