Article
Immunology
Nicole M. Lane Starr, Michael D. Evans, Kristine E. Lee, James E. Gern, Loren C. Denlinger
Summary: The study found that high levels of 15-keto-PGE(2) during acute colds are associated with fewer symptoms during recovery.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Adriano B. Chaves-Filho, Larissa S. Diniz, Rosangela S. Santos, Rodrigo S. Lima, Hector Oreliana, Isabella F. D. Pinto, Lucas S. Dantas, Alex Inague, Rodrigo L. Faria, Marisa H. G. Medeiros, Isaias Glezer, William T. Festuccia, Marcos Y. Yoshinaga, Sayuri Miyamoto
Summary: This study established a high-performance liquid chromatography-high-resolution mass spectrometry method for the analysis of oxylipins in plasma and provided a comprehensive overview of oxylipins involved in the progression of ALS. The study found that oxylipins linked to inflammation and oxidative stress were increased in ALS rats, while oxylipins involved in fatty acid uptake and β-oxidation were decreased.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Oncology
Makoto Kurano, Eri Sakai, Yutaka Yatomi
Summary: Numerous studies have investigated the possible involvement of eicosanoids, lysophospholipids, and sphingolipids in cancer. The comprehensive measurement of these lipid mediators in a mouse model of carcinomatous peritonitis revealed unknown associations with cancer, highlighting the need for further research. The PS/LysoPS pathway could be a novel therapeutic target, and plasma eicosanoids could serve as useful biomarkers for cancer.
Article
Medical Laboratory Technology
Ivan Hartling, Alessio Cremonesi, Ester Osuna, Phing-How Lou, Eliana Lucchinetti, Michael Zaugg, Martin Hersberger
Summary: The study developed a method to quantify 58 lipid mediators and established preliminary reference ranges for adolescent plasma samples. Results showed that TPN containing n-3 PUFA reduced inflammatory lipid mediators in mice compared to n-6 PUFA.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Irma Magaly Rivas Serna, Michal Sitina, Gorazd B. Stokin, Jose R. Medina-Inojosa, Francisco Lopez-Jimenez, Juan P. Gonzalez-Rivas, Manlio Vinciguerra
Summary: The study found that good cardiovascular health metrics are associated with a specific pattern of phospho- and sphingolipids. Circulatory lipid profiling may be a potential biomarker to refine cardiovascular health status in primary prevention strategies.
Article
Nutrition & Dietetics
William Yakah, David Ramiro-Cortijo, Pratibha Singh, Joanne Brown, Barbara Stoll, Madhulika Kulkarni, Berthe C. Oosterloo, Doug Burrin, Krishna Rao Maddipati, Raina N. Fichorova, Steven D. Freedman, Camilia R. Martin
Summary: Comparing the effects of different lipid emulsions on preterm pigs, it was found that soybean oil enhances the ability of the host to respond acutely to an external stimulus, while fish-oil containing emulsions increase DHA levels, exacerbate AA deficiency, and limit initial inflammatory responses induced by LPS in preterm pigs.
Article
Biochemistry & Molecular Biology
Yohannes Abere Ambaw, Martin P. Pagac, Antony S. Irudayaswamy, Manfred Raida, Anne K. Bendt, Federico T. Torta, Markus R. Wenk, Thomas L. Dawson
Summary: Malassezia, common components of human skin, can synthetize steroid-like lipid mediators in vitro, which may be related to metabolic pathways shared with the human skin.
