Review
Biochemistry & Molecular Biology
Justin L. Blaty, Lourdes M. DelRosso
Summary: Healthy sleep is crucial for growth, development, and overall health. Patients, especially children, with Tourette Disorder (TD), experience negative effects on sleep. Common sleep abnormalities in TD include decreased total sleep time, lower sleep efficiency, and higher arousal index. TD is often associated with Attention Deficit Hyperactivity Disorder (ADHD), which further worsens sleep quality. Treatment of TD is essential for improving sleep in these patients.
BIOMEDICAL JOURNAL
(2022)
Article
Psychology, Developmental
Tamara Pringsheim, Elaheh Nosratmirshekarlou, Asif Doja, Davide Martino
Summary: This study found that children with more severe tic symptoms had worse sleep quality, more sedentary activity time, and less light, moderate, and vigorous activity time. There was a significant negative correlation between physical activity and severity of tic, obsessive-compulsive behaviors, anxiety, and depression. Subjective sleep quality was positively correlated with symptom severity, especially with ADHD severity.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2021)
Article
Clinical Neurology
Emily J. Ricketts, Sara Beth Wolicki, Joseph R. Holbrook, Michelle Rozenman, Joseph F. McGuire, Sana N. Charania, John Piacentini, Jonathan W. Mink, John T. Walkup, Douglas W. Woods, Angelika H. Claussen
Summary: This study examined sleep problems in children with Tourette Syndrome (TS). It found that children with sleep disorder were more likely to come from households with lower parental education and poverty, and had more other diagnoses and severe symptoms. These findings highlight the importance of monitoring and intervention for children with TS, as well as considering the socioeconomic context in sleep disorder management and prevention.
PEDIATRIC NEUROLOGY
(2023)
Article
Psychiatry
Sandra-Eve Bamigbade, Samantha L. Rogers, Wendy Wills, Amanda K. Ludlow
Summary: This study investigates the mealtime experiences of families with a child with a tic disorder from the perspective of mothers. The findings highlight the challenges of tics on mealtime activities, affecting a young person's ability to eat, drink, and sit, as well as the negative impact on maternal and familial resilience and wellbeing.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Jennifer Langelage, Julius Verrel, Julia Friedrich, Alina Siekmann, Ronja Schappert, Annet Bluschke, Veit Roessner, Theresa Paulus, Tobias Baumer, Christian Frings, Christian Beste, Alexander Muenchau
Summary: This study investigated the association between premonitory urges and tics in children and adolescents with GTS. Group-level analyses confirmed a positive association between urges and tics. However, at the individual level, not all participants showed a positive association and some even displayed a reversed association. The severity of tics was correlated with subjective urge levels, and participants with more severe tics exhibited stronger urge-tic associations. Compared to adult GTS patients, the association between reported urge levels and instantaneous tic intensity was less pronounced in children and adolescents. The heterogeneity of urge-tic associations casts doubt on the direct causation of tics by urges, suggesting that more severe tics may lead to stronger associations between urges and tics as a byproduct.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Chang-Chun Wu, Lee-Chin Wong, Chia-Jui Hsu, Chianne-Wen Yang, Ying-Chieh Tsai, Feng-Shiang Cheng, Hsiao-Yun Hu, Wang-Tso Lee
Summary: The study suggests that probiotics may not reduce tics in children with Tourette syndrome, but they may benefit comorbidities such as attention deficit and hyperactivity disorder. Further research is needed to clarify the effects of probiotics on the comorbidities of Tourette syndrome children.
Review
Clinical Neurology
Althea Robinson Shelton, Beth Malow
Summary: Neurodevelopmental disorders are often accompanied by sleep disturbances, which can manifest as either insomnia or hypersomnia. Clinicians must consider the specific characteristics and diagnostic findings to accurately diagnose and treat sleep disturbances in individuals with NDD. Understanding the different presentations of sleep disturbances is crucial in providing effective care for these patients.
