Review
Immunology
Kevin Schneider, Sanja Arandjelovic
Summary: Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects about 1% of the human population. It is characterized by joint swelling and bone erosion, causing disability and even death. Immune dysregulation, including circulating autoantibodies and inflammatory mediators, plays an important role in the development of RA. Studies have shown that inducing cell death through apoptosis can reduce the severity of the disease. Apoptotic cells are cleared by phagocytes through a process called efferocytosis, which has anti-inflammatory properties. Dysfunctions in efferocytosis have been linked to autoimmune diseases, while administration of apoptotic cells in RA models effectively inhibits inflammation. However, the signaling pathways and clearance mediators involved in RA are still not well understood.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Ana Carolina Guerta Salina, Leticia de Aquino Penteado, Naiara Naiana Dejani, Ludmilla Silva-Pereira, Breno Vilas Boas Raimundo, Gabriel Ferranti Correa, Karen Cristina Oliveira, Leandra Naira Zambelli Ramalho, Medeton Mahoussi Michael Boko, Vania L. D. Bonato, C. Henrique Serezani, Alexandra Ivo Medeiros
Summary: The removal of dead cells through efferocytosis is crucial for resolving infections and preserving tissues. The efferocytosis of non-infected apoptotic cells promotes the production of anti-inflammatory macrophages, while the impact of efferocytosis of infected apoptotic cells on macrophage activation remains unknown.
Article
Immunology
Mike Aoun, Ana Coelho, Alexander Kramer, Amit Saxena, Pierre Sabatier, Christian Michel Beusch, Erik Lonnblom, Manman Geng, Nhu-Nguyen Do, Zhongwei Xu, Jingdian Zhang, Yibo He, Laura Romero Castillo, Hassan Abolhassani, Bingze Xu, Johan Viljanen, Joanna Rorbach, Gonzalo Fernandez Lahore, Inger Gjertsson, Alf Kastbom, Christopher Sjowall, Jan Kihlberg, Roman A. Zubarev, Harald Burkhardt, Rikard Holmdahl
Summary: The study reveals that autoreactive antigen-specific naive B cells tolerize infiltrating T cells against self-antigens to impede the development of tissue-specific autoimmune inflammation.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Xingyue Zeng, Songsong Lu, Meng Li, Mohan Zheng, Tianci Liu, Rui Kang, Lijuan Xu, Qinzhu Xu, Ying Song, Chen Liu
Summary: This study found that follicular helper T cells and follicular regulatory T cells are increased and functionally enhanced in rheumatoid arthritis. After treatment with inflammatory factor-neutralizing antibodies, these cell subsets and functions return to normal.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Immunology
Konstantin Kotschenreuther, Shuaifeng Yan, David M. Kofler
Summary: Regulatory T (T-reg) cells are crucial in the pathogenesis of rheumatoid arthritis (RA), contributing to immune homeostasis and tissue migration.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Charles Yin, Bryan Heit
Summary: The efficient clearance of apoptotic cells, known as efferocytosis, plays a critical role in maintaining tissue homeostasis by preventing secondary necrosis and inflammation. Efferocytosis differs from phagocytosis in its immunologically silent nature and induction of tissue repair response. This review discusses recent advances in understanding cellular responses to apoptotic cell uptake, signaling events, and the role of efferocytosis in host defense.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Veronica Mendoza-Reinoso, Patricia M. Schnepp, Dah Youn Baek, John R. Rubin, Ernestina Schipani, Evan T. Keller, Laurie K. McCauley, Hernan Roca
Summary: This study reveals that the clearance of apoptotic cancer cells by bone marrow macrophages triggers a pro-inflammatory response through the p-STAT3/HIF-1 alpha/MIF signaling pathway, which promotes the growth of bone-metastatic prostate cancer cells.
Article
Multidisciplinary Sciences
Dao X. Nguyen, Helen M. Baldwin, Amara N. Ezeonyeji, Mohammed Rohan Butt, Michael R. Ehrenstein
Summary: The study revealed that patients with PsA have an increased Th17:Treg ratio, which can be reversed by anti-TNF therapy. Treg from patients treated with different therapies showed contrasting effects on regulating effector T-cell migration, with TNF blockade boosting Treg suppression of migration.
Article
Rheumatology
Imke Redeker, Katinka Albrecht, Joern Kekow, Gerd Ruediger Burmester, Juergen Braun, Martin Schaefer, Angela Zink, Anja Strangfeld
Summary: The study compared the occurrence of herpes zoster in patients with rheumatoid arthritis undergoing different treatments, showing a higher risk associated with targeted synthetic and biologic DMARDs.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Nathalie Luurssen-Masurel, Elise van Mulligen, Angelique Elisabeth Adriana Maria Weel-Koenders, Johanna Maria Wilhelmina Hazes, Pascal Hendrik Pieter de Jong
Summary: This study compared the long-term clinical outcomes of three clinical arthritis phenotypes: undifferentiated arthritis (UA), autoantibody-negative (RA-) and autoantibody-positive RA (RA+). The results showed that there were differences in remission rates and sustained remission rates between these phenotypes. The data confirm that rheumatoid arthritis can be subdivided based on clinical phenotypes and that treatment should be stratified accordingly.
Article
Cell Biology
Chenxi Zheng, Bingdong Sui, Xiao Zhang, Jiachen Hu, Ji Chen, Jin Liu, Di Wu, Qingyuan Ye, Lei Xiang, Xinyu Qiu, Siying Liu, Zhihong Deng, Jun Zhou, Shiyu Liu, Songtao Shi, Yan Jin
Summary: The study revealed that apoptotic vesicles (apoVs) derived from MSCs can modulate liver macrophage homeostasis and counteract type 2 diabetes (T2D) by inducing macrophage reprogramming. Through efferocytosis, apoVs inhibit macrophage accumulation and promote their transformation towards an anti-inflammatory phenotype in the liver to ameliorate T2D phenotypes.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Immunology
Yaling Tian, Ping Shi, Yan Zhou, Rui Yuan, Zhicheng Hu, Yan Tan, Guilan Ma, Lei Yang, Hongmei Jiang
Summary: The study successfully constructed tolDCs, and found that they had long-term tolerogenic potential in vivo, which could improve arthritis in CIA rats with different severity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Surbhi Chaudhary, Anil Patidar, Asmita Dhiman, Gaurav Kumar Chaubey, Rahul Dilawari, Sharmila Talukdar, Radheshyam Modanwal, Manoj Raje
Summary: The study identified a specific form of GAPDH on the surface of apoptotic cells that interacts with CD14 on phagocytes, leading to engulfment. This novel interaction between multifunctional GAPDH and the phagocytic receptor CD14 results in apoptotic cell clearance, demonstrating a new mechanism for efferocytosis.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Eva M. L. Philippon, Lisanne J. E. van Rooijen, Fatemeh Khodadust, Jan Piet van Hamburg, Conny J. van der Laken, Sander W. Tas
Summary: A spheroid-based model of RA synovial tissue was developed to mimic the 3D interactions between cells and pro-inflammatory mediators. It can be used to study the pathogenesis of rheumatoid arthritis, examine the effects of specific cell types and signaling pathways, and evaluate the efficacy of novel diagnostic and therapeutic compounds.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Lisheng Wu, Ran Wang, Yi Zhou, Di Zhao, Feilong Chen, Xianghui Wu, Xiaoguang Chen, Shixian Chen, Juan Li, Junqing Zhu
Summary: In rheumatoid arthritis, the infiltration of NK cells in the joints positively correlates with disease progression, inflammation, and bone destruction, but their pathogenic role may be independent of the NKp46 receptor.
FRONTIERS IN IMMUNOLOGY
(2022)
Letter
Allergy
Anh Poirot, Guillaume Wacht, Christine Lehalle, Philippe Saas, Nelly Frossard, Bernard Geny, Frederic de Blay, Cindy Barnig
Article
Oncology
Caroline Laheurte, Evan Seffar, Eleonore Gravelin, Julie Lecuelle, Adeline Renaudin, Laura Boullerot, Marine Malfroy, Amelie Marguier, Benoit Lecoester, Beatrice Gaugler, Philippe Saas, Caroline Truntzer, Francois Ghiringhelli, Olivier Adotevi
Summary: Plasmacytoid dendritic cells (pDCs) in non-small cell lung cancer patients have been shown to have an ambivalent role in cancer immunity. Higher levels of circulating pDCs are associated with improved overall survival (OS) in NSCLC, especially in early-stage patients, and a high pDC signature in the tumor microenvironment predicts better efficacy of immune checkpoint inhibitors in these patients.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Dermatology
Yasmin El Mahi, Alexis Varin, Mathieu Vetter, Ludivine Dal Zuffo, Loic Mazzeo, Jean-Paul Pais De Barros, Francois Aubin, Philippe Saas, Irene Gallais Serezal
Summary: The relapses of psoriasis are related to T cells that reside in the skin, with the fatty acid intake capacity of tissue-resident memory T cells playing a crucial role in their function. The composition of fatty acids in the skin is linked to the functions of epidermal T cells and may affect the severity of psoriasis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Etienne Daguindau, Cecile Chague, Philippe Saas
M S-MEDECINE SCIENCES
(2023)
Editorial Material
Immunology
Philippe Saas, Guo-Chang Fan
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Maxime Samson, Coraline Genet, Marc Corbera-Bellalta, Helene Greigert, Georgina Espigol-Frigole, Claire Gerard, Claudie Cladiere, Roser Alba-Rovira, Marion Ciudad, Pierre-Henry Gabrielle, Catherine Creuzot-Garcher, Georges Tarris, Laurent Martin, Philippe Saas, Sylvain Audia, Bernard Bonnotte, Maria C. Cid
Summary: This study evaluated the effect of Human Monocyte-derived Suppressor Cells (HuMoSC) on inflammation and vascular remodeling in Giant Cell Arteritis (GCA) treatment. The results showed that HuMoSCs or their supernatant could decrease vascular inflammation and remodeling, which may address the unmet need in GCA treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Eleonora Sosa Cuevas, Philippe Saas, Caroline Aspord
Summary: Immunotherapies using immune checkpoint blockers have shown clinical success in melanoma, but some patients still relapse or do not respond. Dendritic cells (DCs) play a key role in immune responses and their understanding is important for developing effective immunotherapies. This review provides an overview of DC diversity, their role in melanoma pathophysiology and clinical outcomes, tumor-induced DC subversion mechanisms, and DC-based therapeutic developments.
