Article
Critical Care Medicine
Kalin Kempster, Stuart Howell, Stephen Bernard, Karen Smith, Peter Cameron, Judith Finn, Dion Stub, Peter Morley, Janet Bray
Summary: The study found wide variation in survival between different EDs, which was associated with hospital characteristics. It suggests the need for a detailed review of ED deaths, particularly in non-cardiac arrest centres, and potentially the need for monitoring ED survival as a measure of quality.
Article
Medicine, General & Internal
Sanae Hosomi, Tetsuhisa Kitamura, Tomotaka Sobue, Ling Zha, Kosuke Kiyohara, Tasuku Matsuyama, Jun Oda
Summary: This study analyzed the effects of timing of epinephrine administration on survival rates in patients with out-of-hospital cardiac arrest following traffic collisions. The results showed that delayed epinephrine administration was associated with decreased one-month survival rates. Only a few patients showed favorable neurological outcomes after receiving early epinephrine administration.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Aleksandra A. Abrahamowicz, Catherine R. Counts, Kyle R. Danielson, Natalie E. Bulger, Charles Maynard, David J. Carlbom, Erik R. Swenson, Andrew J. Latimer, Betty Yang, Michael R. Sayre, Nicholas J. Johnson
Summary: This study investigated the association between the difference of PaCO2 and ETCO2 and hospital mortality and neurologic outcome. The results showed that the difference of PaCO2-ETCO2 on hospital arrival was not associated with survival to hospital discharge or neurologic status. Therefore, these measures should not be used for prognostication after out-of-hospital cardiac arrest (OHCA).
Article
Critical Care Medicine
Ji Eun Pak, Ki Hong Kim, Sang Do Shin, Kyoung Jun Song, Ki Jeong Hong, Young Sun Ro, Jeong Ho Park
Summary: The study found that OHCA patients with liver cirrhosis showed poor clinical outcomes, while chronic liver disease itself did not have a negative impact on OHCA prognosis unless it progressed to cirrhotic status.
Article
Health Care Sciences & Services
Young Taeck Oh, Chiwon Ahn
Summary: This study investigated the epidemiology, bystander characteristics, and outcomes of out-of-hospital cardiac arrests (OHCA) in public places in South Korea from 2016 to 2021. The findings revealed an increase in bystander-performed CPR but a decrease in bystander automated external defibrillator (AED) use. The survival rates for OHCA remained steady, with a slight decrease observed during the COVID-19 pandemic.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Purav Mody, Ambarish Pandey, Arthur S. Slutsky, Matthew W. Segar, Alex Kiss, Paul Dorian, Janet Parsons, Damon C. Scales, Valeria E. Rac, Sheldon Cheskes, Arlene S. Bierman, Beth L. Abramson, Sara Gray, Rob A. Fowler, Katie N. Dainty, Ahamed H. Idris, Laurie Morrison
Summary: Studies have shown that despite a higher likelihood of return of spontaneous circulation, women do not have higher survival rates after out-of-hospital cardiac arrest, especially among patients considered to have a favorable prognosis.
Review
Cardiac & Cardiovascular Systems
Cameron Dezfulian, Aaron M. Orkin, Bradley A. Maron, Jonathan Elmer, Saket Girotra, Mark T. Gladwin, Raina M. Merchant, Ashish R. Panchal, Sarah M. Perman, Monique Anderson Starks, Sean van Diepen, Eric J. Lavonas
Summary: Opioid overdose is the leading cause of death for Americans aged 25 to 64, with changing epidemiology of opioid-associated out-of-hospital cardiac arrest in the US. Emergency management includes effective ventilation and naloxone administration, and education programs have been developed to teach people how to handle opioid poisoning.
Article
Cardiac & Cardiovascular Systems
Carlo Alberto Barcella, Daniel Molager Christensen, Lars Idorn, Nishan Mudalige, Morten Malmborg, Frederik Folke, Christian Torp-Pedersen, Gunnar Gislason, Mohamad El-Chouli
Summary: This epidemiological study based on a registry found that patients with congenital heart disease (CHD) have a higher risk of out-of-hospital cardiac arrest (OHCA) compared to the general population. However, the 30-day survival rate for OHCA patients with CHD is similar to that of OHCA patients without CHD, and this survival relies on pre-hospital cardiopulmonary resuscitation and defibrillation.
