Journal
FRONTIERS IN IMMUNOLOGY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2017.00104
Keywords
lymphatic endothelial cells; microRNA; inflammation; lineage plasticity; lymphangiogenesis
Categories
Funding
- Medical Research Council New Investigator Research Grant [MR/L008505/1]
- Medical Research Council [MR/K021125]
- Wellcome Trust [097829, WT095024MA]
- Biotechnology and Biological Sciences Research Council Doctoral Training Program in Mechanistic Biology and its Strategic Application [BB/J01113/1]
- Biotechnology and Biological Sciences Research Council [1504182] Funding Source: researchfish
- Medical Research Council [MR/L008505/1] Funding Source: researchfish
- MRC [MR/L008505/1] Funding Source: UKRI
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microRNAs (miRNAs) are highly conserved, small non-coding RNAs that regulate gene expression at the posttranscriptional level. They have crucial roles in organismal development, homeostasis, and cellular responses to pathological stress. The lymphatic system is a large vascular network that actively regulates the immune response through antigen trafficking, cytokine secretion, and inducing peripheral tolerance. Here, we review the role of miRNAs in the lymphatic endothelium with a particular focus on their role in lymphatic endothelial cell (LEC) plasticity, inflammation, and regulatory function. We highlight the lineage plasticity of LECs during inflammation and the importance of understanding the regulatory role of miRNAs in these processes. We propose that targeting miRNA expression in lymphatic endothelium can be a novel strategy in treating human pathologies associated with lymphatic dysfunction.
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