Article
Immunology
Robert Ndege, Omary Ngome, Fiona Vanobberghen, Farida Bani, Yvan Temba, Herieth Wilson, Jerry Hella, Winfrid Gingo, Mohamed Sasamalo, Dorcas Mnzava, Namvua Kimera, Hellen Hiza, John Wigayi, Herry Mapesi, Irene B. Kato, Francis Mhimbira, Klaus Reither, Manuel Battegay, Daniel H. Paris, Maja Weisser, Martin Rohacek
Summary: In this randomized two-center trial, a diagnostic algorithm including Extended Focused Assessment with Sonography for Human Immunodeficiency Virus and Tuberculosis did not increase the proportion of correctly managed patients with suspected extrapulmonary tuberculosis versus control, but increased definite tuberculosis.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Bon-Kwon Koo, Jeehoon Kang, Kyung Woo Park, Tae-Min Rhee, Han-Mo Yang, Ki-Bum Won, Seung-Woon Rha, Jang-Whan Bae, Nam Ho Lee, Seung-Ho Hur, Junghan Yoon, Tae-Ho Park, Bum Soo Kim, Sang Wook Lim, Yoon Haeng Cho, Dong Woon Jeon, Sang-Hyun Kim, Jung-Kyu Han, Eun-Seok Shin, Hyo-Soo Kim
Summary: This study compared the efficacy and safety of clopidogrel and aspirin monotherapy in patients undergoing coronary stenting during the chronic maintenance period. The findings showed that clopidogrel monotherapy was superior to aspirin in preventing adverse clinical events.
Article
Hematology
Jun Ho Jang, Lily Wong, Bor-Sheng Ko, Sung-Soo Yoon, Katie Li, Irina Baltcheva, Prasanna Kumar Nidamarthy, Raghav Chawla, Guido Junge, Eng Soo Yap
Summary: Iptacopan is a novel oral inhibitor of complement factor B under development for the treatment of PNH. This phase 2 study evaluated the efficacy and safety of iptacopan in PNH patients with active hemolysis. The results showed that iptacopan effectively reduced LDH levels, improved hemolytic markers, and rapidly increased Hb levels in most patients.
Article
Biochemistry & Molecular Biology
Adewale Oluwaseun Fadaka, Raphael Taiwo Aruleba, Nicole Remaliah Samantha Sibuyi, Ashwil Klein, Abram Madimabe Madiehe, Mervin Meyer
Summary: This study investigated the inhibitory effects of several drugs on COVID-19 using computational methods. The results showed that Lopinavir and Lamivudine had strong interactions with the virus and demonstrated high inhibitory effects. These findings are important for the search for drugs to treat COVID-19.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Review
Biochemistry & Molecular Biology
Ruxandra-Cristina Marin, Tapan Behl, Nicoleta Negrut, Simona Bungau
Summary: Management of antiretroviral therapy in HIV+ patients faces challenges in improving patient adherence by selecting appropriate treatment regimens to reduce viremia, enhance immune response, and minimize adverse reactions. The use of protease inhibitor darunavir with enzyme inhibitors cobicistat or ritonavir has shown effectiveness in reducing HIV mortality and morbidity by impacting drug interactions and pharmacokinetics.
Article
Pharmacology & Pharmacy
Catia Marzolini, Matthias L. Cavassini, Dominique L. Braun, Anna Hachfeld, Enos Bernasconi, Alexandra Calmy, Patrick Schmid, Manuel Battegay, Luigia Elzi
Summary: This study aimed to investigate whether a common single polymorphism could explain the phenomenon of some HIV patients not achieving their lipid targets despite elevated statin concentrations. The study found that individuals carrying the SLCO1B1 c.521T>C polymorphism had smaller changes in lipid levels after statin initiation compared to those without this polymorphism.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Michael D. Scholle, Patrick T. O'Kane, Sandra Dib, Zachary A. Gurard-Levin
Summary: This study describes a duplexed biochemical assay that can efficiently screen potential drugs against COVID-19. The results provide insights into the structural features required for inhibiting the activity of 3CLpro and guide the development of optimized antiviral compounds.
