Cross Talk between Inhibitory Immunoreceptor Tyrosine-Based Activation Motif-Signaling and Toll-Like Receptor Pathways in Macrophages and Dendritic Cells

Molecular mechanisms of regulation of Toll-like receptor signaling

(2016) Cynthia A. Leifer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Dual Role of the Tyrosine Kinase Syk in Regulation of Toll-Like Receptor Signaling in Plasmacytoid Dendritic Cells

(2016) Besma Aouar et al.   PLoS One

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

A Single Bacterial Immune Evasion Strategy Dismantles Both MyD88 and TRIF Signaling Pathways Downstream of TLR4

(2015) Charles V. Rosadini et al.   Cell Host & Microbe

Anti-BDCA2 monoclonal antibody inhibits plasmacytoid dendritic cell activation through Fc-dependent and Fc-independent mechanisms

(2015) A. Pellerin et al.   EMBO Molecular Medicine

Opposing Roles of Dectin-1 Expressed on Human Plasmacytoid Dendritic Cells and Myeloid Dendritic Cells in Th2 Polarization

(2015) HyeMee Joo et al.   JOURNAL OF IMMUNOLOGY

Specific roles for dendritic cell subsets during initiation and progression of psoriasis

(2014) E. Glitzner et al.   EMBO Molecular Medicine

Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis

(2014) Sanae Ben Mkaddem et al.   JOURNAL OF CLINICAL INVESTIGATION

Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model

(2014) Sarah L. Rowland et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of Fc Receptor Endocytic Trafficking by Ubiquitination

(2014) Rosa Molfetta et al.   Frontiers in Immunology

Molecular Control of Steady-State Dendritic Cell Maturation and Immune Homeostasis

(2013) Gianna Elena Hammer et al.   Annual Review of Immunology

PTPN22 in Autoimmunity: Different Cell and Different Way

(2013) Lionel B. Ivashkiv   IMMUNITY

Interferon-β Production via Dectin-1-Syk-IRF5 Signaling in Dendritic Cells Is Crucial for Immunity to C. albicans

(2013) Carlos del Fresno et al.   IMMUNITY

Breast cancer-derived transforming growth factor-β and tumor necrosis factor-α compromise interferon-α production by tumor-associated plasmacytoid dendritic cells

(2013) Vanja Sisirak et al.   INTERNATIONAL JOURNAL OF CANCER

CD2-Associated Protein Regulates Plasmacytoid Dendritic Cell Migration, but Is Dispensable for Their Development and Cytokine Production

(2013) S. Srivatsan et al.   JOURNAL OF IMMUNOLOGY

Signaling by Myeloid C-Type Lectin Receptors in Immunity and Homeostasis

(2012) David Sancho et al.   Annual Review of Immunology

Human plasmacytoid dendritic cells efficiently cross-present exogenous Ags to CD8+ T cells despite lower Ag uptake than myeloid dendritic cell subsets

(2012) J. Tel et al.   BLOOD

HCV glycoprotein E2 is a novel BDCA-2 ligand and acts as an inhibitor of IFN production by plasmacytoid dendritic cells

(2012) J. Florentin et al.   BLOOD

ICOS-Ligand Expression on Plasmacytoid Dendritic Cells Supports Breast Cancer Progression by Promoting the Accumulation of Immunosuppressive CD4+ T Cells

(2012) J. Faget et al.   CANCER RESEARCH

Impaired IFN-  Production by Plasmacytoid Dendritic Cells Favors Regulatory T-cell Expansion That May Contribute to Breast Cancer Progression

(2012) V. Sisirak et al.   CANCER RESEARCH

Plasmacytoid Dendritic Cells Promote Immunosuppression in Ovarian Cancer via ICOS Costimulation of Foxp3+ T-Regulatory Cells

(2012) C. Conrad et al.   CANCER RESEARCH

C-type lectin receptor-induced NF-κB activation in innate immune and inflammatory responses

(2012) Lara M Kingeter et al.   Cellular & Molecular Immunology

Human Type 2 Myeloid Dendritic Cells Produce Interferon-λ and Amplify Interferon-α in Response to Hepatitis C Virus Infection

(2012) Shuye Zhang et al.   GASTROENTEROLOGY

Constitutive Type I Interferon Modulates Homeostatic Balance through Tonic Signaling

(2012) Daniel J. Gough et al.   IMMUNITY

Essential Role for IKKβ in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells

(2012) Eduardo Pauls et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ITAM-Coupled Receptors Inhibit IFNAR Signaling and Alter Macrophage Responses to TLR4 and Listeria monocytogenes

(2012) L. Huynh et al.   JOURNAL OF IMMUNOLOGY

CD2AP/SHIP1 Complex Positively Regulates Plasmacytoid Dendritic Cell Receptor Signaling by Inhibiting the E3 Ubiquitin Ligase Cbl

(2012) M. Bao et al.   JOURNAL OF IMMUNOLOGY

Cell-Specific TLR9 Trafficking in Primary APCs of Transgenic TLR9-GFP Mice

(2012) A. M. Avalos et al.   JOURNAL OF IMMUNOLOGY

Spontaneous mutation of the Dock2 gene in Irf5-/- mice complicates interpretation of type I interferon production and antibody responses

(2012) W. E. Purtha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of TLR7/9 signaling in plasmacytoid dendritic cells

(2012) Musheng Bao et al.   Protein & Cell

Type I interferon is selectively required by dendritic cells for immune rejection of tumors

(2011) Mark S. Diamond et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Conventional Dendritic Cells Mount a Type I IFN Response against Candida spp. Requiring Novel Phagosomal TLR7-Mediated IFN-  Signaling

(2011) C. Bourgeois et al.   JOURNAL OF IMMUNOLOGY

Proliferating Cell Nuclear Antigen Is a Novel Inhibitory Ligand for the Natural Cytotoxicity Receptor NKp44

(2011) B. Rosental et al.   JOURNAL OF IMMUNOLOGY

Hepatitis C Virus Fails To Activate NF- B Signaling in Plasmacytoid Dendritic Cells

(2011) C. Dental et al.   JOURNAL OF VIROLOGY

How ITAMs Inhibit Signaling

(2011) L. B. Ivashkiv   Science Signaling

Inhibitory ITAM Signaling Traps Activating Receptors with the Phosphatase SHP-1 to Form Polarized "Inhibisome" Clusters

(2011) S. Pfirsch-Maisonnas et al.   Science Signaling

BDCA-2 signaling inhibits TLR-9-agonist-induced plasmacytoid dendritic cell activation and antigen presentation

(2010) Peter S. Jähn et al.   CELLULAR IMMUNOLOGY

Indirect Inhibition of Toll-like Receptor and Type I Interferon Responses by ITAM-Coupled Receptors and Integrins

(2010) Lu Wang et al.   IMMUNITY

Characterization of human DNGR-1+BDCA3+leukocytes as putative equivalents of mouse CD8α+dendritic cells

(2010) Lionel Franz Poulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anti-inflammatory actions of Syk inhibitors in macrophages involve non-specific inhibition of toll-like receptors-mediated JNK signaling pathway

(2010) Ying-Cing Lin et al.   MOLECULAR IMMUNOLOGY

Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b

(2010) Chaofeng Han et al.   NATURE IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Bifurcation of Toll-Like Receptor 9 Signaling by Adaptor Protein 3

(2010) M. Sasai et al.   SCIENCE

Impaired Toll-like receptor 7 and 9 signaling: from chronic viral infections to cancer

(2010) Ivan Hirsch et al.   TRENDS IN IMMUNOLOGY

Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms

(2009) Xiaoyu Hu et al.   IMMUNOLOGICAL REVIEWS

TPL-2 negatively regulates interferon-β production in macrophages and myeloid dendritic cells

(2009) Frank Kaiser et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction

(2009) Wei Cao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor Progression Locus 2 (Map3k8) Is Critical for Host Defense against Listeria monocytogenes and IL-1  Production

(2009) L. A. Mielke et al.   JOURNAL OF IMMUNOLOGY

Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-  production

(2008) F. Meyer-Wentrup et al.   BLOOD

Functional dichotomy of plasmacytoid dendritic cells: Antigen‐specific activation of T cellsversusproduction of type I interferon

(2008) Peter S. Jaehn et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

DCIR is endocytosed into human dendritic cells and inhibits TLR8-mediated cytokine production

(2008) Friederike Meyer-Wentrup et al.   JOURNAL OF LEUKOCYTE BIOLOGY

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

(2008) You-Me Kim et al.   NATURE

The kinase p38α serves cell type–specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

(2008) Chun Kim et al.   NATURE IMMUNOLOGY

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

(2008) Olga Ananieva et al.   NATURE IMMUNOLOGY

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

(2008) Boyoun Park et al.   NATURE IMMUNOLOGY