1810011o10 Rik Inhibits the Antitumor Effect of Intratumoral CD8+ T Cells through Suppression of Notch2 Pathway in a Murine Hepatocellular Carcinoma Model

Adaptive immunity in the liver

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Hepatitis B virus X protein amplifies TGF-β promotion on HCC motility through down-regulating PPM1a

(2016) Yuan Liu et al.   Oncotarget

Amphiregulin promotes the immunosuppressive activity of intrahepatic CD4+regulatory T cells to impair CD8+T-cell immunity against hepatitis B virus infection

(2015) Kai Dai et al.   IMMUNOLOGY

Immunological landscape and immunotherapy of hepatocellular carcinoma

(2015) Jesús Prieto et al.   Nature Reviews Gastroenterology & Hepatology

Interleukin 10-expressing B cells inhibit tumor-infiltrating T cell function and correlate with T cell Tim-3 expression in renal cell carcinoma

(2015) Chen Cai et al.   TUMOR BIOLOGY

The high expression of TC1 (C8orf4) was correlated with the expression of β-catenin and cyclin D1 and the progression of squamous cell carcinomas of the tongue

(2015) Peng Zhang et al.   TUMOR BIOLOGY

C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling

(2015) Pingping Zhu et al.   Nature Communications

Amphiregulin activates regulatory T lymphocytes and suppresses CD8+ T cell-mediated anti-tumor response in hepatocellular carcinoma cells

(2015) Chun-Hui Yuan et al.   Oncotarget

A Critical Role for the Regulated Wnt–Myc Pathway in Naive T Cell Survival

(2014) Chunshu Wong et al.   JOURNAL OF IMMUNOLOGY

TC1(C8orf4) Regulates Hematopoietic Stem/Progenitor Cells and Hematopoiesis

(2014) Yusun Jung et al.   PLoS One

The Notch ligand Jagged1 as a target for anti-tumor therapy

(2014) Demin Li   Frontiers in Oncology

Notch controls generation and function of human effector CD8+ T cells

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Antitumor CD8+T cells in hepatocellular carcinoma: Present but exhausted

(2013) Ka-Kit Li et al.   HEPATOLOGY

Differential roles of KLF4 in the development and differentiation of CD8+ T cells

(2013) Maksim Mamonkin et al.   IMMUNOLOGY LETTERS

Hedgehog Signaling Controls T Cell Killing at the Immunological Synapse

(2013) M. de la Roche et al.   SCIENCE

TC-1 (C8orf4) expression is correlated with differentiation in ovarian carcinomas and might distinguish metastatic ovarian from metastatic colorectal carcinomas

(2013) Hong-Tao Xu et al.   VIRCHOWS ARCHIV

Regulation of mature T cell responses by the Wnt signaling pathway

(2012) Hai-Hui Xue et al.   Annals of the New York Academy of Sciences

Human CCR4+CCR6+Th17 Cells Suppress Autologous CD8+ T Cell Responses

(2012) F. Zhao et al.   JOURNAL OF IMMUNOLOGY

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Inhibiting TGF-β signaling in hepatocellular carcinoma

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Increased liver-infiltrating CD8+FoxP3+ regulatory T cells are associated with tumor stage in hepatocellular carcinoma patients

(2010) Zhi-Qing Yang et al.   HUMAN IMMUNOLOGY

Regulatory T cell depletion enhances tumor specific CD8 T-cell responses, elicited by tumor antigen NY-ESO-1b in hepatocellular carcinoma patients, in vitro

(2010) Chen   INTERNATIONAL JOURNAL OF ONCOLOGY

Notch2 Signaling Is Required for Potent Antitumor Immunity In Vivo

(2010) K. Sugimoto et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: The Transcription Factor Kruppel-Like Factor 4 Regulates the Differentiation of Th17 Cells Independently of ROR t

(2010) L. Lebson et al.   JOURNAL OF IMMUNOLOGY

Up-regulated myeloid-derived suppressor cell contributes to hepatocellular carcinoma development by impairing dendritic cell function

(2010) Cheng-En Hu et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Kupffer Cell Suppression of CD8+ T Cells in Human Hepatocellular Carcinoma Is Mediated by B7-H1/Programmed Death-1 Interactions

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TC1(C8orf4) Is a Novel Endothelial Inflammatory Regulator Enhancing NF- B Activity

(2009) J. Kim et al.   JOURNAL OF IMMUNOLOGY

A New Population of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Induces CD4+CD25+Foxp3+ T Cells

(2008) Bastian Hoechst et al.   GASTROENTEROLOGY

Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development

(2008) F. A. High et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA