Article
Endocrinology & Metabolism
Alana Deutsch, Kosaku Shinoda
Summary: Studies have shown that prolonged exposure to cold can increase the thermogenic capacity of brown adipose tissue through the recruitment of new brown adipocytes. Shamsi et al. and Angueira et al. have identified novel cellular origins of cold-induced brown adipocytes and elucidated the molecular mechanism regulating the expansion of brown adipose tissue.
Article
Cell Biology
Jyoti Rao, Yannis Djeffal, Jerome Chal, Fabio Marchiano, Chih-Hao Wang, Ziad Al Tanoury, Svetlana Gapon, Alicia Mayeuf-Louchart, Ian Glass, Elizabeth M. Sefton, Bianca Habermann, Gabrielle Kardon, Fiona M. Watt, Yu-Hua Tseng, Olivier Pourquie
Summary: This study characterized the development of interscapular brown fat in mice using single-cell RNA sequencing and demonstrated that the sequence of signaling cues identified in mice can efficiently differentiate human pluripotent stem cells into functional BAs.
DEVELOPMENTAL CELL
(2023)
Editorial Material
Endocrinology & Metabolism
Imke L. Lemmer, Alexander Bartelt
Summary: An elegant quantitative analysis of brown fat and skeletal muscle metabolite flux reveals that brown fat predominantly uses glucose and lactate and acts as a nitrogen scavenger during thermogenesis.
Article
Cell Biology
Hailuan Zeng, Weihong Sun, Xinping Ren, Nan Xia, Sheng Zheng, Haixia Xu, Yan Tian, Xianghui Fu, Jingyan Tian
Summary: The study found that adipose-specific overexpression of miR-26a may moderately reduce visceral fat pad mass and lipid levels, independent of white adipose tissue browning, adipogenesis, and adipose lipolysis.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nicolas Cardinault, Franck Tourniaire, Julien Astier, Charlene Couturier, Lauriane Bonnet, Eva Seipelt, Esma Karkeni, Claire Letullier, Naima Dlalah, Stephane George, Lourdes Mounien, Jean-Francois Landrier
Summary: The study showed that poplar propolis extract is effective in reducing weight gain and improving glucose homeostasis, while other two propolis extracts did not have the same effect. Poplar propolis extract induced gene expression related to lipid catabolism and antioxidant enzymes in adipose tissue, suggesting its potential benefits in preventing obesity and associated comorbidities.
Article
Multidisciplinary Sciences
Iokfai Cheang, Xu Zhu, Xin Yue, Yuan Tang, Yujie Gao, Xinyi Lu, Shi Shi, Shengen Liao, Wenming Yao, Yanli Zhou, Haifeng Zhang, Yinsu Zhu, Yi Xu, Xinli Li
Summary: The purpose of this study was to investigate the prognostic values of ventricle epicardial fat volume (EFV) in patients with chronic heart failure (CHF) using cardiac magnetic resonance. A total of 516 CHF patients were recruited, and 136 (26.4%) of them experienced major adverse cardiovascular events (MACE) within a median follow-up of 24 months. The study found that EFV was significantly associated with MACE and showed promising predictive ability for MACE at different time points.
Article
Multidisciplinary Sciences
Hiromi Sakashita, Satoru Yamada, Masaki Kinoshita, Tetsuhiro Kajikawa, Tomoaki Iwayama, Shinya Murakami
Summary: The study found that PLAP-1 enhances adipogenesis and could be a key molecule in understanding the association between periodontal disease and obesity-related metabolic disorders.PLAP-1 knock-out mice counteracted obesity and alveolar bone resorption induced by a high-fat diet, while PLAP-1 knock-down in 3T3-L1 cells resulted in less lipid accumulation.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Taylor B. Scheidl, Amy L. Brightwell, Sarah H. Easson, Jennifer A. Thompson
Summary: Recent studies have shown that the quality of adipose tissue, rather than its quantity, contributes to the risk of obesity-related diseases. Adipose-derived stem cells give rise to adipocytes during the development of adipose depots. In adult depots, progenitor cells serve as a reservoir for replacing aging adipocytes and increasing lipid storage capacity.
Article
Biochemistry & Molecular Biology
Aline Almeida da Silva, Elisangela Martins da Silva Perez, Ingrid Samantha Tavares de Figueiredo, Nylane Maria Nunes de Alencar, Ana Paula Negreiros Nunes Alves, Fabiano Andre Narciso Fernandes, Renata Prado Vasconcelos, Ariclecio Cunha de Oliveira, Socorro Vanesca Frota Gaban
Summary: This study investigated the effects of virgin coconut oil (VCO) on body weight, white fat depots, and biochemical and morphological parameters in male Swiss mice fed standard (SD) or high-fat (HFD) diets. The results showed that low-dose VCO supplementation did not improve obesity, had no effects on hepatic or renal function, and had beneficial effects on the lipid profile only in animals fed HFD.
