Article
Medicine, Research & Experimental
Jian Li, Lijun Yan, Jianghan Luo, Li Tong, Yuan Gao, Wei Feng, Fuling Wang, Wenyu Cui, Siming Li, Zhiwei Sun
Summary: This study identifies MAP4K3 protein kinase as an important regulator in the development and treatment of non-small cell lung carcinoma (NSCLC). Baicalein, a natural product, is shown to induce autophagy in NSCLC cells by degrading MAP4K3, providing a potential therapeutic target for NSCLC treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pathology
Firoozeh Abolhasani Zadeh, Ahmed Raji, Sana Abdul-Jabbar Ali, Walid Kamal Abdelbasset, Natalia Alekhina, A. Heri Iswanto, Ermias Mergia Terefe, Abduladheem Turki Jalil
Summary: This study provides an overview of the complexity of autophagy in response to chemoradiotherapy in lung cancer. It highlights the dual role of autophagy in both sensitizing cancer cells to therapy and promoting their survival.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Review
Biochemistry & Molecular Biology
Aaron C. Tan, Nick Pavlakis
Summary: The management of advanced lung cancer has been transformed by the identification of targetable oncogenic driver alterations, including ALK gene rearrangements. ALK tyrosine kinase inhibitors have become the first-line treatment options for advanced ALK rearranged NSCLC. However, drug resistance remains a challenge, and the role of anti-angiogenic therapy in ALK rearranged NSCLC needs further exploration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Jerome Levallet, Tiphaine Biojout, Celine Bazille, Manon Douyere, Fatemeh Dubois, Dimitri Leite Ferreira, Jasmine Taylor, Sylvain Teulier, Jerome Toutain, Nicolas Elie, Myriam Bernaudin, Samuel Valable, Emmanuel Bergot, Guenaelle Levallet
Summary: The over-activation of NDR2 kinase under hypoxia conditions promotes brain metastasis formation in NSCLC. NDR2 expression serves as a reliable indicator for predicting the risk of metastasis in NSCLC patients.
CELL DEATH & DISEASE
(2023)
Article
Pharmacology & Pharmacy
Hong Liu, Run He, Xuliang Yang, Bo Huang, Hongxiang Liu
Summary: This study aimed to elucidate the regulatory mechanism of transcription factor 21 (TCF21) on the immunosuppressive effect of tumor-associated macrophages (TAM) in non-small cell lung cancer (NSCLC). The experimental results showed that overexpression of TCF21 promoted the polarization of TAM into an immunostimulatory state and enhanced the viability of T cells. Additionally, there may be a targeting relationship between TCF21 and Notch.
Article
Multidisciplinary Sciences
Kentaro Jingushi, Masaya Aoki, Kazuhiro Ueda, Takahiro Kogaki, Masaya Tanimoto, Yuya Monoe, Masayuki Ando, Takuya Matsumoto, Kentaro Minami, Yuko Ueda, Kaori Kitae, Hiroaki Hase, Toshiyuki Nagata, Aya Harada-Takeda, Masatatsu Yamamoto, Kohichi Kawahara, Kazuhiro Tabata, Tatsuhiko Furukawa, Masami Sato, Kazutake Tsujikawa
Summary: The study reveals that high expression of ALKBH4 is associated with the progression of non-small-cell lung cancer, and knockdown of ALKBH4 can inhibit cancer cell proliferation and affect cell cycle and E2F1 expression. Patients with high ALKBH4 expression have a poor prognosis, indicating that ALKBH4 plays a crucial tumour-promoting role in NSCLC.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Medicinal
Fan-Fan Shang, Qing Lu, Tailiang Lin, Miaoxia Pu, Ruoxuan Xiao, Wanmei Liu, Hao Deng, Hongyan Guo, Zhe-Shan Quan, Chunyong Ding, Qing-Kun Shen
Summary: The 2-OH- and 16-OH-modified CuB derivative A11 showed potent antiproliferative activity against A549 lung cancer cells, with a much wider therapeutic window than CuB. A11 directly bound to IGF2BP1 protein, leading to decreased expression of apoptosis- and cell cycle-related proteins. In an A549 xenograft mouse model, A11 exhibited superior anticancer efficacy and in vivo safety profile compared to CuB.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Cell Biology
Tong Zhou, Yong-Hua Sang, Shang Cai, Chun Xu, Min-hua Shi
Summary: POLRMT is overexpressed in NSCLC and plays a crucial role in cell proliferation, migration, and apoptosis. Silencing or knockout of POLRMT inhibits NSCLC cell growth, while overexpression of POLRMT enhances cell proliferation and migration. Regulation of mtDNA content, mRNA levels of mitochondrial transcripts, and respiratory chain complex subunits contribute to the growth of NSCLC.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Ciara Murphy, Gloria Gornes Pons, Anna Keogh, Lisa Ryan, Lorraine Mccarra, Chris Maria Jose, Shagun Kesar, Siobhan Nicholson, Gerard J. Fitzmaurice, Ronan Ryan, Vincent Young, Sinead Cuffe, Stephen P. Finn, Steven G. Gray
Summary: This study investigated the expression and potential clinical utility of JADE2 in non-small cell lung cancer (NSCLC). The results showed that JADE2 expression is significantly altered in NSCLC and high expression of JADE2 is associated with better overall survival. The study also identified associations between JADE2 expression and tumor mutational burden and immune cell infiltration, as well as potential new drugs targeting JADE2. Overall, JADE2 may have potential diagnostic, prognostic, and therapeutic implications in NSCLC.
