Article
Plant Sciences
Yapeng Hou, Jun Li, Yan Ding, Yong Cui, Hongguang Nie
Summary: The study found that Luteolin can alleviate pulmonary edema by enhancing the abundance of membrane ENaC, at least partially through the cGMP/PI3K pathway, providing a promising therapeutic strategy for treating ALI/ARDS.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Physiology
Garett J. Grant, Patrice N. Mimche, Robert Paine, Theodore G. Liou, Wei-Jun Qian, My N. Helms
Summary: Prolonged oxygen therapy can lead to oxidative stress and lung injury by increasing GSSG levels and inhibiting lung fluid reabsorption. Coenzyme FADH(2) plays a crucial role in promoting alveologenesis but does not impact alveolar fluid clearance or attenuate fibrosis after high FIO2 exposure. ENaC is identified as a key factor in sustaining alveologenesis, AFC, and attenuating fibrotic lung injury caused by prolonged oxygen therapy in WT mice.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Oncology
Wang Deng, Jing He, Xu-Mao Tang, Chang-Yi Li, Jin Tong, Di Qi, Dao-Xin Wang
Summary: Chronic alcohol abuse increases the risk of mortality and poor outcomes in patients with acute respiratory distress syndrome by impairing alveolar fluid clearance and exacerbating pulmonary edema. This study demonstrated that alcohol-induced inhibition of cAMP pathway and ENaC expression may contribute to worsened lung injury in individuals with chronic alcohol consumption.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Physiology
Vitalii Kryvenko, Istvan Vadasz
Summary: Many COVID-19 patients develop ARDS, with SARS-CoV-2 infection causing dysfunction of the alveolar barrier, particularly impacting the Na,K-ATPase function. Selectively inhibiting signals that impair Na,K-ATPase may be effective in restoring the alveolar epithelial barrier and promoting fluid clearance, providing benefits specifically for COVID-19 patients with ARDS.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Physiology
Antonio G. Soares, Jorge Contreras, Crystal R. Archer, Elena Mironova, Rebecca Berdeaux, James D. Stockand, Tarek Mohamed Abd El-Aziz
Summary: The study demonstrates that targeted activation of Gs signaling exclusively in renal principal cells (PC) is sufficient to increase ENaC activity and decrease urinary sodium excretion in live animals.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Safa Kinaneh, Yara Knany, Emad E. Khoury, Reem Ismael-Badarneh, Shadi Hamoud, Gidon Berger, Zaid Abassi, Zaher S. Azzam
Summary: This study identified three NHE isoforms in alveolar epithelial cells (AECs) and A549 cell line, with NHE8 primarily located on the apical membrane of AEC. Treatment with Angiotensin II (Ang II) decreased NHE8 protein levels in A549 cells and had varying effects on NHE8 abundance in rats with congestive heart failure (CHF).
Article
Biochemistry & Molecular Biology
Rossana Visigalli, Bianca Maria Rotoli, Francesca Ferrari, Maria Di Lascia, Benedetta Riccardi, Paola Puccini, Valeria Dall'Asta, Amelia Barilli
Summary: In this study, the expression and activity of ABC transporters in human alveoli were analyzed. The results showed that MRP1 was the only transporter expressed and functional at the basolateral side, while the other studied transporters were not expressed on the apical membrane. This suggests the presence of unidentified transporters involved in drug efflux from alveolar epithelium.
Review
Physiology
Nati Hernando, Kenneth Gagnon, Eleanor Lederer
Summary: Phosphate is essential for life, playing a critical role in bone formation, cell signaling, and mineralization. It is tightly regulated in the serum and body, and transportation of phosphate is mediated by specific families of proteins, each with unique functions and tissue expression. Further research is needed to fully understand the function, regulation, and coordination of these phosphate transporters.
