Article
Nutrition & Dietetics
Christina Raftopoulou, George Paltoglou, Evangelia Charmandari
Summary: This review summarizes the impact of childhood obesity on telomere length, revealing a negative association. Lifestyle interventions in children may lead to increased telomere length peripherally, suggesting a potential mechanistic relation worth further investigation.
Article
Endocrinology & Metabolism
Chenxue Bai, Zixiong Shen, Binxu Qiu, Songling Zhang
Summary: The study found that a genetically predicted longer LTL increases the risk of endometriosis, but endometriosis has no causal impact on LTL. The results strengthen the causal link between LTL and endometriosis, suggesting that LTL may serve as a potential biomarker for endometriosis, offering new possibilities for prevention and treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Food Science & Technology
Mahdieh Abbasalizad-Farhangi
Summary: This meta-analysis evaluated the association between central obesity and leukocyte telomere length in adults. The results showed a negative association between higher leukocyte telomere length and waist circumference, while the association with waist to hip ratio was not significant.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Cardiac & Cardiovascular Systems
Manuel Sanchez, Caroline Kannengiesser, Sophie Hoang, Louis Potier, Frederic Fumeron, Nicolas Venteclef, Andre Scheen, Jean-Francois Gautier, Samy Hadjadj, Michel Marre, Ronan Roussel, Kamel Mohammedi, Gilberto Velho
Summary: The study found that leukocyte telomere length is associated with the risk of coronary heart disease (CHD) in people with type 1 diabetes, and short telomeres are an independent risk factor for CHD.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daniela Scarabino, Liana Veneziano, Alessia Fiore, Suran Nethisinghe, Elide Mantuano, Hector Garcia-Moreno, Gianmarco Bellucci, Nita Solanky, Maria Morello, Ginevra Zanni, Rosa Maria Corbo, Paola Giunti
Summary: SCA1, SCA2, and SCA3 have different effects on leukocyte telomere length (LTL), with SCA1 and SCA3 patients showing significant reduction in LTL and SCA2 patients showing significant increase in LTL. The relationship between LTL and age varies among the subtypes, with SCA1 patients having a significant negative relationship between LTL and age. The number of CAG repeats does not affect LTL in these SCAs. These findings suggest that LTL could serve as a potential biomarker for differentiating between SCAs and HD, but further research is needed for validation in larger cohorts and longitudinal studies.
Article
Nutrition & Dietetics
George Paltoglou, Christina Raftopoulou, Nicolas C. Nicolaides, Sofia M. Genitsaridi, Sofia I. Karampatsou, Marina Papadopoulou, Penio Kassari, Evangelia Charmandari
Summary: The study demonstrated a significant increase in LTL after a one-year lifestyle intervention program among 508 children and adolescents aged 10-11, as well as notable improvements in their metabolic profile.
Review
Genetics & Heredity
Mohammad Saeed Kahrizi, Indrajit Patra, Abduladheem Turki Jalil, Harun Achmad, Samira Alesaeidi, Moaed E. Al-Gazally, Sogol Alesaeidi
Summary: Obesity is associated with shorter leukocyte telomere length (LTL) among children and adolescents. However, the relationship between obesity and LTL varies across studies and may be influenced by factors such as geographical location, quality scores, participant weight, and baseline LTL.
FRONTIERS IN GENETICS
(2022)
Article
Environmental Sciences
Teresa Durham, Jia Guo, Whitney Cowell, Kylie W. Riley, Shuang Wang, Deliang Tang, Frederica Perera, Julie B. Herbstman
Summary: This study analyzed the association between prenatal PM2.5 exposure and relative leukocyte telomere length (TL) in mothers and newborns. The results showed a negative relationship between prenatal PM2.5 exposure and TL in both mothers and newborns, particularly in the second trimester.
