Article
Oncology
Dafeng Tong, Jie Yuan, Zhaoming Wang, Enda Yu, E. Jifu
Summary: Ubiquitin-specific peptidase 37 (USP37) is up-regulated in colorectal cancer (CRC) and its high expression is associated with poor patient survival. Up-regulation of USP37 promotes various malignant characteristics of CRC cells, including proliferation, migration, invasion, and stemness, and also enhances angiogenesis. Silencing USP37 shows the opposite effects. Mechanistically, USP37 stabilizes beta-catenin by inhibiting its ubiquitination. CTNNB1, the gene encoding beta-catenin, is positively correlated with USP37 in CRC. Targeting USP37 may hold potential for CRC treatment.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Oncology
Xiangdong Lu, Bin Zhou, Minmin Cao, Qin Shao, Yukai Pan, Tao Zhao
Summary: This study showed that CTEN is downregulated in breast cancer, while VEGFA is upregulated. Overexpression of CTEN can inhibit tumor progression by reducing VEGFA expression, suppressing cell proliferation, migration, and tube formation.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Oncology
Wenjun Luo, Diao He, Jianhao Zhang, Zida Ma, Keling Chen, Zhaoying Lv, Chuanwen Fan, Lie Yang, Yuan Li, Zongguang Zhou
Summary: Our study revealed that PPAR delta regulates VEGFA expression to affect angiogenesis in colorectal cancer, providing a potential target for mCRC treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Rendi Wu, Yawen Zhang, Xinyi Xu, Qingjun You, Chunjing Yu, Weipeng Wang, Yong Mao
Summary: B7-H3 is highly expressed in various types of cancer and plays important roles in tumor immune evasion, carcinogenesis, metastasis, and angiogenesis. This study investigated the effects of cancer cell-derived exosomal B7-H3 on tumor angiogenesis and metastasis. The findings showed that exosomal B7-H3 from colorectal cancer cells was taken up by endothelial cells and activated the AKT1/mTOR/VEGFA signaling pathway, enhancing their migration, invasion, and tube formation abilities. Furthermore, exosomes with reinforced B7-H3 promoted pulmonary angiogenesis and metastasis in mice. High expression of B7-H3 was also observed in urinary exosomes from colorectal cancer patients.
CELLULAR SIGNALLING
(2023)
Article
Biochemistry & Molecular Biology
Mujie Ye, Jinhao Chen, Ping Yu, Chunhua Hu, Bangting Wang, Jinxing Bao, Feiyu Lu, Yuan Zhong, Lijun Yan, Jingbao Kan, Jianan Bai, Ye Tian, Qiyun Tang
Summary: This study demonstrates that the WTAP/YTHDC1/VEGFA axis plays a crucial role in promoting the development of colorectal cancer (CRC), especially angiogenesis. It shows that WTAP over-expression enhances cell proliferation, migration, invasion, and angiogenesis in CRC, while WTAP knockdown inhibits these processes. Mechanistically, WTAP positively regulates VEGFA and activates the MAPK signaling pathway.
Article
Biochemistry & Molecular Biology
Mujie Ye, Jinhao Chen, Ping Yu, Chunhua Hu, Bangting Wang, Jinxing Bao, Feiyu Lu, Yuan Zhong, Lijun Yan, Jingbao Kan, Jianan Bai, Ye Tian, Qiyun Tang
Summary: The study reveals that WTAP is significantly upregulated in CRC cells and patients with CRC, and higher WTAP expression is consistent with the TCGA and CPATC databases in CRC tissues. WTAP over-expression exacerbates cell proliferation, migration, invasion, and angiogenesis, while WTAP knockdown inhibits the malignant biological behavior of CRC cells. Mechanistically, WTAP positively regulates VEGFA expression and YTHDC1 is identified as a downstream effector of the YTHDC1-VEGFA axis in CRC. Furthermore, increased WTAP expression activates the MAPK signaling pathway, which further enhances angiogenesis. The findings suggest that the WTAP/YTHDC1/VEGFA axis promotes CRC development, particularly angiogenesis, and may serve as a potential biomarker of CRC.
Article
Oncology
Minhong Shen, Shanshan Xie, Michelle Rowicki, Sven Michel, Yong Wei, Xiang Hang, Liling Wan, Xin Lu, Min Yuan, John F. Jin, Frank Jaschinski, Tianhua Zhou, Richard Klar, Yibin Kang
Summary: The study found that MTDH promotes the progression of colorectal and lung cancers by facilitating Wnt activation and inducing T-cell exhaustion. Treatment with MTDH antisense oligonucleotides effectively suppresses MTDH expression and significantly attenuates the progression and metastasis of these cancers.
