Article
Chemistry, Analytical
Yiting Wang, Yang Hu, Ru Wang, Wei Zhang, Huiting Mao, Chuanjun Yuan, Ruinian Hua
Summary: In this study, a highly sensitive non-proteinuria assay platform was developed using urinary sialic acid as a biomarker to accurately diagnose diabetic nephropathy within a short time period. This platform incorporated the ninhydrin reaction and the inner filter effect, resulting in stable and high sensitivity with 100% positive prediction for urine samples.
Article
Chemistry, Analytical
Yiting Wang, Yang Hu, Ru Wang, Wei Zhang, Huiting Mao, Chuanjun Yuan, Ruinian Hua
Summary: Diabetic nephropathy (DN), the most common microvascular complication associated with incurable diabetes, can now be accurately diagnosed within 20 minutes using an ultrasensitive non-proteinuria assay platform. This platform utilizes urinary sialic acid as an effective biomarker for DN and combines mimetic immunoassay and inner filter effect to convert imperceptible color into highly sensitive fluorescence signals.
Article
Polymer Science
Ranran Gao, Xiaoning Guo, Li Wang, Wantai Yang
Summary: In this study, Tetraphenylethylene(TPE)-containing styrene-maleic acid copolymers with diverse chain topologies and locations of the TPE moiety were synthesized by reversible activation-fragmentation transfer polymerization (RAFT). The copolymers' fluorescence responsiveness to pH value, Ca2+, and bovine serum albumin (BSA) were systematically investigated, showing significant influence on both the stimuli acceptor and signaling sides of the macromolecular structure.
Article
Pharmacology & Pharmacy
Kangkang Li, Xinlong Zang, Mingyang Cheng, Xuehong Chen
Summary: Recent progresses in fighting against cancer include better understanding of tumor microenvironment and rapid development in nanoscale drug delivery system. Nanocarriers based on polymeric acrylic derivatives have shown high drug encapsulation rate and satisfactory therapeutic outcome in tumor treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Chemistry, Multidisciplinary
Hamidreza Parsimehr, Ali Ehsani
Summary: Electrochemical energy storage devices that respond to external stimuli have been developed rapidly, enhancing performance and applications. The multi-responsive behaviors of these devices stem from their functionality and specific structure. Future research will focus on merging economic, environmental, and multi-responsiveness priorities to improve performance and address complex situations.
Review
Chemistry, Multidisciplinary
Dengshuai Wei, Yong Sun, Hu Zhu, Qinrui Fu
Summary: Stimuli-responsive polymers have been widely used in biomedical applications due to their ability to respond to internal and external stimuli. In the context of the tumor microenvironment, these polymers are used to prepare smart nanovehicles for targeted drug delivery. TME-responsive nanosystems offer many advantages over conventional drug delivery systems, leading to significant advances in cancer diagnosis and therapy.
Article
Engineering, Environmental
Seul Gi Kim, Benny Ryplida, Hyeong Jun Jo, Gibaek Lee, Sung Young Park
Summary: In this study, a stimuli-responsive electrochemical and fluorescence biosensor was developed to examine the activity and inhibition of acetylcholinesterase (AChE). The sensor used carbonized diselenide-crosslinked polymer dot-loaded polydopamine nanoparticles (PDA@dsPD) incorporated into polyvinyl alcohol/chitosan hydrogel. The sensor showed a sensitive response to AChE and could visualize the fluorescence signal expressed by AChE.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Pooyan Makvandi, Rezvan Jamaledin, Guojun Chen, Zahra Baghbantaraghdari, Ehsan Nazarzadeh Zare, Concetta Di Natale, Valentina Onesto, Raffaele Vecchione, Jesse Lee, Franklin R. Tay, Paolo Netti, Virgilio Mattoli, Ana Jaklenec, Zhen Gu, Robert Langer
Summary: Microneedle (MN) patches, made up of miniature needles, have emerged as a promising tool for minimally invasive translocation of biomolecules into the dermis. Stimuli-responsive MN patches are a new drug delivery system that can release cargos in response to internal or external triggers, with various mechanisms of action for different indications. Future opportunities and challenges in clinical translation are also discussed.
