Review
Pharmacology & Pharmacy
Baocheng Xie, Shichun Chen, Yongxiang Xu, Weichao Han, Runkai Hu, Minyi Chen, Yusheng Zhang, Shaobo Ding
Summary: Diabetes mellitus and osteoporosis are closely related, and GLP-1RAs may help in controlling blood sugar levels and promoting bone formation, but more research is needed to clarify their specific effects and mechanisms.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Chemistry, Medicinal
Dihe Cheng, Shuo Yang, Xue Zhao, Guixia Wang
Summary: This article reviews the molecular mechanisms and potential effects of GLP-1 RA in neurodegenerative diseases, particularly diabetes-related Alzheimer's disease and Parkinson's disease.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Medicine, General & Internal
Fei-Fei Xie, Yu-Fang Zhang, Yan-Fang Hu, Yun-Yun Xie, Xiao-Ying Wang, Shu-Zhen Wang, Bao-Qiang Xie
Summary: Serum GLP-1 and MGP levels are significantly decreased in diabetic patients with osteoporosis and are positively correlated with bone mineral density. Age and duration of diabetes are independent risk factors for osteoporosis in diabetic patients.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Orthopedics
Yanzhen Cheng, Peng Liu, Qianru Xiang, Jiamin Liang, Huafeng Chen, Hua Zhang, Li Yang
Summary: GLP-1 receptor agonist liraglutide can have a beneficial effect on bone in diabetes by ameliorating the accumulation of advanced glycation endproducts (AGEs). It prevents deterioration of trabecular microarchitecture and enhances bone strength. In vitro experiments also show that GLP-1 attenuates AGEs-mediated damage in osteogenic proliferation and differentiation.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Review
Endocrinology & Metabolism
Junaid Iqbal, Hui-Xuan Wu, Nan Hu, Ying-Hui Zhou, Long Li, Fen Xiao, Ting Wang, Hong-Li Jiang, Shi-Na Xu, Bi-Ling Huang, Hou-De Zhou
Summary: This study provides an up-to-date systematic review and meta-analysis on the overall weight loss effect of glucagon-like peptide-1 receptor agonists (GLP-1 RA) in adults with obesity and overweight without diabetes mellitus. The results show that GLP-1 RA leads to significant weight loss and improves glycemic control without increasing the risk of hypoglycemia. It also has positive effects on blood pressure and lipid levels.
Article
Clinical Neurology
Ronald M. Goldenberg, Alice Y. Y. Cheng, Tess Fitzpatrick, Jeremy D. Gilbert, Subodh Verma, Julia J. Hopyan
Summary: People with diabetes face higher stroke risks and poorer outcomes. GLP-1RAs have been shown to reduce stroke risk in individuals with type 2 diabetes. This study provides evidence supporting the use of GLP-1RAs for stroke reduction and offers practical resources for neurologists considering this treatment.
Article
Endocrinology & Metabolism
Yun-Yi Liang, Ling-Yu Liu, Yan Jia, Yi Li, Jie-Na Cai, Yi Shu, Jing-Yi Tan, Pei-Yi Chen, Hong-Wei Li, Hui-Hua Cai, Xiang-Sheng Cai
Summary: This study explored the correlation between gut microbiota and blood biochemical traits, especially GLP-1, in GDM patients. The results showed that there are differences in the gut microbiota between GDM and NGT groups, and certain genera are significantly correlated with blood glucose-related indices. These findings contribute to a better understanding of the pathogenesis of GDM and may provide new insights for its treatment.
WORLD JOURNAL OF DIABETES
(2022)
Article
Materials Science, Multidisciplinary
Xingyu Zhao, Xia Cao
Summary: The study aimed to address the issue of Ti screw loosening in patients with osteoporosis. Romosozumab (Rom), a bone resorption inhibitor, and bone morphoprotein 2 (BMP-2), an osteogenic growth factor, were encapsulated into TiO2 nanotubes (TNTs) using polydopamine (pDA). Characterization of Rom and BMP-2 loaded TiO2/Ti materials was done using SEM, WCA, FTIR spectroscopy, and CCK-8 assays. Implantation of Ti screws loaded with Rom and BMP-2 into rat tibiae showed enhanced bone formation, reduced bone resorption, and improved screw mechanical strength. Loading Rom and BMP-2 onto Ti screws surface effectively reduces the risk of screw loosening in osteoporosis patients.