EUROPEAN HEART JOURNAL
(2023)
Article
Critical Care Medicine
Dong Hyun Choi, Young Sun Ro, Ki Hong Kim, Jeong Ho Park, Joo Jeong, Ki Jeong Hong, Kyoung Jun Song, Sang Do Shin
Summary: This study aimed to evaluate the association between alcohol intake shortly before cardiac arrest and survival outcomes after out-of-hospital cardiac arrest (OHCA). The study found that alcohol intake was associated with higher odds of survival to hospital discharge, as well as increased likelihood of receiving coronary angiography and implantable cardioverter defibrillator (ICD) implantation.
Article
Health Care Sciences & Services
Juncheol Lee, Heekyung Lee, Jaehoon Oh, Tae Ho Lim, Hyunggoo Kang, Byuk Sung Ko, Yongil Cho
Summary: This study found that low total serum cholesterol levels may be associated with poor neurological outcomes and in-hospital death in patients hospitalized after out-of-hospital cardiac arrest.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Eujene Jung, Hyun Ho Ryu, Young Sun Ro, Sang Do Shin
Summary: There is no consensus on the appropriate length of time spent on the scene by emergency medical services. This study aimed to investigate the association between scene time interval (STI) and clinical outcomes of out-of-hospital cardiac arrest (OHCA). The study found that prolonged STIs were associated with lower survival rates and poorer neurological recovery. Factors such as witness status, bystander cardiopulmonary resuscitation, and initial electrocardiogram rhythm also affected this association.
Article
Emergency Medicine
Dong-Hyun Jang, Dong Keon Lee, Jonghwan Shin, You Hwan Jo, Seung Min Park
Summary: This study found that a prolonged emergency department length of stay in out-of-hospital cardiac arrest patients is independently associated with a poor neurologic outcome at 28 days.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Critical Care Medicine
Ivan S. Y. Chua, Stephanie M. C. Fook-Chong, Nur Shahidah, Yih Yng Ng, Michael Y. C. Chia, Desmond R. Mao, Benjamin S. H. Leong, Si Oon Cheah, Han Nee Gan, Nausheen E. Doctor, Lai Peng Tham, Marcus E. H. Ong
Summary: The study examined the survival outcomes of out-of-hospital cardiac arrest (OHCA) patients based on the modes of transportation to the Emergency Department (ED). The majority of OHCA patients in Singapore are conveyed by Emergency Medical Services (EMS), while some arrive through alternative transportation without prehospital interventions.
Article
Critical Care Medicine
Takafumi Obara, Tetsuya Yumoto, Tsuyoshi Nojima, Takashi Hongo, Kohei Tsukahara, Naomi Matsumoto, Takashi Yorifuji, Atsunori Nakao, Jonathan Elmer, Hiromichi Naito
Summary: This study aimed to investigate the association between prehospital physician presence and neurologic outcomes in pediatric patients with out-of-hospital cardiac arrest (OHCA). The data from the Japanese Association for Acute Medicine-OHCA Registry were analyzed in a retrospective cohort study. The results showed that among pediatric patients with OHCA, prehospital physician presence was associated with a nearly two-fold increase in the odds of 1-month favorable neurologic outcomes.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Mahshid Abir, Sydney Fouche, Jessica Lehrich, Jason Goldstick, Neil Kamdar, Michael O'Leary, Christopher Nelson, Peter Mendel, Wilson Nham, Claude Setodji, Robert Domeier, Anthony Hsu, Theresa Shields, Rama Salhi, Robert W. Neumar, Brahmajee K. Nallamothu
Summary: The study found substantial differences in sustained ROSC rates upon ED arrival across EMS agencies in Michigan, with an average adjusted rate of 23.8% but notable variation between agencies. The top five agencies had higher rates of sustained ROSC, while the bottom five had lower rates. These differences suggest opportunities for identifying and improving best practices in EMS agencies to enhance OHCA care.
Article
Gerontology
Hanzhang Xu, Yaolin Pei, Matthew E. Dupre, Bei Wu
Summary: Massive rural-to-urban migration in China has a significant impact on informal caregiving arrangements among Chinese older adults. We conducted an inventory of longitudinal aging survey datasets from mainland China and identified seven eligible datasets, five of which included nationally representative samples. These high-quality datasets support research on migration and caregiving arrangements among Chinese older adults.
