Analysis of Amyloid-β Pathology Spread in Mouse Models Suggests Spread Is Driven by Spatial Proximity, Not Connectivity

Connectivity, not region-intrinsic properties, predicts regional vulnerability to progressive tau pathology in mouse models of disease

(2017) Chris Mezias et al.   Acta Neuropathologica Communications

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease

(2016) Rik Ossenkoppele et al.   BRAIN

The amyloid cascade hypothesis: are we poised for success or failure?

(2016) Eric Karran et al.   JOURNAL OF NEUROCHEMISTRY

Transmission of neuronal and glial tau pathology: new models for developing disease modifying therapy for Alzheimer's and related tauopathies

(2016) John Trojanowski   NEUROBIOLOGY OF AGING

Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC’s afferent and efferent connections

(2015) Michiyo Iba et al.   ACTA NEUROPATHOLOGICA

Progression of Seed-Induced Aβ Deposition within the Limbic Connectome

(2015) Lan Ye et al.   BRAIN PATHOLOGY

Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

(2015) Zane Jaunmuktane et al.   NATURE

Titration of biologically active amyloid–β seeds in a transgenic mouse model of Alzheimer's disease

(2015) Rodrigo Morales et al.   Scientific Reports

Network Diffusion Model of Progression Predicts Longitudinal Patterns of Atrophy and Metabolism in Alzheimer’s Disease

(2015) Ashish Raj et al.   Cell Reports

Clearance of amyloid β-protein and its role in the spreading of Alzheimer's disease pathology

(2015) Dietmar R. Thal   Frontiers in Aging Neuroscience

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

(2014) Zeshan Ahmed et al.   ACTA NEUROPATHOLOGICA

Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer’s disease or corticobasal degeneration brains

(2014) Susana Boluda et al.   ACTA NEUROPATHOLOGICA

A mesoscale connectome of the mouse brain

(2014) Seung Wook Oh et al.   NATURE

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

(2013) M. Iba et al.   JOURNAL OF NEUROSCIENCE

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

(2013) David J. Irwin et al.   NATURE REVIEWS NEUROSCIENCE

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

(2012) Kelvin C. Luk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Network Diffusion Model of Disease Progression in Dementia

(2012) Ashish Raj et al.   NEURON

Purified and synthetic Alzheimer's amyloid beta (A ) prions

(2012) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer’s pathogenesis: is there neuron-to-neuron propagation?

(2011) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

(2011) Adam W Bero et al.   NATURE NEUROSCIENCE

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Transsynaptic Progression of Amyloid-β-Induced Neuronal Dysfunction within the Entorhinal-Hippocampal Network

(2010) Julie A. Harris et al.   NEURON

Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction

(2009) Thomas G. Beach et al.   ACTA NEUROPATHOLOGICA

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Induction of cerebral  -amyloidosis: Intracerebral versus systemic A  inoculation

(2009) Y. S. Eisele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessing fetal nerve cell grafts in Parkinson's disease

(2008) Heiko Braak et al.   NATURE MEDICINE