Review
Immunology
Marietta M. Ravesloot-Chavez, Erik Van Dis, Sarah A. Stanley
Summary: Infection with Mycobacterium tuberculosis causes a significant number of deaths annually worldwide, where the role of innate immune cells and the inflammatory response in the infection process are crucial yet complex.Understanding the balance of cell-intrinsic control and inflammation regulation is essential for developing effective therapeutics and vaccines.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 39
(2021)
Article
Biochemistry & Molecular Biology
Fuzhen Zhang, Shanshan Yu, Qiyao Chai, Jing Wang, Tuoya Wu, Rongmei Liu, Yi Liu, Cui Hua Liu, Yu Pang
Summary: Research has shown that TB resisters exhibit higher immune responses and lower intracellular bacterial loads upon infection, largely dependent on the specific immune factor HDAC6.
Article
Immunology
Jean-Yves Dube, Fiona McIntosh, Marcel A. Behr
Summary: Pattern recognition receptors Mincle and NOD2 are associated with mycobacterial immunity, but single gene knockout studies have shown mild phenotypes. Researchers hypothesized that dual knockout of Mincle and Nod2 would result in a more severe immune phenotype, but the results showed no further effect compared to Nod2 knockout alone.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ruoqiong Cao, Afsal Kolloli, Ranjeet Kumar, James Owens, Kayvan Sasaninia, Charles Vaughn, Mohkam Singh, Edward Truong, Nala Kachour, Abrianna Beever, Wael Khamas, Selvakumar Subbian, Vishwanath Venketaraman
Summary: In an in vivo mouse model of active M. tb infection, diethyl maleate (DEM)-induced glutathione (GSH) deficiency led to increased oxidative stress, impaired granuloma response, and increased M. tb survival. These findings provide insights into how GSH deficiency can interfere with the control of M. tb infection.
APPLIED SCIENCES-BASEL
(2021)
Article
Immunology
Noemi Rebecca Meier, Thomas M. Sutter, Marc Jacobsen, Tom H. M. Ottenhoff, Julia E. Vogt, Nicole Ritz
Summary: This study aimed to identify optimal antigen-cytokine combinations using machine learning algorithms to improve immunodiagnostic assays for tuberculosis in children. The results revealed that novel Mycobacterium tuberculosis antigens had the potential to enhance the accuracy of diagnostic tests.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ming Kuang, Yingchi Zhao, Haitao Yu, Siji Li, Tianyi Liu, Luoying Chen, Jingxuan Chen, Yujie Luo, Xuefei Guo, Xuemei Wei, Yunfei Li, Zeming Zhang, Dandan Wang, Fuping You
Summary: XAF1 acts as an epigenetic regulator that promotes the opening of chromatin and activation of antiviral immunity by targeting TRIM28 during infection. It de-SUMOylates TRIM28, leading to increased accessibility of the chromatin and robust induction of antiviral genes. XAF1 deficiency renders mice susceptible to RNA viruses due to impaired induction of antiviral genes.
Article
Immunology
Phillip Ssekamatte, Marjorie Nakibuule, Rose Nabatanzi, Moses Egesa, Carol Musubika, Mudarshiru Bbuye, Matthew R. Hepworth, Derek G. Doherty, Stephen Cose, Irene Andia Biraro
Summary: The study showed that patients with LTBI and T2DM, as well as T2DM patients, had slight alterations in ILC immune responses, and poor T2DM control also slightly changed these immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jean-Yves Dube, Vinicius M. Fava, Erwin Schurr, Marcel A. Behr
Summary: Human genetic control plays a significant role in Mycobacterium tuberculosis infection outcomes, with genetic variation affecting immunoreactivity and tuberculosis disease. Pattern recognition receptors (PRRs) help facilitate the interaction between humans and Mtb, although they are less critical for infection outcomes compared to effector molecules like IFN-gamma. Redundancy in the innate immune system may contribute to PRRs playing a more subtle role in limiting the pathogen.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Tesia L. Cleverley, Siri Peddineni, Jeannette Guarner, Francesca Cingolani, Pamela K. Garcia, Heather Koehler, Edward S. Mocarski, Daniel Kalman
Summary: Infections caused by MTC and NTM can lead to widespread morbidity and mortality. Imatinib mesylate may be a new therapeutic approach for mycobacterial infections, reducing lesion size and inflammation, accelerating immune response, and inhibiting granuloma formation and growth, thereby mitigating lung damage and morbidity.
Review
Biochemistry & Molecular Biology
Mohd Hatimi Tukiman, Mohd Nor Norazmi
Summary: Tuberculosis remains a major threat to global public health. This review seeks to explore the mucosal immunometabolism of resident effector cells in response to Mtb infection and how Mtb manipulates them for its survival and growth, with the aim of filling knowledge gaps and potentially contributing to future vaccination and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Na Zhang, Fei Wang, Gaomeng Zhang, Qi Zhang, Yuhong Liu, Qiao Wang, Mohamed Shafey Elsharkawy, Maiqing Zheng, Jie Wen, Guiping Zhao, Qinghe Li
Summary: Toll-like receptors (TLRs) are important immune sensors involved in host defense. In this study, the researchers discovered that the deubiquitinase USP7 interacts with MyD88 protein, regulating its expression and participating in bacteria-induced inflammation. This finding contributes to our understanding of the regulatory mechanisms in immune signaling.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ye-yu Li, Han-Mei Liu, Decheng Wang, Yan Lu, Cairong Ding, Li-Shuang Zhou, Xiang-Yang Wu, Zi-Wei Zhou, Shu-qin Xu, Chen Lin, Lian-Hua Qin, Yao Li, Jun Liu, Hai-Peng Liu, Lu Zhang
Summary: The study found that the AG of Mycobacterium can suppress host immune responses and enhance bacterial intracellular proliferation. The arabinose chains of AG have a greater impact on the virulence and pathogenicity of Mycobacterium.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Poornima Sankar, Bibhuti Bhusan Mishra
Summary: Tuberculosis remains a global health challenge, causing a significant number of deaths every year. The interaction between Mycobacterium tuberculosis and innate immune cells, such as macrophages and dendritic cells, plays a crucial role in the host defense against the infection. However, our understanding of these interactions is still limited. This review focuses on exploring the early host-pathogen interactions and the contribution of various innate immune cells and mucosal barrier in tuberculosis immunity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Sandra Wuest, Paulina Schad, Sandy Burkart, Marco Binder
Summary: The study revealed the crucial roles of IRF3 and IRF9 in establishing the antiviral state of the cell, while IRF1, 5 and 7 were relatively dispensable.
Article
Immunology
Darragh Duffy, Elisa Nemes, Alba Llibre, Vincent Rouilly, Munyaradzi Musvosvi, Nikaia Smith, Elizabeth Filander, Hadn Africa, Simbarashe Mabwe, Lungisa Jaxa, Bruno Charbit, Humphrey Mulenga, Michele Tameris, Gerhard Walzl, Stephanus Malherbe, Stephanie Thomas, Mark Hatherill, Nicole Bilek, Thomas J. Scriba, Matthew L. Albert
Summary: TruCulture method can effectively distinguish active tuberculosis from latent infection by stimulating blood samples, providing a more accurate diagnosis for TB cases. The ratio between Mtb antigen and BCG IFN can further improve the stratification of TB diagnosis.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Oncology
Yu-Chen Enya Chen, Melinda Burgess, Sally Mapp, Peter Mollee, Devinder Gill, Antje Blumenthal, Nicholas A. Saunders
Article
Cell Biology
Kaustav Das Gupta, Melanie R. Shakespear, James E. B. Curson, Ambika M. V. Murthy, Abishek Iyer, Mark P. Hodson, Divya Ramnath, Vikas A. Tillu, Jessica B. von Pein, Robert C. Reid, Kathryn Tunny, Daniel M. Hohenhaus, Shayli Varasteh Moradi, Gregory M. Kelly, Takumi Kobayashi, Jennifer H. Gunter, Alexander J. Stevenson, Weijun Xu, Lin Luo, Alun Jones, Wayne A. Johnston, Antje Blumenthal, Kirill Alexandrov, Brett M. Collins, Jennifer L. Stow, David P. Fairlie, Matthew J. Sweet
Review
Chemistry, Medicinal
Brooke Benner, Logan Good, Dionisia Quiroga, Thomas E. Schultz, Mahmoud Kassem, William E. Carson, Mathew A. Cherian, Sagar Sardesai, Robert Wesolowski
DRUG DESIGN DEVELOPMENT AND THERAPY
(2020)
Article
Chemistry, Organic
Osama G. Mohamed, Zeinab G. Khalil, Angela A. Salim, Hui Cui, Antje Blumenthal, Robert J. Capon
Summary: Cultivation profiling of Streptomyces lincolnensis led to the discovery of four new isomeric bianthracenes, lincolnenins A-D, with relative stereostructures determined by detailed spectroscopic analysis. Lincolnenins A and B exhibit restricted rotation, while C and D are thermally interconvertible atropisomers. Lincolnenin A showed significant bactericidal activity against various drug-resistant Gram-positive pathogens.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Microbiology
Giorgia Mori, Mark Morrison, Antje Blumenthal
Summary: This article discusses the impact of the microbiota on tuberculosis susceptibility, manifestation, and progression, as well as its potential as a target for clinical manipulation.
