CCN5/WISP2 and metabolic diseases

Therapeutic potential of mesenchymal stem cells for diabetes

(2017) Alvaro Moreira et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Concise Review: Mending a Broken Heart: The Evolution of Biological Therapeutics

(2017) Caressa Chen et al.   STEM CELLS

Concise Review: Mesenchymal Stem Cells in Neurodegenerative Diseases

(2017) Rotem Volkman et al.   STEM CELLS

BMP4 Gene Therapy in Mature Mice Reduces BAT Activation but Protects from Obesity by Browning Subcutaneous Adipose Tissue

(2017) Jenny M. Hoffmann et al.   Cell Reports

Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance

(2017) John R. Grünberg et al.   Scientific Reports

Matricellular Protein CCN5 Reverses Established Cardiac Fibrosis

(2016) Dongtak Jeong et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Emerging roles of CCN proteins in vascular development and pathology

(2016) Philip A. Klenotic et al.   Journal of Cell Communication and Signaling

CCN2 and CCN5 exerts opposing effect on fibroblast proliferation and transdifferentiation induced by TGF-β

(2015) Honghai Xu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

CCN5 attenuates profibrotic phenotypes of fibroblasts through the Smad6-CCN2 pathway: Potential role in epidural fibrosis

(2015) HONGHAI XU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Mesenchymal stem cells for the management of inflammation in osteoarthritis: state of the art and perspectives

(2015) Y.-M. Pers et al.   OSTEOARTHRITIS AND CARTILAGE

Longitudinal muscle gene expression patterns associated with differential intramuscular fat in cattle

(2014) N. J. Hudson et al.   Animal

[Br]eaking FAt

(2014) Siegfried Ussar et al.   CELL

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

(2014) Mark M. Yore et al.   CELL

IGF-I Stimulates CCN5/WISP2 Gene Expression in Pancreatic β-Cells, Which Promotes Cell Proliferation and Survival Against Streptozotocin

(2014) Subrata Chowdhury et al.   ENDOCRINOLOGY

The Novel Secreted Adipokine WNT1-inducible Signaling Pathway Protein 2 (WISP2) Is a Mesenchymal Cell Activator of Canonical WNT

(2014) John R. Grünberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Adipogenesis of Human Adipose-Derived Stem Cells on Polycaprolactone Fiber Matrices

(2014) Cecilia Brännmark et al.   PLoS One

The matricellular protein CCN5 regulates podosome function via interaction with integrin αvβ3

(2014) Ronald B. Myers et al.   Journal of Cell Communication and Signaling

Distinction of white, beige and brown adipocytes derived from mesenchymal stem cells

(2014) Anna Park   World Journal of Stem Cells

CCN5 overexpression inhibits profibrotic phenotypes via the PI3K/Akt signaling pathway in lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis and in an in vivo model of lung fibrosis

(2013) LIN ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

CTGF Mediates Smad-Dependent Transforming Growth Factor β Signaling To Regulate Mesenchymal Cell Proliferation during Palate Development

(2013) Carolina Parada et al.   MOLECULAR AND CELLULAR BIOLOGY

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Tracking adipogenesis during white adipose tissue development, expansion and regeneration

(2013) Qiong A Wang et al.   NATURE MEDICINE

WISP2 regulates preadipocyte commitment and PPAR  activation by BMP4

(2013) A. Hammarstedt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1

(2013) Shuyu Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional Control of Hepatic Lipid Metabolism by SREBP and ChREBP

(2013) Xu Xu et al.   SEMINARS IN LIVER DISEASE

CCN proteins: A centralized communication network

(2013) Bernard Perbal   Journal of Cell Communication and Signaling

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Wnt Signaling Activation in Adipose Progenitors Promotes Insulin-Independent Muscle Glucose Uptake

(2012) Daniel Zeve et al.   Cell Metabolism

The WNT Inhibitor Dickkopf 1 and Bone Morphogenetic Protein 4 Rescue Adipogenesis in Hypertrophic Obesity in Humans

