Journal
NEOPLASIA
Volume 19, Issue 11, Pages 928-931Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neo.2017.08.007
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Funding
- Pro-reitoria de Pesquisa da Universidade Federal de Minas Gerais (PRPq/UFMG) [Edital 05/2016]
- National Institutes of Health [1R01CA179072-01A1]
- American Cancer Society Mentored Research Scholar grant [124443-MRSG-13-121-01-CDD]
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Prostate cancer cells metastasize to the bones, causing ectopic bone formation, which results in fractures and pain. The cellular mechanisms underlying new bone production are unknown. In a recent study, Lin and colleagues, by using state-of-the-art techniques, including prostate cancer mouse models in combination with sophisticated in vivo lineage-tracing technologies, revealed that endothelial cells form osteoblasts induced by prostate cancer metastasis in the bone. Strikingly, genetic deletion of osteorix protein from endothelial cells affected prostate cancer-induced osteogenesis in vivo. Deciphering the osteoblasts origin in the bone microenvironment may result in the development of promising new molecular targets for prostate cancer therapy.
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