Article
Biochemistry & Molecular Biology
Maria Abancens, Brian J. Harvey, Jean McBryan
Summary: Women have lower incidence and mortality rates for colorectal cancer compared to men. Estrogen may protect against colorectal cancer progression through GPER-mediated modulation of the Wnt/beta-catenin pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Heyu Song, Ricky A. Sontz, Matthew J. Vance, Julia M. Morris, Sulaiman Sheriff, Songli Zhu, Suzann Duan, Jiping Zeng, Erika Koeppe, Ritu Pandey, Curtis A. Thorne, Elena M. Stoffel, Juanita L. Merchant
Summary: The incidence of early-onset colorectal cancer (EO-CRC) is rising, with lifestyle factors and genetic background playing a potential role. The study found a missense mutation, HNF1AA98V, in the Hepatic Nuclear Factor 1α (HNF1A) gene, which reduces DNA binding ability. In mice, introducing the HNF1AA98V variant and feeding a high-fat or high-sugar diet led to an increased formation of colonic polyps. The study also revealed alterations in gene expression and signaling pathways related to metabolism, immunity, and lipid biogenesis.
Article
Biochemistry & Molecular Biology
Yutian Zhang, Kang Hu, Ziyi Qu, Zhihong Xie, Fei Tian
Summary: ADAMTS8 inhibits lung cancer progression by suppressing VEGFA and is associated with overall survival rate of patients.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Chuan-Jian Shi, Shi-Ying Li, Chun-Hui Shen, Fei-Fei Pan, Li-Qiang Deng, Wei-Ming Fu, Ji-Yong Wang, Jin-Fang Zhang
Summary: In this study, it was found that Icariside II suppressed the proliferation of colorectal cancer (CRC) by inducing cell cycle arrest and apoptosis. It also inhibited tumor growth in vivo by suppressing the expression of beta-catenin and inactivating the Wnt/beta-catenin signaling pathway. Furthermore, Icariside II was shown to epigenetically target DNA methyltransferases (DNMTs) and decrease global DNA methylation levels, resulting in the suppression of circ beta-catenin biogenesis.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Junrong Liang, Lina Sun, Yujun Li, Wanning Liu, Danxiu Li, Ping Chen, Xin Wang, Juan Hui, Jinchi Zhou, Hao Liu, Tianyu Cao, Maogui Pang, Meng Guo, Xin Wang, Xiaodi Zhao, Yuanyuan Lu
Summary: This study investigated the expression and function of DKK4 in colorectal cancer (CRC). The results showed that DKK4 was upregulated in CRC cell lines and tissues, and it inhibited cell metastasis by repressing the Wnt signaling pathway. Through experiments and analysis, the researchers also revealed the regulatory mechanism of DKK4 and its potential therapeutic application.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Cell Biology
Vikash Singh, Vonn Walter, Irina Elcheva, Yuka Imamura Kawasawa, Vladimir S. Spiegelman
Summary: In this study, the role of IGF2BP1 in the post-transcriptional regulation of Wnt/beta-catenin-induced genes in colorectal cancer (CRC) cells was investigated using iCLIP and RNA sequencing techniques. The study revealed that CRC cells exhibit a stronger dependency on IGF2BP1 expression for Wnt/beta-catenin-regulated genes compared to normal cells. iCLIP analysis showed significant changes in IGF2BP1-binding sites and enrichment of 6-mer motifs associated with IGF2BP1 binding in response to Wnt/beta-catenin signaling. Additionally, a signature of IGF2BP1-regulated genes significantly associated with colon cancer-free survival in humans was identified.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Pu-Hyeon Cha, Jeong-Ha Hwang, Dong-Kyu Kwak, Eunjin Koh, Kyung-Sup Kim, Kang-Yell Choi
Summary: In colorectal cancer, the loss of APC activates Wnt/beta-catenin signaling, leading to the Warburg effect and affecting cancer cell metabolism. PKM2 and LDHA were identified as key molecules regulated by Wnt/beta-catenin signaling, with APC loss increasing their expression, resulting in increased glucose consumption and lactate secretion.