Article
Immunology
Emilie Gaiffe, Mathilde Colladant, Maxime Desmaret, Jamal Bamoulid, Franck Leroux, Caroline Laheurte, Sophie Brouard, Magali Giral, Philippe Saas, Cecile Courivaud, Nicolas Degauque, Didier Ducloux
Summary: Unsupervised hierarchical clustering analysis was performed on pre-transplant immunological phenotype in 1113 renal transplant recipients, identifying three immune profiles correlated with clinical phenotypes. The memory immune cluster was associated with older age and diabetes, while the activated immune cluster was associated with younger age and previous exposure to CMV. Both were associated with an increased risk of acute rejection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Emilie Gaiffe, Dewi Vernerey, Laurent Bardiaux, Franck Leroux, Aurelia Meurisse, Jamal Bamoulid, Cecile Courivaud, Philippe Saas, Marc Hazzan, Pierre Tiberghien, Didier Ducloux
Summary: A longer storage duration of red blood cells (RBC) was associated with a decreased risk of transplant failure among patients who received kidney transplants and RBC transfusions. Preferential use of RBC with longer storage duration might improve kidney graft survival following transplant and transfusion.
Article
Rheumatology
Sophie Hecquet, Perle Totoson, Helene Martin, Marie-Paule Algros, Philippe Saas, Jean-Paul Pais-de-Barros, Alban Atchon, Benoit Valot, Didier Hocquet, Maude Tournier, Clement Prati, Daniel Wendling, Celine Demougeot, Frank Verhoeven
Summary: Intestinal inflammation and alterations of the intestinal barrier are not the consequence of joint damage, and intestinal changes occurred in the absence of bacterial translocation.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Immunology
Camille Niveau, Eleonora Sosa Cuevas, Benoit Roubinet, Mylene Pezet, Michel Thepaut, Stephane Mouret, Julie Charles, Franck Fieschi, Ludovic Landemarre, Laurence Chaperot, Philippe Saas, Caroline Aspord
Summary: Dendritic cell subsets play a crucial role in shaping anti-tumour immunity. The study found that melanoma tumour cells display aberrant glycan motifs which can be sensed by dendritic cells through specific receptors. This interaction may lead to abnormal immune responses. The study suggests that targeting the glycan/receptor axis could be a promising strategy for improving cancer immunotherapy.
Article
Critical Care Medicine
Claire Chaignat, Laurent Lagrost, Karena Moretto, Jean-Paul Pais de Barros, Hadrien Winiszewski, Jacques Grober, Philippe Saas, Gael Piton
Summary: The aim of this study was to investigate the correlation between plasma citrulline levels and plasma lipopolysaccharide (LPS) concentration, as well as the impact of sepsis on gut function in critically ill patients. The results showed no correlation between plasma citrulline concentration and plasma LPS concentration or activity. However, septic patients had significantly lower plasma citrulline levels. Additionally, abdominal sepsis was associated with higher plasma LPS activity compared to extra-abdominal sepsis.
JOURNAL OF CRITICAL CARE
(2024)
Meeting Abstract
Dermatology
Y. El Mahi, A. Varin, J. Pais-De-Barros, F. Aubin, P. Saas, I. Gallais Serezal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Meeting Abstract
Pharmacology & Pharmacy
C. Peyronnel, P. Totoson, V. Petitcolin, F. Bonnefoy, X. Guillot, P. Saas, H. Martin, C. Demougeot
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2022)
Article
Rheumatology
C. Peyronnel, P. Totoson, V Petitcolin, F. Bonnefoy, X. Guillot, P. Saas, F. Verhoeven, H. Martin, C. Demougeot
Summary: This study found that local cryotherapy can reduce systemic endothelial activation, immune cell infiltration, and endothelial dysfunction in rats with adjuvant-induced arthritis. This effect may be achieved by reducing circulating levels of IL-17A.
ARTHRITIS RESEARCH & THERAPY
(2022)