Article
Chemistry, Analytical
Kening Lu, Dongqing Liu, Danyang Zhao, Xinyu Bai, Chenghui Hong, Nengqin Jia
Summary: A dual-photoelectrode molecular imprinted photoelectrochemical (PEC) sensor is developed for the determination of sialic acid (SA) without requiring additional energy supply. The sensor utilizes a WO3/Bi2S3 heterojunction as the photoanode to provide stable and amplified photocurrent, while CuInS2 micro-flowers functionalized with molecularly imprinted polymers (MIPs) serve as the photocathode for recognizing SA. The PEC sensor exhibits a wide linear range, high selectivity, and a low detection limit, making it a valuable approach for detecting various molecules.
Review
Polymer Science
Zahra Abousalman-Rezvani, Hossein Roghani-Mamaqani, Hossein Riazi, Ozra Abousalman-Rezvani
Summary: Water treatment utilizes stimuli-responsive polymers to eliminate contaminants by dynamically changing their properties. These polymers can effectively remove heavy metal ions, aqueous anions, and dyes. The review also discusses the application of pH, CO2, temperature, and light-responsive polymers, as well as the potential of dual- and multi-responsive polymers.
Article
Materials Science, Multidisciplinary
Dalei Wang, Xiaoxia Han, Bin Dong, Feng Shi
Summary: In the past decade, there have been significant advances in the field of micromotors, especially in the development of stimuli-responsive polymer based micromotors. These micromotors show unprecedented properties and have potential applications in various fields.
APPLIED MATERIALS TODAY
(2021)
Article
Nanoscience & Nanotechnology
Misato Kanjo, Masayuki Gon, Kazuo Tanaka
Summary: This study reports luminescent conjugated polymers with boron-fused azomethine structure and tridentate ligands, which can respond to acid vapor and are used for film-type sensors. The acid responsiveness is due to the lone-pair electrons on the nitrogen atom in the boron-fused azomethine unit. The polymer films exhibit red shifts in emission wavelengths under acid vapor and reversible responses. Furthermore, the films show unique luminescent color changes due to environmental sensitivity. The bilayer films of the BAm polymer coated with poly(n-butyl methacrylate) show vapochromic luminescence with blue shifts depending on exposure time, allowing for the evaluation of solvent-vapor permeability.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Chunchun Liang, Mengwei Li, Yulan Chen
Summary: This study reports a series of amphiphilic diazapyrenes that exhibit switchable fluorescence under mechanical force or water vapor stimulation. Through comprehensive studies of their photophysical properties, a stimuli-induced excimer-based sensing mechanism was revealed, and the relationship between molecular structures and optical responsive properties was illustrated. The unique fluorescent, stimuli-responsive behaviors of these compounds in the solid state were used to create sensory films for sensing mechanical force and water vapor, showing potential applications in biocompatible force sensors, data storage, and humidity sensors.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Multidisciplinary
Habib M. N. Ahmad, Gaurab Dutta, John Csoros, Bo Si, Rongfang Yang, Jeffrey M. Halpern, W. Rudolf Seitz, Edward Song
Summary: The development of a single-chain stimuli-responsive templated polymer without covalent interchain cross-linkers shows promise as a target recognition element for a label-free electrochemical sensing platform.