ANTIVIRAL RESEARCH
(2022)
Article
Medicine, General & Internal
Sarah Dunn, Victoria Brocklebank, Andrew Bryant, Sonya Carnell, Thomas J. Chadwick, Sally Johnson, David Kavanagh, Jan Lecouturier, Michal Malina, Eoin Moloney, Yemi Oluboyede, Christopher Weetman, Edwin Kwan Soon Wong, Len Woodward, Neil Sheerin
Summary: This study aims to investigate the safety of stopping eculizumab treatment in patients with atypical haemolytic uraemic syndrome (aHUS) by monitoring disease activity and tracking thrombotic microangiopathy-related serious adverse events. It evaluates the effectiveness and feasibility of this treatment strategy.
Article
Oncology
Walter Heindel, Stefanie Weigel, Joachim Gerss, Hans-Werner Hense, Alexander Sommer, Miriam Krischke, Laura Kerschke
Summary: Digital breast tomosynthesis plus s2D mammography showed a significantly higher detection rate for invasive breast cancer compared to digital mammography alone.
Article
Infectious Diseases
Olivia Peuchant, Edouard Lhomme, Pervenche Martinet, Anne Grob, Dounia Baita, Claire Bernier, Sophie Anne Gibaud, Isabelle Le Hen, Erwan Le Naour, Nathalie Trignol-Viguier, Philippe Lanotte, Philippe Lefebvre, Anne Vachee, Thomas Girard, Julien Loubinoux, Cecile Bebear, Bellabes Ghezzoul, Caroline Roussillon, Marion Kret, Bertille de Barbeyrac
Summary: The study compared the treatment efficacy of a single dose of azithromycin with a 7-day course of doxycycline for anorectal Chlamydia trachomatis infection in women with concurrent vaginal infection. The microbiological anorectal cure rate was significantly lower in women who received azithromycin compared to those who received doxycycline, suggesting that doxycycline should be the first-line therapy for C trachomatis infection in women.
LANCET INFECTIOUS DISEASES
(2022)
Article
Endocrinology & Metabolism
Sae Jeong Yang, Kyung Wan Min, Sandeep Kumar Gupta, Joong Yeol Park, Vyankatesh K. Shivane, Pankaj Kumar Agarwal, Doo Man Kim, Yong Esong Kim, Sei Hyun Baik
Summary: The extension study evaluated the long-term efficacy and safety of gemigliptin 50 mg in patients with type 2 diabetes mellitus. Results showed a significant reduction in HbA1c levels and overall safety and tolerability up to 52 weeks, highlighting the positive effects of gemigliptin in managing T2DM.
DIABETES & METABOLISM JOURNAL
(2021)
Article
Medicine, General & Internal
David M. Gershenson, Austin Miller, William E. Brady, James Paul, Karen Carty, William Rodgers, David Millan, Robert L. Coleman, Kathleen N. Moore, Susana Banerjee, Kate Connolly, Angeles Alvarez Secord, David M. O'Malley, Oliver Dorigo, Stephanie Gaillard, Hani Gabra, Brian Slomovitz, Parviz Hanjani, John Farley, Michael Churchman, Ailith Ewing, Robert L. Hollis, C. Simon Herrington, Helen Q. Huang, Lari Wenzel, Charlie Gourley
Summary: The MEK inhibitor trametinib shows superiority over standard of care in improving progression-free survival in patients with recurrent low-grade serous carcinoma.
Article
Endocrinology & Metabolism
Bin Gao, Weiguo Gao, Hailong Wan, Fengmei Xu, Rong Zhou, Xia Zhang, Qiuhe Ji
Summary: This study demonstrated the noninferiority of alogliptin to acarbose in terms of antidiabetic efficacy in Chinese patients with high cardiovascular risk. Alogliptin showed comparable glycemic control to acarbose but had better gastrointestinal tolerability.