Article
Biotechnology & Applied Microbiology
Dong Cui, Yu Feng, Rulin Qian
Summary: The research indicates that miR-101-3p can enhance the sensitivity of NSCLC cells to cisplatin by regulating autophagy mediated by ATG4D, which has the potential to be a therapeutic target for NSCLC treatment.
Article
Biochemistry & Molecular Biology
Yuening Sun, Peng Lin, Xiumin Zhou, Ying Ren, Yuanming He, Jingpei Liang, Zhigang Zhu, Xiaofeng Xu, Xinliang Mao
Summary: The transcription factor PBX1 is downregulated in non-small cell lung cancer (NSCLC) and inhibits NSCLC cell proliferation and migration. TRIM26, as a ubiquitin ligase, binds to PBX1 and mediates its degradation. TRIM26 further promotes NSCLC growth by inhibiting PBX1 transcriptional activity and downregulating its downstream genes. Therefore, TRIM26 might be a potential therapeutic target for NSCLC treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Cell Biology
Patricia Gonzalez-Rodriguez, Mathilde Cheray, Jens Fullgrabe, Maria Salli, Pinelopi Engskog-Vlachos, Lily Keane, Virginia Cunha, Agata Lupa, Wenbo Li, Qi Ma, Kristian Dreij, Michael G. Rosenfeld, Bertrand Joseph
Summary: Autophagy is a catabolic pathway that maintains cellular homeostasis and can be stimulated under cellular stress. The persistent downregulation of MAP1LC3 expression upon autophagy induction indicates an epigenetic memory of autophagy, offering insights into its long-term effects.
Article
Chemistry, Multidisciplinary
Agnieszka Maria Jelen, Bartlomiej Strehl, Dagmara Szmajda-Krygier, Milena Pazik, Ewa Balcerczak
Summary: P-glycoprotein (P-gp) plays a role in lung cancer development, progression, and patient survival. Changes in ABCB1 expression level may be related to tumorigenesis and multidrug resistance (MDR). Epigenetic modifications, such as DNA methylation, also regulate the gene's activity. Our analysis found downregulated ABCB1 expression and associated methylation changes in lung cancer cells, with variations based on age, gender, ethnicity, and smoking cessation. Decreased transcript levels were linked to advanced cancer stage and lower survival probability. Notably, ABCB1 expression changes were often unique to specific tumor subtypes. Methylation promoter was identified as a cause of decreased gene expression in lung cancer cells. These findings establish ABCB1 as an important prognostic factor in lung cancer.
APPLIED SCIENCES-BASEL
(2023)
Article
Multidisciplinary Sciences
Guozhen Gao, Simone Hausmann, Natasha M. Flores, Ana Morales Benitez, Jianjun Shen, Xiaojie Yang, Maria D. Person, Sitaram Gayatri, Donghang Cheng, Yue Lu, Bin Liu, Pawel K. Mazur, Mark T. Bedford
Summary: CARM1 promotes transcription by modifying histones and chromatin bound proteins, and NFIB utilizes CARM1 as a coactivator. In small cell lung cancer, both CARM1 and methylated NFIB are critical for rapid tumor growth.
NATURE COMMUNICATIONS
(2023)
Review
Immunology
Li-Chung Chiu, Shu-Min Lin, Yu-Lun Lo, Scott Chih-Hsi Kuo, Cheng-Ta Yang, Ping-Chih Hsu
Summary: Early-stage NSCLC patients face high risks of recurrence and death even after surgery, with limited improvements from traditional treatments like chemotherapy and radiation. Immunotherapies, including immune checkpoint inhibitors and cancer vaccination, have shown potential in improving survival rates and are being actively researched in clinical trials.
