Pharmacological targeting of peptidylarginine deiminase 4 prevents cancer-associated kidney injury in mice

Tumor-Induced NETosis as a Risk Factor for Metastasis and Organ Failure

(2016) J. Cedervall et al.   CANCER RESEARCH

Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress

(2016) Samer Tohme et al.   CANCER RESEARCH

Tumor-Produced Interleukin-8 Attracts Human Myeloid-Derived Suppressor Cells and Elicits Extrusion of Neutrophil Extracellular Traps (NETs)

(2016) C. Alfaro et al.   CLINICAL CANCER RESEARCH

Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps

(2016) J. Park et al.   Science Translational Medicine

Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis

(2016) Silvia Guglietta et al.   Nature Communications

PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock

(2015) K. Martinod et al.   BLOOD

Neutrophil Extracellular Traps Accumulate in Peripheral Blood Vessels and Compromise Organ Function in Tumor-Bearing Animals

(2015) J. Cedervall et al.   CANCER RESEARCH

Tumor-Induced Local and Systemic Impact on Blood Vessel Function

(2015) J. Cedervall et al.   MEDIATORS OF INFLAMMATION

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

(2015) Huw D Lewis et al.   Nature Chemical Biology

Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

(2015) Siu Ling Wong et al.   NATURE MEDICINE

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

(2015) A. Warnatsch et al.   SCIENCE

Peptidylarginine Deiminase Inhibition Reduces Vascular Damage and Modulates Innate Immune Responses in Murine Models of Atherosclerosis

(2014) Jason S. Knight et al.   CIRCULATION RESEARCH

Reduced Estimated GFR and Cancer Mortality

(2013) Samuel Iff et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

NETosis: how vital is it?

(2013) B. G. Yipp et al.   BLOOD

Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis

(2013) Jonathan Cools-Lartigue et al.   JOURNAL OF CLINICAL INVESTIGATION

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

(2012) M. Demers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic Kidney Disease in Cancer Patients: An Independent Predictor of Cancer-Specific Mortality

(2011) Sun Young Na et al.   AMERICAN JOURNAL OF NEPHROLOGY

NGAL is a Precocious Marker of Therapeutic Response

(2011) Valeria Cernaro et al.   CURRENT PHARMACEUTICAL DESIGN

PAD4-Mediated Neutrophil Extracellular Trap Formation Is Not Required for Immunity against Influenza Infection

(2011) Saskia Hemmers et al.   PLoS One

Cancer and renal insufficiency results of the BIRMA study

(2010) N Janus et al.   BRITISH JOURNAL OF CANCER

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidemiology of Chronic Kidney Disease in Cancer Patients: Lessons From the IRMA Study Group

(2010) Vincent Launay-Vacher   SEMINARS IN NEPHROLOGY

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

Neutrophil Gelatinase–Associated Lipocalin (NGAL) as a Marker of Kidney Damage

(2008) Davide Bolignano et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Patient selection has a strong impact on cystatin C and Modification of Diet in Renal Disease (MDRD) estimated glomerular filtration rate

(2008) Anders Larsson et al.   CLINICAL BIOCHEMISTRY