Journal
FRONTIERS IN PSYCHIATRY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fpsyt.2017.00037
Keywords
Toxoplasma gondii; N-methyl-D-aspartate receptors; NMDA 2D; peptide commonality; immune crossreactivity; schizophrenia; parvalbumin-positive interneurons; gamma oscillations
Categories
Funding
- Deutscher Akademischer Austauschdienst (DAAD)
- Deutsche Forschungsgemeinschaft (DFG)
- Freie Universitat Berlin, Germany
Ask authors/readers for more resources
The present work aims at investigating how Toxoplasma gondii (T. gondii) infection may be linked to N-methyl-D-aspartate receptor (NMDAR) dysfunction in schizophrenia and related disorders and puts forward the hypothesis that immune responses against T. gondii may involve NMDARs. Indeed, the analysis of the protozoan proteome and NMDAR subunits for peptide commonalities shows a massive peptide overlap and supports the possibility that anti-T. gondii immune responses raised during active protozoan infection may cross-react with host NMDARs, determining disruption of neural circuits and cognitive deficits. In particular, the NMDA 2D subunit, which is mainly expressed in parvalbumin-positive interneurons, appears to be a hotspot for potential T. gondii-induced cross-reactive immune attacks.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available