Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

Genomic and Epigenomic Alterations in Cancer

(2016) Balabhadrapatruni V.S.K. Chakravarthi et al.   AMERICAN JOURNAL OF PATHOLOGY

Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma

(2016) Willy Hugo et al.   CELL

Microsatellite Instability as a Biomarker for PD-1 Blockade

(2016) J. C. Dudley et al.   CLINICAL CANCER RESEARCH

Current status and perspectives in translational biomarker research for PD-1/PD-L1 immune checkpoint blockade therapy

(2016) Weijie Ma et al.   Journal of Hematology & Oncology

Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial

(2016) Roy S Herbst et al.   LANCET

Unmasking PD-1 Resistance by Next-Generation Sequencing

(2016) Carlo B. Bifulco et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mismatch Repair and Colon Cancer: Mechanisms and Therapies Explored

(2016) Stephen K.H. Li et al.   TRENDS IN MOLECULAR MEDICINE

Deficient mismatch repair: Read all about it (Review)

(2015) SUSAN RICHMAN   INTERNATIONAL JOURNAL OF ONCOLOGY

Immune Checkpoint Blockade in Cancer Therapy

(2015) Michael A. Postow et al.   JOURNAL OF CLINICAL ONCOLOGY

Co-expression of PD-1 and PD-L1 predicts poor outcome in nasopharyngeal carcinoma

(2015) Jianwei Zhang et al.   MEDICAL ONCOLOGY

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

(2015) Christina Twyman-Saint Victor et al.   NATURE

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer

(2015) Edward B. Garon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy

(2015) W. Peng et al.   Cancer Discovery

Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin

(2014) Katherine A. Hoadley et al.   CELL

Association of PD-1, PD-1 Ligands, and Other Features of the Tumor Immune Microenvironment with Response to Anti-PD-1 Therapy

(2014) J. M. Taube et al.   CLINICAL CANCER RESEARCH

Comprehensive molecular characterization of gastric adenocarcinoma

(2014) Adam J. Bass et al.   NATURE

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

(2014) Roy S. Herbst et al.   NATURE

The Vigorous Immune Microenvironment of Microsatellite Instable Colon Cancer Is Balanced by Multiple Counter-Inhibitory Checkpoints

(2014) Nicolas J. Llosa et al.   Cancer Discovery

Somatic Mutations in MLH1 and MSH2 Are a Frequent Cause of Mismatch-Repair Deficiency in Lynch Syndrome-Like Tumors

(2013) Arjen R. Mensenkamp et al.   GASTROENTEROLOGY

Comprehensive genome- and transcriptome-wide analyses of mutations associated with microsatellite instability in Korean gastric cancers

(2013) K. Yoon et al.   GENOME RESEARCH

Frequent microsatellite instability in papillary and solid-type, poorly differentiated adenocarcinomas of the stomach

(2012) Tomio Arai et al.   Gastric Cancer

Immunostaining for mismatch repair (MMR) protein expression in colorectal cancer is better and easier to interpret when performed on diagnostic biopsies

(2012) Wakkas Fadhil et al.   HISTOPATHOLOGY

Risks of Less Common Cancers in Proven Mutation Carriers With Lynch Syndrome

(2012) Christoph Engel et al.   JOURNAL OF CLINICAL ONCOLOGY

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microsatellite Instability Is Associated With a Better Prognosis for Gastric Cancer Patients After Curative Surgery

(2012) Wen-Liang Fang et al.   WORLD JOURNAL OF SURGERY

Neoadjuvant Therapy Induces Loss of MSH6 Expression in Colorectal Carcinoma

(2010) Fei Bao et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Lynch Syndrome in Women Less Than 50 Years of Age With Endometrial Cancer

(2010) Kellie S. Matthews et al.   OBSTETRICS AND GYNECOLOGY

The Association of Tumor Microsatellite Instability Phenotype with Family History of Colorectal Cancer

(2009) B. Bapat et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome

(2008) Patrice Watson et al.   INTERNATIONAL JOURNAL OF CANCER