PHYSIOLOGICAL REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Vitalii Kryvenko, Miriam Wessendorf, Khodr Tello, Susanne Herold, Rory E. Morty, Werner Seeger, Istvan Vadasz
Summary: Elevated CO2 levels lead to rapid decrease of NKA-beta abundance in the ER and cell surface, potentially through activation of IRE1 alpha and promotion of ERAD. Calcium-dependent mechanisms may be involved in the hypercapnia-induced phosphorylation of IRE1 alpha, suggesting a role of Ca2+ efflux in ERAD of NKA-beta.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Cell Biology
Jian Deng, Shao-Hua Wang, Xue-Mei Zheng, Zan-Mei Tang
Summary: The study showed that CGRP can promote cell viability and inhibit hyperoxia-induced transdifferentiation of AECII, reducing oxidative injury and inflammation. Additionally, CGRP activates the Notch signaling pathway, promoting structural and functional regeneration.
Article
Immunology
Hao-Ran Xu, Qian Yang, Shu-Yang Xiang, Pu-Hong Zhang, Yang Ye, Yan Chen, Ke-Wen Xu, Xi-Ya Ren, Hong-Xia Mei, Chen-Xi Shen, Hong-Yu Ma, Fang-Gao Smith, Sheng-Wei Jin, Qian Wang
Summary: In summary, rosuvastatin showed potential in the management of ALI/ARDS by improving alveolar fluid clearance through increasing sodium channel and Na, K-ATPase protein expression, and regulating alveolar fluid clearance through the PI3K/AKT/Nedd4-2 pathway.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Critical Care Medicine
Wang Deng, Di Qi, Xu-Mao Tang, Xin-Yu Deng, Jing He, Dao-Xin Wang
Summary: The study demonstrated that the WNK4/SPAK signaling pathway improved alveolar fluid clearance in LPS-induced ARDS by upregulating ENaC and reducing pulmonary edema, resulting in enhanced survival rate.
Article
Biochemistry & Molecular Biology
Amelia Barilli, Rossana Visigalli, Francesca Ferrari, Maria Di Lascia, Benedetta Riccardi, Paola Puccini, Valeria Dall'Asta, Bianca Maria Rotoli
Summary: The alveolar epithelium plays key roles in gas exchange, surfactant production, host defense, and inflammation, with pathological conditions including ARDS, asthma, COPD, and IPF. In vitro models of human alveolar epithelium are essential for studying disease mechanisms and pharmacokinetics of pulmonary drug delivery. The EpiAlveolar (TM) model shows promise as a tool for screening biopharmaceuticals molecules due to its similarities with tracheal/bronchial epithelium.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Cell Biology
Jessica L. Christenson, Michelle M. Williams, Jennifer K. Richer
Summary: The alveolar epithelium plays a significant role in the progression of metastatic cancer, not only influencing the site of metastasis within the lungs but also impacting metastatic progression through interactions with surrounding cells.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Masashi Kawami, Shinnosuke Takenaka, Yuri Kadekaru, Mizuki Akai, Takashi Konaka, Ryoko Yumoto, Mikihisa Takano
Summary: Studies suggest that EMT may occur before pulmonary fibrosis in alveolar epithelial cells, and miR-222 could be a potential marker for early prediction of pulmonary fibrosis.
Article
Critical Care Medicine
Roxana Wasnick, Martina Korfei, Katarzyna Piskulak, Ingrid Henneke, Jochen Wilhelm, Poornima Mahavadi, Ruth Charlotte Dartsch, Daniel von der Beck, Miriam Koch, Irina Shalashova, Astrid Weiss, Oleksiy Klymenko, Ingolf Askevold, Ludger Fink, Heiko Witt, Holger Hackstein, Elie El Agha, Saverio Bellusci, Walter Klepetko, Melanie Koenigshoff, Oliver Eickelberg, Ralph Theo Schermuly, Thomas Braun, Werner Seeger, Clemens Ruppert, Andreas Guenther
Summary: This study reveals that Notch signaling plays a crucial role in the proliferation and dedifferentiation of type II alveolar epithelial cells (AEC2s), as well as the development of lung fibrosis in idiopathic pulmonary fibrosis (IPF).