Article
Biochemistry & Molecular Biology
Daniela Scarabino, Liana Veneziano, Elide Mantuano, Ivan Arisi, Alessia Fiore, Marina Frontali, Rosa Maria Corbo
Summary: Identification of potential biomarkers, such as leukocyte telomere length (LTL), is crucial for monitoring disease progression in neurodegenerative disorders like Huntington's disease. The study found that LTL reduction independently of CAG number could accurately discriminate pre-HD subjects from controls and even pre-HD from manifest HD, providing robust prognostic value in pre-HD individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Ram K. Chandyo, Catherine Schwinger, Ingrid Kvestad, Manjeswori Ulak, Suman Ranjitkar, Merina Shrestha, Linda Vy Nguyen, Diana Corona-Perez, Immaculata DeVivo, Laxman Shrestha, Tor A. Strand
Summary: This study aims to investigate the association between household biomass fuel exposure in infancy and leukocyte telomere length (LTL) in children. The results showed that children living in households using biomass fuel had significantly shorter LTL. These findings highlight the importance of reducing biomass fuel exposure in resource-poor settings.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Article
Andrology
Masoumeh Amirzadegan, Niloofar Sadeghi, Marziyeh Tavalaee, Mohammad Hossein Nasr-Esfahani
Summary: The study found that men with oligozoospermia had shorter telomere length, significantly increased sperm DNA damage and protamine deficiency, indicating poor sperm quality. Low sperm concentration may be a sign of issues during meiotic division in the spermatogenesis process.
Article
Pediatrics
Joshua Garfein, Kerry S. J. Flannagan, Mercedes Mora-Plazas, Henry Oliveros, Constanza Marin, Eduardo Villamor
Summary: This study found that longer LTL among girls in middle childhood is associated with smaller increases in waist circumference, an indicator of abdominal adiposity.
Article
Medicine, General & Internal
Zhenfei Chi, Xuesong Bai, Zhe Zhang
Summary: This study used a two-sample Mendelian randomization analysis to investigate the association between aging and constipation using leukocyte telomere length (LTL) as a marker. The results showed that LTL does not necessarily indicate an increased likelihood of constipation.
FRONTIERS IN MEDICINE
(2023)
Article
Cell Biology
Zhu Lin, Hongmei Gao, Bing Wang, Yongqiang Wang
Summary: Previous CMV infection is associated with shorter leukocyte telomere length, independently of CRP levels.
MEDIATORS OF INFLAMMATION
(2021)
Article
Health Care Sciences & Services
LaShaunta M. Glover, Crystal W. Cene, Alexander Reiner, Samson Gebreab, David R. Williams, Kari E. North, Mario Sims
Summary: The study found that discrimination and coping with discrimination have different effects on LTL in individuals of different genders and levels of depressive symptoms. In some cases, actively coping with lifetime discrimination may help maintain longer LTL.
Article
Biochemistry & Molecular Biology
Danielle L. Michell, Ryan M. Allen, Ashley B. Cavnar, Danielle M. Contreras, Minzhi Yu, Elizabeth M. Semler, Clark Massick, Chase A. Raby, Mark Castleberry, Marisol A. Ramirez, Wanying Zhu, Linda May-Zhang, Anca Ifrim, John Jeffrey Carr, James G. Terry, Anna Schwendeman, Sean S. Davies, Quanhu Sheng, MacRae F. Linton, Kasey C. Vickers
Summary: This study reveals that human HDL can transport specific types of sRNAs, which are associated with the development of atherosclerosis. The binding of HDL to sRNA is primarily mediated by its apolipoprotein A-I (apoA-I) and regulated by RNA-specific features.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Praitayini Kanakaraj, Karthik Ramadass, Shunxing Bao, Melissa Basford, Laura M. Jones, Ho Hin Lee, Kaiwen Xu, Kurt G. Schilling, John Jeffrey Carr, James Gregory Terry, Yuankai Huo, Kim Lori Sandler, Allen T. Netwon, Bennett A. Landman
Summary: The field of AI in medical imaging, particularly in Radiology, has seen explosive growth. To overcome the challenges of security and privacy, an AI Imaging Incubator has been developed, allowing for streamlined deployment of AI methods in a clinical enterprise.
JOURNAL OF DIGITAL IMAGING
(2022)
Article
Endocrinology & Metabolism
Marnie G. Silverstein-Metzler, Brett M. Frye, Jamie N. Justice, Thomas B. Clarkson, Susan E. Appt, J. Jeffrey Carr, Thomas C. Register, Mays Albu-Shamah, Hossam A. Shaltout, Carol A. Shively
Summary: Chronic psychosocial stress is associated with an increased risk of type 2 diabetes. This study found that social subordination stress and a Western diet have significant effects on body composition and carbohydrate metabolism in middle-aged female primates.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Sahil Khanna, John T. Wilkins, Hongyan Ning, Norrina B. Allen, Cora E. Lewis, J. Jeffrey Carr, Donald Lloyd-Jones, Lisa B. VanWagner
Summary: This study evaluated the association of apolipoprotein B (apoB) with LDL-C, non-HDL-C, and TG in early adulthood, and found that TG levels have the strongest and most consistent association with midlife NAFLD.