(2012) Birgit Gustafson et al.   DIABETES

Interplay between Mesenchymal Stem Cells and Lymphocytes

(2012) L. Wang et al.   JOURNAL OF DENTAL RESEARCH

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism

(2012) Mark A. Herman et al.   NATURE

Ectopic Fat and Insulin Resistance: Pathophysiology and Effect of Diet and Lifestyle Interventions

(2012) M. Snel et al.   International Journal of Endocrinology

Wnt Proteins

(2012) K. Willert et al.   Cold Spring Harbor Perspectives in Biology

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

(2012) Alfiya Akhmetshina et al.   Nature Communications

Concise Review: Mesenchymal Stem Cells and Translational Medicine: Emerging Issues

(2012) Guangwen Ren et al.   Stem Cells Translational Medicine

Functional annotation of the human fat cell secretome

(2012) Ingrid Dahlman et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

CCN5/WISP-2: A micromanager of breast cancer progression

(2012) Sushanta K. Banerjee et al.   Journal of Cell Communication and Signaling

CCN5 Expression in mammals. III. Early embryonic mouse development

(2012) Ronald B. Myers et al.   Journal of Cell Communication and Signaling

Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC

(2011) Ralf Hass et al.   Cell Communication and Signaling

CCN5, a Novel Transcriptional Repressor of the Transforming Growth Factor   Signaling Pathway

(2011) M. Sabbah et al.   MOLECULAR AND CELLULAR BIOLOGY

Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets

(2011) Joon-Il Jun et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition of PI3K Prevents the Proliferation and Differentiation of Human Lung Fibroblasts into Myofibroblasts: The Role of Class I P110 Isoforms

(2011) Enrico Conte et al.   PLoS One

Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome — An allostatic perspective

(2010) Sam Virtue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Activation of Canonical Wingless-type MMTV Integration Site Family (Wnt) Signaling in Mature Adipocytes Increases β-Catenin Levels and Leads to Cell Dedifferentiation and Insulin Resistance

(2010) Birgit Gustafson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular models for understanding adipogenesis, adipose dysfunction, and obesity

(2010) Andrea Armani et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The opposing effects of CCN2 and CCN5 on the development of cardiac hypertrophy and fibrosis

(2010) Pyoung Oh Yoon et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Transcriptional control of preadipocyte determination by Zfp423

(2010) Rana K. Gupta et al.   NATURE

Lipoexpediency: de novo lipogenesis as a metabolic signal transmitter

(2010) Irfan J. Lodhi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

CCN5, a secreted protein, localizes to the nucleus

(2010) Kristina C. Wiesman et al.   Journal of Cell Communication and Signaling

Inflammation and impaired adipogenesis in hypertrophic obesity in man

(2009) Birgit Gustafson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Effect of Wnt-1 inducible signaling pathway protein-2 (WISP-2/CCN5), a downstream protein of Wnt signaling, on adipocyte differentiation

(2009) Hidekuni Inadera et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology

(2009) E. Arner et al.   DIABETES

Thiazolidinediones increase the wingless-type MMTV integration site family (WNT) inhibitor Dickkopf-1 in adipocytes: a link with osteogenesis

(2009) B. Gustafson et al.   DIABETOLOGIA

Domain-and species-specific monoclonal antibodies recognize the Von Willebrand Factor-C domain of CCN5

(2009) Lan Wei et al.   Journal of Cell Communication and Signaling

Abdominal Obesity and the Metabolic Syndrome: Contribution to Global Cardiometabolic Risk

(2008) Jean-Pierre Després et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Assessment of a Nuclear Affinity Labeling Method for Tracking Implanted Mesenchymal Stem Cells

(2008) Merced Leiker et al.   CELL TRANSPLANTATION

Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy

(2008) Massimiliano Gnecchi et al.   CIRCULATION RESEARCH

Adipogenesis and WNT signalling

(2008) Constantinos Christodoulides et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM