Genetically Engineered Vaccinia Viruses As Agents for Cancer Treatment, Imaging, and Transgene Delivery

Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy

(2017) Zuqiang Liu et al.   Nature Communications

Primary Tumor Location as a Predictive Factor for First-line Bevacizumab Effectiveness in Metastatic Colorectal Cancer Patients

(2017) Wen-Zhuo He et al.   Journal of Cancer

Oncolytic vaccinia virus as a vector for therapeutic sodium iodide symporter gene therapy in prostate cancer

(2016) D C Mansfield et al.   GENE THERAPY

Phase 1 Study of Intravenous Oncolytic Poxvirus (vvDD) in Patients With Advanced Solid Cancers

(2016) Stephanie Downs-Canner et al.   MOLECULAR THERAPY

Oncolytic vaccinia virus combined with radiotherapy induces apoptotic cell death in sarcoma cells by down-regulating the inhibitors of apoptosis

(2016) Michelle J. Wilkinson et al.   Oncotarget

Molecular network, pathway, and functional analysis of time-dependent gene changes associated with pancreatic cancer susceptibility to oncolytic vaccinia virotherapy

(2016) Dana Haddad et al.   Molecular Therapy-Oncolytics

Defining Effective Combinations of Immune Checkpoint Blockade and Oncolytic Virotherapy

(2015) J. J. Rojas et al.   CLINICAL CANCER RESEARCH

Oncolytic vaccinia virus synergizes with irinotecan in colorectal cancer

(2015) Kathryn Ottolino-Perry et al.   Molecular Oncology

Phase 1b Trial of Biweekly Intravenous Pexa-Vec (JX-594), an Oncolytic and Immunotherapeutic Vaccinia Virus in Colorectal Cancer

(2015) Se Hoon Park et al.   MOLECULAR THERAPY

Phase 1 Study of Intratumoral Pexa-Vec (JX-594), an Oncolytic and Immunotherapeutic Vaccinia Virus, in Pediatric Cancer Patients

(2015) Timothy P Cripe et al.   MOLECULAR THERAPY

Armed Oncolytic Virus Enhances Immune Functions of Chimeric Antigen Receptor-Modified T Cells in Solid Tumors

(2014) N. Nishio et al.   CANCER RESEARCH

A novel oncolytic viral therapy and imaging technique for gastric cancer using a genetically engineered vaccinia virus carrying the human sodium iodide symporter

(2014) Kyong-Hwa Jun et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Combination treatment with oncolytic Vaccinia virus and cyclophosphamide results in synergistic antitumor effects in human lung adenocarcinoma bearing mice

(2014) Elisabeth Hofmann et al.   Journal of Translational Medicine

Vaccinia virus GLV-1h153 in combination with 131I shows increased efficiency in treating triple-negative breast cancer

(2013) Sepideh Gholami et al.   FASEB JOURNAL

Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer

(2013) Jeong Heo et al.   NATURE MEDICINE

Synergistic cytotoxicity of radiation and oncolytic Lister strain vaccinia in V600D/EBRAF mutant melanoma depends on JNK and TNF-α signaling

(2013) J N Kyula et al.   ONCOGENE

Vaccinia virus-mediated melanin production allows MR and optoacoustic deep tissue imaging and laser-induced thermotherapy of cancer

(2013) Jochen Stritzker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An oncolytic vaccinia virus expressing the human sodium iodine symporter prolongs survival and facilitates SPECT/CT imaging in an orthotopic model of malignant pleural mesothelioma

(2013) Laurence J. Belin et al.   SURGERY

A Novel Genetically Modified Oncolytic Vaccinia Virus in Experimental Models is Effective Against a Wide Range of Human Cancers

(2012) Dana Haddad et al.   ANNALS OF SURGICAL ONCOLOGY

A Vaccinia Virus Encoding the Human Sodium Iodide Symporter Facilitates Long-Term Image Monitoring of Virotherapy and Targeted Radiotherapy of Pancreatic Cancer

(2012) D. Haddad et al.   JOURNAL OF NUCLEAR MEDICINE

Imaging Characteristics, Tissue Distribution, and Spread of a Novel Oncolytic Vaccinia Virus Carrying the Human Sodium Iodide Symporter

(2012) Dana Haddad et al.   PLoS One

Oncolytic vaccinia virus for the treatment of cancer

(2011) Kilian Guse et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Insertion of the human sodium iodide symporter to facilitate deep tissue imaging does not alter oncolytic or replication capability of a novel vaccinia virus

(2011) Dana Haddad et al.   Journal of Translational Medicine

A Mechanistic Proof-of-concept Clinical Trial With JX-594, a Targeted Multi-mechanistic Oncolytic Poxvirus, in Patients With Metastatic Melanoma

(2011) Tae-Ho Hwang et al.   MOLECULAR THERAPY

Chemokine Expression From Oncolytic Vaccinia Virus Enhances Vaccine Therapies of Cancer

(2011) Jun Li et al.   MOLECULAR THERAPY

Novel therapy for anaplastic thyroid carcinoma cells using an oncolytic vaccinia virus carrying the human sodium iodide symporter

(2011) Sepideh Gholami et al.   SURGERY

Enhanced tumor therapy using vaccinia virus strain GLV-1h68 in combination with a β-galactosidase-activatable prodrug seco-analog of duocarmycin SA

(2010) C M Seubert et al.   CANCER GENE THERAPY

TRAIL gene-armed oncolytic poxvirus and oxaliplatin can work synergistically against colorectal cancer

(2010) M F Ziauddin et al.   GENE THERAPY

Regression of Human Prostate Tumors and Metastases in Nude Mice following Treatment with the Recombinant Oncolytic Vaccinia Virus GLV-1h68

(2010) Ivaylo Gentschev et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Synergistic Interaction Between Oncolytic Viruses Augments Tumor Killing

(2010) Fabrice Le Boeuf et al.   MOLECULAR THERAPY

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vaccinia Virus–Encoded Ribonucleotide Reductase Subunits Are Differentially Required for Replication and Pathogenesis

(2010) Don B. Gammon et al.   PLoS Pathogens

Systemic treatment of xenografts with vaccinia virus GLV-1h68 reveals the immunologic facet of oncolytic therapy

(2009) Andrea Worschech et al.   BMC GENOMICS

Autofluorescent Proteins with Excitation in the Optical Window for Intravital Imaging in Mammals

(2009) Michael Z. Lin et al.   CHEMISTRY & BIOLOGY

Imaging a Genetically Engineered Oncolytic Vaccinia Virus (GLV-1h99) Using a Human Norepinephrine Transporter Reporter Gene

(2009) P. Brader et al.   CLINICAL CANCER RESEARCH

Efficacy of Systemically Administered Oncolytic Vaccinia Virotherapy for Malignant Gliomas Is Enhanced by Combination Therapy with Rapamycin or Cyclophosphamide

(2009) X. Q. Lun et al.   CLINICAL CANCER RESEARCH

Lister strain vaccinia virus, a potential therapeutic vector targeting hypoxic tumours

(2009) C T Hiley et al.   GENE THERAPY

Lister strain of vaccinia virus armed with endostatin–angiostatin fusion gene as a novel therapeutic agent for human pancreatic cancer

(2009) J R Tysome et al.   GENE THERAPY

Antiangiogenic Arming of an Oncolytic Vaccinia Virus Enhances Antitumor Efficacy in Renal Cell Cancer Models

(2009) K. Guse et al.   JOURNAL OF VIROLOGY

Oncolytic vaccinia therapy of squamous cell carcinoma

(2009) Zhenkun Yu et al.   Molecular Cancer

Regression of human pancreatic tumor xenografts in mice after a single systemic injection of recombinant vaccinia virus GLV-1h68

(2009) Y. A. Yu et al.   MOLECULAR CANCER THERAPEUTICS

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(2009) Nanhai Chen et al.   MOLECULAR MEDICINE

Treatment With Cyclooxygenase-2 Inhibitors Enables Repeated Administration of Vaccinia Virus for Control of Ovarian Cancer

(2009) Chih-Long Chang et al.   MOLECULAR THERAPY

Intelligent Design: Combination Therapy With Oncolytic Viruses

(2009) Kathryn Ottolino-Perry et al.   MOLECULAR THERAPY

Anti-VEGF single-chain antibody GLAF-1 encoded by oncolytic vaccinia virus significantly enhances antitumor therapy

(2009) A. Frentzen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural and genetically engineered viral agents for oncolysis and gene therapy of human cancers

(2008) Joseph G. Sinkovics et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Use of an oncolytic vaccinia virus for the treatment of canine breast cancer in nude mice: preclinical development of a therapeutic agent

(2008) I Gentschev et al.   CANCER GENE THERAPY

Enhancing Poxvirus Oncolytic Effects through Increased Spread and Immune Evasion

(2008) D. H. Kirn et al.   CANCER RESEARCH

Bevacizumab for the treatment of advanced non-small-cell lung cancer

(2008) Christian Manegold   Expert Review of Anticancer Therapy

Targeted delivery of a suicide gene to human colorectal tumors by a conditionally replicating vaccinia virus

(2008) J Foloppe et al.   GENE THERAPY

Novel Oncolytic Agent GLV-1h68 Is Effective Against Malignant Pleural Mesothelioma

(2008) Kaitlyn J. Kelly et al.   HUMAN GENE THERAPY

Real-time intraoperative detection of melanoma lymph node metastases using recombinant vaccinia virus GLV-1h68 in an immunocompetent animal model

(2008) Kaitlyn J. Kelly et al.   INTERNATIONAL JOURNAL OF CANCER

Oncolytic Vaccinia Virotherapy of Anaplastic Thyroid Cancerin Vivo

(2008) Shu-Fu Lin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Radiation quality-dependent bystander effects elicited by targeted radionuclides

(2008) Marie Boyd et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial

(2008) Byeong-Ho Park et al.   LANCET ONCOLOGY

Oncolytic virotherapy for multiple myeloma using a tumour-specific double-deleted vaccinia virus

(2008) H Deng et al.   LEUKEMIA

Antiangiogenic Gene Therapy With Soluble VEGFR-1, -2, and -3 Reduces the Growth of Solid Human Ovarian Carcinoma in Mice

(2008) Hanna Sallinen et al.   MOLECULAR THERAPY