Article
Materials Science, Multidisciplinary
Jonathan Phelipot, Nicolas Ledos, Thomas Dombray, Matthew P. Duffy, Mathieu Denis, Ting Wang, Yahia Didane, Meriem Gaceur, Qinye Bao, Xianjie Liu, Mats Fahlman, Pietro Delugas, Alessandro Mattoni, Denis Tondelier, Bernard Geffroy, Pierre-Antoine Bouit, Olivier Margeat, Joerg Ackermann, Muriel Hissler
Summary: Fluorescent nanohybrids based on pi-extended hydroxyoxophosphole ligands grafted onto ZnO nanoparticles are designed and studied for potential use in OLEDs as solution-processed emissive layers. The restriction of intramolecular motions of the organic fluorophore leads to highly emissive materials due to aggregation induced emission effect. Theoretical calculations and XPS analyses were conducted to analyze the interactions between organic and inorganic components.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Chemistry, Analytical
Mengke Wang, Ning Li, Shun Wang, Junyang Chen, Mengjun Wang, Lu Liu, Xingguang Su
Summary: The study developed a ratiometric fluorescent sensing platform based on Ag-AuNCs@SiNPs nanohybrids for detecting AChE activity, which showed high sensitivity and stability, making it suitable for reliable detection of AChE activity in human serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
Juan Ferrera-Gonzalez, Maria Gonzalez-Bejar, Julia Perez-Prieto
Summary: This study utilized a nanohybrid consisting of rose bengal dye and upconversion nanoparticles to investigate the fundamental mechanisms underlying the interaction between the two and its impact on the dye's photophysical behavior.
Article
Multidisciplinary Sciences
Z. Wang, L. Balembois, M. Rancic, E. Billaud, M. Le Dantec, A. Ferrier, P. Goldner, S. Bertaina, T. Chaneliere, D. Esteve, D. Vion, P. Bertet, E. Flurin
Summary: Electron spin resonance spectroscopy is the preferred method for characterizing paramagnetic impurities, but it only provides ensemble-averaged quantities due to limited signal-to-noise ratio. To achieve single-electron spin sensitivity, we use spin fluorescence detection method and a microwave photon counter at millikelvin temperatures. By coupling individual paramagnetic erbium ions in a scheelite crystal to a high-quality-factor planar superconducting resonator to enhance their radiative decay rate, we obtain a fluorescence signal with a signal-to-noise ratio of 1.9 in one second integration time. This method has the potential for single-spin detection in a volume as large as the resonator magnetic mode volume, making it orders of magnitude larger than other single-spin detection techniques.
Article
Chemistry, Multidisciplinary
Yanhua Zhai, Ming Liu, Tao Yang, Jie Luo, Chaogang Wei, Junkang Shen, Xue Song, Hengte Ke, Peng Sun, Miao Guo, Yibin Deng, Huabing Chen
Summary: In this study, self-activated arsenic manganite nanohybrids were developed for high-contrast magnetic resonance imaging (MRI) and arsenotherapy in triple-negative breast cancer (TNBC). The nanohybrids enabled precise tumor targeting, delivered high levels of arsenic trioxide (ATO) to the tumor cells, and exhibited potent antitumor efficacy. The nanohybrids also showed synergistic effects when combined with thermotherapy and induced immunogenic cell death (ICD) to activate the tumor microenvironment and enhance the antitumor immune response.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Biomedical
Prem Pandey, Govind Pandey, Roger Narayan
Summary: The study demonstrates the synthesis of PBNPs and AuNPs nanoparticles mediated by PEI, forming PBNP-AuNP nanohybrids with significant changes in Prussian blue characteristics. The control of polymeric cation capping of AuNPs is achieved through a wide range of PEI concentrations, enabling non-enzymatic detection of serum glucose levels.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Sebastian P. Schwaminger, David Bauer, Paula Fraga-Garcia
Summary: This study aimed to combine iron oxide nanoparticles with nanoscale gold for improved dye detection. By testing various approaches, the impact of colloidal stability of iron oxide nanoparticles on the properties of the hybrid material was explored. The optimized method showed enhanced Raman scattering capabilities, potentially expanding applications in diagnostics and environmental fields.
NANOSCALE ADVANCES
(2021)
Article
Biochemistry & Molecular Biology
Juan Ferrera-Gonzalez, Laura Frances-Soriano, Cristina Galiana-Rosello, Jorge Gonzalez-Garcia, Maria Gonzalez-Bejar, Eleonore Froehlich, Julia Perez-Prieto
Summary: Research demonstrates that upconversion nanoparticles coated with cucurbit[7]uril (CB[7]) show no cytotoxicity or endotoxin contamination in endothelial cells for biological applications. However, higher cytotoxicity is observed in other cell types, possibly due to differences in lysosome content and particle uptake rate.
