Article
Oncology
Bo Wang, Zhihua He, Hao Yu, Ziwei Ou, Junyu Chen, Meihua Yang, Xinxiang Fan, Tianxin Lin, Jian Huang
Summary: BCG immunotherapy can prevent recurrence and progression in NMIBC patients, but significant adverse events and treatment failure call for alternative agents. PA-MSHA, a genetically engineered heat-killed Pseudomonas aeruginosa vaccine, shows potential as an alternative effective treatment for NMIBC by modulating the balance between adaptive and innate immune responses.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Immunology
Na Zhang, Fei Wang, Gaomeng Zhang, Qi Zhang, Yuhong Liu, Qiao Wang, Mohamed Shafey Elsharkawy, Maiqing Zheng, Jie Wen, Guiping Zhao, Qinghe Li
Summary: Toll-like receptors (TLRs) are important immune sensors involved in host defense. In this study, the researchers discovered that the deubiquitinase USP7 interacts with MyD88 protein, regulating its expression and participating in bacteria-induced inflammation. This finding contributes to our understanding of the regulatory mechanisms in immune signaling.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Joshua Bennett, Chiharu Ishikawa, Puneet Agarwal, Jennifer Yeung, Avery Sampson, Emma Uible, Eric Vick, Lyndsey C. Bolanos, Kathleen Hueneman, Mark Wunderlich, Amal Kolt, Kwangmin Choi, Andrew Volk, Kenneth D. Greis, Jan Rosenbaum, Scott B. Hoyt, Craig J. Thomas, Daniel T. Starczynowski
Summary: This study reveals the functional compensation and complementation of IRAK1 in leukemic cells upon inhibition of IRAK4. Cotargeting IRAK1 and IRAK4 is necessary to suppress leukemic stem/progenitor cell function and induce differentiation. IRAK1 and IRAK4 maintain the undifferentiated state of MDS/AML LSPCs through noncanonical MyD88-independent pathways.
Article
Chemistry, Applied
Quanwei Zhang, Man Liu, Lifeng Li, Miaomiao Chen, Pema Tenzin Puno, Wanrong Bao, Hongming Zheng, Xin Wen, Huiyuan Cheng, Hauyee Fung, Tinlong Wong, Zhongzhen Zhao, Aiping Lyu, Quanbin Han, Handong Sun
Summary: The study discovered that the Cordyceps quality marker CCP modulates the immune response by regulating the TLR4/MyD88/p38 signaling pathway in macrophages. These findings provide a better understanding of the molecular mechanism behind Cordyceps' immunomodulatory benefits.
CARBOHYDRATE POLYMERS
(2021)
Article
Fisheries
Feifei Yu, Jiayu Chen, Jinji Lin, Zhiming Zhong, Yishan Lu, Xiangrong Zeng, Xiaoya Lei
Summary: In this study, a new TLR4 gene was identified from the Crassostrea hongkongensis (C. hongkongensis). The ChTLR4 played a crucial role in the innate immune response against V. parahaemolyticus.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Shanshan Shen, Fei Ren, Junping He, Jie Wang, Yawei Sun, Jianhe Hu
Summary: OaBac5mini has been shown to effectively inhibit the inflammatory response caused by Salmonella Pullorum in chickens, thereby reducing organ damage and bacterial load. This has significant potential for the treatment of Pullorum disease in poultry.
Article
Fisheries
Pengzhi Qi, Yashu Wu, Zhongqi Gu, Hongfei Li, Jiji Li, Baoying Guo, Zhi Liao, Xiaojun Yan
Summary: This study identified a novel TLR isoform called McTLRlike1 in the mollusk Mytilus coruscus. McTLR-like1 was highly expressed in immune-related tissues and its levels increased when challenged with V. alginolyticus. It was found that McTLR-like1 activated NF-kappa B and influenced the expression and phosphorylation of its subunit P65. Silencing McTLR-like1 led to downregulation of pro-inflammatory cytokines and increased resistance to V. alginolyticus challenge. McTLR-like1 also showed affinity with McMyD88a. These findings contribute to our understanding of TLR signaling in mollusks and provide insights into TLR evolution.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Fisheries
Baolan Cao, Yan Zhao, Qiang Luo, Ya Chen, Tianjun Xu, Yuena Sun
Summary: In this study, Vclb was found to inhibit the NF-KB signaling pathway, and its inhibitory effect was enhanced by LPS induction. Furthermore, Vclb inhibits NF-KB activation by targeting MyD88, thereby suppressing the production of inflammatory cytokines. Mechanistically, Vclb inhibits the NF-KB signaling pathway by targeting MyD88 ubiquitin-proteasome pathway.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xiaotong Xu, Naping Li, Yongrong Wu, Ke Yan, Yilin Mi, Nanxing Yi, Xuyi Tan, Gaoyan Kuang, Min Lu
Summary: ZFTG capsules alleviate cartilage degeneration and inflammatory injury, promote chondrocyte survival, and inhibit the apoptosis of inflammatory chondrocytes in a rabbit model of KOA. The underlying mechanism involves the inhibition of the TLR4/MyD88/NF-kB signaling pathway and secretion of inflammatory factors.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Fufa Qu, Qing She, Jialing Li, Xuan Zeng, Yumiao Li, Xinyu Liu, Lingxin Ren, Zhenzhen Liu, Chaoran Gao, Xinyu Lu, Mengyao Long, Xinya Li
Summary: This study identifies a novel freshwater shellfish MyD88 and demonstrates its crucial role in the host defense response to bacterial challenge.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Swathy O. Vasudevan, Ashley J. Russo, Puja Kumari, Sivapriya Kailasan Vanaja, Vijay A. Rathinam
Summary: CD14 plays a vital role in intracellular LPS sensing by mediating the cytosolic localization of LPS, leading to the activation of caspase-11. This study provides evidence for the critical role of CD14 in noncanonical inflammasome sensing of LPS.
Article
Cell Biology
Milton Pereira, Danielle F. Durso, Clare E. Bryant, Evelyn A. Kurt-Jones, Neal Silverman, Douglas T. Golenbock, Ricardo T. Gazzinelli
Summary: This study examines the importance of IRAK proteins in TLR4 activation and confirms the essential role of IRAK4 kinase activity in MYD88 signaling. It also reveals the crucial role of the IRAK4 scaffold in integrating MYD88 and TRIF in TLR4 signaling.
Article
Fisheries
Jiayu Chen, Jinji Lin, Feifei Yu, Zhiming Zhong, Qiwen Liang, Huanying Pang, Siyu Wu
Summary: This study analyzed the immune strategy of Crassostrea hongkongensis (C. hongkongensis) against Vibrio parahaemolyticus (V. Parahemolyticus) infection through immune enzyme activities and transcriptome analysis. The findings revealed significant increases in immune enzyme activities and differential gene expression after infection, suggesting the stimulation of immune response in C. hongkongensis by V. parahaemolyticus. The enrichment of immune-related genes in Toll-like receptor (TLR) pathway was identified through transcriptome analysis, and the upregulation of TLR4-MyD88 pathway genes was validated using qRT-PCR. These results indicate the involvement of TLR4-MyD88 pathway in the immune response of C. hongkongensis against Vibrio infection.
AQUACULTURE REPORTS
(2022)
Article
Immunology
Wenjuan Liu, Jilv Ma, Jiwen Chen, Baoyu Huang, Fengchen Liu, Lingling Li, Nini Fan, Fangshu Li, Yanxin Zheng, Xuekai Zhang, Xiaona Wang, Xiaomei Wang, Lei Wei, Yaqiong Liu, Meiwei Zhang, Yijing Han, Xiaotong Wang
Summary: In this study, the IKK gene, CfIKK3, was cloned and characterized in the Zhikong scallop Chlamys farreri. The expression of CfIKK3 was found to be ubiquitous in all tested scallop tissues and significantly induced after challenge with various pathogen-associated molecular patterns. Co-immunoprecipitation assays confirmed the interaction between CfIKK3 and key adaptors in the TLR and RLR pathways, indicating its crucial role in the scallop innate immune signal transduction. Moreover, overexpression of CfIKK3 activated the NF-kappa B reporter gene in a dose-dependent manner.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Manigandan Krishnan, Joonhyeok Choi, Ahjin Jang, Sungjae Choi, Jiwon Yeon, Mihee Jang, Yeongjoon Lee, Kkabi Son, Soon Young Shin, Myeong Seon Jeong, Yangmee Kim
Summary: This article investigates the molecular mechanism underlying the TLR4-signaling and antibacterial activities of papiliocin and finds that it can inhibit LPS-induced TLR4 signaling by binding to TLR4/MD-2 and causing dissociation of LPS from the complex, thus combating gram-negative bacteria infection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)