Journal
HLA
Volume 90, Issue 3, Pages 165-170Publisher
WILEY
DOI: 10.1111/tan.13077
Keywords
allele; canine; class I; DLA-88; dog; dog leukocyte antigen; major histocompatibility complex
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Funding
- National Institutes of Health, Bethesda, MD [P01 CA078902, P30 DK056465, U54 DK106829, U01 HL099993]
- Storb Endowment
- AKC Canine Health Foundation Oak [01771]
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Major histocompatibility complex (MHC) genes in mammals include highly polymorphic class I and class II genes that are critical for donor-recipient matching for transplantation. Dogs have served as an effective, directly translatable model for stem/progenitor cell transplantation. Previous analyses of MHC class I genes in dogs point to a single highly polymorphic gene, dog leukocyte antigen (DLA)-88, as an important factor in the success or failure of hematopoietic stem cell transplants. Fifty-nine DLA-88 alleles have been identified and reported so far. Here, we extend this list by presenting 13 novel DLA-88 alleles found in domestic dogs.
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