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Vitalii Kryvenko, Andres Alberro-Brage, Athanasios Fysikopoulos, Miriam Wessendorf, Khodr Tello, Rory E. Morty, Susanne Herold, Werner Seeger, Christos Samakovlis, Istvan Vadasz
Summary: A study investigated the mechanisms of cellular albumin uptake in a three-dimensional culture of precision-cut lung slices (PCLS). The study found that PCLS cells incorporate labeled albumin in a time- and concentration-dependent manner and identified a receptor-driven internalization process for albumin uptake. The findings highlight the potential for improving outcomes in patients with respiratory failure through pulmonary drug delivery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Manuel J. Richter, Federico Fortuni, Fawaz Alenezi, Michele D'Alto, Roberto Badagliacca, Nathan W. Brunner, Arie P. van Dijk, Philipp Douschan, Henning Gall, Stefano Ghio, Francesco Lo Giudice, Ekkehard Grunig, Francois Haddad, Luke Howard, Sudarshan Rajagopal, Niels Stens, Davide Stolfo, Dick H. J. Thijssen, Carmine Dario Vizza, Roham T. Zamanian, Liang Zhong, Werner Seeger, Hossein A. Ghofrani, Khodr Tello
Summary: A meta-analysis of 35 studies found that right atrial (RA) imaging assessment is a relevant prognostic marker in patients with pulmonary hypertension (PH). RA area, RA indexed area, RA peak longitudinal strain, and RA total emptying fraction were significantly associated with combined end-points including death, clinical worsening, and/or lung transplantation. RA volume and volume index showed marginal significant associations.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
William G. Herrington, Natalie Staplin, Christoph Wanner, Jennifer B. Green, Sibylle J. Hauske, Jonathan R. Emberson, David Preiss, Parminder Judge, Kaitlin J. Mayne, Sarah Y. A. Ng, Emily Sammons, Doreen Zhu, Michael Hill, Will Stevens, Karl Wallendszus, Susanne Brenner, Alfred K. Cheung, Zhi-Hong Liu, Jing Li, Lai Seong Hooi, Wen Liu, Takashi Kadowaki, Masaomi Nangaku, Adeera Levin, David Cherney, Aldo P. Maggioni, Roberto Pontremoli, Rajat Deo, Shinya Goto, Xavier Rossello, Katherine R. Tuttle, Dominik Steubl, Michaela Petrini, Dan Massey, Jens Eilbracht, Martina Brueckmann, Martin J. Landray, Colin Baigent, Richard Haynes
Summary: Empagliflozin therapy reduces the risk of disease progression or cardiovascular death in patients with chronic kidney disease.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Respiratory System
Katharina Schaefer, Khodr Tello, Oleg Pak, Manuel Richter, Mareike Gierhardt, Grazyna Kwapiszewska, Christine Veith, Ludger Fink, Henning Gall, Matthias Hecker, Baktybek Kojonazarov, Simone Kraut, Kevin Lo, Jochen Wilhelm, Friedrich Grimminger, Werner Seeger, Ralph T. Schermuly, Hossein A. Ghofrani, Daniel Zahner, Rudiger Gerstberger, Norbert Weissmann, Akylbek Sydykov, Natascha Sommer
Summary: BDNF levels are decreased in patients with pulmonary hypertension and negatively correlated with right ventricular dilatation. However, decreased BDNF levels do not worsen RV dilatation in animal models.
