Review
Food Science & Technology
Bo Wang, Min Du
Summary: The rising prevalence of obesity is a serious public health threat. Vitamin A promotes adipose tissue vascular development, increases the number of adipose progenitors, and stimulates the browning process in white adipocytes as well as the thermogenic activity in brown/beige adipocytes. Hence, vitamin A is a promising anti-obesity micronutrient.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Immunology
Md Shamim Rahman, Heejin Jun
Summary: This review explains the impact of fat types and tissue microenvironment on energy expenditure, focusing on the role and regulation of macrophages in adaptive thermogenic fat.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Graciano da Nadyellem Silva, Angelica Amorim Amato
Summary: Adipose tissue undergoes significant changes with aging, leading to an increased risk of metabolic diseases. These changes include defective adipogenesis, dysfunctional adipokine secretion, inflammation, and impaired thermogenesis. Brown and beige adipocytes play a role in regulating energy homeostasis. Age-related reduction in thermogenic adipocyte mass and function can be attributed to diminished adipose precursor cell pool size and adipogenic potential, mitochondrial dysfunction, decreased sympathetic signaling, and altered paracrine and endocrine signals.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Lugen Zuo, Zhijun Geng, Xue Song, Jing Li, Yueyue Wang, Xiaofeng Zhang, Sitang Ge, Lian Wang, Guangyong Liu, Lele Zhang, Mengyu Xu, Yajing Zhao, Li Shen, Yuanyuan Ge, Rong Wu, Jianguo Hu
Summary: In this study, it was found that white adipocyte browning occurs in hypertrophic mesenteric adipose tissue (htMAT) of Crohn's disease (CD) patients and has anti-inflammatory and lipid-depleting effects. Browning can be induced in both human htMAT and primary mesenteric adipocytes from CD patients and controls, and this induction increases their anti-inflammatory and lipid-depleting activities. Inducing MAT browning can ameliorate mesenteric hypertrophy, inflammation, and colitis in mice, suggesting that it could be a potential therapeutic target for CD.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Multidisciplinary Sciences
Jacinta I. Kalisch-Smith, Nikita Ved, Dorota Szumska, Jacob Munro, Michael Troup, Shelley E. Harris, Helena Rodriguez-Caro, Aimee Jacquemot, Jack J. Miller, Eleanor M. Stuart, Magda Wolna, Emily Hardman, Fabrice Prin, Eva Lana-Elola, Rifdat Aoidi, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz, Timothy J. Mohun, Samira Lakhal-Littleton, Sarah De Val, Eleni Giannoulatou, Duncan B. Sparrow
Summary: Congenital heart disease is a common human birth defect with many cases potentially caused by maternal iron deficiency, which can be prevented by iron administration in early pregnancy. Genetic predisposition and environmental factors may interact to impact the development of heart disease.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Sierra R. Scamfer, Mark D. Lee, Keren Hilgendorf
Summary: This review summarizes the role of the primary cilium in regulating the fate of adipocyte progenitor cells and highlights its importance in energy storage and adipose tissue function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Ilaria Scambi, Daniele Peroni, Alice Nodari, Flavia Merigo, Donatella Benati, Federico Boschi, Silvia Mannucci, Andrea Frontini, Silvia Visona, Andrea Sbarbati, Mauro Krampera, Mirco Galie
Summary: In this study, it was found that adipose-derived stromal cells (ASC) in mice undergo transcriptional changes from brown/beige-like to white-like with age. These changes may be related to alterations in the activity of the transcription factors E2F1 and NFkB.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2022)
Review
Medicine, General & Internal
Eun Hye Lee, So Young Chun, Jun Nyung Lee, Jae-Wook Chung, Bo Hyun Yoon, Hyun Tae Kim, Tae Gyun Kwon, Yun-Sok Ha, Bum Soo Kim
Summary: Perirenal adipose tissue, obtained from healthy donors during a kidney transplant, is now recognized to have a direct effect on metabolic diseases due to its characteristics like a large number of brown adipose cells and high energy consumption efficiency. Despite these advantages, all perirenal adipose tissue from healthy donors is currently being incinerated as medical waste. This review discusses the potential clinical application of brown adipocytes and beige cells in perirenal adipose tissue.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Anna Goddi, Alanis Carmona, Soo-Young Park, Gokhan Dalgin, Maria A. Gonzalez Porras, Eric M. Brey, Ronald N. Cohen
Summary: This study found that LAMA4 negatively regulates thermogenic phenotype and pathways involving mitochondrial biogenesis in adipocytes through the suppression of AMPK alpha.