Article
Psychology, Clinical
Abigail Rodin, Kirstie Fleetwood-Meade, Jane Gilmour, Rosco Kasujja, Tara Murphy
Summary: Healthcare professionals in Uganda believe that Tourette syndrome is present in the country, but various factors hinder detection and reporting rates of the disease, highlighting the need for increased training for healthcare workers and raising public awareness of the condition.
CHILD AND ADOLESCENT MENTAL HEALTH
(2021)
Article
Clinical Neurology
David Mataix-Cols, Kayoko Isomura, Gustaf Brander, Isabell Brikell, Paul Lichtenstein, Zheng Chang, Henrik Larsson, Ralf Kuja-Halkola, Kevin J. Black, Anna Sidorchuk, Lorena Fernandez de la Cruz
Summary: A Swedish study found that 20% of children with tic disorders continued to have chronic tic disorders into adulthood, with childhood psychiatric comorbidities and family history of psychiatric disorders being the strongest risk factors for tic disorder persistence.
MOVEMENT DISORDERS
(2023)
Article
Psychiatry
Raymond A. Clarke, Teri M. Furlong, Valsamma Eapen
Summary: Gilles de la Tourette syndrome (GTS) is a neurodevelopmental disorder characterized by motor and vocal tics, with high rates of inheritance and involvement of mitochondrial pathways. Mutations in genes related to mitochondrial dynamics and function may contribute to the pathogenesis of GTS.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychology, Developmental
Noa Gur, Sharon Zimmerman-Brenner, Aviva Fattal-Valevski, Michael Rotstein, Tammy Pilowsky Peleg
Summary: There is increasing evidence suggesting that behavioral techniques, such as Comprehensive Behavioral Intervention for Tics (CBIT), are effective in managing tics in youth with Tourette syndrome and tics disorders (TDs). This study aimed to explore the contribution of CBIT to cognitive inhibition and emotion regulation beyond tic control. The findings revealed that following CBIT intervention, cognitive inhibition and cognitive reappraisal significantly increased. These results suggest that CBIT may have a broader impact on improving cognitive and emotional regulation abilities.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Pediatrics
Katarzyna Anna Dylag, Bozena Bando, Zbigniew Baran, Paulina Dumnicka, Katarzyna Kowalska, Paulina Kulaga, Katarzyna Przybyszewska, Jakub Radlinski, Sylvia Roozen, Leopold Curfs
Summary: The study investigated sleep problems related to FASD and found that the occurrence of sleep disturbances in patients with FASD was significantly higher compared to typically developing children. Significant differences were observed in areas such as sleep onset delay, night wakings, sleep disordered breathing, and daytime sleepiness. The sleep quality and respiratory indices of FASD patients were worse than those of typically developing children.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Review
Biochemistry & Molecular Biology
Yuan-Shuo Chan, Jia-Tzer Jang, Chin-Shan Ho
Summary: Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children, characterized by deficits in executive functions and motor abilities. Physical exercise has been shown to have positive effects on ADHD symptoms, cognitive function, and motor abilities. Aerobic exercise increases neurotransmitters and brain blood flow, while perceptual motor activities and meditation promote neuroplasticity. Strengthening sensory-motor base improves attention. Physical exercise can serve as an adjunctive treatment for ADHD.
BIOMEDICAL JOURNAL
(2022)
Article
Clinical Neurology
Yelizaveta Sapozhnikov, Jonathan W. Mink, Erika F. Augustine, Heather R. Adams, Amy Vierhile, Adam B. Lewin, Alyssa T. Collins, Michael P. McDermott, Thomas O'Connor, Roger Kurlan, Tanya K. Murphy, Jennifer Vermilion
Summary: This study aimed to investigate factors associated with teacher knowledge of TS. The results showed that teachers of students with TS have more knowledge about TS and use more sources of information to learn about TS compared to teachers of students without TS.