Article
Biochemical Research Methods
Ahmed M. M. Abdel-Megied, Isaac A. A. Monreal, Limian Zhao, Alex Apffel, Hector C. C. Aguilar, Jace W. W. Jones
Summary: Emerging and re-emerging zoonotic viral diseases, particularly enveloped viruses like SARS-CoV-2, have a significant impact on public health. The lipid composition of the viral envelope and changes in host cell lipid metabolism during viral infection provide an opportunity to understand how these viruses infect cells. In this study, the lipid composition of VeroE6-TMPRSS2 cells infected with SARS-CoV-2 was characterized, with a focus on the ceramide to sphingomyelin ratio. This lipid profile can help in the development of antiviral strategies and vaccines.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Denise Biagini, Maria Franzini, Paolo Oliveri, Tommaso Lomonaco, Silvia Ghimenti, Andrea Bonini, Federico Vivaldi, Lisa Macera, Laurence Balas, Thierry Durand, Camille Oger, Jean-Marie Galano, Fabrizio Maggi, Alessandro Celi, Aldo Paolicchi, Fabio Di Francesco
Summary: “The role of oxylipins in COVID-19 inflammation has been poorly understood. However, a recent study found that oxylipins can differentiate between samples collected from COVID-19 wards and ICU. Patients in ICU showed lower levels of anti-inflammatory and pro-resolving lipid mediators, indicating impaired inflammation response. This study highlights the importance of targeting lipid mediators for a better understanding of COVID-19 inflammation and the potential for biomarker-based prediction models.”
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jing Kai Chang, Guoshou Teo, Yael Pewzner-Jung, Daniel J. Cuthbertson, Anthony H. Futerman, Markus R. Wenk, Hyungwon Choi, Federico Torta
Summary: In this study, an untargeted lipidomics workflow using Q-RAI DIA approach was proposed, which enables simultaneous identification and reproducible relative quantification of lipids. This method was validated using lipid extracts from human plasma and serum samples from CerS2 null mice, and several lipid species significantly different between groups were identified.
SCIENTIFIC REPORTS
(2023)
Article
Agriculture, Multidisciplinary
Omar S. Ahmed, Sami Sedraoui, Bingqing Zhou, Guillaume Reversat, Amandine Rocher, Valerie Bultel-Ponce, Alexandre Guy, Joseph Vercauteren, Samy Selim, Jean-Marie Galano, Thierry Durand, Camille Oger, Claire Vigor
Summary: This study evaluated for the first time the presence of special plant metabolites called PhytoPs in five different varieties of date palm fruit pulps and pits. The results showed that these matrices could be potential sources of several PhytoPs, which may help unravel the biological activities associated with date palm fruit consumption.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Applied
Iris Samarra, Clara Masdevall, Elisabet Foguet-Romero, Maria Guirro, Marc Riu, Pol Herrero, Nuria Canela, Antoni Delpino-Rius
Summary: Oxylipins derived from various polyunsaturated fatty acids show promise as biomarkers for distinguishing between organic and conventional milks, as they do not correlate with their fatty acid precursors. This suggests that oxylipins could be utilized as diet-dependent biomarkers for organic milk assessment.
Article
Biochemistry & Molecular Biology
Dragana Fabris, Ivana Karmelic, Hasan Muharemovic, Tomislav Sajko, Mia Jurilj, Slavica Potocki, Ruder Novak, Zeljka Vukelic
Summary: Aberrations in ganglioside composition strongly correlate with tumor growth and invasiveness. Anaplastic ganglioglioma shows distinct ganglioside composition compared to peritumoral and healthy brain tissues, despite having lower total content. The specific ganglioside composition in anaplastic ganglioglioma demonstrates realistic expression patterns and corresponds to high-grade malignancy brain tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kosuke Saito, Kotaro Hattori, Shinsuke Hidese, Daimei Sasayama, Tomoko Miyakawa, Ryo Matsumura, Megumi Tatsumi, Yuuki Yokota, Miho Ota, Hiroaki Hori, Hiroshi Kunugi
Summary: Lipidomics study on CSF and plasma samples from healthy Japanese individuals revealed significant differences in global lipid profiles between CSF and plasma, with only a small number of lipids showing correlation between the two matrices. CSF total protein content was identified as the primary factor associated with CSF lipids.
Article
Biochemistry & Molecular Biology
James F. Markworth, Kristoffer B. Sugg, Dylan C. Sarver, Krishna Rao Maddipati, Susan V. Brooks
Summary: This study found that tendon overuse can lead to a delayed and prolonged local inflammatory response, characterized by an increase in pro-inflammatory eicosanoids and a relative lack of specialized pro-resolving lipid mediators.
