Review
Biochemistry & Molecular Biology
Laura Gaspari, Francoise Paris, Nicolas Kalfa, Marie-Odile Soyer-Gobillard, Charles Sultan, Samir Hamamah
Summary: Previous studies indicate the potential for transgenerational inheritance of disease susceptibility due to endocrine disruptors. While there is substantial evidence on the multigenerational and transgenerational effects of TCDD, studies on its impact on human reproductive health are limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Physiology
Xiaoxi Yao, Weijing Liu, Yidong Xie, Mingrong Xi, Li Xiao
Summary: There has been a global decline in fertility rates, with ovulatory disorders emerging as the leading cause, contributing to a global lifetime infertility prevalence of 17.5%. Increasing exposure to environmental toxins in daily life is a growing concern, identified as significant risk factors for oogenesis in women. This review aims to enhance understanding of female reproductive system diseases and their implications, providing an overview of oogenesis and discussing the genetic and molecular mechanisms by which environmental toxins affect female oogenesis.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Environmental Sciences
Amber Cathey, Marcela Tamayo-Ortiz, Juan Tamayo-Orozco, John D. Meeker, Karen E. Peterson, Belem Trejo-Valdivia, Martha Maria Tellez-Rojo, Deborah J. Watkins
Summary: Phthalates exposure during pregnancy is associated with perinatal bone health, particularly affecting bone remodeling. The study highlights the importance of considering calcium supplementation and body mass index as effect modifiers in understanding the effects of environmental exposures on bone health.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Delnia Ahmadpour, Sakina Mhaouty-Kodja, Valerie Grange-Messent
Summary: Exposure to low doses of DEHP or an environmental phthalate mixture was found to increase BBB permeability, affect glial activation and neuroinflammation in specific brain regions. This suggests that exposure to endocrine disruptors like phthalates may pose a risk to cerebrovascular function.
Article
Cell Biology
Marinella Rosselli, Barbara P. S. Cometti, Brigitte Leeners, Marta Ewa Szutkowska, Edwin K. Jackson, Raghvendra K. Dubey
Summary: The study found that E2 and environmental estrogens stimulate cAMP synthesis in FTCs via GPER, which may have detrimental effects on reproduction.
Review
Environmental Sciences
Shiyu Zhang, Haohao Liu, Xingde Du, Xinghai Chen, Pavankumar Petlulu, Zhihui Tian, Linjia Shi, Bingyu Zhang, Shumeng Yuan, Xing Guo, Yongshui Wang, Hongxiang Guo, Huizhen Zhang
Summary: This review evaluates the rationality of classifying MCs as environmental endocrine disruptors (EDCs) and finds that MCs meet most of the key characteristics of EDCs and have endocrine-disrupting properties. The endocrine-disrupting effect of MCs may be an important cause of adverse health outcomes such as metabolic disorders and reproductive disorders.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Andrej Grobin, Robert Roskar, Jurij Trontelj
Summary: This study measured the concentrations of a group of hormonal compounds in water and evaluated the removal efficiency of wastewater treatment plants (WWTPs). The results showed that the concentrations of hormonal compounds in water were influenced by the removal efficiency of WWTPs, and there might be other sources of contamination. Most of the hormonal compounds were effectively removed, but improvement of removal techniques is still needed. The compounds E2 and EE2 contributed the most to the total endocrine disruptor risk. A comprehensive risk assessment determined high risk values for several compounds in water.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Mingzhao Li, Ren Wang, Pan Wang
Summary: In this study, computational docking was used to identify two novel environmental androgens that can activate androgen receptor and induce toxicological effects on male reproductive organs.
Article
Environmental Sciences
Andrea Corrales Vargas, Jorge Penaloza Castaneda, Emelie Rietz Liljedahl, Ana Maria Mora, Jose Antonio Menezes-Filho, Donald R. Smith, Donna Mergler, Brian Reich, Andrew Giffin, Jane A. Hoppin, Christian H. Lindh, Berna van Wendel de Joode
Summary: This study evaluates the effects of pesticide and metal exposures on thyroid function in pregnant women. The findings suggest that certain pesticides and metals are associated with alterations in thyroid hormone levels, potentially leading to hypothyroidism or hyperthyroidism.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Analytical
Karla Lara Lopes, Hanna Leijoto de Oliveira, Jessica Aparecida Silva Serpa, Juliana Arriel Torres, Francisco Guilherme Esteves Nogueira, Victor Augusto Araujo de Freitas, Keyller Bastos Borges, Maria Cristina Silva
Summary: Endocrine disruptors (EDs) are exogenous compounds that alter the endocrine system's normal functioning, raising environmental concerns. The use of a magnetic nanosorbent for extraction and detection of pollutants in water samples proved to be efficient and convenient, showing high specific surface area and good recovery rates.