Article
Endocrinology & Metabolism
Xueyuan Guo, Caihua Sang, Ribo Tang, Chenxi Jiang, Songnan Li, Nian Liu, Deyong Long, Xin Du, Jianzeng Dong, Changsheng Ma
Summary: This meta-analysis aimed to assess the effects of GLP-1RAs on major coronary events in patients with T2DM. The results showed that GLP-1RAs can reduce the risk of myocardial infarction, especially human-based and once-weekly GLP-1RAs. However, no significant benefit was observed for hospitalization for unstable angina or coronary revascularization.
DIABETES OBESITY & METABOLISM
(2023)
Article
Integrative & Complementary Medicine
Li Qiang, Yang Qimeng, Han Jing, Liu Xiaohan, Fu Junjie, Yin Jian
Summary: Peptide dual agonists that target both GLP-1R and GCGR receptors have emerged as potential therapeutics for treating type 2 diabetes with obesity. O-GlcNAcylation was shown to improve the stability of a dual GLP-1R/GCGR agonist, leading to significant weight loss and hypoglycemic effects.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Article
Endocrinology & Metabolism
Shiau Chin Chong, Norlela Sukor, Sarah Anne Robert, Kim Fong Ng, Nor Azmi Kamaruddin
Summary: This study aimed to resolve conflicting findings about GLP-1 levels in different glucose tolerance states among Malay, Chinese, and Indian ethnicities. The results showed that GLP-1 levels were higher in T2DM and pre-DM compared to NGT, suggesting a possible adaptive compensatory response. Among the three ethnic groups, Indians had the highest levels of GLP-1 and insulin resistance, supporting the notion of an adaptive compensatory secretion of GLP-1.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Medicinal
Neng Jiang, Lin Jing, Qing Li, Sibiao Su, Qimeng Yang, Feng Zhou, Xinyu Chen, Jing Han, Chunli Tang, Weizhong Tang
Summary: Dual activation of the glucagon receptor (GCGR) and glucagon-like peptide 1 receptor (GLP-1R) can potentially lead to effective therapy for diabetes and obesity. Novel peptides with dual activity on GLP-1R and GCGR were discovered through rational design, with xGLP/GCG-15 showing promising anti-obesity and anti-diabetic effects in preclinical studies.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Ni Su, Cassandra Villicana, Carl Zhang, Jeehee Lee, Sauradeep Sinha, Andrew Yang, Fan Yang
Summary: Mineral particle-coated scaffolds combined with aspirin have a synergistic effect in promoting endogenous bone regeneration and reducing bone resorption. The optimized formulation shows promising potential for repairing critical-sized cranial bone defects.
Review
Biochemistry & Molecular Biology
Jiayuan Fang, Xunming Zhang, Xi Chen, Zhaoguo Wang, Shuo Zheng, Yunyun Cheng, Songcai Liu, Linlin Hao
Summary: Insulin-like growth factor (IGF)-1 is a polypeptide hormone that plays a vital role in bone cells. Abnormal expression of IGF-1 affects bone growth and remodeling, leading to significant changes in bone mass and development. This review highlights the functions and mechanisms of IGFs in bone and emphasizes the critical role of IGF-1 in bone remodeling through both bone resorption and bone formation. It provides a theoretical basis for further research on the maintenance of bone mass and homeostasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Medicine, Research & Experimental
Rong Wang, Han Na, Shaowen Cheng, Yanglin Zheng, Jiangling Yao, Yangyang Bian, Yuntao Gu
Summary: Osteoporosis is a common disease characterized by reduced bone mass and fragility fractures, particularly among the elderly population. A study on rats with osteoporotic fractures found that treatment with GLP-1 RAs improved bone formation, inhibited osteoclast formation, and improved bone strength and mineral density. These findings suggest that GLP-1 RAs may be a novel treatment for osteoporotic fractures.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Orthopedics
Hui Li, Juyang Jiao, Shutao Zhang, Haozheng Tang, Xinhua Qu, Bing Yue
Summary: The purpose of this study was to develop a predictive model for length of stay (LOS) after total knee arthroplasty (TKA). Risk factors that could affect LOS were identified, and machine learning models were found to have better predictive performance compared to logistic regression models.
