The differentiation and plasticity of Tc17 cells are regulated by CTLA-4-mediated effects on STATs

Naïve CD8+ T cell derived tumor-specific cytotoxic effectors as a potential remedy for overcoming TGF-β immunosuppression in the tumor microenvironment

(2016) Hong Hanh Nguyen et al.   Scientific Reports

Dendritic Cells in Irradiated Mice Trigger the Functional Plasticity and Antitumor Activity of Adoptively Transferred Tc17 Cells via IL12 Signaling

(2015) J. S. Bowers et al.   CLINICAL CANCER RESEARCH

Immune Checkpoint Blockade in Cancer Therapy

(2015) Michael A. Postow et al.   JOURNAL OF CLINICAL ONCOLOGY

IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling

(2015) Anneli Peters et al.   JOURNAL OF IMMUNOLOGY

Nivolumab and Ipilimumab versus Ipilimumab in Untreated Melanoma

(2015) Michael A. Postow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8+ T cells

(2015) Valérie Martinet et al.   Nature Communications

Long-lasting multifunctional CD8+T cell responses in end-stage melanoma patients can be induced by dendritic cell vaccination

(2015) Florian Wimmers et al.   OncoImmunology

Curing Mice with Large Tumors by Locally Delivering Combinations of Immunomodulatory Antibodies

(2014) M. Dai et al.   CLINICAL CANCER RESEARCH

CTLA-4 (CD152) enhances the Tc17 differentiation program

(2014) Jonas Pick et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells

(2014) Andreas Herrmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of IFN- -Induced STAT1 Tyrosine Phosphorylation by Human CMV Is Mediated by SHP2

(2014) M. Baron et al.   JOURNAL OF IMMUNOLOGY

Local CTLA4 blockade effectively restrains experimental pancreatic adenocarcinoma growth in vivo

(2014) Linda C Sandin et al.   OncoImmunology

Adoptive Transfer of Tc1 or Tc17 Cells Elicits Antitumor Immunity against Established Melanoma through Distinct Mechanisms

(2013) Y. Yu et al.   JOURNAL OF IMMUNOLOGY

Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma

(2012) Lina Y Dimberg et al.   BMC CANCER

CD8+ T Cells That Produce Interleukin-17 Regulate Myeloid-Derived Suppressor Cells and Are Associated With Survival Time of Patients With Gastric Cancer

(2012) Yuan Zhuang et al.   GASTROENTEROLOGY

IL-17/IFN-  double producing CD8+ T (Tc17/IFN- ) cells: A novel cytotoxic T-cell subset converted from Tc17 cells by IL-12

(2011) M. Tajima et al.   INTERNATIONAL IMMUNOLOGY

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

(2011) Xiang-Ping Yang et al.   NATURE IMMUNOLOGY

Increased Number of Tc17 and Correlation with Th17 Cells in Patients with Immune Thrombocytopenia

(2011) Yu Hu et al.   PLoS One

Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab

(2011) J. Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Targeting STAT3 in Adoptively Transferred T Cells Promotes Their In Vivo Expansion and Antitumor Effects

(2010) M. Kujawski et al.   CANCER RESEARCH

Selective Depletion of Foxp3+ Regulatory T Cells Improves Effective Therapeutic Vaccination against Established Melanoma

(2010) K. Klages et al.   CANCER RESEARCH

Adoptive Transfer of Tumor-Specific Tc17 Effector T Cells Controls the Growth of B16 Melanoma in Mice

(2010) M. d. l. L. Garcia-Hernandez et al.   JOURNAL OF IMMUNOLOGY

STAT1-Activating Cytokines Limit Th17 Responses through Both T-bet-Dependent and -Independent Mechanisms

(2010) A. V. Villarino et al.   JOURNAL OF IMMUNOLOGY

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Single dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance

(2010) V. A. Pedicord et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type 17 CD8+ T cells display enhanced antitumor immunity

(2009) C. S. Hinrichs et al.   BLOOD

CD152 (CTLA-4) regulates effector functions of CD8+T lymphocytes by repressing Eomesodermin

(2009) Johannes K. Hegel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Th17-like developmental process leads to CD8+Tc17 cells with reduced cytotoxic activity

(2009) Magdalena Huber et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD28 and CTLA-4 coreceptor expression and signal transduction

(2009) Christopher E. Rudd et al.   IMMUNOLOGICAL REVIEWS

Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse

(2009) Roberto A. Maldonado et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tc17 CD8 T Cells: Functional Plasticity and Subset Diversity

(2009) H.-R. Yen et al.   JOURNAL OF IMMUNOLOGY

IL-23 Drives Pathogenic IL-17-Producing CD8+ T Cells

(2009) B. Ciric et al.   JOURNAL OF IMMUNOLOGY

Transforming Growth Factor   Subverts the Immune System into Directly Promoting Tumor Growth through Interleukin-17

(2008) J.-S. Nam et al.   CANCER RESEARCH

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit

(2008) J. Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anomalous Type 17 Response to Viral Infection by CD8+ T Cells Lacking T-bet and Eomesodermin

(2008) A. M. Intlekofer et al.   SCIENCE

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY