Journal
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 12, Issue 6, Pages 521-531Publisher
HONG KONG ASIAMED PUBLISH HOUSE
DOI: 10.1016/j.ajps.2017.05.009
Keywords
Polymers for pharmaceuticals; Emulsions; Physical stability; Stabilization mechanism
Categories
Funding
- National Natural Science Foundation of China [81273445, 81473161]
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Macromolecules of polysaccharides, proteins and poloxamers have a hydrophobic portion and a hydrophilic one that can be used as emulsifiers. Parts of these emulsifiers are safe pharmaceutical excipients, which can replace the irritant low molecular weight surfactants to formulate emulsions for the pharmaceutical field. This project focused on preparing O/W emulsions stabilized with polymers for pharmaceuticals such as polysaccharides, proteins and poloxamers, including hydroxypropyl methylcellulose (HPMC), methylcellulose (MC), gelatin, poloxamer 407 (F127) and poloxamer 188 (F68). Emulsion physical stability was assessed by centrifugation, autoclaving sterilization and droplet size measurements. The stabilization mechanisms of emulsions were determined by interfacial tension and rheological measurements. Results stated that the efficacy of these polymers for pharmaceuticals stabilized emulsions was sorted in the order: F127 > F68 > HPMC > MC > Gelatin. (C) 2017 Shenyang Pharmaceutical University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license.
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