DIABETES OBESITY & METABOLISM
(2022)
Article
Oncology
Jiyun Lee, Jiae Koh, Hee Kyung Kim, Sungsoo Hong, Kyunga Kim, Sehhoon Park, Hyun Ae Jung, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Myung-Ju Ahn
Summary: The combination of bevacizumab and atezolizumab in patients with metastatic NSCLC who experienced disease progression after atezolizumab monotherapy showed promising antitumor activity with good tolerability.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Oncology
Matthias Fischer, Lucas Moreno, David S. Ziegler, Lynley Marshall, C. Michel Zwaan, Meredith S. Irwin, Michela Casanova, Constantino Sabado, Beate Wulff, Mario Stegert, Luojun Wang, Felipe K. Hurtado, Fabrice Branle, Birgit Geoerger, Johannes H. Schulte
Summary: This study investigated the safety, pharmacokinetics, and efficacy of ceritinib in paediatric patients with ALK-positive malignancies. Results showed that the recommended dose for paediatric patients with ALK-positive malignancies is 500 mg/m(2) of ceritinib, which demonstrated promising antitumor activity.
Article
Public, Environmental & Occupational Health
Fabio Mauri, Sara Cottler-Casanova, Matthias Cavassini, Marcel Stoeckle, Gilles Wandeler, Patrick Schmid, Dominique L. Braun, Alexandra Scherrer, Enos Bernasconi, Alexandra Calmy, Jasmine Abdulcadir
Summary: FGM/C is a harmful practice that involves injury to the female genitalia without medical purpose, and it is prevalent worldwide. There is a lack of knowledge on how to care for women with FGM/C, and improvements in care and prevention are needed.
JOURNAL OF IMMIGRANT AND MINORITY HEALTH
(2023)
Article
Immunology
Fanny Blondet, Vanessa Kraege, Matthias Cavassini, Jose Damas Fernandez, Peter Vollenweider, Gilles Wandeler, Matthias Hoffman, Alexandra Calmy, Marcel Stoeckle, Enos Bernasconi, Barbara Hasse, Pedro Marques-Vidal, Marie Mean, Swiss HIV Cohort Study
Summary: This study suggests that conventional diabetes risk scores have promising performance in people with HIV, especially for Balkau and FINDRISC2, which showed good discriminatory power. These scores may help identify patients at a low risk of type 2 diabetes, sparing the need for careful assessment of modifiable risk factors.
Article
Immunology
Anna Hachfeld, Andrew Atkinson, Petra Stute, Alexandra Calmy, Philip E. Tarr, Katharine E. A. Darling, Baharak Babouee Flury, Christian Polli, Leila Sultan-Beyer, Irene A. Abela, Karoline Aebi-Popp
Summary: The study found that the increased rates of depression and psychiatric care during the transition through menopause do not lead to lower levels of treatment adherence or viral suppression in women living with HIV in Switzerland.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2023)
Article
Infectious Diseases
Suraj Balakrishna, Tom Loosli, Maryam Zaheri, Paul Frischknecht, Michael Huber, Katharina Kusejko, Sabine Yerly, Karoline Leuzinger, Matthieu Perreau, Alban Ramette, Chris Wymant, Christophe Fraser, Paul Kellam, Astrid Gall, Hans H. Hirsch, Marcel Stoeckle, Andri Rauch, Matthias Cavassini, Enos Bernasconi, Julia Notter, Alexandra Calmy, Huldrych F. Gunthard, Karin J. Metzner, Roger D. Kouyos