JOURNAL OF KNEE SURGERY
(2022)
Article
Engineering, Biomedical
Bo Jia, Hongtao Yang, Zechuan Zhang, Xinhua Qu, Xiufeng Jia, Qiang Wu, Yu Han, Yufeng Zheng, Kerong Dai
Summary: Bone defects caused by trauma, tumors, or diseases present challenges for orthopedic surgeons, especially when critical in size. Biodegradable zinc-based metals, particularly Zn-Sr alloys, show promising biocompatibility and osteogenic properties. The Zn-0.8Sr alloy, with its ability to activate multiple signaling pathways for osteogenesis, proves to be an ideal candidate for bone repair, demonstrating favorable in vivo properties and biosafety.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Haozheng Tang, Xinhua Qu, Wenkai Zhang, Xuan Chen, Shutao Zhang, Yang Xu, Hongtao Yang, You Wang, Jianping Yang, Wei-en Yuan, Bing Yue
Summary: In this study, an ultra-micro photosensitizer, AgB nanodots, were used to efficiently clear multidrug-resistant bacteria MRSA through photothermal therapy, photodynamic therapy, and Ag+ ion sterilization. The AgB nanodots were found to enhance host immunogenicity and establish immunological memory in a murine model, providing a novel platform for the effective treatment of postoperative infection and a systematic immunotherapeutic strategy to combat persistent infections, thereby reducing the incidence of recurrence.
ADVANCED MATERIALS
(2022)
Article
Endocrinology & Metabolism
Jingke Du, Zihao He, Mingming Xu, Xinhua Qu, Junqi Cui, Shuangyan Zhang, Shuhong Zhang, Hanjun Li, Zhifeng Yu
Summary: Cold temperature activates the sympathetic nervous system (SNS) to induce bone loss by altering bone remodeling. Brown adipose tissue (BAT), which is influenced by the SNS in cold environments, has been found to have a positive relationship with bone mass. This study showed that bone volume can be restored after cold exposure due to enlarged BAT, which has a beneficial effect on bone mass by facilitating osteogenesis and suppressing osteoclastogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Jialian Xu, Jindou Ji, Juyang Jiao, Liangjun Zheng, Qimin Hong, Haozheng Tang, Shutao Zhang, Xinhua Qu, Bing Yue
Summary: The self-repair of cartilage and subchondral bone is challenging due to the vasculature defects, complex gradients, and layered zonal architecture. However, three-dimensional (3D) printing technology provides a new strategy for bone-cartilage interface regeneration, offering rapid and accurate molding and personalized therapy. Challenges still remain, such as determining the optimal bioink concentrations and finding biomaterials with dual bioactivities.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Bin'en Nie, Shicheng Huo, Xinhua Qu, Jingjing Guo, Xi Liu, Qimin Hong, You Wang, Jianping Yang, Bing Yue
Summary: The bone-and-bacteria dual-targeted nanoparticles show excellent targeting efficacy and antibacterial properties for bone infection treatment.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Shutao Zhang, Xinhua Qu, Juyang Jiao, Haozheng Tang, Minqi Wang, You Wang, Hongtao Yang, Weien Yuan, Bing Yue
Summary: Felodipine has antibacterial effects against MRSA, biofilm, and persisters. It can inhibit the expression of proteins associated with aminoglycoside resistance, eradicate formed biofilms and kill persisters. Felodipine also reduces MRSA virulence and modulates bacterial metabolism. It inhibits the growth of persisters by binding to a protease. In a mouse infection model, felodipine in combination with gentamicin alleviates bacterial burden and inflammation.
BIOACTIVE MATERIALS
(2022)
Article
Surgery
Zhengyu Cai, Xinhua Qu, Yaochao Zhao, Zhiguo Yuan, Liangjun Zheng, Teng Long, Qiuying Yao, Bing Yue, You Wang
Summary: This study conducted a clinical trial of the world's first totally modular polyetheretherketone (PEEK) total knee arthroplasty (TKA) to determine bone density values around the prosthesis, reconstructing a three-dimensional model. Results showed excellent CT compatibility of the PEEK knee joint prosthesis and the ability to assess periprosthetic bone volume changes using Hounsfield units (HU) after CT scans. The assessment may potentially guide future improvements in knee prosthesis alignment techniques and artificial knee prosthesis designs.