Article
Gastroenterology & Hepatology
Cristina Lopez-Vicario, Antonio Checa, Arantxa Urdangarin, Ferran Aguilar, Jose Alcaraz-Quiles, Paolo Caraceni, Alex Amoros, Marco Pavesi, David Gomez-Cabrero, Jonel Trebicka, Karl Oettl, Richard Moreau, Nuria Planell, Vicente Arroyo, Craig E. Wheelock, Joan Claria
JOURNAL OF HEPATOLOGY
(2020)
Article
Food Science & Technology
Begona De Ancos, Maria J. Rodrigo, Concepcion Sanchez-Moreno, M. Pilar Cano, Lorenzo Zacarias
FOOD RESEARCH INTERNATIONAL
(2020)
Article
Food Science & Technology
Irene Fernandez-Jalao, Claudia Balderas, Concepcion Sanchez-Moreno, Begona De Ancos
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2020)
Article
Food Science & Technology
Maria Janeth Rodriguez-Roque, Begona De Ancos, Rogelio Sanchez-Vega, Concepcion Sanchez-Moreno, Pedro Elez-Martinez, Olga Martin-Belloso
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2020)
Article
Agriculture, Multidisciplinary
Maria Florencia Bambace, Maria del Rosario Moreira, Concepcion Sanchez-Moreno, Begona De Ancos
Summary: The study shows that HPP treatment can effectively reduce L. monocytogenes and E. coli levels, while the addition of active coatings can improve the firmness and color retention of apple cubes. HPP leads to a decrease in phenolic compounds, but active coatings have a protective effect on some phenolics.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Biochemistry & Molecular Biology
Irene Fernandez-Jalao, Claudia Balderas, Maria V. Calvo, Javier Fontecha, Concepcion Sanchez-Moreno, Begona De Ancos
Summary: The study showed that HPP-treated onion modulated the metabolism of human gut microbiota. Chronic feeding with HPP-treated onion increased beneficial colon bacteria and the production of total SCFAs in different colon regions. The DGID-CF proved to be an effective system to study these changes.
Article
Chemistry, Applied
Begona Olmedilla-Alonso, Fernando Granado-Lorencio, Begona de Ancos, Concepcion Sanchez-Moreno, Olga Martin-Belloso, Inmaculada Blanco, Carmen Herrero-Barbudo, Pedro Elez-Martinez, Lucia Plaza, M. Pilar Cano
Summary: This study found a significant increase in serum xanthophyll concentrations after drinking orange juice. The processing technologies applied may affect the serum carotenoid concentrations, suggesting a need for further studies with larger sample sizes.
Article
Biochemistry & Molecular Biology
Claudia Balderas, Javier Angulo, Alejandro Sevilleja-Ortiz, Concepcion Peiro, Susana Vallejo, Pilar Dongil, Begona de Ancos, Concepcion Sanchez-Moreno
Summary: This study investigated the effects of onion and apple functional ingredients in obese Zucker rats and found that the administration of high pressure-processed onion and apple had beneficial effects on metabolic health, lipid levels, glycemia, insulinemia, hepatic injury biomarkers, antioxidant activity, oxidative stress, inflammatory and vascular injury biomarkers, metabolic hormones, endothelial function, and proinflammatory gene expression.
Article
Chemistry, Applied
Gonzalo Adrian Ojeda, Sonia Cecilia Sgroppo, Concepcion Sanchez Moreno, Begon de Ancos Siguero
Summary: Ultrasound assisted extraction (UAE) is a green method for the recovery of phenolic compounds with antioxidant capacity from underutilized mango. Response surface methodology and HPLC-QTOF-MS/MS were used to optimize the extraction conditions and identify the phenolic composition. UAE improved the extraction efficiency of phenolic compounds and resulted in higher concentrations of certain compounds in different parts of the mango.
Article
Nutrition & Dietetics
Claudia Balderas, Begona de Ancos, Concepcion Sanchez-Moreno
Summary: The intake of onion and apple can increase the abundance of beneficial bacteria, promote the production of short-chain fatty acids and decrease the excretion of certain bile acids. This finding is important for further research on the relationship between specific diseases and the microbiome, as well as the formation of fatty acids and bile acids.
Article
Biochemistry & Molecular Biology
Antonio Cilla, Maria J. Rodrigo, Begona De Ancos, Concepcion Sanchez-Moreno, M. Pilar Cano, Lorenzo Zacarias, Reyes Barbera, Amparo Alegria