Article
Cell Biology
Leslie C. Domi'nguez Cadena, Thomas E. Schultz, Alina Zamoshnikova, Meg L. Donovan, Carmen D. Mathmann, Chien-Hsiung Yu, Giorgia Mori, Jennifer L. Stow, Antje Blumenthal
Summary: The study demonstrates that Rab6b plays a positive regulatory role in promoting TNF release induced by M. bovis BCG infection in macrophages, localized to the Golgi complex. These findings help to elucidate the molecular mechanisms of Rab6b in regulating inflammatory cytokine responses in macrophages.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Article
Immunology
Roma Sinha, Minh Dao Ngo, Stacey Bartlett, Helle Bielefeldt-Ohmann, Sahar Keshvari, Sumaira Z. Hasnain, Meg L. Donovan, Jessica C. Kling, Antje Blumenthal, Chen Chen, Kirsty R. Short, Katharina Ronacher
Summary: This study found that pre-diabetes increases susceptibility to TB, while a high body mass index without dysglycemia is protective. The murine model established in this study provides an opportunity to further study the underlying immunological, metabolic, and endocrine mechanisms of this association.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Oncology
Leeann Geraghty, Thomas E. Schultz, Sarah E. Hoffman, Kyle Porter, Majd Issa, Vidhya Karivedu, Marcelo Bonomi
Summary: The study found that weekly PCC had a lower risk of G3/4 toxicity and better overall efficacy compared to PCC administered every 3 weeks in patients with recurrent/metastatic squamous cell carcinoma of the head and neck.
MOLECULAR AND CLINICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Alicia S. Wilson, Katrina L. Randall, Jessica A. Pettitt, Julia Ellyard, Antje Blumenthal, Anselm Enders, Benjamin J. Quah, Tobias Bopp, Christopher R. Parish, Anne Bruestle
Summary: This study reveals the mechanism by which neutrophil extracellular traps (NETs) directly activate T cells and specifically enhance Th17 cell differentiation. This suggests a direct link between neutrophils, NETs, and T cell autoimmunity.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Meg L. Donovan, Helle Bielefeldt-Ohmann, Rachel F. Rollo, Stephen J. McPherson, Thomas E. Schultz, Giorgia Mori, Jessica C. Kling, Antje Blumenthal
Summary: In this study, the researchers used a mouse model to investigate the role of TLR2 and RP105 in the formation and architecture of tuberculosis granulomas. They found that TLR2 and RP105 play important roles in controlling the extent and spatial positioning of lung pathology in tuberculosis infection. The researchers also observed that TLR2 and RP105 have different functions in different strains of Mycobacterium tuberculosis. This study highlights the significance of TLRs as molecular determinants of tuberculosis granuloma formation and architecture.
Article
Health Care Sciences & Services
Adrian C. Mattke, Kerry Johnson, Kristen Gibbons, Debbie Long, Jeremy Robertson, Prem S. Venugopal, Antje Blumenthal, Andreas Schibler, Luregn Schlapbach
Summary: This article describes a study on the feasibility and safety of mixing nitric oxide (NO) into extracorporeal membrane oxygenation (ECMO) systems. The study aims to assess the impact of NO on inflammation and coagulation system activation during ECMO support. The goal is to improve outcomes for children receiving ECMO treatment.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Microbiology
Rachel F. Rollo, Giorgia Mori, Timothy A. Hill, Doris Hillemann, Stefan Niemann, Susanne Homolka, David P. Fairlie, Antje Blumenthal
Summary: Shorter and more effective treatment regimens as well as new drugs are urgently needed to reduce the global burden of tuberculosis (TB). This study discovered a new compound called wollamide B1, which has antimycobacterial activity and can synergize with existing TB antibiotics, enhancing their effectiveness. Wollamide B1 also remains effective against drug-resistant TB strains.
MICROBIOLOGY SPECTRUM
(2023)