MICROCHEMICAL JOURNAL
(2021)
Review
Food Science & Technology
Yuan Liang, Yiyao Gong, Qiuyan Jiang, Yifan Yu, Jie Zhang
Summary: This review summarizes the modulation of pregnane X receptor (PXR) by environmental endocrine disruptors (EEDs), including agonists and antagonists. The modular structure of PXR is described, and pharmacological variations of PXR among different species are discussed. Furthermore, the key role of PXR in endocrine regulation and the systematic summary of endocrine disruption by EEDs via PXR and its related pathways are provided.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Chemistry, Analytical
Lucas A. Cavalcante Minho, Eduard F. Valenzuela, Zenilda de L. Cardeal, Helvecio C. Menezes
Summary: Phthalic acid esters (PAEs) are considered endocrine disruptors and possible carcinogens, so efficient environmental monitoring of them is important. A miniaturized passive sampling device (MPSD) based on HF-LPME was developed and calibrated in the lab, then deployed in lagoons for monitoring. Analysis showed low levels of PAEs and the device was also able to detect other hazardous pollutants.
ANALYTICA CHIMICA ACTA
(2022)
Article
Environmental Sciences
Frederik Damsgaard Hojsager, Annika Sigvaldsen, Marianne Skovsager Andersen, Anders Juul, Flemming Nielsen, Soren Moller, Henrik Boye Thybo Christesen, Anders Grontved, Philippe Grandjean, Tina Kold Jensen
Summary: This study found that prenatal and early postnatal exposure to perfluoroalkyl substances (PFAS) is associated with lower bone mineral density (BMD) at age 7. The association is stronger for exposure at 18 months than prenatal exposure.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
F. D. Hojsager, M. Andersen, A. Juul, F. Nielsen, S. Moller, H. T. Christensen, A. Grontved, P. Grandjean, T. K. Jensen
Summary: This study found associations between prenatal and early postnatal exposure to PFAS and lower bone mineral density at age 7 years. These findings suggest that PFAS exposure may have adverse effects on pediatric bone health.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
Delnia Ahmadpour, Sakina Mhaouty-Kodja, Valerie Grange-Messent
Summary: This study found that exposure of adult male mice to low doses of di(2-ethylhexyl)phthalate (DEHP) can lead to loss of blood-brain barrier (BBB) integrity and damage in the medial preoptic area (mPOA) involved in male sexual behavior. The exposure to DEHP resulted in reduced androgen receptor (AR) levels and decreased components of the basement membrane and cell-matrix interaction, leading to neurodegeneration. The findings suggest that environmental exposure to endocrine disruptors like phthalates can disrupt glio-neurovascular coupling and alter sexual behavior.
ENVIRONMENTAL RESEARCH
(2022)
Article
Clinical Neurology
Harry T. Mai, Danielle S. Chun, Andrew D. Schneider, Andrew C. Hecht, Joseph C. Maroon, Wellington K. Hsu
CLINICAL SPINE SURGERY
(2018)
Article
Orthopedics
Ryan J. Lubbe, Ryan D. Freshman, Gurmit Singh, Karina M. Katchko, Andrew D. Schneider, Sumender Sharma, Brett Riederman, Alec Chang, Wellington K. Hsu
Summary: The study evaluated return-to-sport rates and performance outcomes in NHL athletes after common orthopedic surgeries, finding that most athletes successfully returned to play, but certain procedures had a negative impact on their careers.