JOURNAL OF NUTRITION AND METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Allison L. Kuipers, J. Jeffrey Carr, James G. Terry, Sangeeta Nair, Emma Barinas-Mitchell, Victor Wheeler, Joseph M. Zmuda, Iva Miljkovic
Summary: This study is the first to test the association of aortic area measured at multiple points with subclinical CVD. The findings suggest that combined CT assessment of ascending and descending aortic area may indicate a high risk of prevalent subclinical CVD elsewhere in the body independent of age, body size, and blood pressure.
OPEN CARDIOVASCULAR MEDICINE JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Ellen Boakye, Zeina Dardari, Olufunmilayo H. Obisesan, Albert D. Osei, Frances M. Wang, Yasuyuki Honda, Omar Dzaye, Ngozi Osuji, John Jeffery Carr, Candace M. Howard-Claudio, Lynne Wagenknecht, Suma Konety, Josef Coresh, Kunihiro Matsushita, Michael J. Blaha, Seamus P. Whelton
Summary: This study investigated the sex-and race-specific burden of aortic valve calcification (AVC) and its association with cardiovascular risk factors among adults >= 75 years. The results showed that the prevalence of AVC increased with age and varied among different race-sex groups, with White males having the highest prevalence. Several cardiovascular risk factors were independently associated with AVC.
Article
Geriatrics & Gerontology
Adam J. Santanasto, Joseph M. Zmuda, Ryan K. Cvejkus, Christopher L. Gordon, Sangeeta Nair, J. Jeffrey Carr, James G. Terry, Victor W. Wheeler, Iva Miljkovic
Summary: This study examined the association between myosteatosis and physical function in African Caribbean men. The results showed that myosteatosis in the calf and thigh was strongly associated with grip strength and performance measures of physical function, while myosteatosis in the abdomen may have some utility when abdominal images are all that are available.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Alexander C. Razavi M. D. Mph, Norrina B. Allen PhD, Omar Dzaye M. D. Mph, Erin D. Michos Md, Matthew J. Budoff, Joao A. C. Lima Md, James M. Shikany DrPH, Kiang Liu, Wendy S. Post Md, Roger S. Blumenthal, Michael J. Blaha Md, J. Jeffrey Carr, Seamus P. Whelton Md
Summary: The prognostic value of traditional atherosclerotic cardiovascular disease (ASCVD) risk factors may decrease with age, and they are more strongly associated with incident coronary artery calcium (CAC) in young adults compared to older adults.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Geriatrics & Gerontology
Corey W. Bown, Omair A. Khan, Dandan Liu, Samuel W. Remedios, Kimberly R. Pechman, James G. Terry, Sangeeta Nair, L. Taylor Davis, Bennett A. Landman, Katherine A. Gifford, Timothy J. Hohman, John Jeffrey Carr, Angela L. Jefferson
Summary: This study found that enlarged perivascular spaces (ePVS) are difficult to quantify and their etiologies and consequences are unclear. The results suggest that higher aortic stiffness is associated with greater basal ganglia ePVS burden, and ePVS burden is associated with adverse cognitive trajectory, highlighting the clinical relevance of ePVS.
NEUROBIOLOGY OF AGING
(2023)
Article
Cardiac & Cardiovascular Systems
Venkat S. Manubolu, Song Mao, April Kinninger, Suraj Dahal, Khadije Ahmad, Ruby Havistin, Yanlin Gao, Chris Dailing, J. Jeffrey Carr, Sion K. Roy, Matthew J. Budoff
Summary: This study examined the relationship between thoracic spine bone mineral density (BMD) and severity of coronary artery calcium (CAC) score. The results showed a significant inverse relationship between BMD and CAC in both genders. Further research is needed to explore the underlying pathophysiological mechanisms.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yingnan Song, Ammar Hoori, Hao Wu, Mani Vembar, Sadeer Al-Kindi, Leslie Ciancibello, James G. Terry, David R. R. Jacobs Jr, John Jeffrey Carr, David L. Wilson
Summary: Our goal is to improve CT calcium scores by extracting quantitative features from individual calcifications. We performed deconvolution to improve the bias/reproducibility of small calcification assessments, which can be degraded at the normal CT calcium score image resolution.