ACS APPLIED POLYMER MATERIALS
(2021)
Review
Polymer Science
Siyang Wang, Qianhui Liu, Lei Li, Marek W. Urban
Summary: Responsive polymers, known for their adaptability and capability of transport control of molecules, play a significant role in advancing scientific discoveries. Recent developments in commodity polymers with stimuli-responsiveness to various factors have diverse applications, ranging from drug delivery to color-changing coatings. Current technological advances and future opportunities and applications in stimuli-responsive chemistries are also discussed in this review.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Chemistry, Analytical
Shushu Ding, Yingzi Liu, Chunrong Ma, Junqi Zhang, Anwei Zhu, Guoyue Shi
Article
Chemistry, Analytical
Chunling Pu, Yunxia Xu, Qi Liu, Anwei Zhu, Guoyue Shi
ANALYTICAL CHEMISTRY
(2019)
Article
Chemistry, Analytical
Miao Yang, Chunrong Ma, Shushu Ding, Yujie Zhu, Guoyue Shi, Anwei Zhu
ANALYTICAL CHEMISTRY
(2019)
Article
Chemistry, Analytical
Shushu Ding, Meina Li, Haoyang Gong, Qing Zhu, Guoyue Shi, Anwei Zhu
ANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Chuanping Zhang, Zhichao Liu, Limin Zhang, Anwei Zhu, Fumin Liao, Jingjing Wan, Jian Zhou, Yang Tian
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Analytical
Shushu Ding, Chunyan Liu, Dingyi Fu, Guoyue Shi, Anwei Zhu
Summary: This study introduces a unique concept for transforming liquid-phase fluorometric assay into enhanced nanopore analysis, utilizing bovine serum albumin-protected gold nanoclusters for biothiol determination as a proof of concept. The system showed potential in detecting and quantifying biothiols, enhancing sensitivity and selectivity in the glass nanopipette platform by coupling electrical and optical signals.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Tingting Zheng, Yujie Zhu, Anwei Zhu
Summary: A dual-signal-output glass nanopore system was developed for sensing glucose by modifying the boronic acid-containing stimuli-responsive polymer and electrostatic assembly of cationic pyrene. By immobilizing the polymer on the inner wall of the nanopore, sensitive evaluation of glucose was achieved through ion rectification, while observing pyrene excimer emission. This design simplifies the detection process by avoiding fluorescence labeling of the target and nanopore.
Article
Chemistry, Analytical
Qi Liu, Shushu Ding, Rui Gao, Guoyue Shi, Anwei Zhu
Summary: A smart copolymer modified nanochannel was designed to mimic the structure and mechanism of K-ATP channels, achieving ATP responsiveness and demonstrating a possible mechanism for ATP gating.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
Qi Liu, Shushu Ding, Guoyue Shi, Anwei Zhu
Summary: In this study, a generalizable method based on the formation of a self-assembled surfactant film was used to build a nanopipette system. By using this nanopipette, an age-related difference in arginine metabolism was observed in Alzheimer's disease.
CHEMICAL COMMUNICATIONS
(2022)
Review
Chemistry, Analytical
Shidi Wang, Yuandong Liu, Anwei Zhu, Yang Tian
Summary: Electrochemical biosensors are powerful tools for studying dynamic neurochemical signals in the brain, providing insight into brain physiology and pathology. Recent advancements in integrating in vivo electrochemical sensors with diverse disciplines have revitalized the development of sensors with improved performance. This review summarizes recent advances in molecular design, electrode materials, and electrochemical devices for in vivo sensors, highlighting high-performance strategies through flexible and smart design. Future prospects for next-generation in vivo electrochemical biosensors are also discussed.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Shushu Ding, Guoyue Shi, Anwei Zhu
Summary: Neurochemical monitoring is important for understanding brain chemical communications and neurological diseases. However, the limited analytical performance of existing electrochemical sensors hinders our understanding of the roles of chemical signals in the brain. Stimuli-responsive polymers can enhance target recognition and modulate electrochemical signals, improving the analytical performance of neurochemical sensors. This review focuses on the design and application of electrochemical sensors based on stimuli-responsive polymers, highlighting their contribution to the conversion of chemical/electrochemical reactions into electric signals. The development of advanced devices using novel materials, electrochemical techniques, and microelectronic engineering can greatly benefit the evaluation of neurochemicals, deepening our understanding of brain events and improving the diagnosis and treatment of neurological diseases.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Chuanping Zhang, Chenxiao Tang, Yuxiao Mei, Limin Zhang, Anwei Zhu, Yang Tian
Summary: An electrochemical method was reported for selectively sensing and accurately quantifying monoamine oxidase A (MAO-A) in the cortex and thalamus of a live mouse brain. Using this tool, it was found that MAO-A increased Ca2+ entry into neurons via the TPRM2 channel in the live mouse brain of an AD model.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Wenting Chen, Shushu Ding, Jiaren Wu, Guoyue Shi, Anwei Zhu
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Analytical
Shushu Ding, Yunxia Xu, Qi Liu, Hui Gu, Anwei Zhu, Guoyue Shi
Meeting Abstract
Chemistry, Multidisciplinary
Anwei Zhu, Sumei Cao, Guoyue Shi
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)