Article
Urology & Nephrology
Esther N. M. de Rooij, Johan W. de Fijter, Saskia Le Cessie, Ewout J. Hoorn, Kitty J. Jager, Nicholas C. Chesnaye, Marie Evans, Karin Windahl, Fergus J. Caskey, Claudia Torino, Maciej Szymczak, Christiane Drechsler, Christoph Wanner, Friedo W. Dekker, Ellen K. Hoogeveen
Summary: This study found a U-shaped relationship between serum potassium and the risk of death or initiation of kidney replacement therapy in patients with stage 4-5 chronic kidney disease, with the lowest risk observed at a potassium level of approximately 4.9 mmol/L.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Infectious Diseases
Yanyan Shi, Ralf Strobl, Christian Apfelbacher, Thomas Bahmer, Ramsia Geisler, Peter Heuschmann, Anna Horn, Hanno Hoven, Thomas Keil, Michael Krawczak, Lilian Krist, Christina Lemhoefer, Wolfgang Lieb, Bettina Lorenz-Depiereux, Rafael Mikolajczyk, Felipe A. Montellano, Jens Peter Reese, Stefan Schreiber, Nicole Skoetz, Stefan Stoerk, Jorg Janne Vehreschild, Martin Witzenrath, Eva Grill
Summary: This study aimed to assess symptoms in patients after SARS-CoV-2 infection and identify factors predicting prolonged time to symptom-free. The results showed that over half of the participants still reported COVID-19-related symptoms 9 months after infection. Symptom persistence was predominantly determined by participant characteristics that are difficult to modify.
Article
Medicine, General & Internal
Fritz C. Roller, Armin Schuessler, Nils Kremer, Sebastian Harth, Steffen D. Kriechbaum, Christoph B. Wiedenroth, Stefan Guth, Andreas Breithecker, Manuel Richter, Khodr Tello, Werner Seeger, Eckhard Mayer, Gabriele A. Krombach
Summary: The aim of this study was to assess the RV and LV blood pool T1 and T2 values in CTEPH patients and their correlation to pulmonary hemodynamic. Results showed that compared to control subjects, CTEPH patients had significantly reduced RV T2 values, which increased significantly after balloon pulmonary angioplasty. RV T2 values were positively correlated with hemodynamic measures. Therefore, RV T2 mapping can be a novel non-invasive CMR imaging marker for assessing disease severity, prognosis, follow-up, and therapy monitoring in PH.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Athiththan Yogeswaran, Manuel J. Richter, Faeq Husain-Syed, Zvonimir Rako, Natascha Sommer, Friedrich Grimminger, Werner Seeger, Hossein Ardeschir Ghofrani, Henning Gall, Khodr Tello
Summary: In patients with idiopathic pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension, estimated plasma volume status is associated with central venous congestion and prognosis. Patients with high estimated plasma volume status and without edema have a poorer transplant-free survival rate, which may represent an under-recognized subgroup.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Baktybek Kojonazarov, Norbert Weissmann, Werner Seeger, Ralph Theo Schermuly
CARDIOLOGY JOURNAL
(2023)
Article
Infectious Diseases
Fridolin Steinbeis, Charlotte Thibeault, Sarah Steinbrecher, Yvonne Ahlgrimm, Ira An Haack, Dietrich August, Beate Balzuweit, Carla Bellinghausen, Sarah Berger, Irina Chaplinskaya-Sobol, Oliver Cornely, Patrick Doeblin, Matthias Endres, Claudia Fink, Carsten Finke, Sandra Frank, Sabine Hanss, Tim Hartung, Johannes Christian Hellmuth, Susanne Herold, Peter Heuschmann, Jan Heyckendorf, Ralf Heyder, Stefan Hippenstiel, Wolfgang Hoffmann, Sebastian Ulrich Kelle, Philipp Knape, Philipp Koehler, Lucie Kretzler, David Manuel Leistner, Jasmin Lienau, Roberto Lorbeer, Bettina Lorenz-Depiereux, Constanze Dorothea Luettke, Knut Mai, Uta Merle, Lil Antonia Meyer-Arndt, Olga Miljukov, Maximilian Muenchhoff, Moritz Mueller-Plathe, Julia Neuhann, Hannelore Neuhauser, Alexandra Nieters, Christian Otte, Daniel Pape, Rafaela Maria Pinto, Christina Pley, Annett Pudszuhn, Philipp Reuken, Siegberg Rieg, Petra Ritter, Gernot Rohde, Maria Roennefarth, Michael Ruzicka, Jens Schaller, Anne Schmidt, Sein Schmidt, Verena Schwachmeyer, Georg Schwanitz, Werner Seeger, Dana Stahl, Nicole Stobaeus, Hans Christian Stubbe, Norbert Suttorp, Bettina Temmesfeld, Sylvia Thun, Paul Triller, Frederik Trinkmann, Istvan Vadasz, Heike Valentin, Maria Vehreschild, Christof von Kalle, Marie von Lilienfeld-Toal, Joachim Weber, Tobias Welte, Christian Wildberg, Robert Wizimirski, Saskia Zvork, Leif Erik Sander, Janne Vehreschild, Thomas Zoller, Florian Kurth, Martin Witzenrath
Summary: The NAPKON-HAP study is a multi-centered observational study aimed at providing comprehensive data and biospecimen collection for the investigation of the pathophysiology and pathology of COVID-19. It will contribute significant scientific insights and high-quality data to aid researchers in understanding the acute and long-term outcomes of the disease.