Article
Endocrinology & Metabolism
Atefeh Rabiee, Kaja Plucinska, Marie Sophie Isidor, Erin Louise Brown, Marco Tozzi, Simone Sidoli, Patricia Stephanie S. Petersen, Marina Agueda-Oyarzabal, Silje Boen Torsetnes, Galal Nazih Chehabi, Morten Lundh, Ali Altintas, Romain Barres, Ole Norregaard Jensen, Zachary Gerhart-Hines, Brice Emanuelli
Summary: This study investigated the molecular mechanisms driving the differentiation of precursor cells into thermogenic adipocytes. Proteomic analysis revealed dynamic changes in subcutaneous white adipose tissue during browning, with YBX1 identified as a novel factor coordinating the genomic mechanisms for brite/beige lineage commitment in preadipocytes.
MOLECULAR METABOLISM
(2021)
Article
Agriculture, Dairy & Animal Science
Dong-Hwan Kim, Joonbum Lee, Chanhee Lee, Beom-Jin Shin, Buom-Yong Ryu, Kichoon Lee
Summary: This study found that an in ovo injection of atRA can promote adipose deposition in chicken embryos, but its effects are not maintained in the early posthatch stage.
Review
Endocrinology & Metabolism
Johanna Bruder, Tobias Fromme
Summary: Within the first month after birth, mice undergo a drastic but transient remodeling process in their adipose tissue depots. This process involves the sudden emergence and subsequent reversal of beige adipocytes in white fat depots, along with an opposite phenomenon in brown fat depots. The remodeling process is influenced by various environmental and genetic factors and may contribute to the lasting adaptive capacity in adult animals.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yukimasa Takeda, Yoshinori Harada, Toshikazu Yoshikawa, Ping Dai
Summary: Brown fats specialize in thermogenesis by increasing the utilization of circulating blood glucose and fatty acids, and they prevent the incidence of obesity-associated metabolic diseases and several types of cancers in humans. Mitochondrial energy metabolism in brown/beige adipocytes regulates both uncoupling protein 1 (UCP1)-dependent and -independent thermogenesis, and the mass and activity of human BAT are inversely correlated with the body mass index (BMI) and visceral adiposity. Modulation of obesity-associated repression in human brown fats is a promising strategy to counteract obesity and related metabolic diseases through the activation of thermogenic capacity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Noriko Takahashi, Daisuke Saito, Shinya Hasegawa, Masahiro Yamasaki, Masahiko Imai
Summary: This paper introduces the circulation of vitamin A in the body, the actions and mechanisms of retinal and RA, retinoylation as an RA mechanism independent of RA receptors, the relationship between cancer and the actions of retinol or beta-carotene, and the anti-cancer actions of vitamin A derivatives derived from fenretinide. The study suggests that nutritional management of vitamin A is effective in cancer prevention.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Medicine, Research & Experimental
A. Alzamendi, I. Miguel, M. G. Zubiria, S. E. Gambaro, E. Spinedi, A. Giovambattista
Summary: The study found that offspring born to mothers who consumed a fructose-rich diet during pregnancy showed a higher capacity for white adipose tissue (WAT) browning in response to cold exposure in adulthood. However, these offspring exhibited a lower basal thermogenic capacity.