CLINICAL JOURNAL OF SPORT MEDICINE
(2021)
Article
Clinical Neurology
Kevin A. Sonn, Stephen J. Wallace, Feng Ning F. Yuan, Andrew D. Schneider, Erin L. Hsu, Robert M. Havey, Avinash G. Patwardhan, John J. Callaci
Article
Clinical Neurology
Harry T. Mai, Andrew D. Schneider, Andrew P. Alvarez, Sohaib Z. Hashmi, Justin T. Smith, Ryan D. Freshman, Sean M. Mitchell, Charles D. Qin, Wellington K. Hsu
CLINICAL SPINE SURGERY
(2019)
Article
Cell & Tissue Engineering
J. Adam Driscoll, Ryan Lubbe, Adam E. Jakus, Kevin Chang, Meraaj Haleem, Chawon Yun, Gurmit Singh, Andrew D. Schneider, Karina M. Katchko, Carmen Soriano, Michael Newton, Tristan Maerz, Xin Li, Kevin Baker, Wellington K. Hsu, Ramille N. Shah, Stuart R. Stock, Erin L. Hsu
TISSUE ENGINEERING PART A
(2020)
Article
Clinical Neurology
Kelly Wun, Sohaib Z. Hashmi, Joseph Maslak, Andrew D. Schneider, Karina M. Katchko, Gurmit Singh, Alpesh A. Patel, Wellington K. Hsu
CLINICAL SPINE SURGERY
(2019)
Article
Orthopedics
Casey S. Whale, Joseph D. Henningsen, Scott Huff, Andrew D. Schneider, Fady Y. Hijji, Andrew W. Froehle
JOURNAL OF ARTHROPLASTY
(2020)
Article
Orthopedics
Scott Huff, Joseph Henningsen, Andrew Schneider, Fady Hijji, Breanna Dominguez, Andrew Froehle, Michael Prayson, Jennifer Jerele
ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
(2020)
Article
Orthopedics
Fady Y. Hijji, Tyler Sanda, Scott D. Huff, Andrew W. Froehle, Joseph D. Henningsen, Andrew D. Schneider, Joseph G. Lyons, Humza M. Mian, Jennifer Jerele, Indresh Venkatarayappa
Summary: This study aimed to evaluate the accuracy of self-reported opioid usage in orthopaedic trauma patients. The results showed that most patients accurately reported their narcotic usage within the preceding 3 months. Hospital admissions and lower medication doses were associated with increased accuracy, while higher medication doses or an emergency department visit prior to the initial visit were associated with underreporting.
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sou Hyun Kim, Chawon Yun, Doyoung Kwon, Yun-Hee Lee, Jae-Hwan Kwak, Young-Suk Jung
Summary: Liver metabolic disorders and oxidative stress play important roles in the development of NAFLD and there is currently a lack of established treatment strategies for this disease. This study investigates the impact of isoquercitrin on lipid accumulation induced by exogenous free fatty acids (FFA) in HepG2 cells and explores the underlying mechanisms. The results show that isoquercitrin can inhibit FFA-induced lipid production by suppressing endoplasmic reticulum stress and reducing the expression of proteins and genes involved in lipid synthesis. Furthermore, isoquercitrin activates AMPK, a key regulator of hepatic fatty acid oxidation, to suppress new lipid production. Overall, these findings suggest that isoquercitrin may be a potential therapeutic agent for improving NAFLD by targeting lipid metabolism through the AMPK/ACC and SREBP1/FAS pathways.
Review
Pharmacology & Pharmacy
Chawon Yun, Sou Hyun Kim, Young-Suk Jung
Summary: The liver is a chemical plant that produces and stores necessary nutrients for the body and detoxifies harmful substances. Culturing liver cells in a three-dimensional system enhances the ability to predict tissue function, including drug metabolism and toxicity.
Article
Medicine, General & Internal
Fady Y. Hijji, Andrew D. Schneider, Jeffrey T. Reeves, Michael L. Wilson, Logan Nye, Joseph G. Lyons, Michael J. Prayson, Louis J. Rubino
Summary: The study demonstrates that the UV-C filtration device can effectively reduce airborne bioburden in standard operating rooms, suggesting its potential to decrease the risk of wound and hardware infections. Further clinical trials are needed to determine the impact of this air filtration system on postoperative infection rates.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Ryan A. Davis, Joseph D. Henningsen, Scott Huff, Andrew D. Schneider, Fady Y. Hijji, Andrew Froehle, Indresh Venkatarayappa
Summary: Basicervical femoral neck fractures are uncommon injuries with a higher risk of implant failure with traditional fixation constructs. This study aims to evaluate the incidence and treatment methods of basicervical hip fractures and compare postoperative complications between different treatment options.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Orthopedics
Fady Y. Hijji, Andrew D. Schneider, Michael Pyper, Richard T. Laughlin
FOOT & ANKLE SPECIALIST
(2020)