Interleukin-25 Produced by Synoviocytes Has Anti-inflammatory Effects by Acting As a Receptor Antagonist for Interleukin-17A Function

IL-25 attenuates rheumatoid arthritis through suppression of Th17 immune responses in an IL-13-dependent manner

(2016) Dan Liu et al.   Scientific Reports

A cell-based bioassay for circulating bioactive IL-17: application to destruction in rheumatoid arthritis

(2015) Ndiémé Ndongo-Thiam et al.   ANNALS OF THE RHEUMATIC DISEASES

Identification of Functional Roles for Both IL-17RB and IL-17RA in Mediating IL-25-Induced Activities

(2014) E. A. Rickel et al.   JOURNAL OF IMMUNOLOGY

Neutrophils produce interleukin-17B in rheumatoid synovial tissue

(2013) V.-P. Kouri et al.   RHEUMATOLOGY

A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-IL-17R antibody, in methotrexate-resistant rheumatoid arthritis

(2013) David A Martin et al.   ARTHRITIS RESEARCH & THERAPY

Bone marrow-derived and synovium-derived mesenchymal cells promote Th17 cell expansion and activation through caspase 1 activation: Contribution to the chronicity of rheumatoid arthritis

(2012) Assia Eljaafari et al.   ARTHRITIS AND RHEUMATISM

Targeting IL-17 and TH17 cells in chronic inflammation

(2012) Pierre Miossec et al.   NATURE REVIEWS DRUG DISCOVERY

T-helper cell type 2 (Th2) memory T cell-potentiating cytokine IL-25 has the potential to promote angiogenesis in asthma

(2011) C. J. Corrigan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changes and significance of IL-25 in chicken collagen II-induced experimental arthritis (CIA)

(2011) Wang Kaiwen et al.   RHEUMATOLOGY INTERNATIONAL

Inhibitory Effect of Recombinant IL-25 on the Development of Dextran Sulfate Sodium-Induced Experimental Colitis in Mice

(2010) S S Salum Mchenga et al.   Cellular & Molecular Immunology

Interleukin-25 production is differently regulated by TNF-α and TGF-β1 in the human gut

(2010) D Fina et al.   Mucosal Immunology

Role of Interleukin 17 in Arthritis Chronicity through Survival of Synoviocytes via Regulation of Synoviolin Expression

(2010) Myew-Ling Toh et al.   PLoS One

Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

(2010) W. Hueber et al.   Science Translational Medicine

Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3

(2009) R. Caruso et al.   BLOOD

Inhibition of Th17 Cells Regulates Autoimmune Diabetes in NOD Mice

(2009) J. A. Emamaullee et al.   DIABETES

Interleukin-25 Inhibits Interleukin-12 Production and Th1 Cell-Driven Inflammation in the Gut

(2009) Roberta Caruso et al.   GASTROENTEROLOGY

Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis

(2009) Beatrix Bartok et al.   IMMUNOLOGICAL REVIEWS

Interleukin-25 Expressed by Brain Capillary Endothelial Cells Maintains Blood-Brain Barrier Function in a Protein Kinase Cϵ-dependent Manner

(2009) Yoshifumi Sonobe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pulmonary IL-17E (IL-25) Production and IL-17RB+ Myeloid Cell-Derived Th2 Cytokine Production Are Dependent upon Stem Cell Factor-Induced Responses during Chronic Allergic Pulmonary Disease

(2009) V. Dolgachev et al.   JOURNAL OF IMMUNOLOGY

Interleukin-17 and Type 17 Helper T Cells

(2009) Pierre Miossec et al.   NEW ENGLAND JOURNAL OF MEDICINE

T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis

(2008) Chris J. Hedegaard et al.   IMMUNOLOGY

Commensal-dependent expression of IL-25 regulates the IL-23–IL-17 axis in the intestine

(2008) Colby Zaph et al.   JOURNAL OF EXPERIMENTAL MEDICINE