Summary: This study compared the reliability of Sanger sequencing and Next-generation sequencing (NGS) in detecting HIV drug resistance mutations (DRMs). The results showed good agreement between the two methods when detecting mutations at a threshold of 5% or higher. However, at lower thresholds, NGS detected a substantial number of low-frequency mutations, which were likely to be sequencing errors.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Immunology
Marco Labarile, Tom Loosli, Marius Zeeb, Katharina Kusejko, Michael Huber, Hans H. Hirsch, Matthieu Perreau, Alban Ramette, Sabine Yerly, Matthias Cavassini, Manuel Battegay, Andri Rauch, Alexandra Calmy, Julia Notter, Enos Bernasconi, Christoph Fux, Huldrych F. Gunthard, Chloe Pasin, Roger D. Kouyos
Summary: This study investigated and predicted the dynamics of HIV transmission in Switzerland using a network-based clustering method and statistical learning approaches. The study found that network characteristics can capture major heterogeneities in transmission and that cluster structure has the potential for real-time prediction of ongoing transmission.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Virology
Marie-Laure Chaix, Nicolas Leturque, Audrey Gabassi, Isabelle Charreau, Marine Minier, Gilles Pialoux, Eric Cua, Christian Chidiac, Francois Raffi, Cecile Tremblay, Laurence Meyer, Jean-Michel Molina, Constance Delaugerre
Summary: The seroprevalence and incidence of hepatitis E virus (HEV) infection were investigated in 416 men who have sex with men (MSM). Older age was the only factor associated with testing seropositive for HEV. Factors such as geographical origin, use of recreational drugs, number of sexual partners, and other sexually transmitted infections were not associated. Among the HEV-seronegative patients, 9 individuals seroconverted during the follow-up period.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Article
Immunology
Johannes M. Schwenke, Christian W. Thorball, Isabella C. Schoepf, Lene Ryom, Barbara Hasse, Olivier Lamy, Alexandra Calmy, Gilles Wandeler, Catia Marzolini, Christian R. Kahlert, Enos Bernasconi, Roger D. Kouyos, Huldrych F. Gunthard, Bruno Ledergerber, Jacques Fellay, Felix Burkhalter, Philip E. Tarr, Swiss HIV Cohort Study
Summary: Individual polygenic risk score is associated with osteoporosis in people living with HIV, even after adjusting for traditional and HIV-related risk factors. This study highlights the importance of a polygenic risk score in predicting low bone mineral density in HIV patients.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Editorial Material
Medicine, General & Internal
Antoine Flahault, Alexandra Calmy, Dominique Costagliola, Oxana Drapkina, Isabella Eckerle, Heidi J. Larson, Helena Legido-Quigley, Catherine Noakes, Michel Kazatchkine, Hans Kluge
Article
Medicine, General & Internal
Oriol Mitja, Andrea Alemany, Michael Marks, Jezer I. Lezama Mora, Juan Carlos Rodriguez-Aldama, Mayara Secco Torres Silva, Ever Arturo Corral Herrera, Brenda Crabtree-Ramirez, Jose Luis Blanco, Nicolo Girometti, Valentina Mazzotta, Aniruddha Hazra, Macarena Silva, Juan Jose Montenegro-Idrogo, Kelly Gebo, Jade Ghosn, Maria Fernanda Pena Vazquez, Eduardo Matos Prado, Uche Unigwe, Judit Villar-Garcia, Noah Wald-Dickler, Jason Zucker, Roger Paredes, Alexandra Calmy, Laura Waters, Cristina Galvan-Casas, Sharon Walmsley, Chloe M. Orkin
Summary: In the 2022 multicountry mpox outbreak, 38-50% of those affected were people living with HIV. Clinical outcomes and mortality were worse in people with more advanced HIV.