Review
Food Science & Technology
Qi Sun, Min Du, Yifei Kang, Mei-Jun Zhu
Summary: The prevalence of inflammatory bowel disease (IBD) is increasing. Goji berry, as an ancient tonic food and nutraceutical supplement, has protective effects against IBD by regulating gut microbiota and their metabolites.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Chemistry, Applied
Fanxun Guan, Zhaoyuan He, Yayun Tang, Pengfei Gao, Lan Chen, Yawen Guo, Kaizhou Xie
Summary: A sensitive, selective, and quick method for the simultaneous detection of Albendazole and its three metabolites in poultry eggs has been established. The method showed good linearity and recoveries, and all target analytes could be detected within a short period of time.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Mengting Ji, Zhao Deng, Xiaoyin Rong, Ruixiao Li, Ziwei You, Xiaohong Guo, Chunbo Cai, Yan Zhao, Pengfei Gao, Guoqing Cao, Bugao Li, Yang Yang
Summary: Inflammation and oxidative damage can lead to hepatic dysfunction. Naringenin, a natural flavanone, has antioxidant and anti-inflammatory properties, but its role in regulating liver dysfunction is not well understood. This study investigated the effect of naringenin on lipopolysaccharide-induced oxidative stress and inflammation in the liver, as well as its mechanism of action. The results showed that naringenin increased the mRNA levels of antioxidant factors and reduced the expression of inflammatory factors. Transcriptome sequencing identified differentially expressed lncRNAs and mRNAs, and KEGG enrichment analysis revealed the involvement of oxidative stress and inflammation pathways. Tissue expression profiles and cell experiments further confirmed the role of lncRNAs and target mRNAs in the regulation of liver dysfunction by naringenin.
Review
Oncology
Peng Fei Gao, Na Lu, Wen Liu
Summary: This study aimed to compare the diagnostic values of MRI and FDG-PET for predicting the response to neoadjuvant chemoradiotherapy (NACT) in patients with locally advanced rectal cancer (RC). A total of 74 studies involving 4,105 patients were included in the analysis. The results showed that MRI may be superior to FDG-PET in predicting the response to NACT in patients with locally advanced RC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Toxicology
Pengfei Gao, Wenying Duan, Huiyan Shi, Qingxiu Wang
Summary: In this study, the researchers found that circPalm2 inhibited the dysfunction of pulmonary epithelial cells induced by LPS and alleviated the abnormal inflammation and cell apoptosis in lung tissues induced by CLP through the miR-376b-3p/MAP3K1 axis. This finding is of great biological significance for understanding the pathogenesis of sepsis-induced acute lung injury.
TOXICOLOGICAL RESEARCH
(2023)
Article
Chemistry, Physical
Qian Li, Yue Xu, Wei He, Yuan Fang Li, Peng Fei Gao, Cheng Zhi Huang
Summary: A plasmon-dependent photophysical (PDPP) process was developed to prepare Au@Safranine T core-shell nanostructures with reversible properties. The ST was initially absorbed onto negatively charged gold nanospheres (AuNSs) through electrostatic attraction and then controllably deposited by adjusting plasmonic illumination. The PDPP process was monitored in real-time using dark field microscopy (DFM) imaging system, confirming the occurrence of plasmon-dependent light-matter interaction. The as-prepared Au@ST nanostructures were successfully applied for a reversible process of edit and erase suitable for encryption application with nanosized precision.
APPLIED SURFACE SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Jiale Yun, Xiaoyu Huang, Chang Liu, Mingyue Shi, Wenxia Li, Jin Niu, Chunbo Cai, Yang Yang, Pengfei Gao, Xiaohong Guo, Bugao Li, Chang Lu, Guoqing Cao
Summary: In this study, circRNA expression profiles in the skeletal muscle of Jinfen White pigs at different stages of development were constructed using RNA-seq. Among the identified circRNAs, 584 circRNAs showed differential expression. Enrichment analysis revealed that the host genes of these differentially expressed circRNAs were mainly involved in muscle contraction, muscle organ development, muscle system processes, as well as AMPK and cAMP-related signal pathways. A circRNA-miRNA-mRNA co-expression network was also constructed to identify key circRNAs involved in the regulation of porcine skeletal muscle development through the competitive endogenous RNA (ceRNA) mechanism. Notably, the circ_0018595/miR-1343/PGM1 axis may play a regulatory role in the development of porcine skeletal muscle.