Article
Oncology
Liusheng Wu, Yuzhen Zheng, Xin Ruan, Dingwang Wu, Pengcheng Xu, Jixian Liu, Da Wu, Xiaoqiang Li
Summary: This study aimed to construct a prognostic model of autophagy-related long-chain noncoding ribonucleic acids and identify potential therapeutic targets for esophageal adenocarcinoma. The findings indicate that autophagy-related long-chain noncoding ribonucleic acids might affect tumor development and prognosis in esophageal adenocarcinoma patients.
Article
Cell Biology
Jixian Liu, Ruixing Luo, Junbin Wang, Xinyu Luan, Da Wu, Hua Chen, Qinghua Hou, Guangxian Mao, Xiaoqiang Li
Summary: The study identified that tumor cell-derived exosomal miR-770 inhibited M2 macrophage polarization via targeting MAP3K1, thus suppressing the invasion and growth of NSCLC cells. This provides a new strategy for the treatment of NSCLC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Jianxing He, Hengrui Liang, Wei Wang, Andrey Akopov, Alberto Aiolfi, Keng-Leong Ang, Luca Bertolaccini, Kaican Cai, Qingdong Cao, Baojun Chen, Chang Chen, Chun Chen, Donglai Chen, Fengxia Chen, Jun Chen, Lei Chen, Mingwu Chen, Yongbing Chen, Zhuxing Chen, Chao Cheng, Dong Cui, Fei Cui, Tianyang Dai, Qinglong Dong, Paolo A. Ferrari, Raja M. Flores, Junke Fu, Soichiro Funaki, Marios E. Froudarakis, Xiangfeng Gan, Mingfei Geng, Jialong Guo, Qiang Guo, Yongtao Han, Jintao He, Kaiming He, Kyoji Hirai, Jian Hu, Shuqiao Hu, Jian Huang, Jun Huang, Wenfa Jiang, Kyung Soo Kim, Gabor Kiss, Fanyi Kong, Lan Lan, Xuefeng Leng, Bin Li, Gaofeng Li, Hecheng Li, Hefei Li, Heng Li, Jiwei Li, Xiaoqiang Li, Shuben Li, Yinfen Li, Zhuoyi Li, Yi Liang, Lixia Liang, Wenhua Liang, Yongde Liao, Wanli Lin, Xu Lin, Hongxu Liu, Hui Liu, Jixian Liu, Jun Liu, Xiang Liu, Zihao Liu, Xingzhao Lu, Qingquan Luo, Naiquan Mao, Qi Pan, Dazhi Pang, Jun Peng, Jun Peng, Eugenio Pompeo, Rulin Qian, Kun Qiao, Bassam Redwan, Zi Sang, Wenlong Shao, Jianfei Shen, Weiyu Shen, Sook-Whan Sung, Wenfang Tang, Tianhu Wang, Guangsuo Wang, Haitao Wang, Huien Wang, Jiyong Wang, Wen Wang, Yongyong Wang, Zhenyuan Wang, Li Wei, Wei Wei, Hao Wu, Jie Wu, Zhaohua Xia, Chenyang Xu, Enwu Xu, Hai Xu, Ning Xu, Quan Xu, Rongyu Xu, Shun Xu, Chaokun Yang, Hanyu Yang, Shengli Yang, Jun Yi, Guangjian Zhang, Hao Zhang, Jia Zhang, Man Zhang, Xiao Zhang, Yajie Zhang, Zhe Zhang, Zhifeng Zhang, Honglin Zhao, Jian Zhao, Xiaodong Zhao, Jianping Zhou, Yanran Zhou, Chengchu Zhu, Shaojin Zhu, Xinhai Zhu, Jian Cui, Yubo Yan, Ke-Neng Chen
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Environmental Sciences
Qingqing Cheng, Xiaodong Lai, Yuqing Liu, Zhijiang Yang, Jixian Liu
Summary: Green credit has a positive impact on the upgrading of China's industrial structure, especially in promoting the greenization and advancement of industrial structure. However, the effects of green credit on the regional level are more complex.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Tian Hao, Yao Wang, Zhipeng Liu, Jie Li, Liangang Shan, Wenchao Wang, Jixian Liu, Jianguo Tang
Summary: Research on nano-modification of polyester using silica nanoparticles has shown great potential in improving crystalline properties, enhancing strength, and fabricating fluorescent polyester. The focus is on synthesis approaches for silica modifiers, surface modification methods, and processing techniques of silica-polyester nanocomposites to enhance the properties of composite materials. This work aims to provide guidance for researchers working in the fields of silica nanoparticles and modifying polyester.
Article
Oncology
Qinghua Hou, Yanfeng Zhong, Linzhuang Liu, Liusheng Wu, Jixian Liu
Summary: This study constructed a prognostic model based on m6A-related lncRNAs for predicting the prognosis of lung adenocarcinoma (LUAD) patients and screened potential therapeutic drugs. The results showed that the prognostic model could effectively predict the survival rate of LUAD patients, and the screened drugs had potential clinical application value.
Article
Materials Science, Multidisciplinary
Tian Hao, Yao Wang, Miaorong Zhang, Zhipeng Liu, Jixian Liu, Linjun Huang, Jie Li, Yao Peng, Jianguo Tang
Summary: The graphene oxide-silica (GO-SiO2) nanoparticles were grafted with block polymers PEG and LPET to prepare the additive GS-IPTES plus PEG-LPET (GSIP). The addition of small amounts of GSIP dramatically enhanced the crystallization and mechanical properties of the PET/GSIP composite. The improvements in properties were attributed to the synergistic effects of GS and block polymer chains.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Article
Oncology
Liusheng Wu, Yanfeng Zhong, Xiaoya Yu, Dingwang Wu, Pengcheng Xu, Le Lv, Xin Ruan, Qi Liu, Yu Feng, Jixian Liu, Xiaoqiang Li
Summary: This study aimed to investigate the application value of selective polyadenylation in lung adenocarcinoma (LUAD), particularly in immune cell infiltration, biological transcription function, and survival prognosis. The research analyzed mRNA expression data and immune cell content from LUAD patients to construct a LUAD risk score prognostic model. The study found that the immune score significantly affected the prognosis of LUAD patients, and identified specific immune cell types and immunosuppressor genes correlated with the risk score. The findings highlight the importance of selective polyadenylation in LUAD development, immune invasion, and survival prognosis.
Article
Biotechnology & Applied Microbiology
Chao Chen, Haozhen Liu, Qumiao Xu, Xiuqing Zhang, Feng Mu, Jixian Liu
Summary: PTPRT gene is associated with cancer metastasis, and its mutation is correlated with poor prognosis, serving as a potential biomarker for cancer metastasis.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Liusheng Wu, Yanfeng Zhong, Dingwang Wu, Pengcheng Xu, Xin Ruan, Jun Yan, Jixian Liu, Xiaoqiang Li
Summary: By using multi-omics research methods, we identified key genes related to cytolytic activity in lung adenocarcinoma, and found that the expression of these genes is affected by the immunoregulatory factor HAVCR2 (TIM3). These findings highlight the significance of HAVCR2 in the survival and prognosis of lung adenocarcinoma patients.
Article
Respiratory System
Junbin Wang, Jixian Liu, Qinghua Hou, Mengmeng Xu
Summary: This study found that LINC02126 is significantly downregulated in lung adenocarcinoma and has significant expression differences in certain clinical variables. In the low LINC02126 expression group, the infiltration degree of immune cells is significantly lower compared to the high expression group. Additionally, the tumor mutation burden level and somatic mutation frequency are significantly higher in the low expression group.
BMC PULMONARY MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jie Li, Yao Wang, Liangang Shan, Lei Qian, Wenchao Wang, Jixian Liu, Jianguo Tang
Summary: In this study, a general protocol for synthesizing thiolated folate derivatives was reported. The high purity S-S-containing diol was synthesized through a newly developed green oxidation protocol without catalyst, and it was then used to modify folic acid through esterification to synthesize thiolated folate. The effectiveness of this method was demonstrated by the successful modification of silver nanoparticles using thiolated folate.
Article
Biochemistry & Molecular Biology
Liusheng Wu, Qi Liu, Xin Ruan, Xinyu Luan, Yanfeng Zhong, Jixian Liu, Jun Yan, Xiaoqiang Li
Summary: The RNA-binding protein RBM10 is highly expressed in lung adenocarcinoma and is involved in immune regulation, affecting immune cell numbers and tumor sensitivity. RBM10 inhibits the proliferation and invasion of lung adenocarcinoma cells through negative regulation and promotes apoptosis through immunomodulatory mechanisms.
Review
Chemistry, Multidisciplinary
Jinqi Wang, Zhiheng Wang, Wei Wang, Yao Wang, Xiaoli Hu, Jixian Liu, Xuezhong Gong, Wenli Miao, Linliang Ding, Xinbo Li, Jianguo Tang
Summary: This article mainly discusses the aspects of TiO2-modified nanoparticles including synthetic methods, modifications, and applications, which are of great significance for improving the performance of TiO2.
Article
Nanoscience & Nanotechnology
Zhihuan Zhao, Yao Wang, Haoyang Jiang, Jixian Liu, Linjun Huang, Yanna Zhang, Yanqi Wang, Laurence A. Belfiore, Jianguo Tang
Summary: Inorganic/polymer hybrid hydrogels with stable luminescence, especially those coordinated with RE (Eu3+) complex, exhibit excellent mechanical properties and long luminescence lifetime, showing great potential in soft material applications.
SCIENCE OF ADVANCED MATERIALS
(2021)