FRONTIERS IN SURGERY
(2022)
Article
Chemistry, Multidisciplinary
Xinhua Qu, Minqi Wang, Miaochen Wang, Haozheng Tang, Shutao Zhang, Hongtao Yang, Weien Yuan, You Wang, Jianping Yang, Bing Yue
Summary: This study proposes a novel antimicrobial system to address the challenges of refractory Staphylococcus aureus-related implant infection. The system provides a continuous, prolonged antibacterial effect at the site of infection and significantly reduces immunosuppression, thereby restoring the antimicrobial immune response.
ADVANCED MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Zhen Liu, Weiwei Xin, Jindou Ji, Jialian Xu, Liangjun Zheng, Xinhua Qu, Bing Yue
Summary: Three-dimensional (3D) printing has been used in medical research and practice for several years. Hydrogels, as the most advantageous biological raw materials for 3D printing, have shown significant potential in orthopedics. They can promote tissue repair and prevent infection. However, there are still some challenges associated with hydrogel materials that need to be addressed through a multi-disciplinary approach.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Yihan Wang, Shutao Zhang, Bin'en Nie, Xinhua Qu, Bing Yue
Summary: This review summarizes the modification strategies to biofunctionalize PEEK for antibacterial purposes, including surface-coating modifications, controlled release of antimicrobials, blending modifications, and 3D printing technology. The aim is to provide an in-depth understanding and optimize the design of PEEK orthopedic implants.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Bo Jia, Zechuan Zhang, Yifu Zhuang, Hongtao Yang, Yu Han, Qiang Wu, Xiufeng Jia, Yanhui Yin, Xinhua Qu, Yufeng Zheng, Kerong Dai
Summary: Implant-related infections caused by drug-resistant bacteria are a major challenge in orthopedic surgery. This study focuses on the antibacterial and osteogenic properties of Zn alloys, specifically the Zn-Li-Ag ternary alloy, which showed significant bactericidal effects on MRSA and improved mechanical properties. In vivo experiments on a rat femoral model demonstrated the alloy's effectiveness in controlling infection and promoting bone retention.
Article
Engineering, Biomedical
Hongtao Yang, Bo Jia, Xinhua Qu, Kerong Dai, Yufeng Zheng
Summary: The addition of a small amount of gadolinium can modify the degradation behavior and microstructure of zinc, leading to more uniform degradation and improved bone regeneration and implant integration.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Orthopedics
Haozheng Tang, Jialian Xu, Wei'en Yuan, You Wang, Bing Yue, Xinhua Qu
Summary: This study aimed to evaluate and unify diagnostic criteria for periprosthetic joint infection (PJI) and found that laboratory-based synovial alpha-defensin and synovial calprotectin are the two best independent preoperative diagnostic tests for PJI. A cut off of 70% for synovial PMN% and tighter cut-offs for synovial WBC and serum CRP could have a better diagnostic accuracy for non-IA patients with chronic PJI.
ORTHOPAEDIC SURGERY
(2022)
Article
Biotechnology & Applied Microbiology
Juyang Jiao, Qimin Hong, Dachen Zhang, Minqi Wang, Haozheng Tang, Jingzhou Yang, Xinhua Qu, Bing Yue
Summary: Porous tantalum scaffolds with three different porosities (60%, 70%, and 80%) were prepared using laser powder bed fusing technique to investigate the effects on the adhesion, proliferation, and osteogenic differentiation of rat mesenchymal stem cells in vitro. The in vivo bone ingrowth and osseointegration effects of each scaffold were evaluated in a rat femoral bone defect model. The results showed that scaffolds with 70% and 80% porosity exhibited better osteogenic proliferation and differentiation capacity, as well as bone ingrowth, suggesting that the 3D printed trabecular tantalum scaffold with 70% porosity could be the optimal choice for implant design.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
