Article
Chemistry, Multidisciplinary
Zhu-Qi Huang, Wu Luo, Wei-Xin Li, Pan Chen, Zhe Wang, Rui-Jie Chen, Yi Wang, Wei-Jian Huang, Guang Liang
Summary: Costunolide (CTD) has anti-atherosclerotic effects by reducing inflammatory responses and oxLDL uptake, and its mechanism involves the inhibition of NF-kappa B signaling pathway through covalent binding to IKKβ.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Oncology
Paula Gonzalez-Lopez, Marta Alvarez-Villarreal, Ruben Ruiz-Simon, Andrea R. Lopez-Pastor, Melina Vega de Ceniga, Leticia Esparza, Jose L. Martin-Ventura, Oscar Escribano, Almudena Gomez-Hernandez
Summary: MicroRNAs miR-15a-5p and miR-199a-3p are significantly decreased in aortic and carotid samples from atherosclerosis patients and mice. Overexpression of these miRNAs can reduce inflammation and progression of atherosclerosis. MiR-15a-5p may serve as a novel diagnostic biomarker for advanced atherosclerosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Denuja Karunakaran, My-Anh Nguyen, Michele Geoffrion, Dianne Vreeken, Zachary Lister, Henry S. Cheng, Nicola Otte, Patricia Essebier, Hailey Wyatt, Joshua W. Kandiah, Richard Jung, Francis J. Alenghat, Ana Mompeon, Richard Lee, Calvin Pan, Emma Gordon, Adil Rasheed, Aldons J. Lusis, Peter Liu, Ljubica Perisic Matic, Ulf Hedin, Jason E. Fish, Liang Guo, Frank Kolodgie, Renu Virmani, Janine M. van Gils, Katey J. Rayner
Summary: The study indicates that RIPK1 plays a central role in driving inflammation in atherosclerosis by activating the NF-kappa B pathway and promoting the release of inflammatory cytokines. Knockdown of RIPK1 reduces inflammatory cell activation and protects against the progression of atherosclerosis. These findings suggest RIPK1 as a potential therapeutic target to reduce residual inflammation in patients at high risk of coronary artery disease.
Article
Chemistry, Medicinal
Weifeng Li, Jinjin Yu, Jinmeng Zhao, Xin Xiao, Wenqi Li, Lulu Zang, Jiabao Yu, Haijing Liu, Xiaofeng Niu
Summary: Poria cocos polysaccharides can intervene in atherosclerosis by reducing inflammatory factors and blood lipid levels.
PHYTOTHERAPY RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Shuangjin Ding, Jiankun Liu, XiaoRui Han, Wanqiu Ding, Zhirui Liu, Ying Zhu, Wenxing Zhan, Yiqi Wan, Shujie Gai, Junjie Hou, Xiaoxia Wang, Yixia Wu, Andong Wu, Chuan-Yun Li, Zhe Zheng, Xiao-Li Tian, Huiqing Cao
Summary: This study identified the key role of long noncoding RNA (lncRNA) ICR in early atherosclerosis. ICR promotes the formation of atherosclerotic plaques through regulation of the nuclear factor kappa B (NF-kappa B) signaling pathway. Inhibiting ICR could be a promising early intervention strategy for atherosclerosis.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Plant Sciences
Zheng Jin, Yuan Luo, Huanyi Zhao, Jiayan Cui, Weifeng He, Junlong Li, Jianbin Pi, Lijin Qing, Wei Wu
Summary: This study investigated the effect and mechanism of Qingre Huoxue Decoction (QRHX) on the treatment of atherosclerosis (AS) using both in vivo and in vitro experiments. The results demonstrated that QRHX induced M2 polarization of macrophages through the NF-kappa B signaling pathway, leading to reduced inflammatory response and stabilization of plaques.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuan-ru Zheng, Chun-lin Fan, Ye Chen, Jing-yu Quan, Ling-zhu Shi, Chun-yang Tian, Xiao Shang, Ni-shan Xu, Wen-cai Ye, Lin-zhong Yu, Jun-shan Liu
Summary: This study discovered that dammarane-type triterpenoid saponins from Panax notoginseng have anti-inflammatory, anti-angiogenetic, and anti-dengue virus effects. They may be developed as potential functional foods for treating inflammation, angiogenesis, and dengue-related diseases.
