Article
Gastroenterology & Hepatology
Gangarao Davuluri, Nicole Welch, Jinendiran Sekar, Mahesha Gangadhariah, Khaled Alsabbagh Alchirazi, Maradumane L. Mohan, Avinash Kumar, Sashi Kant, Samjhana Thapaliya, McKenzie Stine, Megan R. McMullen, Rebecca L. McCullough, George R. Stark, Laura E. Nagy, Sathyamangla V. Naga Prasad, Srinivasan Dasarathy
Summary: Despite the high clinical significance of sarcopenia in alcohol-associated cirrhosis, the mechanisms of ethanol-induced impaired protein homeostasis are poorly understood. This study identified PP2A as a key mediator in ethanol-induced dysregulation of protein balance, suggesting potential therapeutic approaches targeting the PI3K gamma-PP2A axis.
Article
Cell Biology
Chang-Ning Fu, Jia-Wen Song, Zhi-Peng Song, Qian-Wen Wang, Wen-Wu Bai, Tao Guo, Peng Li, Chao Liu, Shuang-Xi Wang, Bo Dong
Summary: Statin-induced skeletal injury is mediated by the excessive expression of miR-1a, leading to decreased MAP3K1 gene expression and subsequent apoptosis of skeletal muscle cells.
Article
Biochemistry & Molecular Biology
Jeong Hyeon Lee, Myoung Eun Choi, Hongchan An, Ju Won Moon, Hye Jin Yeo, Youngsup Song, Sung Eun Chang
Summary: BCI-215 effectively inhibits melanogenesis by suppressing the expression of microphthalmia-associated transcription factor (MITF) and its downstream enzymes. This study provides a new therapeutic strategy for treating pigmentation disorders using DUSP-related signaling modulators.
Article
Biochemistry & Molecular Biology
Qianqian Xu, Peiyu Zhang, Xiaoyan Han, Huwei Ren, Weiyue Yu, Wei Hao, Bowen Luo, Muhammad Imran Khan, Ni Chen
Summary: This study investigates the pivotal role of Nuclear factor-erythroid 2-related factor 2 (NRF2) in the activation of DNA damage repair in lung cancer cells after x-rays exposure. The study shows that NRF2 knockdown disrupts damaged DNA repair and homologous recombination, and NRF2 activation mediates DNA damage response via the MAPK pathway. These findings suggest that NRF2 plays a critical role in the development of radioresistance, which is of great significance for the development of radiotherapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Junjun Wei, Wei Sun, Xinhang Zheng, Shanshan Qiu, Shuangyu Jiao, Kevin Babilonia, Hisashi Koiwa, Ping He, Libo Shan, Wenxian Sun, Fuhao Cui
Summary: CPL1 functions as a negative regulator in plant defense, suppressing MAMP-induced MAPK cascade activation and immunity against bacterial pathogens.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2023)
Article
Chemistry, Applied
Jinyang Cai, Xin Li, Xing Wang, Chengfei Jiang, Dan Shen, Xianwei Cui, Kaipeng Xie, Chenbo Ji, Yan Cao
Summary: In this study, a novel peptide named BCCY-1 corresponding to human beta-casein sequence was identified in human milk, showing immunomodulatory activity by enhancing monocyte migration. BCCY-1 exerts its effects by activating NF-κB and MAPK signaling pathways.
Article
Biochemistry & Molecular Biology
Rong Liu, Guangxi Yang, Min Bao, Zhongmei Zhou, Xiaoyun Mao, Wenjing Liu, Xiaoyan Jiang, Di Zhu, Xinle Ren, Jian Huang, Ceshi Chen
Summary: This study identifies STAMBPL1 as a deubiquitinase of MKP-1 in breast cancer cells, which stabilizes MKP-1 protein by deubiquitination. Depletion of STAMBPL1 and MKP-1 increases breast cancer sensitivity to cisplatin and activates the JNK signaling pathway. These findings suggest that the STAMBPL1/MKP-1 axis could be a potential therapeutic target in breast cancer.