PEDIATRIC NEUROLOGY
(2023)
Review
Behavioral Sciences
Lisa Keenan, Clara Sherlock, Jessica Bramham, Michelle Downes
Summary: Persistent tic disorders (PTDs) and attention-deficit hyperactivity disorder (ADHD) have distinct sleep profiles, with the PTD + ADHD group showing more pronounced differences, while the ADHD-only group did not significantly differ from controls in terms of sleep parameters. Further research is needed to understand disorder-specific sleep problems for appropriate identification and monitoring in clinical settings.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Otorhinolaryngology
Kun-Tai Kang, Wen-Chin Weng, Pei-Lin Lee, Wei-Chung Hsu
Summary: This study found that children with obstructive sleep apnea (OSA) had elevated levels of C-reactive protein (CRP) in the serum, and adenotonsillectomy could significantly reduce abnormal CRP levels.
AURIS NASUS LARYNX
(2022)
Review
Medicine, General & Internal
Hsin-Pei Wang, Lee-Chin Wong, Chia-Jui Hsu, Su-Ching Hu, Yen-Ju Chu, Wang-Tso Lee
Summary: Neurometabolic diseases are a complex group of rare neurogenetic disorders with diverse clinical manifestations, of which ocular motor problems are an important feature. Early recognition and intervention play a crucial role in treatment and prognosis.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Behavioral Sciences
Lu-Chi Hsiao, Shuenn-Nan Chiu, Ling-Yin Chang, Chia-Ching Wang, Wen-Chin Weng, Hsing-Yi Chang
Summary: This study aims to examine patterns of changes in emotional and behavioral problems among children with congenital heart disease (CHD) and investigate associated factors. The results show that parenting stress is consistently associated with different patterns of change in emotional and behavioral problems. Therefore, intervention programs aimed at relieving parenting stress may help reduce the development and worsening of emotional and behavioral problems among children with CHD.
JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
(2022)
Article
Orthopedics
Shih-Ya Wang, Wang-Tso Lee, Jeng-Yi Shieh, Yen-Hsun Huang, Lee-Chin Wong, Chih-Hsuan Tsao, Yi-Lun Chiu, Yen-Tzu Wu
Summary: This study aimed to examine clinical severity, multidimensional development, and adaptive behavioral functioning in younger and older children with Rett syndrome (RTT) in stage III. Differences were found between young and old RTT patients in terms of severity, fine motor skills, social interaction abilities, but not in adaptive behavioral and daily functional skills. Greater severity of RTT was associated with poorer motor, sociocommunicative, adaptive behavioral, and daily functional skills.
Letter
Clinical Neurology
Wei-Sheng Lin
Article
Nutrition & Dietetics
Ya-Chun Tang, Po-Hsiang Tsui, Chiao-Yin Wang, Yin-Hsiu Chien, Hui-Ling Weng, Chung-Yi Yang, Wen-Chin Weng
Summary: Growing evidence suggests that patients with Duchenne muscular dystrophy (DMD) have an increased risk of obesity and metabolic syndrome (MetS). This study investigated the potential risk factors for MetS and hepatic steatosis in different stages of DMD. The results showed that ultrasound NPI increased with DMD progression, and a high proportion of the patients had significant hepatic steatosis.
Article
Multidisciplinary Sciences
Srinivasulu Yerukala Sathipati, Sanjay K. Shukla, Shinn-Ying Ho
Summary: This study proposes a spike protein predictor SPIKES, incorporating with a genetic algorithm, to determine the biochemical properties of spike proteins and their specificity to human hosts. The study identifies compositional differences at the amino acid sequence level between human and diverse animal coronaviruses, which may provide insights into the development and transmission of SARS-CoV-2 in humans and other species.
Article
Multidisciplinary Sciences
Srinivasulu Yerukala Sathipati, Ming-Ju Tsai, Sanjay K. Shukla, Shinn-Ying Ho, Yi Liu, Afshin Beheshti
Summary: This study successfully identified a miRNA signature and developed a survival estimation method for patients with bladder urothelial carcinoma (BLC). The miRNA signature can be used to estimate survival and also includes potential biomarkers for diagnosis and prognosis of BLC. This finding is important for understanding BLC and developing miRNA-targeted therapies.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Hsueh-Wen Hsueh, Wen-Chin Weng, Pi-Chuan Fan, Yin-Hsiu Chien, Feng-Jung Yang, Wang-Tso Lee, Ru-Jen Lin, Wuh-Liang Hwu, Chih-Chao Yang, Ni-Chung Lee
Summary: This single-center study utilized next-generation sequencing to diagnose hereditary neuromuscular diseases. The results revealed a great diversity in hereditary NMDs and highlighted the importance of high-quality clinical and laboratory evaluations. Positive family history had a positive impact on the diagnostic rate.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Review
Nutrition & Dietetics
Wei-Sheng Lin, Shan-Ju Lin, Pei-Yin Liao, Divya Suresh, Ting-Rong Hsu, Pei-Yu Wang
Summary: The ketogenic diet shows promise as a safe and potentially effective therapy for multiple sclerosis, but more research is needed to confirm its effects and mechanisms.
ADVANCES IN NUTRITION
(2022)
Letter
Clinical Neurology
Wei-Sheng Lin
Article
Genetics & Heredity
Yu-Kang Hsu, Yin-Hsiu Chien, Steven Shinn-Forng Peng, Wuh-Liang Hwu, Wang-Tso Lee, Ni-Chung Lee, Eric Po-Yu Huang, Wen-Chin Weng
Summary: The study aimed to investigate the CNS progression in patients with infantile-onset Pompe disease (IOPD) and its clinical impact and predictors. The findings showed that CNS involvement in IOPD expanded from white matter to gray matter, and the MRI scores were positively correlated with age and negatively correlated with IQ scores. Neuroaxonal injury and decreased IQ scores may be associated with the progression of CNS involvement in IOPD. Neurofilament light chain could serve as a biomarker for CNS involvement in IOPD.
GENETICS IN MEDICINE
(2023)
Article
Clinical Neurology
Pin-Shiuan Chen, Ni-Chung Lee, Chieh-Ju Sung, Ya-Wen Liu, Wen-Chin Weng, Pi-Chuan Fan, Wang-Tso Lee, Yin-Hsiu Chien, Chao-Szu Wu, Yueh-Feng Sung, Ming-Chen Tsai, Yi-Chung Lee, Hsueh-Wen Hsueh, Sabrina Mai-Yi Fan, Meng-Chen Wu, Hsun Li, Huan-Yun Chen, Han- Lin, Chih-Hsin Ou-Yang, Wuh-Liang Hwuh, Chin-Hsien Lin
Summary: This study describes the clinical characteristics and functional findings in a cohort of patients with NDUFAF5 mutations, and reveals significant heterogeneity and divergent prognosis based on age at onset. This research is important for understanding the association between NDUFAF5 mutations and Leigh syndrome.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Wei-Chen Lee, Hsin-Hung Chen, Tsui-Fen Yang, Tse-Hao Lee, Ting-Rong Hsu, Chien Chen, Kai-Ping Chang, Shang-Yeong Kwan, Wei-Sheng Lin
PEDIATRIC NEUROLOGY
(2023)
Article
Clinical Neurology
Chia-Jui Hsu, Lee Chin Wong, Hsin-Pei Wang, Yi-Chun Chung, Te-Wei Kao, Chen-Hsiang Weng, Wen-Chau Wu, Shinn-Forng Peng, Wen-Yih Isaac Tseng, Wang-Tso Lee
Summary: This study used diffusion spectrum imaging to investigate microstructural changes in treatment-naive pediatric patients with pure Gilles de la Tourette syndrome (GTS). The results showed increased connectivity within the cortico-striato-thalamocortical (CSTC) circuit in GTS patients, suggesting possible CSTC circuit dysregulation and highlighting the need for further investigation into the underlying pathological changes in GTS. The altered connectivity observed in GTS patients could potentially serve as a target for therapeutic intervention.
JOURNAL OF NEURODEVELOPMENTAL DISORDERS
(2023)
