Journal
OPEN MEDICINE
Volume 12, Issue 1, Pages 19-23Publisher
DE GRUYTER OPEN LTD
DOI: 10.1515/med-2017-0004
Keywords
Periodontal ligament stem cells; Neutrophil; Interleukin-6; Apoptosis
Categories
Funding
- National Natural Science Foundation of China [81570945]
- Natural Science Foundation of Shandong Province [ZR2015HL055]
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Periodontal ligament stem cells (PDLSCs) are promising cell resource for the cell-based therapy for periodontitis and regeneration of bio-root. In this study, we investigated the effect of PDLSCs on neutrophil, a critical constituent of innate immunity, and the underlying mechanisms. The effect of PDLSCs on the proliferation and apoptosis of resting neutrophils and IL-8 activated neutrophils was tested under cell-cell contact culture and Transwell culture, with or without anti-IL-6 neutralizing antibody. We found that PDLSCs could promote the proliferation and reduce the apoptosis of neutrophils whether under cell-cell contact or Transwell culture. Anti-IL-6 antibody reduced PDLSCs-mediated inhibition of neutrophil apoptosis. IL-6 at the concentration of 10ng/ml and 20ng/ml could inhibit neutrophil apoptosis statistically. Collectively, PDLSCs could reduce the apoptosis of neutrophils via IL-6.
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