Journal
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
Volume 4, Issue 12, Pages 897-901Publisher
WILEY
DOI: 10.1002/acn3.466
Keywords
Obesity; Prader-Willi syndrome; deep brain stimulation; hypothalamus; hunger; satiety
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo - FAPESP
- Projeto PROADI SUS - IEP Hospital Sirio-Libanes
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Lateral hypothalamic area (LHA) local field potentials (LFPs) were recorded in a Prader-Willi patient undergoing deep brain stimulation (DBS) for obesity. During hunger, exposure to food-related cues induced an increase in beta/low-gamma activity. In contrast, recordings during satiety were marked by prominent alpha rhythms. Based on these findings, we have delivered alpha-frequency DBS prior to and during food intake. Despite reporting an early sensation of fullness, the patient continued to crave food. This suggests that the pattern of activity in LHA may indicate hunger/satiety states in humans but attest to the complexity of conducting neuromodulation studies in obesity.
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