JOURNAL OF MEDICAL IMAGING
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Yariv Gerber, Kelley Pettee Gabriel, David R. Jacobs, Jennifer Y. Liu, Jamal S. Rana, Barbara Sternfeld, J. Jeffrey Carr, Paul D. Thompson, Stephen Sidney
Article
Cardiac & Cardiovascular Systems
Vinithra Varadarajan, Samuel S. Gidding, Colin Wu, J. Jeffrey Carr, Joao A. C. Lima
Summary: The increasing prevalence of obesity, hypertension, and diabetes, along with worsening environmental factors, has led to a growing burden of cardiovascular diseases worldwide. Noninvasive imaging techniques, including vascular ultrasound, echocardiography, and magnetic resonance imaging, play a significant role in identifying early cardiovascular disease phenotypes. This article reviews the various imaging modalities used for the evaluation, characterization, and quantification of early subclinical cardiovascular diseases.
CIRCULATION RESEARCH
(2023)
Article
Endocrinology & Metabolism
Brian T. Steffen, David R. Jacobs, So-Yun Yi, Simon J. Lees, James M. Shikany, James G. Terry, Cora E. Lewis, John J. Carr, Xia Zhou, Lyn M. Steffen
Summary: This study aimed to determine whether long-term intake of artificial sweeteners and diet beverages is associated with higher fat deposition and risk of obesity. The results showed that long-term intake of sweeteners and diet beverages was associated with increased fat deposition, weight gain, and higher risk of obesity.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kaiwen Xu, Mirza S. Khan, Thomas Z. Li, Riqiang Gao, James G. Terry, Yuankai Huo, Thomas A. Lasko, John Jeffrey Carr, Fabien Maldonado, Bennett A. Landman, Kim L. Sandler
Summary: This study evaluated the added value of CT-based AI-derived body composition measurements in predicting the risk of lung cancer incidence, lung cancer death, cardiovascular disease death, and all-cause mortality. The results showed that these measurements improved the risk prediction for lung cancer death, CVD death, and all-cause mortality, but not for lung cancer incidence.
Editorial Material
Cardiac & Cardiovascular Systems
Jose E. Exaire, Timothy A. Mixon
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Giuseppe Di Gioia, Federica Coletti, Lorenzo Buzzelli, Viviana Maestrini, Sara Monosilio, Andrea Segreti, Maria Rosaria Squeo, Erika Lemme, Antonio Nenna, Antonio Pelliccia
Summary: Dyslipidemia is common in Paralympic athletes, with lipid levels influenced by the type of disability and sporting discipline.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Esra Donmez, Sevgi Ozcan, Irfan Sahin, Murat Ziyrek, Ertugrul Okuyan
Summary: This study aimed to evaluate the predictive value of the GRACE risk score in acute pulmonary embolism (PE) patients for 30-day mortality and the need for thrombolytic treatment. The study found that the GRACE risk score, along with the PESI score, were independent risk factors associated with 30-day mortality and the need for thrombolytic treatment. The GRACE risk score showed high sensitivity and specificity in predicting mortality, and its combination with the PESI score helped define high-risk PE patients and predict poor prognosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Tom Kai Ming Wang, Reza Reyaldeen, Kevser Akyuz, Zoran B. Popovic, A. Marc Gillinov, Bo Xu, Brian P. Griffin, Milind Y. Desai
Summary: Transthoracic echocardiography (TTE) is commonly used to evaluate isolated tricuspid regurgitation (TR), but there is limited research comparing its quantification with magnetic resonance imaging (MRI). In this study, a novel TTE algorithm was developed to identify severe TR based on TTE parameters. The algorithm had a higher accuracy than the current guidelines' criteria in detecting severe TR by MRI.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Enkhtsogt Sainbayar, Ramzi Ibrahim, Hoang Nhat Pham, Wisam Beauti, Mahek Shahid, Natalie Hickerson, Mohammed Salih, Joao Paulo Ferreira, Mamas A. Mamas
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Richard E. Casazza, Hymie Chera, Carlos Adolfo Rodriguez, Sergey Ayzenberg
Summary: This article presents a case of a patient with known situs inversus who underwent cardiac catheterization and was found to have chronic total occlusion in the right coronary artery. Situs inversus is a rare congenital abnormality characterized by the inverted position of chest and abdominal organs. Cardiac catheterization is uncommon in patients with this particular abnormality, highlighting the importance of customizing techniques to engage coronary arteries and optimize guide support for percutaneous coronary intervention if needed.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Georgiana Pintea Bentea, Brahim Berdaoui, Sophie Samyn, Marielle Morissens, Philippe van de Borne, Jose Castro Rodriguez
