Journal
3D PRINTING AND ADDITIVE MANUFACTURING
Volume 4, Issue 1, Pages 19-29Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/3dp.2016.0052
Keywords
biodegradable polymer stent; computational modeling; minimally invasive surgery; tissue-engineered heart valve replacement
Funding
- European Union's Seventh Framework Programme (FP7) [242008]
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The evolution of minimally invasive implantation procedures and the in vivo remodeling potential of decellularized tissue-engineered heart valves require stents with growth capacity to make these techniques available for pediatric patients. By means of computational tools and 3D printing technology, this proof-of-concept study demonstrates the design and manufacture of a polymer stent with a mechanical performance comparable to that of conventional nitinol stents used for heart valve implantation in animal trials. A commercially available 3D printing polymer was selected, and crush and crimping tests were conducted to validate the results predicted by the computational model. Finally, the degradability of the polymer was assessed via accelerated hydrolysis.
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