Article
Chemistry, Physical
Qi Lu, Huaiyu Gong, Qingfeng Guo, Xuren Huang, Jiayi Cai
Summary: The study compares the gemological, spectroscopic, and luminescent properties of CVD synthetic diamonds with natural diamonds, showing that CVD diamonds have high-order interference color and more apparent abnormal birefringence. Infrared spectra confirm CVD samples as type IIa and natural samples as type Ia. CVD diamonds exhibit lamellar growth structure, while natural diamonds show irregular ring-like growth structure.
Article
Chemistry, Physical
Vsevolod Borovkov
Summary: A novel experimental approach is proposed to study spin-correlated polaron pairs on conjugated polymer molecules, with the migration, recombination, and evolution of the spin state of the pairs monitored at nanosecond resolution by observing recombination fluorescence under different magnetic fields.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Engineering, Biomedical
Zhijun Ouyang, Yue Gao, Mingwu Shen, Xiangyang Shi
Summary: This review summarizes the applications of dendrimer-based nanohybrids in cancer photomedicine, including molecular imaging, photothermal therapy, photodynamic therapy, combination therapy, and cancer theranostics. Researchers have made significant efforts in developing these multifunctional nanoplatforms.
MATERIALS TODAY BIO
(2021)
Article
Chemistry, Multidisciplinary
Koustav Sahoo, Tapu Raihan Gazi, Soumyadip Roy, Indranath Chakraborty
Summary: Atomically precise metal nanoclusters have exciting optical and catalytic properties, but their long-term stability under ambient conditions is a challenge for practical applications. Creating nanohybrids from atomically precise nanoclusters and more stable nanomaterials can improve their stability and useful properties.
COMMUNICATIONS CHEMISTRY
(2023)
Article
Chemistry, Analytical
Xinying Gong, Yayun Ji, Fanqiang Meng, Yulu Tian, Dongmei Wang, Huan Chen, Zhengjun Gong
Summary: In this work, a dual-emission nitrogen-doped carbon dots/AuNCs nanohybrid was fabricated and used for the sensitive detection of Pb2+. The sensor achieved quantitative analysis of Pb2+ by measuring the change in fluorescence intensities, and showed good selectivity and anti-interference ability in real water samples. Furthermore, a paper-based sensor was developed for the semi-quantitative determination of Pb2+ by visual observation of color transition.
MICROCHEMICAL JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Goeun Choi, N. Sanoj Rejinold, Huiyan Piao, Jin-Ho Choy
Summary: Advanced nanotechnology is rapidly advancing in the field of novel hybrid nanomaterials, with materials like gold, iron, and silica showing great potential in biomedical applications. Recent research also indicates the promising use of up-conversion nanomaterials in treating deep-seated tumor tissues.
Review
Chemistry, Multidisciplinary
Niko Hildebrandt, Mihye Lim, Namjun Kim, Da Yeon Choi, Jwa-Min Nam
Summary: Plasmonic metal nanoparticles and semiconductor quantum dots are widely used nanomaterials in optical biosensing and bioimaging. While their combination for fluorescence quenching via nanosurface energy transfer or Forster resonance energy transfer is common, metal-QD nanohybrids for plasmon-enhanced fluorescence have been less prevalent. This article discusses the challenges in optimizing distances, orientations, and spectral overlap for maximum plasmon-enhanced fluorescence and reviews the different nanomaterials, their combinations, and applications in advanced optical biosensing and bioimaging.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Yuen Yung Hui, Yi-Xiu Tang, Terumitsu Azuma, Hsin-Hung Lin, Fang-Zhen Liao, Qing-Ying Chen, Jen-Hwa Kuo, Yuh-Lin Wang, Huan-Cheng Chang
Summary: In this study, a low-cost and portable lateral flow immunoassay (LFIA) reader based on photothermal detection was developed. The LFIA reader utilized a low-power green laser as the heating source and a single-element infrared sensor as the detector for accurate quantitative detection of reporters captured on LFIA strips. The results showed that photothermal detection significantly enhanced the sensitivity of LFIA and enabled quantitative analysis to support critical decision-making.
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2022)
Article
Multidisciplinary Sciences
Terumitsu Azuma, Yuen Yung Hui, Oliver Y. Chen, Yuh-Lin Wang, Huan-Cheng Chang
Summary: Temperature sensing is a promising method for enhancing the detection sensitivity of lateral flow immunoassay (LFIA) in point-of-care testing. By exciting fluorescent particles or colored latex beads, a temperature increase of over 100 degrees C can be achieved with a low-power laser. This study provides a fundamental understanding of thermometric assay using non-fluorescent latex beads deposited on a nitrocellulose membrane. The research reveals that the absorption of light by red and black latex beads at 520 nm is enhanced by 1.3-fold and 3.2-fold, respectively, due to the multiple scattering of light in the highly porous medium. The CLB-based thermometric assay demonstrates a 10x higher sensitivity than color visualization, similar to previous studies using gold nanoparticles. The practical application of this thermometric immunoassay for rapid antigen tests of COVID-19 is demonstrated.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Analytical
Wesley Wei -Wen Hsiao, Neha Sharma, Trong-Nghia Le, Yu-Yuan Cheng, Cheng-Chung Lee, Duc-Thang Vo, Yuen Yung Hui, Huan-Cheng Chang, Wei- Hung Chiang
Summary: This report presents a novel detection platform called SELFIA for rapid testing of different variants of SARS-CoV-2 virus. The platform shows comparable accuracy and sensitivity with traditional testing methods.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Trong-Nghia Le, Wesley Wei-Wen Hsiao, Yu-Yuan Cheng, Cheng-Chung Lee, Tan-Thanh Huynh, Dinh Minh Pham, Marvin Chen, Ming-Wei Jen, Huan-Cheng Chang, Wei-Hung Chiang
Summary: Dengue fever is a global viral infectious disease, and early detection is crucial for disease prevention and clinical care. In this study, a novel rapid and highly sensitive tool for dengue detection was developed, which can differentiate different NS1 protein serotypes, potentially enabling early detection in high-risk and limited-resource areas.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Vijayanath Elakkat, Eskedar Tessema, Chia-Her Lin, Xiaoping Wang, Huan-Cheng Chang, You-Ning Zheng, Yu-Cheng Huang, Zhong-Yun Gurumallappa, Zhong-Yun Zhang, Ka Long A. Chan, Hening A. S. Rahayu, Joseph S. Francisco, Norman Lu
Summary: To understand the effect of non-covalent weak interactions on molecules, we investigated different types of weak interactions in fluorinated chiral zinc complexes, including improper H-bonding, tetrel bonds, and halogen bonds. High resolution neutron diffraction studies revealed elongation and shortening of the methylene carbon-hydrogen bond due to tetrel bonds and improper H-bond interactions, respectively. We demonstrated how multiple weak interactions can cumulatively affect the C-H bond and offset its elongation through formation of an improper H-bond. Non-covalent interaction and electrostatic potential analysis investigations confirmed the nature of these interactions using density functional theory (DFT) and related calculations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Teng- Yang, Yu-Wen Huang, Prabesh Bista, Chien-Fang Ding, Jeson Chen, Cheng-Tien Chiang, Huan-Cheng Chang
Summary: The study reveals that fluorescent nanodiamonds emit red fluorescence when exposed to specific wavelength lasers. At low power, the emission is mainly due to excitation of electrons from the valence band of diamond to the NV0 centers, while at high power, nonresonant two-photon interband excitation dominates.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Teng- Yang, Terumitsu Azuma, Yu-Wen Huang, Yuen Yung Hui, Cheng-Tien Chiang, Huan-Cheng Chang
Summary: This work measured the stimulated emission cross sections of neutral nitrogen-vacancy (NV0) defects in single-crystal diamond by two-photon excitation. The peak stimulated emission cross section of NV0 centers was found to be 1.43 +/- 0.07 x 10(-17) cm(2) at 650 nm. The thermal shifts of the zem-phonon line of NV0 centers in nanoscale diamonds were also examined, and a temperature measurement sensitivity of 0.2 K.Hz(-1/2) was achieved.
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Ching-Shuan Huang, Chih-Hsun Hsiao, Yu-Chia Chang, Chih-Hsiang Chang, Jen-Chang Yang, James L. Gutmann, Huan-Cheng Chang, Haw-Ming Huang, Sung-Chih Hsieh
Summary: This study aimed to investigate the efficacy of using nano and submicron diamonds in irrigation solutions with sonic and ultrasonic oscillation for removing the smear layer during endodontic treatment. The results showed that specific sizes of nano and submicron diamond irrigation solutions can be used as an alternative approach to removing the smear layer through sonic and ultrasonic oscillation. The potential clinical application of root canal treatments can be expected.