Article
Clinical Neurology
Meiyuzhen Qi, Imke Janssen, Emma Barinas-Mitchell, Matthew Budoff, Maria M. Brooks, Arun S. Karlamangla, Carol A. Derby, Chung-Chou H. Chang, Kelly J. Shields, Samar R. El Khoudary
Summary: This study found that the quantity and quality of thoracic perivascular adipose tissue (PVAT) in middle age are related to cognitive performance in later years. Higher thoracic PVAT volume is associated with better future episodic memory, while higher thoracic PVAT radiodensity is related to poorer future working and episodic memories, particularly at higher thoracic PVAT volume.
ALZHEIMERS & DEMENTIA
(2023)
Article
Pediatrics
Esther Lizarraga-Mollinedo, Gemma Carreras-Badosa, Silvia Xargay-Torrent, Xavier Remesar, Berta Mas-Pares, Anna Prats-Puig, Francis de Zegher, Lourdes Ibanez, Abel Lopez-Bermejo, Judit Bassols
Summary: The study identified upregulated genes related to immune and metabolic processes in the retroperitoneal adipose tissue following catch-up growth in juvenile rats, which were associated with fat expansion and metabolic parameters. The dysregulated genes in white adipose tissue could potentially lead to the development of novel strategies to prevent metabolic abnormalities associated with catch-up growth.
PEDIATRIC RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Monika Gawalko, Arnela Saljic, Na Li, Issam Abu-Taha, Thomas Jespersen, Dominik Linz, Stanley Nattel, Jordi Heijman, Anke Fender, Dobromir Dobrev
Summary: Obesity is a significant contributing factor to atrial fibrillation (AF) by causing systemic changes and affecting different adipose tissue depots. Adipose tissue secretes various mediators that promote AF and cardiac remodeling. This review discusses the role of obesity-related factors, specific adipose tissue depots, and molecular mechanisms in AF, highlighting gaps in current knowledge and implications for clinical management.
CARDIOVASCULAR RESEARCH
(2023)
Article
Nutrition & Dietetics
Diana Sousa, Mariana Rocha, Andreia Amaro, Marcos Divino Ferreira-Junior, Keilah Valeria Naves Cavalcante, Tamaeh Monteiro-Alfredo, Catia Barra, Daniela Rosendo-Silva, Lucas Paulo Jacinto Saavedra, Jose Magalhaes, Armando Caseiro, Paulo Cezar de Freitas Mathias, Susana P. Pereira, Paulo J. Oliveira, Rodrigo Mello Gomes, Paulo Matafome
Summary: Obesogenic environments during the perinatal period can reprogram offspring energy balance mechanisms and increase the risk of metabolic diseases in adulthood. Different obesogenic models have varying effects on metabolic parameters and energy storage pathways in offspring.
Review
Nutrition & Dietetics
Lloyd Noriega, Cheng-Ying Yang, Chih-Hao Wang
Summary: Brown and beige adipocytes have the ability to generate heat and can be activated by various methods. Understanding the molecular mechanisms of their differentiation and function is crucial for developing clinical therapies. Drugs and nutritional interventions can activate these adipocytes while minimizing potential side effects.
Article
Nutrition & Dietetics
Magdalena Sylwia Kaminska, Anna Lubkowska, Mariusz Panczyk, Ireneusz Walaszek, Szymon Grochans, Elzbieta Grochans, Anna Maria Cybulska
Summary: This study aimed to assess the relationship between different measures of obesity (BMI, WC, RFM, VAI, WHtR) and parameters of chronic inflammation (CRP, TNF-α, IL-6) in perimenopausal women. The results showed that BMI, WC, RFM, VAI, and WHtR are clearly related to selected parameters of chronic inflammation.