Article
Chemistry, Medicinal
Xinxin Zhang, Yating Qin, Weibin Ruan, Xiaoning Wan, Chao Lv, Lin He, Li Lu, Xiaomei Guo
Summary: Baicalein, a flavonoid phytochemical, demonstrates anti-inflammatory properties in macrophages, endothelial cells, and vascular smooth muscle cells by activating the AMPK/Mfn-2 axis and inhibiting MAPKs/NF-kappa B signaling transduction pathway. Baicalein effectively reduces proinflammatory cytokine levels, suggesting its potential role in atherosclerosis treatment. Further studies may be needed to fully understand the mechanisms of baicalein's anti-inflammatory effects.
PHYTOTHERAPY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Takashi Imai, Trieu-My Van, Manolis Pasparakis, Apostolos Polykratis
Summary: The canonical NF-kappa B signaling in smooth muscle cells (SMCs) plays a critical role in the development of atherosclerosis. SMC-specific ablation of NEMO, an essential subunit for NF-kappa B activation, was found to inhibit high fat diet induced atherosclerosis and reduce inflammation and plaque size in a mouse model. In vitro experiments also showed that NEMO-deficient SMCs exhibited reduced proliferation and migration in response to inflammatory stimulus.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Weiwei Zhao, Huizhen Wei, Jun Lu, Wenjun Sha, Dusang Sun, Ting Pan, Tao Lei
Summary: The study aimed to investigate the regulatory effects of tyrosol on pro-inflammatory phenotypes. The results showed that tyrosol significantly inhibited cell adhesion, reduced cell migration, and decreased the release of pro-inflammatory factors and expression levels of adhesion-related molecules. These findings suggest that tyrosol could be a novel pharmacological approach for treating inflammatory vascular diseases.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Binjie Yan, Yanan Guo, Yu Gui, Zhi-Sheng Jiang, Xi-Long Zheng
Summary: MCPIP1 is a potent regulator of innate immunity with anti-inflammatory effects, acting through its ribonuclease and deubiquitinating enzyme activities. It is expressed in immune cells and various other cell types, playing roles in regulating cardiac functions and processes of vascular diseases.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Yanyan Cen, Yalan Xiong, Rongxin Qin, Hui Tao, Qunfang Yang, Xichun Pan
Summary: In this study, it was demonstrated that anti-malarial artesunate (Art) has a dose-dependent protective effect in a rat model of atherosclerosis (AS). Art regulates arterial inflammatory responses by inhibiting the activation of the NF-kappa B - NLRP3 inflammasome pathway, thus exerting its anti-AS effects.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Min Jeong Kim, Hyun-Hee Kang, Yeung Jin Seo, Kyung-Min Kim, Young-Jun Kim, Sung Keun Jung
Summary: The study showed that Paeonia lactiflora extract and its compounds have antiatherosclerotic and antioxidant effects, inhibiting cell adhesion and inflammatory factor expression. Among them, methyl gallate demonstrated the strongest inhibitory effect on these activities.
Article
Cell Biology
Chao Zhu, Wei Chen, Haiming Cui, Zhigang Huang, Ru Ding, Na Li, Qinqin Wang, Feng Wu, Yanmin Zhao, Xiaoliang Cong
Summary: Oxidized low-density lipoprotein (ox-LDL) promotes the expression of TRIM64, enhancing the activation of NLRP3 inflammasomes and the expression of downstream molecules. TRIM64 interacts with I kappa B alpha, promoting I kappa B alpha ubiquitination to activate the NF-kappa B signaling pathway. TRIM64 and NF-kappa B form a positive feedback mechanism in the development of atherosclerosis.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Cell Biology
Xuan Li, Wanlu Xie, Qiong Pan, Xiaoxun Zhang, Liangjun Zhang, Nan Zhao, Qiaoling Xie, Jingjing Ding, Jin Chai
Summary: This study found that both SEMA7A mutation and overexpression can activate the NF-κB p50/p65 pathway through integrin beta 1 and play a crucial role in inflammatory responses.
CELL COMMUNICATION AND SIGNALING
(2023)