JOURNAL OF AGING & SOCIAL POLICY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Thomas M. Roston, Derek Y. So, Shuangbo Liu, Christopher B. Fordyce, Brian Grunau, Jacob C. Jentzer, Akshay Bagai, Adriana Luk, Shaun G. Goodman, Sean van Diepen
Summary: Although survival rates for cardiogenic shock (CS) have improved over time, mortality remains high (30%-50%) despite timely revascularisation and the potential use of temporary mechanical circulatory support (tMCS). Variability in CS management and outcomes between different hospitals suggests the need for a hub-and-spoke model of care to improve current practices. Leveraging existing regional relationships and infrastructure, particularly in regions with established ST-segment elevation myocardial infarction (STEMI) networks, could lead to more timely and equitable access to CS care and improved survival.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Madeleine Barker, Mypinder Sekhon, Konstantin A. Krychtiuk, Sean van Diepen, Carlos L. Alviar, Christopher B. Granger, Christopher B. Fordyce
Summary: Targeted temperature management (TTM) has been a topic of discussion in improving outcomes after out-of-hospital cardiac arrest (OHCA). Trials suggest that targeting normothermia should be the standard care for comatose survivors. However, there is a lack of representation of important subgroups in clinical trials compared to real-world registries. The review suggests integrating clinical trial evidence into practice and recommends targeted normothermia as the strategy of choice for OHCA.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Siddharth M. Patel, David D. Berg, Erin A. Bohula, Vivian M. Baird-Zars, Christopher F. Barnett, Gregory W. Barsness, Sunit-Preet Chaudhry, Lori B. Daniels, Sean van Diepen, Shahab Ghafghazi, Michael J. Goldfarb, Jacob C. Jentzer, Jason N. Katz, Benjamin B. Kenigsberg, Patrick R. Lawler, P. Elliot Miller, Alexander I. Papolos, Jeong-Gun Park, Brian J. Potter, Rajnish Prasad, N. Sarma V. Singam, Shashank S. Sinha, Michael A. Solomon, Jeffrey J. Teuteberg, David A. Morrow
Summary: Algorithmic application of the 2019 SCAI shock stages effectively stratifies mortality risk for patients with cardiogenic shock, but clinician assessment of SCAI staging may differ. Moreover, the implications of the 2022 SCAI criteria update remain incompletely defined. Updated algorithmic staging using the 2022 SCAI criteria and vasoactive-inotropic score further refines risk stratification.
CIRCULATION-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Manan Pareek, Kristian H. Kragholm, Anna Meta Dyrvig Kristensen, Muthiah Vaduganathan, Jannik L. Pallisgaard, Christina Byrne, Tor Biering-Sorensen, Christina Ji-Young Lee, Anders Nissen Bonde, Martin Bodtker Mortensen, Michael Maeng, Emil L. Fosbol, Lars Kober, Niels Thue Olsen, Gunnar H. Gislason, Deepak L. Bhatt, Christian Torp-Pedersen
Summary: The study found that individuals suspected of acute coronary syndrome who had consecutively elevated high-sensitivity troponin concentrations had the highest risk of death, while those with consecutively normal hsTnT concentrations had very low mortality rates, regardless of changes between measurements.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Jonas Bruhn, Morten Malmborg, Caroline H. Garred, Pauline Ravn, Deewa Zahir, Charlotte Andersson, Gunnar Gislason, Christian Torp-Pedersen, Kristian Kragholm, Emil Fosbol, Jawad H. Butt, Ninian N. Lang, Mark C. Petrie, John McMurray, Lars Kober, Morten Schou
Summary: This study investigated the temporal trends of new onset cancer in patients with HF between 1997 and 2016. It found that the incidence of cancer did not increase over time in HF patients, but long-term survival following an HF diagnosis significantly increased.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Lecia Dixen Wolder, Claus Graff, Kirstine H. Baadsgaard, Monica Lykke Langgaard, Christoffer Polcwiartek, Christina Ji-Young Lee, Morten Wagner Skov, Christian Torp-Pedersen, Daniel J. Friedman, Brett Atwater, Thure Filskov Overvad, Jonas Bille Nielsen, Steen Moeller Hansen, Peter Sogaard, Kristian H. Kragholm
Summary: This study investigated the association between the components of P-terminal force V1 (PTFV1) and incident atrial fibrillation (AF) and stroke/transient ischemic attack (TIA). Abnormal PTFV1 was found to be associated with an increased risk of AF and stroke/TIA. Among patients with abnormal PTFV1, the highest tertile of duration (PTDV1) and amplitude (PTAV1) showed the highest risks of AF and stroke/TIA.