Article
Engineering, Multidisciplinary
Jinxiu Yu, Pengfei Gao, Yulu Yang, Dan Peng, Xianhui Zhang, Danyang Wang, Weihu Yang, Yu Tang, Kaiyong Cai
Summary: In this study, a functionalized titanium implant was developed by incorporating H2S donors into Ti nanotubes and coating with chitosan/gelatin multilayers to enhance osteointegration. By optimizing the polarization regulation of M1 to M2 macrophages, the phagocytosis and neovascularization functions of M1 macrophages can be maintained, while the anti-inflammatory response can be improved by M2 macrophages polarization. The immunomodulation of macrophages leads to efficient osteogenic differentiation of MSCs, promoting neovascularization and osteogenesis around the implants.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Zhipeng Qiu, Zheng Liu, Xiaolong Lu, Su Zhang, Yingchun Yan, Chunlei Chi, Huangfu Chao, Guanwen Wang, Pengfei Gao, Weihao Chi, Zheng Xu, Tong Wei, Zhuangjun Fan
Summary: This study presents a dual molecule (1,5-dihydroxyanthraquinone (DHAQ) and 2,6-diamino anthraquinone (DAQ)) confined between edge-oxygen-rich graphene sheets as high-performance electrodes for supercapacitors. The cooperative electrostatic interaction and pi-pi interaction lead to increased loading mass and structural stability of dual molecules. The constructed electron tunneling paths between edge-oxygen groups and dual molecules effectively enhance electron transfer rate and redox reaction kinetics. The obtained electrode exhibits high capacitance, unprecedented rate capability, and remarkable stability, making it promising for efficient utilization of organic materials in energy storage and conversion.
Article
Engineering, Biomedical
Feng Cheng, Yongjian Jiang, Bo Kong, Huarong Lin, Xinjia Shuai, Pingping Hu, Pengfei Gao, Lei Zhan, Chengzhi Huang, Chunmei Li
Summary: Cell signal transduction mediated by cell surface ligand-receptor is crucial for regulating cell behavior. However, the construction of a stable model of cytomembrane receptor aggregation and the development of a universal anti-tumor therapy model on the cellular surface remain challenging.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Applied
Zhaoyuan He, Xinrui Shi, Yawen Guo, Fanxun Guan, Pengfei Gao, Yayun Tang, Shuyu Liu, Yali Zhu, Kaizhou Xie, Hailan Chen
Summary: A simple and efficient HPLC-PDA method was developed for the simultaneous quantitative screening of six common residues of antiparasitic drugs in beef and chicken. The LODs and LOQs for the target compounds in beef and chicken were determined to be 3.2-12.5 μg/kg and 9.0-30.0 μg/kg, respectively. The calibration curves exhibited good linearity (R2 ≥ 0.9990) between the peak area and concentration. The method was successfully demonstrated by analyzing real samples.
Article
Agriculture, Dairy & Animal Science
Mao Ning, Yihan Zhao, Dongmei Dai, Chang Yao, Huatao Liu, Lingzhao Fang, Bo Wang, Yi Zhang, Jie Cao
Summary: Ketosis is a common metabolic disease in dairy cows. This study analyzed the transcriptome of subcutaneous white adipose tissue in cows with and without type II ketosis and identified neurotrophic tyrosine kinase receptor type 2 (NTRK2) as a key gene associated with the disease. The downregulation of NTRK2 in the adipose tissue suggests a potential involvement of impaired central nervous system regulation in abnormal lipid mobilization during type II ketosis in cows.
JOURNAL OF DAIRY SCIENCE
(2023)
Review
Medicine, Research & Experimental
Pengfei Gao, Chanjuan Liu, Hui Dong, Qi Li, Yunfang Chen
Summary: The research shows that TGF-beta can promote the proliferation and osteogenesis of dental pulp stem cells, but it has no significant effect on the number of mineralized nodules.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Pengkang Song, Xiaoyou Chen, Jiamin Zhao, Qiang Li, Xinrui Li, Yu Wang, Bo Wang, Junxing Zhao
Summary: This study investigates the effects of early intramuscular vitamin A injection on the muscle growth of lambs. The results suggest that vitamin A treatment accelerates lamb growth and increases loin eye area.
Article
Agriculture, Dairy & Animal Science
Hammed Ayansola, Yanhui Luo, Yan Wan, Xiaoxiao Yu, Jiaqi Lei, Kewei Yu, Chaoyong Liao, Yuming Guo, Bingkun Zhang, Bo Wang
Summary: This study investigated the effects of intermittent feeding (IF) and fasting strategies on muscle growth and white striping (WS) breast development. The results showed that IF strategies decreased the number of satellite cells and downregulated the expression of PAX7 and MYF5, while fasting upregulated angiogenic genes and MYOD expression. Both IF and fasting strategies promoted muscular angiogenesis, increased satellite cell number, prevented muscle degeneration, and reduced WS development.