BRITISH JOURNAL OF CANCER
(2021)
Article
Pharmacology & Pharmacy
Young Yun Jung, Jae-Young Um, Arunachalam Chinnathambi, Chandramohan Govindasamy, Acharan S. Narula, Ojas A. Namjoshi, Bruce E. Blough, Gautam Sethi, Kwang Seok Ahn
Summary: This study investigated the effects of Withaferin A (WFA) on apoptosis and autophagy in human colorectal cancer cells. The results showed that WFA could induce cell cycle arrest, increase apoptotic cell death, and activate autophagy. The WFA-induced effects on apoptosis and autophagy were mediated through the modulation of the beta-catenin pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Oncology
Zanxi Fang, Jing Tang, Yongying Bai, Huayue Lin, Hanyu You, Hongwei Jin, Lingqing Lin, Pan You, Juan Li, Zhang Dai, Xianming Liang, Yuanhui Su, Qing Hu, Fen Wang, Zhong-Ying Zhang
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2015)
Article
Oncology
Lingqing Lin, Zanxi Fang, Huayue Lin, Hanyu You, Jiajia Wang, Yuanhui Su, Fen Wang, Zhong-Ying Zhang
Article
Multidisciplinary Sciences
Huayue Lin, Wenjuan Liu, Zanxi Fang, Xianming Liang, Juan Li, Yongying Bai, Lingqing Lin, Hanyu You, Yihua Pei, Fen Wang, Zhong-Ying Zhang
SCIENTIFIC REPORTS
(2015)
Article
Medical Laboratory Technology
Jingkun Wang, Yizhen Fang, Peihua Li, Huayue Lin, Hongwei Jin, Lei Gao, Shengxiang Ge, Zhong-Ying Zhang
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2018)
Article
Medical Laboratory Technology
Zhi-yuan Lin, Yi-zhen Fang, Hong-wei Jin, Hua-yue Lin, Zhang Dai, Qing Luo, Hong-wei Li, Yan-ling Lin, Shui-zhen Huang, Lei Gao, Fei-hai Xu, Zhong-ying Zhang
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2018)
Article
Biochemistry & Molecular Biology
H. Lin, Q. Lin, M. Liu, Y. Lin, X. Wang, H. Chen, Z. Xia, B. Lu, F. Ding, Q. Wu, H-R Wang
Article
Biochemistry & Molecular Biology
Maoyuan Tian, Taoling Zeng, Mingdong Liu, Shang Han, Huayue Lin, Qi Lin, Li Li, Tingting Jiang, Gao Li, Hong Lin, Ting Zhang, Qiaofeng Kang, Xianming Deng, Hong-Rui Wang
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Multidisciplinary Sciences
Zhiyuan Lin, Yongquan Chen, Yanling Lin, Huayue Lin, Hongwei Li, Xiaosong Su, Zanxi Fang, Jiajia Wang, Qingchun Wei, Jing Teng, Zhongying Zhang
SCIENTIFIC REPORTS
(2020)
Review
Oncology
Qingchun Wei, Jinting Geng, Yongquan Chen, Huayue Lin, Jiajia Wang, Zanxi Fang, Fen Wang, Zhongying Zhang
Summary: DHX32 is an RNA helicase involved in various biological processes associated with RNA, and abnormal expression may contribute to cancer initiation and development; it is downregulated in acute lymphoblastic leukemia and upregulated in solid tumors such as colorectal and breast cancer; DHX32 expression levels are associated with the pathological and clinical features of the cancer, making it a potential liquid biopsy marker and therapeutic target for cancer.
Article
Medicine, Research & Experimental
Yongying Bai, Huayue Lin, Zanxi Fang, Qing Luo, Yizhen Fang, Yuanhui Su, Qing Hu, Hongbing Duan, Falin Chen, Zhong-Ying Zhang
BIOMARKERS IN MEDICINE
(2017)
Review
Medicine, Research & Experimental
Yizhen Fang, Huayue Lin, Jingkun Wang, Xiaosong Su, Fen Wang, Pan You, Jianjun Niu, Zhongying Zhang
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2017)
Meeting Abstract
Biotechnology & Applied Microbiology
Dangni Zhang, Lianming Zheng, Weiwei Li, Hua Lin, Wenqing Cao, Lvping Fang
Meeting Abstract
Biotechnology & Applied Microbiology
Lianming Zheng, Weiwei Li, Hua Lin, Lvping Fang, Wenqing Cao
Review
Oncology
Hanyu You, Huayue Lin, Zhongying Zhang
MOLECULAR AND CLINICAL ONCOLOGY
(2015)