Ex-vivo assessment of drug response on breast cancer primary tissue with preserved microenvironments

Pembrolizumab in Patients With Advanced Triple-Negative Breast Cancer: Phase Ib KEYNOTE-012 Study

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Validation of a Next-Generation–Sequencing Cancer Panel for Use in the Clinical Laboratory

(2015) Birgitte B. Simen et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Bioreactor-engineered cancer tissue-like structures mimic phenotypes, gene expression profiles and drug resistance patterns observed “in vivo”

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Three dimensional multi-cellular muscle-like tissue engineering in perfusion-based bioreactors

(2015) Giulia Cerino et al.   BIOTECHNOLOGY AND BIOENGINEERING

Abstract 2859: Inhibition of PD-L1 by MPDL3280A leads to clinical activity in patients with metastatic triple-negative breast cancer (TNBC)

(2015) Leisha A. Emens et al.   CANCER RESEARCH

Anti-PD-L1 for metastatic triple-negative breast cancer

(2015) Josefine Gibson   LANCET ONCOLOGY

Validation of an NGS Approach for Diagnostic BRCA1/BRCA2 Mutation Testing

(2015) Daniela Dacheva et al.   Molecular Diagnosis & Therapy

Translational value of mouse models in oncology drug development

(2015) Stephen E Gould et al.   NATURE MEDICINE

Clinical management of breast cancer heterogeneity

(2015) Dimitrios Zardavas et al.   Nature Reviews Clinical Oncology

Flow perfusion effects on three-dimensional culture and drug sensitivity of Ewing sarcoma

(2015) Marco Santoro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity

(2015) Biswanath Majumder et al.   Nature Communications

The Effect of Primary Cancer Cell Culture Models on the Results of Drug Chemosensitivity Assays: The Application of Perfusion Microbioreactor System as Cell Culture Vessel

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“In vitro” 3D models of tumor-immune system interaction

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The PD-1/PD-L1 pathway: biological background and clinical relevance of an emerging treatment target in immunotherapy

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Accurate de novo and transmitted indel detection in exome-capture data using microassembly

(2014) Giuseppe Narzisi et al.   NATURE METHODS

Tissue engineering perfusable cancer models

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Patient-Derived Tumor Xenografts: Transforming Clinical Samples into Mouse Models

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Mesenchymal stromal cells induce epithelial-to-mesenchymal transition in human colorectal cancer cells through the expression of surface-bound TGF-β

(2013) Valentina Mele et al.   INTERNATIONAL JOURNAL OF CANCER

From Bench to Bedside: Lessons Learned in Translating Preclinical Studies in Cancer Drug Development

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Scientists and the 3Rs: attitudes to animal use in biomedical research and the effect of mandatory training in laboratory animal science

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Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples

(2013) Kristian Cibulskis et al.   NATURE BIOTECHNOLOGY

Strelka: accurate somatic small-variant calling from sequenced tumor–normal sample pairs

(2012) Christopher T. Saunders et al.   BIOINFORMATICS

The tumor microenvironment is a dominant force in multidrug resistance

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VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing

(2012) D. C. Koboldt et al.   GENOME RESEARCH

Cartilage graft engineering by co-culturing primary human articular chondrocytes with human bone marrow stromal cells

(2012) Maria Antonietta Sabatino et al.   Journal of Tissue Engineering and Regenerative Medicine

The clonal and mutational evolution spectrum of primary triple-negative breast cancers

(2012) Sohrab P. Shah et al.   NATURE

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Engineering of large osteogenic grafts with rapid engraftment capacity using mesenchymal and endothelial progenitors from human adipose tissue

(2011) Sinan Güven et al.   BIOMATERIALS

Tumour evolution inferred by single-cell sequencing

(2011) Nicholas Navin et al.   NATURE

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

(2011) Yoko S DeRose et al.   NATURE MEDICINE

Bioreactor based engineering of large-scale human cartilage grafts for joint resurfacing

(2010) Rosaria Santoro et al.   BIOMATERIALS

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

(2010) Shinichi Yachida et al.   NATURE

Computational evaluation of oxygen and shear stress distributions in 3D perfusion culture systems: Macro-scale and micro-structured models

(2008) M. Cioffi et al.   JOURNAL OF BIOMECHANICS

Unraveling the microenvironmental influences on the normal mammary gland and breast cancer

(2008) Britta Weigelt et al.   SEMINARS IN CANCER BIOLOGY