Article
Biochemistry & Molecular Biology
Chuwei Lin, Aneirin Alan Lott, Wei Zhu, Craig P. Dufresne, Sixue Chen
Summary: This study used metabolomics and proteomics to investigate the metabolites and protein profiles of the mpk4 mutant and the wild type plants. It revealed the involvement of MPK4 in polyamine synthesis and photosynthesis, providing insights into the metabolic networks potentially regulated by MPK4.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Jacob Sellers, Abigail Brooks, Savanie Fernando, Gabrielle Westenberger, Sadie Junkins, Shauri Smith, Kisuk Min, Ahmed Lawan
Summary: The liver plays a crucial role in regulating glucose and lipid homeostasis in response to nutritional signals. Activation of MKP-1 in overnutrition helps control lipid metabolism in the liver, while the impact of MKP-1 in response to fasting is still unclear. Fasting induces upregulation of MKP-1, leading to resistance to hepatic steatosis and changes in key transcription factors involved in fatty acid and cholesterol metabolism, suggesting a beneficial role of MKP-1 in hepatic lipid utilization during fasting.
Review
Biochemistry & Molecular Biology
Fatma Zohra Khoubai, Christophe F. Grosset
Summary: Mitogen-activated protein kinases (MAPKs) are crucial for cell functioning, with DUSP9 playing a significant role in regulating MAPK activity. Dysregulation of MAPKs by phosphatases like DUSP9 can lead to various human pathologies, emphasizing the importance of careful regulation in maintaining proper cell functioning.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hitesh Soni, Ravi Kumar, Praghalathan Kanthakumar, Adebowale Adebiyi
Summary: IL-1 beta induces Ca2+ entry via TRPA1 channels, leading to MAPK-dependent mesangial cell proliferation without stimulating fibronectin production.
Article
Peripheral Vascular Disease
Mohammad Shafid, Kumaravelu Jagavelu, Hina Iqbal, Pankaj Yadav, Debabrata Chanda, Neeraj Kumar Verma, Jimut Kanti Ghosh, Matthias Gaestel, Kashif Hanif
Summary: MK2 plays a significant role in pulmonary hypertension, and its inhibition may be a novel target for PH treatment. Inhibition of MK2 alleviated right ventricle pressure and hypertrophy in PH rats, improved cardiac function, reversed pulmonary vascular remodeling, and enhanced pulmonary vascular relaxation.
Review
Medicine, General & Internal
Jing Zhang, Long-Min Chen, Yuan Zou, Shu Zhang, Fei Xiong, Cong-Yi Wang
Summary: Type 1 diabetes (T1D) is an autoimmune disease caused by severe destruction of insulin-producing beta cells, with both genetic predisposition and environmental factors playing critical roles in its pathogenesis. Epigenetics serves as a bridge linking T1D risk genes and environmental exposures, modulating gene expression relevant to T1D development beyond DNA sequence changes.
CHINESE MEDICAL JOURNAL
(2021)
Article
Medicine, Research & Experimental
Enkhtuya Radnaa, Lauren Richardson, Brett Goldman, Jared K. Burks, Tuvshintugs Baljinnyam, Natasha Vora, Hui-Juan Zhang, Elizabeth A. Bonney, Arum Han, Ramkumar Menon
Summary: This study investigated the impact of oxidative stress on p38 MAPK signaling and cell fate, using amnion epithelial cells. The results showed that excessive activation of p38 can have adverse effects on cell behavior and tissue homeostasis.