Article
Biochemical Research Methods
Vladyslav Mishyn, Teresa Rodrigues, Yann R. Leroux, Laura Butruille, Eloise Woitrain, David Montaigne, Patrik Aspermair, Henri Happy, Wolfgang Knoll, Rabah Boukherroub, Sabine Szunerits
Summary: The study investigates electric and electrochemical point-of-care sensors for the detection of cTnI in serum samples using aptamer-functionalized CVD graphene-coated interdigated gold electrodes. Both sensors have comparable analytical performances with different equilibrium dissociation constant (K-D) values, indicating the advantage of label-free electric readout over electrochemical sensor when detecting cTnI in serum samples.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Lucie Marousez, Norbert Sprenger, Marie De Lamballerie, Sarahi Jaramillo-Ortiz, Lea Tran, Edwina Micours, Frederic Gottrand, Michael Howsam, Frederic J. Tessier, Delphine Ley, Jean Lesage
Summary: This study evaluated the impact of HHP processing on human milk components and found that HHP treatment preserves HMOs and avoids the formation of Maillard reaction products. In contrast, Holder pasteurization significantly increased the levels of Maillard reaction products.
CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Eve Wemelle, Lucie Marousez, Marie de Lamballerie, Claude Knauf, Jean Lesage
Summary: This study found that high hydrostatic pressure (HHP) processing preserves apelin and glucagon-like peptide 1 (GLP-1) in breast milk (BM) compared to Holder pasteurization (HoP). It also improves glucose tolerance by acting on gut contractions.
Article
Nutrition & Dietetics
Camille Dugardin, Lea Fleury, Veronique Touche, Farah Ahdach, Jean Lesage, Mathie Tenenbaum, Nadia Everaert, Olivier Briand, Sophie Lestavel, Rozenn Ravallec, Benoit Cudennec
Summary: High protein diets have been shown to improve glucose homeostasis. This study investigates the acute effects of proteins from different sources on intestinal glucose absorption. The digested proteins were found to decrease intestinal glucose absorption and ingestion of certain proteins improved glucose tolerance without affecting insulin secretion. These results suggest that protein-derived peptides and amino acids play a key role in regulating glucose homeostasis and intestinal glucose absorption.
FRONTIERS IN NUTRITION
(2022)
Article
Chemistry, Applied
Lucie Marousez, Lea Tran, Edwina Micours, Marie De Lamballerie, Frederic Gottrand, Veronique Pierrat, Delphine Eberle, Delphine Ley, Jean Lesage
Summary: This study evaluated the impact of high hydrostatic pressure (HHP) processing on the concentration of metabolic hormones in donor milk (DM). Compared with Holder pasteurization (HoP), HHP processing maintained the levels of insulin, nesfatin-1, cortisol, and leptin in raw DM, while reducing apelin and adiponectin levels and increasing GLP-1 level.
Article
Nutrition & Dietetics
Eve Wemelle, Lionel Carneiro, Anne Abot, Jean Lesage, Patrice D. Cani, Claude Knauf
Summary: This study investigates the role of glucose in duodenal contraction in the fasted and fed states in normal and diabetic mice. The findings suggest that glucose acts as an enterosyne to control intestinal motility and glucose absorption through the enteric nervous system. Alterations in glucose sensing and mechanosensing are observed in type 2 diabetes.
Article
Biochemistry & Molecular Biology
Eve Wemelle, Lucie Marousez, Jean Lesage, Marie De Lamballerie, Claude Knauf, Lionel Carneiro
Summary: The study found that high hydrostatic pressure (HHP) processing of donor milk provides better protection against gut and liver pathologies in preterm infants compared to Holder pasteurization (HoP). HHP treatment preserves vitamins and reduces H2O2 content in the milk. In mice experiments, HHP-DM administration stimulates antioxidant defenses and reduces inflammatory markers.
Article
Cardiac & Cardiovascular Systems
Augustin Coisne, David Montaigne, Sandro Ninni, Nicolas Lamblin, Gilles Lemesle, Pascal Delsart, Alexandre Filiot, Paul Andrey, Pierre Balaye, Laura Butruille, Raphael Decoin, Eloise Woitrain, Juan F. Granada, Bart Staels, Christophe Bauters
Summary: This study investigated the impact of diabetes mellitus (DM) on cardiovascular mortality in patients with aortic stenosis (AS) across different severities. The results showed that DM was not associated with cardiovascular mortality in patients with mild or moderate AS, but it was strongly associated with higher cardiovascular mortality, death from heart failure, and sudden death in patients with severe AS.
Article
Developmental Biology
Sandy Hanssens, Lucie Marousez, Oceane Pecheux, Capucine Besengez, Laurent Storme, Philippe Deruelle, Delphine Eberle, Jean Lesage
Summary: This study found that obesity reduces the levels of apelin in cord blood, but has no effect on maternal and cord blood levels of elabela or placental gene expression of this system.
Article
Nutrition & Dietetics
Lucie Marousez, Lea Chantal Tran, Edwina Micours, Matthieu Antoine, Frederic Gottrand, Jean Lesage, Delphine Ley
Summary: Inadequate perinatal nutrition can affect the maturity of the intestinal barrier and the development of the intestinal microbiota in mice. Supplementing with prebiotic fiber appears to improve gut microbiota establishment in postnatal-growth-restricted mice and can lead to changes in intestinal morphology and microbial composition.
Article
Cell Biology
Clement Philippe Delannoy, Egon Heuson, Adrien Herledan, Frederik Oger, Bryan Thiroux, Mickael Chevalier, Xavier Gromada, Laure Rolland, Philippe Froguel, Benoit Deprez, Sebastien Paul, Jean-Sebastien Annicotte
Summary: Type 2 diabetes is a metabolic disorder affecting over 537 million people worldwide, characterized by loss of pancreatic beta-cell function and insulin resistance. Long-term control of glycemia is challenging, highlighting the need for new drugs and targets to improve beta-cell function and insulin secretion. In this study, a high-throughput screening method using automated cellular assays and mass spectrometry was developed, identifying potential regulators of insulin secretion and synthesis among siRNA and chemical compounds.
Article
Cell Biology
Yasmina Kahoul, Xi Yao, Frederik Oger, Maeva Moreno, Souhila Amanzougarene, Mehdi Derhourhi, Emmanuelle Durand, Raphael Boutry, Amelie Bonnefond, Philippe Froguel, Christian Dani, Jean-Sebastien Annicotte, Christophe Breton
Summary: Human induced pluripotent stem cells (hiPSCs) have the potential to differentiate into any cell type, making them relevant for therapeutic applications. In particular, they hold promise for obesity treatment by providing an unlimited source of brown/beige adipose progenitors (hiPSC-BAPs). However, the limited differentiation potential of brown/beige adipocytes in 2D cultures poses a challenge for clinical use.
Article
Gastroenterology & Hepatology
Bart Staels, Laura Butruille, Sven Francque
Summary: The pathophysiology of non-alcoholic steatohepatitis (NASH) involves various metabolic, inflammatory, vascular, and fibrogenic pathways. Peroxisome proliferator-activated receptors (PPARs) play a significant role in regulating NASH development.
JOURNAL OF HEPATOLOGY
(2023)
Article
Virology
Peggy Bouquet, Virginie Alexandre, Marie De Lamballerie, Delphine Ley, Jean Lesage, Anne Goffard, Laurence Cocquerel
Summary: In this study, the efficacy of high hydrostatic pressure (HHP) processing and Holder pasteurization method (HoP) in inactivating surrogate virus models in donor milk were compared. It was demonstrated that HCoV-229E can be inactivated by both HHP and HoP treatment, with the 4xHP350 protocol being highly effective. However, the milk matrix has a matrix effect on HCoV-229E inactivation. HEV is stable to moderate pressure HHP treatment, but the milk matrix does not protect it from high-pressure HHP treatment.
Article
Nutrition & Dietetics
Lionel Carneiro, Lucie Marousez, Matthias Van Hul, Lea Chantal Tran, Marie De Lamballerie, Delphine Ley, Patrice D. Cani, Claude Knauf, Jean Lesage
Summary: This study demonstrates that high hydrostatic pressure processing can reinforce intestinal barrier integrity without affecting gut microbiota composition and short chain fatty acid production.
Article
Endocrinology & Metabolism
Liujun Chen, Lisha Li, Donghong Cui, Yiheng Huang, Haibin Tong, Haleh Zabihi, Shuxia Wang, Yadan Qi, Ted Lakowski, Lin Leng, Suixin Liu, Hong Wu, Lawrence H. Young, Richard Bucala, Dake Qi
Summary: Attenuation of adipose hormone sensitive lipase (HSL) may impair lipolysis and exacerbate obesity. Cytokine macrophage migration inhibitory factor (MIF) plays a role in regulating adipose HSL and adipocyte hypertrophy. Both intracellular and extracellular MIF have opposing effects on HSL, but extracellular action predominates to downregulate HSL and exacerbate obesity development during high-fat diet (HFD).
MOLECULAR METABOLISM
(2024)
Article
Endocrinology & Metabolism
Mengyang Tang, Yi Zhang, Rong Zhang, Yuemei Zhang, Jiangfei Zheng, Daixi Wang, Xinyu Wang, Jing Yan, Cheng Hu
Summary: This study aimed to explore the role of GPSM1 in POMC neurons and the underlying mechanisms in metabolic homeostasis. Through various molecular, biochemical, immunofluorescent, immunohistochemical analyses, and cell culture studies, the study revealed the pathophysiological role of GPSM1 in POMC neurons and its regulation of POMC neuron activity.
MOLECULAR METABOLISM
(2024)