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Bulbul Ahmed, Melissa G. Farb, Shakun Karki, Sophia D'Alessandro, Niloo M. Edwards, Noyan Gokce
Summary: This study evaluated the angiogenic capacity of adipose tissue in patients undergoing cardiac surgeries and found that patients with coronary artery disease (CAD) had reduced angiogenic capacity in their pericardial adipose tissue. Gene expression analysis revealed upregulated expression of the anti-angiogenic gene TSP-1 in CAD patients, with no significant differences in other angiogenic factors. Additionally, inhibiting TSP-1 expression significantly improved angiogenic deficiency in CAD patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moshe Rav-Acha, Orli Wube, Oholi Tovia Brodie, Yoav Michowitz, Michael Ilan, Tal Ovdat, Robert Klempfner, Mahmud Suleiman, Ilan Goldenberg, Michael Glikson
Summary: The current guidelines recommend prophylactic implantable cardioverter-defibrillator (ICD) for patients with symptomatic heart failure (HF) and low left ventricular ejection fraction. However, not all patients will benefit from ICD treatment. This study evaluated the feasibility of using the MADIT-II-based Risk Stratification Score (MRSS) to predict the survival benefit of prophylactic ICDs in patients with HF. The results showed that different risk subgroups had varying levels of ICD survival benefit.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ariel Banai, Rachel Retsky, Lior Lupu, Erez Levi, David Zahler, Omri Feder, Roei Merin, Yan Topilsky, Raphael Rosso, Shmuel Banai, Sami Viskin, Ehud Chorin
Summary: This study aims to evaluate the association between electromechanical window (EMW) and ventricular tachyarrhythmias in patients with Takotsubo syndrome (TTS). The study found that TTS patients had a lower EMW value, which was associated with an increased risk of ventricular tachyarrhythmias.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Harun Kundi, Kobina Hagan, Tamer Yahya, Garima Sharma, Sadeer Al-Kindi, Zulqarnain Javed, Khurram Nasir
Summary: Using latent class analysis (LCA), the study identified clinical, demographic, and social subphenotypes in ASCVD population and assessed the risk of all-cause and cardiovascular mortality across different socioclinical classes. The results showed that the younger, female, non-Hispanic Black or Hispanic individuals with a high burden of co-morbidities and unfavorable social determinants of health had the highest risk of mortality in the identified latent classes.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moises A. Vasquez, Mina Iskander, Mohammed Mustafa, Juan A. Quintero-Martinez, Antonio Luna, Joel Mintz, Jose Noy, Juan Uribe, Ivan Mijares, Eduardo de Marchena, Yiannis S. Chatzizisis
Summary: The benefits of pericardiocentesis (PC) in patients with pulmonary hypertension (PH) and pericardial effusions are unclear. The study found that PC in PH patients is associated with higher in-hospital mortality and rates of cardiovascular complications.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ken Kuwajima, Mana Ogawa, Irving Ruiz, Hiroko Hasegawa, Nobuichiro Yagi, Florian Rader, Robert J. Siegel, Takahiro Shiota
Summary: After cardiac surgery, the longitudinal function of the right ventricle and left ventricle is reduced, despite preserved global functions. In particular, tricuspid annular plane systolic excursion (TAPSE) remains decreased after surgery.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Min -Jung Kim, Robert H. Aseltine Jr, Sara R. Tabtabai
Summary: This study evaluated the rates and causes of 30-day readmissions after discharge for heart failure (HF) as a primary and secondary diagnosis. The findings indicate that efforts to reduce readmission rates should include patients with secondary HF diagnosis, and surveillance should extend to 2 weeks postdischarge to identify at-risk patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ya He, Jianzhong Zhou
Summary: This study aimed to examine the relation between reverse septal curvature (RSC) and nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy (HCM). The study found that patients with RSC were younger and had a higher incidence of NSVT, and RSC was identified as a strong independent risk factor for NSVT.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