Article
Chemistry, Multidisciplinary
Haotian Wen, David Kordahl, Inga C. Kuschnerus, Philipp Reineck, Alexander Macmillan, Huan-Cheng Chang, Christian Dwyer, Shery L. Y. Chang
Summary: Nitrogen vacancy (NV) centers in fluorescent nanodiamonds (FNDs) are important for quantum sensors due to their luminescence, stability, and biocompatibility. The shape of FNDs significantly affects their fluorescence brightness, with thin, flake-shaped particles being several times brighter and decreasing particle sphericity leading to increased fluorescence.
Article
Chemistry, Analytical
Trong-Nghia Le, Hsin-Yi Chen, Xuan Mai Lam, Chi-Chia Wang, Huan-Cheng Chang
Summary: Nanodiamonds (NDs) have been developed as in vitro diagnostic sensors for two complementary assays: particle-enhanced turbidimetric immunoassay (PETIA) and spin-enhanced lateral flow immunoassay (SELFIA). These NDs, with a largerefractiveindex, emit bright red fluorescence when excited by green light. In experiments using CRP as the target antigen, anti-CRP-conjugated NDs displayed high colloidal stability and low limits of detection.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Teng- Yang, Yuen Yung Hui, Jen-Iu Lo, Yu-Wen Huang, Yin-Yu Lee, Bing-Ming Cheng, Huan-Cheng Chang
Summary: This study demonstrates the use of fluorescent nanodiamonds (FNDs) with nitrogen-vacancy (NV) centers as scintillators for imaging and characterizing extreme ultraviolet (EUV) radiation. The FNDs form a stable thin film and can emit bright red fluorescence when excited by EUV light. An FND-based imaging device has been developed for beam diagnostics of synchrotron radiations.
Article
Biotechnology & Applied Microbiology
Hsin-Hung Lin, Chih-Yen Wang, Feng-Jen Hsieh, Fang-Zhen Liao, Yu-Kai Su, Minh Dinh Pham, Chih-Yuan Lee, Huan-Cheng Chang, Hsao-Hsun Hsu
Summary: This study investigated the use of nanodiamonds (NDs) and fluorescent nanodiamonds (FNDs) as additives in Freund's adjuvant to enhance immune responses and inhibit tumor growth. The results showed that the new formulation significantly enhanced immune responses and had therapeutic effects on tumor growth.
Article
Physics, Multidisciplinary
Hai-Yin Wu, Gokberk Kabacaoglu, Ehssan Nazockdast, Huan-Cheng Chang, Michael J. Shelley, Daniel J. Needleman
Summary: This article introduces two methods for studying subcellular dynamics, one using laser ablation and the other assessing fluid flow. It is found that cortical pulling forces can explain various behaviors of centrosomes.
Article
Chemistry, Analytical
Wesley Wei -Wen Hsiao, Gianna Fadhilah, Cheng-Chung Lee, Ryu Endo, Yu-Jou Lin, Stefanny Angela, Chia-Chi Ku, Huan-Cheng Chang, Wei -Hung Chiang
Summary: Avian influenza virus (AIV), a zoonotic virus, can infect humans with a high mortality rate. The development of rapid, selective, and accurate detection methods is crucial. Nanotechnology provides a promising approach as nanomaterial-based biosensors offer eco-friendly, portable, and sensitive diagnostic systems with a low detection limit. This paper reviews advanced nanomaterial-based biosensors for AIV detection and discusses potential trial protocols and key issues in their development.
Article
Physics, Applied
Nadezda Varkentina, Yves Auad, Steffi Y. Woo, Florian Castioni, Jean-Denis Blazit, Marcel Tence, Huan-Cheng Chang, Jeson Chen, Kenji Watanabe, Takashi Taniguchi, Mathieu Kociak, Luiz H. G. Tizei
Summary: Electron-photon temporal correlations in electron energy loss spectroscopy and cathodoluminescence spectroscopy have been used to measure the relative quantum efficiency of materials. It has been found that cathodoluminescence excitation spectroscopy can also be used to measure the decay time of excitations and explore the energy dependence of decay time. By using well-known insulating materials, nanodiamonds with NV0 defects and hexagonal boron nitride with 4.1 eV defects, the instrumental response function has been characterized, and the measured lifetimes of the defects match previous reports.
APPLIED PHYSICS LETTERS
(2023)