Article
Immunology
Andres Alberro-Brage, Vitalii Kryvenko, Christina Malainou, Stefan Guenther, Rory E. Morty, Werner Seeger, Susanne Herold, Christos Samakovlis, Istvan Vadasz
Summary: Acute respiratory distress syndrome (ARDS) is a common complication of influenza virus (IV) infection, which leads to the accumulation and impairment of alveolar protein. It has been found that IV infection inhibits the clearance of alveolar protein, possibly through upregulation of a proteinase called MMP. In addition, inhibition of MMP proteinase may improve the clearance of alveolar protein and thus provide a potential therapeutic approach for ARDS.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Dirk Bandorski, Khodr Tello, Harun Erdal, Janine Sommerlad, Jochen Wilhelm, Istvan Vadasz, Matthias Hecker, Dieter Walmrath, Werner Seeger, Ekaterina Krauss, Stefan Kuhnert
Summary: This study evaluates the diagnostic value of gastric biomarkers, such as pepsin and bile acid, in detecting aspiration in the intensive care unit (ICU). The results indicate that measuring pepsin and bile acid does not reliably diagnose aspiration or significantly impact survival outcomes. Further validation studies are needed to assess the clinical usefulness and reliability of these biomarkers in diagnosing aspiration-related conditions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Dharmesh V. Hirani, Florian Thielen, Siavash Mansouri, Soula Danopoulos, Christina Vohlen, Pinar Haznedar-Karakaya, Jasmine Mohr, Rebecca Wilke, Jaco Selle, Thomas Grosch, Ivana Mizik, Margarete Odenthal, Cristina M. Alvira, Celien Kuiper-Makris, Gloria S. Pryhuber, Christian Pallasch, S. van Koningsbruggen-Rietschel, Denise Al-Alam, Werner Seeger, Rajkumar Savai, Joerg Doetsch, Miguel A. Alejandre Alcazar
Summary: Through experimental and clinical studies, it has been discovered that macrophage-derived CXCL10 plays a crucial role in the pathogenesis of BPD by causing macrophage chemotaxis through CXCR3, leading to lung fibrosis and alveolarization arrest. Targeting the CXCL10-CXCR3 axis could offer a new therapeutic approach for BPD.
INFLAMMATION AND REGENERATION
(2023)
Letter
Urology & Nephrology
Hristos Karakizlis, Vipul Agarwal, Mostafa Aly, Kevin Strecker, Benjamin Csala, Isla Esso, Jiangping Chen, Christian Nahrgang, Martin Wolter, Heiko Slanina, Christian G. Schuettler, Soenke Jessen, Claudio Ronco, Werner Seeger, Rolf Weimer, Martina Sester, Horst-Walter Birk, Faeq Husain-Syed
JOURNAL OF NEPHROLOGY
(2023)