Letter
Hematology
Olivier Pantet, Christophe Combescure, Zied Ltaief, Lucia Mazzolai, Severin Jeanneret, Sara Manzocchi-Besson, Hans Stricker, Sara Cereghetti, Jerome Pugin, Alexandra Calmy, Christophe Marti, Helia Robert-Ebadi, Pierre Fontana, Marc Righini, Alessandro Casini, Marc Blondon
THROMBOSIS RESEARCH
(2023)
News Item
Virology
Sabrina Kali, Josephine Bourner, Alexandra Calmy, Cedric Laouenan, Laura Merson, Minerva Cervantes-Gonzalez, Amanda Rojek, Elise Pesonel, Laetitia Guiraud, Coralie Tardivon, Diane Descamps, Alpha Diallo, Severine Gibowski, Eric Rosenthal, Ventzislava Petrov-Sanchez, Sophie Letrou, Isabelle Hoffmann, Soizic Le Mestre, France Mentre, Yazdan Yazdanpanah, Piero Olliaro, Francois-Xavier Lescure
Article
Infectious Diseases
Bashkim Jaha, Corinne D. Schenkel, Lisa Jorimann, Michael Huber, Maryam Zaheri, Kathrin Neumann, Christine Leemann, Alexandra Calmy, Matthias Cavassini, Roger D. Kouyos, Huldrych F. Gunthard, Karin J. Metzner, Swiss HIV Cohort Study
Summary: A new method was used to analyze HIV-1 DNA, including the detection of drug resistance. The results showed varying levels of drug resistance mutations, which were associated with the duration of antiretroviral therapy.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Letter
Biochemistry & Molecular Biology
Erica Telford, Beatriz Grinsztejn, Inge Christoffer Olsen, Nicolas Pulik, France Mentre, Skerdi Haviari, Maxime Hentzien, Olivier Segeral, Miquel B. Ekkelenkamp, Dimie Ogoina, Nathalie Strub-Wourgaft, Alpha Diallo, Yazdan Yazdanpanah, Alexandra Calmy
Article
Virology
Martine Peeters, Maeliss Champagne, Innocent Ndong Bass, Souana Goumou, Simon-Pierre Ndimbo Kumugo, Audrey Lacroix, Amandine Esteban, Dowbiss Meta Djomsi, Abdoul Karim Soumah, Placide Mbala Kingebeni, Flaubert Auguste Mba Djonzo, Guy Lempu, Guillaume Thaurignac, Eitel Mpoudi Ngole, Charles Kouanfack, Daniel Mukadi Bamuleka, Jacques Likofata, Jean-Jacques Muyembe Tamfum, Helene De Nys, Julien Capelle, Abdoulaye Toure, Eric Delaporte, Alpha Kabinet Keita, Steve Ahuka Mundeke, Ahidjo Ayouba
Summary: The seroprevalence of orthoebolaviruses was studied in bats from Cameroon, the Democratic Republic of Congo, and Guinea. The results showed that frugivorous bats had a higher seroprevalence compared to insectivorous bats. Gender and age had a minor impact on seroprevalence, but subadult bats had a higher seroprevalence. Further research is needed to determine the birthing pulses of bats and to detect viral RNA in order to understand the genetic diversity of filoviruses in bats and their potential pathogenicity to humans.
Article
Critical Care Medicine
Marius Troseid, Jose R. Arribas, Lambert Assoumou, Aleksander Rygh Holten, Julien Poissy, Vida Terzic, Fulvia Mazzaferri, Jesus Rodriguez Bano, Joe Eustace, Maya Hites, Michael Joannidis, Jose-Artur Paiva, Jean Reuter, Isabel Puentmann, Thale D. J. H. Patrick-Brown, Elin Westerheim, Katerina Nezvalova-Henriksen, Lydie Beniguel, Tuva Borresdatter Dahl, Maude Bouscambert, Monika Halanova, Zoltan Peterfi, Sotirios Tsiodras, Michael Rezek, Matthias Briel, Serhat Unal, Martin Schlegel, Florence Ader, Karine Lacombe, Cecilie Delphin Amdal, Serge Rodrigues, Kristian Tonby, Alexandre Gaudet, Lars Heggelund, Joy Mootien, Asgeir Johannessen, Jannicke Horjen Moller, Beatriz Diaz Pollan, Anders Aune Tveita, Anders Benjamin Kildal, Jean-Christophe Richard, Olav Dalgard, Victoria Charlotte Simensen, Aliou Balde, Lucie de Gastines, Marta del Alamo, Burc Aydin, Fridtjof Lund-Johansen, Mary-Anne Trabaud, Alpha Diallo, Bente Halvorsen, John-Arne Rottingen, Evelina Tacconelli, Yazdan Yazdanpanah, Inge C. Olsen, Dominique Costagliola
Summary: The study conducted a placebo-controlled trial of baricitinib in severe/critical COVID cases. The results showed that baricitinib did not reduce mortality within 60 days, and there may be safety risks in vaccinated participants, which require further investigation.