Article
Critical Care Medicine
Anthony P. Carnicelli, Ryan Keane, Kelly M. Brown, Daniel B. Loriaux, Payton Kendsersky, Carlos L. Alviar, Kelly Arps, David Berg, Erin A. Bohula, James A. Burke, Jeffrey A. Dixson, Daniel A. Gerber, Michael Goldfarb, Christopher B. Granger, Jianping Guo, Robert W. Harrison, Michael Kontos, Patrick R. Lawler, P. Elliott Miller, Jose Nativi-Nicolau, L. Kristin Newby, Lekha Racharla, Robert Roswell, Kevin S. Shah, Shashank S. Sinha, Michael A. Solomon, Jeffrey Teuteberg, Graham Wong, Sean van Diepen, Jason N. Katz, David Morrow
Summary: This study compared the characteristics, care patterns, and outcomes of patients admitted to cardiac intensive care units (CICU) after in-hospital cardiac arrest (IHCA) or out-of-hospital cardiac arrest (OHCA). The study found that IHCA patients were older and had a higher prevalence of coronary disease, atrial fibrillation, and heart failure. IHCA patients had lower lactate levels, higher utilization of invasive hemodynamics, mechanical circulatory support, and renal replacement therapy. Additionally, IHCA patients had lower mortality rates.
Article
Cardiac & Cardiovascular Systems
Andrew Kochan, Terry Lee, Nima Moghaddam, Grace Milley, Joel Singer, John A. Cairns, Graham C. Wong, Jacob C. Jentzer, Sean van Diepen, Carlos Alviar, Christopher B. Fordyce
Summary: This study analyzed the association between the time from first medical contact to percutaneous coronary angiography and mortality and major adverse cardiovascular events in patients with ST-segment-elevation myocardial infarction (STEMI) with and without cardiogenic shock (CS). The results showed that delays in reperfusion were associated with worse outcomes in patients with STEMI complicated by CS. Therefore, strategies are needed to reduce the time from first medical contact to device for these patients.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Public, Environmental & Occupational Health
Britta Jensen, Henrik Vardinghus-Nielsen, Elisabeth Helen Anna Mills, Amalie Lykkemark Moller, Filip Gnesin, Nertila Zylyftari, Kristian Kragholm, Fredrik Folke, Helle Collatz Christensen, Stig Nikolaj Blomberg, Christian Torp-Pedersen, Henrik Boggild
Summary: This study investigated the way callers with atypical symptoms of myocardial infarction interpreted their condition in telephone consultations. Unclear symptoms led to callers' uncertainty and worry, affecting their interaction with call-takers.
PATIENT EDUCATION AND COUNSELING
(2023)
Article
Critical Care Medicine
Jacob C. Jentzer, Parag C. Patel, Sean Van Diepen, David A. Morrow, Gregory W. Barsness, Kianoush B. Kashani
Summary: We evaluated the combination of vasoactive-inotropic score (VIS) and Society for Cardiovascular Angiography and Intervention (SCAI) Shock Classification for mortality risk stratification. The results showed that patients who required vasoactive drugs had higher in-hospital mortality, particularly in the early stages of admission. The VIS provides incremental prognostic information beyond the SCAI Shock Classification.
Article
Geriatrics & Gerontology
Lene T. T. Hansen, Johannes Riis, Kristian H. H. Kragholm, Lis K. K. Larsen, Christian Cavallius, Marianne M. M. Morch, Silas Z. Z. Clemmensen, Maria L. L. Krogager, Dorte Melgaard
Summary: This study examined whether intravenous iron supplements reduced the rate of postoperative infections within 30 days after hip fracture surgery in older adults. The results showed that intravenous iron supplements had no effect on postoperative infections.
Editorial Material
Cardiac & Cardiovascular Systems
Carlos L. Alviar, Sean van Diepen
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2023)
Article
Cardiac & Cardiovascular Systems
Athira J. Jacob, Ola Abdelkarim, Salma Zook, Kristian Hay Kragholm, Prantik Gupta, Myra Cocker, Juan Ramirez Giraldo, Jim O. Doherty, Max Schoebinger, Chris Schwemmer, Mehmet A. Gulsun, Saikiran Rapaka, Puneet Sharma, Su-Min Chang
Summary: This study validates a new, fully automated, AI-based method for quantifying chamber volumes from NCCT scans, which shows good agreement with measurements from contrasted CT angiography.
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2023)
Letter
Respiratory System
Kiki Waeijen-Smit, Peter A. Jacobsen, Sarah Houben-Wilke, Sami O. Simons, Frits M. E. Franssen, Martijn A. Spruit, Christian T. Pedersen, Kristian H. Kragholm, Ulla M. Weinreich
Summary: This study aimed to determine the 5-year all-cause hospital admission trajectories of patients with COPD following their first ever exacerbation-related hospitalisation. The results showed that nonrespiratory causes contribute significantly to hospital admissions in COPD patients, highlighting the importance of targeting these causes for preventive interventions.