Article
Plant Sciences
Xiangyu Guo, Xiangdan Li, Yanru Dong, Wei Xie, Toufeng Jin, Dongyuan Xu, Lan Liu
Summary: This study aimed to investigate the preventive and protective effect of cod skin collagen peptide powder (CP) on mice with ulcerative colitis (UC) and explore the underlying mechanism. The results showed that CP reduced inflammation by upregulating mitogen-activated protein kinase phosphatase-1 (MKP-1) and polarizing macrophages toward the M2 phenotype. It also inhibited the development of fibrosis complicating UC by regulating the expression of ZO-1, Occludin, α-SMA, Vimentin, Snail, and Slug.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Behavioral Sciences
Zachary Johnson, Linda Brent, Juan Carlos Alvarenga, Anthony G. Comuzzie, Wendy Shelledy, Stephanie Ramirez, Laura Cox, Michael C. Mahaney, Yung-Yu Huang, J. John Mann, Jay R. Kaplan, Jeffrey Rogers
Article
Genetics & Heredity
Elizabeth G. Atkinson, Jeffrey Rogers, Michael C. Mahaney, Laura A. Cox, James M. Cheverud
Article
Genetics & Heredity
Elizabeth G. Atkinson, Jeffrey Rogers, Michael C. Mahaney, Laura A. Cox, James M. Cheverud
Article
Biochemistry & Molecular Biology
Cheng Xue, Muthuswamy Raveendran, R. Alan Harris, Gloria L. Fawcett, Xiaoming Liu, Simon White, Mahmoud Dandouli, David Rio Deiros, Jennifer E. Below, William Salerno, Laura Cox, Guoping Fan, Betsy Ferguson, Julie Horvath, Zach Johnson, Sree Kanthaswamy, H. Michael Kubisch, Dahai Liu, Michael Platt, David G. Smith, Binghua Sun, Eric J. Vallenderi, Feng Wang, Roger W. Wiseman, Rui Chen, Donna M. Muzny, Richard A. Gibbs, Fuli Yu, Jeffrey Rogers
Article
Biochemistry & Molecular Biology
Jeffrey D. Wall, Stephen A. Schlebusch, Susan C. Alberts, Laura A. Cox, Noah Snyder-Mackler, Kimberly A. Nevonen, Lucia Carbone, Jenny Tung
Article
Veterinary Sciences
Laura A. Cox, Michael Olivier, Kimberly Spradling-Reeves, Genesio M. Karere, Anthony G. Comuzzie, John L. VandeBerg
Article
Veterinary Sciences
Michael C. Mahaney, Genesio M. Karere, David L. Rainwater, Venkata S. Voruganti, Edward J. Dick, Michael A. Owston, Karen S. Rice, Laura A. Cox, Anthony G. Comuzzie, John L. VandeBerg
JOURNAL OF MEDICAL PRIMATOLOGY
(2018)
Article
Veterinary Sciences
Cun Li, Susan Jenkins, Vicki Mattern, Anthony G. Comuzzie, Laura A. Cox, Hillary F. Huber, Peter W. Nathanielsz
JOURNAL OF MEDICAL PRIMATOLOGY
(2017)
Article
Peripheral Vascular Disease
Kimberly D. Spradling-Reeves, Robert E. Shade, Joseph R. Haywood, Laura A. Cox
JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
(2017)
Article
Neurosciences
Sobha Puppala, Cun Li, Jeremy P. Glenn, Romil Saxena, Samer Gawrieh, Amy Quinn, Jennifer Palarczyk, Edward J. Dick, Peter W. Nathanielsz, Laura A. Cox
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Veterinary Sciences
Laura A. Cox, Anthony G. Comuzzie, Lorena M. Havill, Genesio M. Karere, Kimberly D. Spradling, Michael C. Mahaney, Peter W. Nathanielsz, Daniel P. Nicolella, Robert E. Shade, Saroja Voruganti, John L. VandeBerg
Article
Biochemistry & Molecular Biology
Genesio M. Karere, Jeremy P. Glenn, Shifra Birnbaum, David L. Rainwater, Michael C. Mahaney, John L. VandeBerg, Laura A. Cox
JOURNAL OF LIPID RESEARCH
(2013)
Article
Biotechnology & Applied Microbiology
J. Michael Proffitt, Jeremy Glenn, Anthony J. Cesnik, Avinash Jadhav, Michael R. Shortreed, Lloyd M. Smith, Kylie Kavanagh, Laura A. Cox, Michael Olivier
Article
Physiology
Susana P. Pereira, Paulo J. Oliveira, Ludgero C. Tavares, Antonio J. Moreno, Laura A. Cox, Peter W. Nathanielsz, Mark J. Nijland
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2015)